KEGG   Rhinolophus ferrumequinum (greater horseshoe bat): 117035064
Entry
117035064         CDS       T07722                                 
Symbol
PIK3CA
Name
(RefSeq) phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
  KO
K00922  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
Organism
rfq  Rhinolophus ferrumequinum (greater horseshoe bat)
Pathway
rfq00562  Inositol phosphate metabolism
rfq01100  Metabolic pathways
rfq01521  EGFR tyrosine kinase inhibitor resistance
rfq01522  Endocrine resistance
rfq01524  Platinum drug resistance
rfq04012  ErbB signaling pathway
rfq04014  Ras signaling pathway
rfq04015  Rap1 signaling pathway
rfq04024  cAMP signaling pathway
rfq04062  Chemokine signaling pathway
rfq04066  HIF-1 signaling pathway
rfq04068  FoxO signaling pathway
rfq04070  Phosphatidylinositol signaling system
rfq04071  Sphingolipid signaling pathway
rfq04072  Phospholipase D signaling pathway
rfq04081  Hormone signaling
rfq04140  Autophagy - animal
rfq04150  mTOR signaling pathway
rfq04151  PI3K-Akt signaling pathway
rfq04152  AMPK signaling pathway
rfq04210  Apoptosis
rfq04211  Longevity regulating pathway
rfq04213  Longevity regulating pathway - multiple species
rfq04218  Cellular senescence
rfq04360  Axon guidance
rfq04370  VEGF signaling pathway
rfq04380  Osteoclast differentiation
rfq04510  Focal adhesion
rfq04550  Signaling pathways regulating pluripotency of stem cells
rfq04611  Platelet activation
rfq04613  Neutrophil extracellular trap formation
rfq04620  Toll-like receptor signaling pathway
rfq04625  C-type lectin receptor signaling pathway
rfq04630  JAK-STAT signaling pathway
rfq04650  Natural killer cell mediated cytotoxicity
rfq04660  T cell receptor signaling pathway
rfq04662  B cell receptor signaling pathway
rfq04664  Fc epsilon RI signaling pathway
rfq04666  Fc gamma R-mediated phagocytosis
rfq04668  TNF signaling pathway
rfq04670  Leukocyte transendothelial migration
rfq04722  Neurotrophin signaling pathway
rfq04725  Cholinergic synapse
rfq04750  Inflammatory mediator regulation of TRP channels
rfq04810  Regulation of actin cytoskeleton
rfq04910  Insulin signaling pathway
rfq04914  Progesterone-mediated oocyte maturation
rfq04915  Estrogen signaling pathway
rfq04917  Prolactin signaling pathway
rfq04919  Thyroid hormone signaling pathway
rfq04923  Regulation of lipolysis in adipocytes
rfq04926  Relaxin signaling pathway
rfq04929  GnRH secretion
rfq04930  Type II diabetes mellitus
rfq04931  Insulin resistance
rfq04932  Non-alcoholic fatty liver disease
rfq04933  AGE-RAGE signaling pathway in diabetic complications
rfq04935  Growth hormone synthesis, secretion and action
rfq04960  Aldosterone-regulated sodium reabsorption
rfq04973  Carbohydrate digestion and absorption
rfq05010  Alzheimer disease
rfq05017  Spinocerebellar ataxia
rfq05020  Prion disease
rfq05100  Bacterial invasion of epithelial cells
rfq05132  Salmonella infection
rfq05135  Yersinia infection
rfq05142  Chagas disease
rfq05146  Amoebiasis
rfq05160  Hepatitis C
rfq05161  Hepatitis B
rfq05162  Measles
rfq05163  Human cytomegalovirus infection
rfq05164  Influenza A
rfq05165  Human papillomavirus infection
rfq05166  Human T-cell leukemia virus 1 infection
rfq05167  Kaposi sarcoma-associated herpesvirus infection
rfq05168  Herpes simplex virus 1 infection
rfq05169  Epstein-Barr virus infection
rfq05170  Human immunodeficiency virus 1 infection
rfq05171  Coronavirus disease - COVID-19
rfq05200  Pathways in cancer
rfq05203  Viral carcinogenesis
rfq05205  Proteoglycans in cancer
rfq05206  MicroRNAs in cancer
rfq05207  Chemical carcinogenesis - receptor activation
rfq05208  Chemical carcinogenesis - reactive oxygen species
rfq05210  Colorectal cancer
rfq05211  Renal cell carcinoma
rfq05212  Pancreatic cancer
rfq05213  Endometrial cancer
rfq05214  Glioma
rfq05215  Prostate cancer
rfq05218  Melanoma
rfq05220  Chronic myeloid leukemia
rfq05221  Acute myeloid leukemia
rfq05222  Small cell lung cancer
rfq05223  Non-small cell lung cancer
rfq05224  Breast cancer
rfq05225  Hepatocellular carcinoma
rfq05226  Gastric cancer
rfq05230  Central carbon metabolism in cancer
rfq05231  Choline metabolism in cancer
rfq05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
rfq05415  Diabetic cardiomyopathy
rfq05417  Lipid and atherosclerosis
rfq05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:rfq00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    117035064 (PIK3CA)
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    117035064 (PIK3CA)
   04014 Ras signaling pathway
    117035064 (PIK3CA)
   04015 Rap1 signaling pathway
    117035064 (PIK3CA)
   04370 VEGF signaling pathway
    117035064 (PIK3CA)
   04630 JAK-STAT signaling pathway
    117035064 (PIK3CA)
   04668 TNF signaling pathway
    117035064 (PIK3CA)
   04066 HIF-1 signaling pathway
    117035064 (PIK3CA)
   04068 FoxO signaling pathway
    117035064 (PIK3CA)
   04070 Phosphatidylinositol signaling system
    117035064 (PIK3CA)
   04072 Phospholipase D signaling pathway
    117035064 (PIK3CA)
   04071 Sphingolipid signaling pathway
    117035064 (PIK3CA)
   04024 cAMP signaling pathway
    117035064 (PIK3CA)
   04151 PI3K-Akt signaling pathway
    117035064 (PIK3CA)
   04152 AMPK signaling pathway
    117035064 (PIK3CA)
   04150 mTOR signaling pathway
    117035064 (PIK3CA)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    117035064 (PIK3CA)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    117035064 (PIK3CA)
  09143 Cell growth and death
   04210 Apoptosis
    117035064 (PIK3CA)
   04218 Cellular senescence
    117035064 (PIK3CA)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    117035064 (PIK3CA)
   04550 Signaling pathways regulating pluripotency of stem cells
    117035064 (PIK3CA)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    117035064 (PIK3CA)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    117035064 (PIK3CA)
   04613 Neutrophil extracellular trap formation
    117035064 (PIK3CA)
   04620 Toll-like receptor signaling pathway
    117035064 (PIK3CA)
   04625 C-type lectin receptor signaling pathway
    117035064 (PIK3CA)
   04650 Natural killer cell mediated cytotoxicity
    117035064 (PIK3CA)
   04660 T cell receptor signaling pathway
    117035064 (PIK3CA)
   04662 B cell receptor signaling pathway
    117035064 (PIK3CA)
   04664 Fc epsilon RI signaling pathway
    117035064 (PIK3CA)
   04666 Fc gamma R-mediated phagocytosis
    117035064 (PIK3CA)
   04670 Leukocyte transendothelial migration
    117035064 (PIK3CA)
   04062 Chemokine signaling pathway
    117035064 (PIK3CA)
  09152 Endocrine system
   04910 Insulin signaling pathway
    117035064 (PIK3CA)
   04923 Regulation of lipolysis in adipocytes
    117035064 (PIK3CA)
   04929 GnRH secretion
    117035064 (PIK3CA)
   04915 Estrogen signaling pathway
    117035064 (PIK3CA)
   04914 Progesterone-mediated oocyte maturation
    117035064 (PIK3CA)
   04917 Prolactin signaling pathway
    117035064 (PIK3CA)
   04926 Relaxin signaling pathway
    117035064 (PIK3CA)
   04935 Growth hormone synthesis, secretion and action
    117035064 (PIK3CA)
   04919 Thyroid hormone signaling pathway
    117035064 (PIK3CA)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    117035064 (PIK3CA)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    117035064 (PIK3CA)
  09156 Nervous system
   04725 Cholinergic synapse
    117035064 (PIK3CA)
   04722 Neurotrophin signaling pathway
    117035064 (PIK3CA)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    117035064 (PIK3CA)
  09158 Development and regeneration
   04360 Axon guidance
    117035064 (PIK3CA)
   04380 Osteoclast differentiation
    117035064 (PIK3CA)
  09149 Aging
   04211 Longevity regulating pathway
    117035064 (PIK3CA)
   04213 Longevity regulating pathway - multiple species
    117035064 (PIK3CA)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    117035064 (PIK3CA)
   05206 MicroRNAs in cancer
    117035064 (PIK3CA)
   05205 Proteoglycans in cancer
    117035064 (PIK3CA)
   05207 Chemical carcinogenesis - receptor activation
    117035064 (PIK3CA)
   05208 Chemical carcinogenesis - reactive oxygen species
    117035064 (PIK3CA)
   05203 Viral carcinogenesis
    117035064 (PIK3CA)
   05230 Central carbon metabolism in cancer
    117035064 (PIK3CA)
   05231 Choline metabolism in cancer
    117035064 (PIK3CA)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    117035064 (PIK3CA)
  09162 Cancer: specific types
   05210 Colorectal cancer
    117035064 (PIK3CA)
   05212 Pancreatic cancer
    117035064 (PIK3CA)
   05225 Hepatocellular carcinoma
    117035064 (PIK3CA)
   05226 Gastric cancer
    117035064 (PIK3CA)
   05214 Glioma
    117035064 (PIK3CA)
   05221 Acute myeloid leukemia
    117035064 (PIK3CA)
   05220 Chronic myeloid leukemia
    117035064 (PIK3CA)
   05218 Melanoma
    117035064 (PIK3CA)
   05211 Renal cell carcinoma
    117035064 (PIK3CA)
   05215 Prostate cancer
    117035064 (PIK3CA)
   05213 Endometrial cancer
    117035064 (PIK3CA)
   05224 Breast cancer
    117035064 (PIK3CA)
   05222 Small cell lung cancer
    117035064 (PIK3CA)
   05223 Non-small cell lung cancer
    117035064 (PIK3CA)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    117035064 (PIK3CA)
   05170 Human immunodeficiency virus 1 infection
    117035064 (PIK3CA)
   05161 Hepatitis B
    117035064 (PIK3CA)
   05160 Hepatitis C
    117035064 (PIK3CA)
   05171 Coronavirus disease - COVID-19
    117035064 (PIK3CA)
   05164 Influenza A
    117035064 (PIK3CA)
   05162 Measles
    117035064 (PIK3CA)
   05168 Herpes simplex virus 1 infection
    117035064 (PIK3CA)
   05163 Human cytomegalovirus infection
    117035064 (PIK3CA)
   05167 Kaposi sarcoma-associated herpesvirus infection
    117035064 (PIK3CA)
   05169 Epstein-Barr virus infection
    117035064 (PIK3CA)
   05165 Human papillomavirus infection
    117035064 (PIK3CA)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    117035064 (PIK3CA)
   05135 Yersinia infection
    117035064 (PIK3CA)
   05100 Bacterial invasion of epithelial cells
    117035064 (PIK3CA)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    117035064 (PIK3CA)
   05142 Chagas disease
    117035064 (PIK3CA)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    117035064 (PIK3CA)
   05017 Spinocerebellar ataxia
    117035064 (PIK3CA)
   05020 Prion disease
    117035064 (PIK3CA)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    117035064 (PIK3CA)
   05418 Fluid shear stress and atherosclerosis
    117035064 (PIK3CA)
   05415 Diabetic cardiomyopathy
    117035064 (PIK3CA)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    117035064 (PIK3CA)
   04932 Non-alcoholic fatty liver disease
    117035064 (PIK3CA)
   04931 Insulin resistance
    117035064 (PIK3CA)
   04933 AGE-RAGE signaling pathway in diabetic complications
    117035064 (PIK3CA)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    117035064 (PIK3CA)
   01524 Platinum drug resistance
    117035064 (PIK3CA)
   01522 Endocrine resistance
    117035064 (PIK3CA)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:rfq04131]
    117035064 (PIK3CA)
Enzymes [BR:rfq01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     117035064 (PIK3CA)
Membrane trafficking [BR:rfq04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    117035064 (PIK3CA)
SSDB
Motif
Pfam: PI3Ka PI3_PI4_kinase PI3K_C2 PI3K_rbd PI3K_p85B DUF2321 ABC1 Ribosomal_S15
Other DBs
NCBI-GeneID: 117035064
NCBI-ProteinID: XP_032984579
Ensembl: ENSRFEG00010021761
UniProt: A0A671G512
LinkDB
Position
2:complement(64765669..64838248)
AA seq 1068 aa
MPPRPSSGELWGIHLMPPRILVECLLPNGMIVTLECLREATLITIKHELFKEARKYPLHQ
LLQDESSYIFVSVTQEAEREEFFDETRRLCDLRLFQPFLKVIEPVGNREEKILNREIGFA
IGMPVCEFDMVKDPEVQDFRRNILNVCKEAVDLRDLNSPHSRAMYVYPPNVESSPELPKH
IYNKLDKGQIIVVIWVIVSPNNDKQKYTLKINHDCVPEQVIAEAIRKKTRSMLLSSEQLK
LCVLEYQGKYILKVCGCDEYFLEKYPLSQYKYIRSCIMLGRLPNLMLMAKESLYSQLPMD
CFTMPSYSRRISTATPYMNGETSTKSLWVINSALRIKILCATYVNVNIRDIDKIYVRTGI
YHGGEPLCDNVNTQRVPCSNPRWNEWLNYDIYIPDLPRAARLCLSICSVKGRKGAKEEHC
PLAWGNINLFDYTDTLVSGKMALNLWPVPHGLEDLLNPIGVTGSNPNKETPCLELEFDWF
SSVVKFPDMSVIEEHANWSVSREAGFSYSHAGLSNRLARDNELRENDKEQLRAICTRDPL
SEITEQEKDFLWSHRHYCVTIPEILPKLLLSVKWNSRDEVAQMYCLVKDWPPIKPEQAME
LLDCNYPDPMVRGFAVRCLEKYLTDDKLSQYLIQLVQVLKYEQYLDNLLVRFLLKKALTN
QRIGHFFFWHLKSEMHNKTVSQRFGLLLESYCRACGMYLKHLNRQVEAMEKLINLTDILK
QEKKDETQKVQMKFLVEQMRRPDFMDALQGFLSPLNPAHQLGNLRLEECRIMSSAKRPLW
LNWENPDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCLS
IGDCVGLIEVVRSSHTIMQIQCKGGLKGALQFNSHTLHQWLKDKNKGEIYDAAIDLFTRS
CAGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKKKFGYKRERVPFVLTQDF
LIVISKGAQECTKTREFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPELQSFDDIA
YIRKTLALDKTEQEALEYFMKQMNDAHHGGWTTKMDWIFHTIKQHALN
NT seq 3207 nt   +upstreamnt  +downstreamnt
atgcctccaagaccatcatcaggtgaactgtggggcatccacttgatgcccccaagaatc
ctagtggaatgtttactaccaaatggaatgatagtgactttagaatgcctccgtgaggct
accttaataactataaagcatgaactatttaaagaagcaagaaaataccctctccatcaa
cttcttcaagatgaatcttcttacattttcgtaagtgttacccaagaagcagaaagggaa
gaattttttgatgaaacaagacgactttgtgaccttcggctctttcaaccatttttaaaa
gtaattgagccagtaggcaaccgtgaagaaaagatcctcaatcgagaaattggctttgct
atcggcatgccagtgtgtgaatttgatatggttaaagatccagaagtacaggacttccga
agaaatattctgaatgtttgtaaagaagctgtggatcttagggatcttaattcacctcat
agtagagcaatgtatgtctaccctccaaatgtagaatcttcaccagaactgccaaagcac
atatataataaattagataaagggcaaataatagtggtgatttgggtaatagtttctcca
aataatgacaagcagaagtatactctgaaaatcaatcatgactgtgtgccagaacaagta
attgctgaagcaatcaggaaaaaaactcgaagtatgttgctgtcatctgaacaactaaaa
ctttgtgttttagaatatcagggcaagtatattttaaaagtatgtggatgtgatgaatac
ttcctagaaaaatatcctctgagtcagtataagtatataagaagctgtataatgcttggg
aggttgcccaatttgatgctgatggctaaagaaagcctttactcacaactaccaatggac
tgtttcacaatgccatcttattccaggcgcatctccacagccacaccgtatatgaatgga
gaaacatctacaaaatccctttgggttataaatagtgcactcagaataaaaattctttgt
gcaacctatgtgaatgtaaatattcgagacattgacaagatctatgttagaacaggtatc
taccatggaggagaacccttatgtgacaatgtgaacactcaaagagtaccttgttctaat
cccaggtggaacgaatggctgaattacgacatatacattcctgatcttcctcgtgcggct
cgactttgcctttccatttgttctgtcaaaggccgaaaaggtgctaaggaggaacactgt
ccattggcctggggaaatataaacttgtttgattacacagatactctagtatctgggaaa
atggctttgaatctttggccagtacctcatggattagaagatttgctgaaccctattggt
gttactggatcaaatccaaataaagaaactccctgcttagagttggagtttgactggttc
agcagtgtggtcaagtttccagatatgtcagtgattgaagagcatgctaattggtctgtg
tcccgagaagcaggatttagttattcccatgcaggactgagtaacagactagctagagac
aacgaattaagggaaaatgataaagaacagctccgagcaatttgtacccgagatcctcta
tctgaaatcactgagcaagagaaagattttctgtggagccacagacactactgtgtaact
atccctgaaattctacccaaattgcttctgtccgttaaatggaattctagagatgaagta
gctcagatgtactgcttggtaaaagactggcctccaatcaaacctgaacaggctatggag
ctcctggactgcaactacccagaccctatggttcgaggttttgctgttcgatgcttggaa
aaatatttaacagacgacaaactttctcagtacctaattcagctagtccaggtactaaaa
tatgaacagtatttggataacctgcttgtgagatttttactcaagaaagcattgactaat
caaaggattgggcactttttcttttggcatttaaaatctgagatgcacaataaaacagtt
agtcagaggtttggcctgcttttggagtcctattgtcgtgcatgtgggatgtatttgaag
cacctgaataggcaagttgaagctatggaaaagctcattaacttaactgacattctcaag
caagagaagaaggatgagacacaaaaggtacagatgaagtttttagttgagcaaatgcgg
cgaccagatttcatggacgctttacagggctttctgtctcctctaaatcctgctcatcaa
ctaggaaatctcaggcttgaagagtgtcgaattatgtcctctgcaaaaaggccactgtgg
ttgaattgggagaacccagacatcatgtcagagttactgtttcagaacaatgagatcatc
tttaaaaatggggatgatttacggcaagatatgctaacacttcagattattcgcattatg
gaaaatatctggcaaaatcaaggtcttgatcttcgaatgttaccttatggttgtctgtca
attggtgactgcgtgggacttattgaggtagtgagaagttctcatactattatgcaaatt
cagtgcaaaggtggcctgaaaggtgcactgcagttcaatagccacacactacatcagtgg
ctcaaagacaagaacaaaggagaaatatacgatgcagccattgatctgtttacacgttcg
tgtgctggatattgtgtcgctaccttcattttgggaattggggatcgtcacaatagtaac
atcatggttaaagatgatggacaactgtttcatatagattttggacactttctggatcac
aagaagaaaaaatttggctataaacgagaacgtgtaccatttgttttgacacaagatttc
ttaatagtgattagtaaaggagcccaagaatgcacaaagacaagagaatttgaaaggttt
caggagatgtgttacaaagcttatctagctattcggcagcatgccaatctcttcataaat
cttttctcaatgatgcttggctctggaatgccagaactacaatcttttgatgacattgca
tacattcgaaagaccctagctttagataaaactgagcaagaggctttggaatatttcatg
aaacaaatgaatgatgcacatcatggtggctggacaacaaaaatggattggatcttccac
acaattaagcagcatgctttgaactga

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