KEGG   Rhinolophus hipposideros (lesser horseshoe bat): 308507894
Entry
308507894         CDS       T12007                                 
Symbol
CHUK
Name
(RefSeq) inhibitor of nuclear factor kappa-B kinase subunit alpha isoform 1
  KO
K04467  inhibitor of nuclear factor kappa-B kinase subunit alpha [EC:2.7.11.10]
Organism
rhii  Rhinolophus hipposideros (lesser horseshoe bat)
Pathway
rhii01523  Antifolate resistance
rhii04010  MAPK signaling pathway
rhii04014  Ras signaling pathway
rhii04062  Chemokine signaling pathway
rhii04064  NF-kappa B signaling pathway
rhii04068  FoxO signaling pathway
rhii04150  mTOR signaling pathway
rhii04151  PI3K-Akt signaling pathway
rhii04210  Apoptosis
rhii04380  Osteoclast differentiation
rhii04519  Cadherin signaling
rhii04620  Toll-like receptor signaling pathway
rhii04621  NOD-like receptor signaling pathway
rhii04622  RIG-I-like receptor signaling pathway
rhii04623  Cytosolic DNA-sensing pathway
rhii04625  C-type lectin receptor signaling pathway
rhii04657  IL-17 signaling pathway
rhii04658  Th1 and Th2 cell differentiation
rhii04659  Th17 cell differentiation
rhii04660  T cell receptor signaling pathway
rhii04662  B cell receptor signaling pathway
rhii04668  TNF signaling pathway
rhii04920  Adipocytokine signaling pathway
rhii04936  Alcoholic liver disease
rhii05010  Alzheimer disease
rhii05132  Salmonella infection
rhii05135  Yersinia infection
rhii05142  Chagas disease
rhii05145  Toxoplasmosis
rhii05160  Hepatitis C
rhii05161  Hepatitis B
rhii05162  Measles
rhii05163  Human cytomegalovirus infection
rhii05164  Influenza A
rhii05165  Human papillomavirus infection
rhii05166  Human T-cell leukemia virus 1 infection
rhii05167  Kaposi sarcoma-associated herpesvirus infection
rhii05168  Herpes simplex virus 1 infection
rhii05169  Epstein-Barr virus infection
rhii05170  Human immunodeficiency virus 1 infection
rhii05171  Coronavirus disease
rhii05200  Pathways in cancer
rhii05208  Chemical carcinogenesis - reactive oxygen species
rhii05212  Pancreatic cancer
rhii05215  Prostate cancer
rhii05220  Chronic myeloid leukemia
rhii05221  Acute myeloid leukemia
rhii05222  Small cell lung cancer
rhii05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
rhii05417  Lipid and atherosclerosis
rhii05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:rhii00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    308507894 (CHUK)
   04014 Ras signaling pathway
    308507894 (CHUK)
   04064 NF-kappa B signaling pathway
    308507894 (CHUK)
   04668 TNF signaling pathway
    308507894 (CHUK)
   04068 FoxO signaling pathway
    308507894 (CHUK)
   04151 PI3K-Akt signaling pathway
    308507894 (CHUK)
   04150 mTOR signaling pathway
    308507894 (CHUK)
  09133 Signaling molecules and interaction
   04519 Cadherin signaling
    308507894 (CHUK)
 09140 Cellular Processes
  09143 Cell growth and death
   04210 Apoptosis
    308507894 (CHUK)
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    308507894 (CHUK)
   04621 NOD-like receptor signaling pathway
    308507894 (CHUK)
   04622 RIG-I-like receptor signaling pathway
    308507894 (CHUK)
   04623 Cytosolic DNA-sensing pathway
    308507894 (CHUK)
   04625 C-type lectin receptor signaling pathway
    308507894 (CHUK)
   04660 T cell receptor signaling pathway
    308507894 (CHUK)
   04658 Th1 and Th2 cell differentiation
    308507894 (CHUK)
   04659 Th17 cell differentiation
    308507894 (CHUK)
   04657 IL-17 signaling pathway
    308507894 (CHUK)
   04662 B cell receptor signaling pathway
    308507894 (CHUK)
   04062 Chemokine signaling pathway
    308507894 (CHUK)
  09152 Endocrine system
   04920 Adipocytokine signaling pathway
    308507894 (CHUK)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    308507894 (CHUK)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    308507894 (CHUK)
   05208 Chemical carcinogenesis - reactive oxygen species
    308507894 (CHUK)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    308507894 (CHUK)
  09162 Cancer: specific types
   05212 Pancreatic cancer
    308507894 (CHUK)
   05221 Acute myeloid leukemia
    308507894 (CHUK)
   05220 Chronic myeloid leukemia
    308507894 (CHUK)
   05215 Prostate cancer
    308507894 (CHUK)
   05222 Small cell lung cancer
    308507894 (CHUK)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    308507894 (CHUK)
   05170 Human immunodeficiency virus 1 infection
    308507894 (CHUK)
   05161 Hepatitis B
    308507894 (CHUK)
   05160 Hepatitis C
    308507894 (CHUK)
   05171 Coronavirus disease
    308507894 (CHUK)
   05164 Influenza A
    308507894 (CHUK)
   05162 Measles
    308507894 (CHUK)
   05168 Herpes simplex virus 1 infection
    308507894 (CHUK)
   05163 Human cytomegalovirus infection
    308507894 (CHUK)
   05167 Kaposi sarcoma-associated herpesvirus infection
    308507894 (CHUK)
   05169 Epstein-Barr virus infection
    308507894 (CHUK)
   05165 Human papillomavirus infection
    308507894 (CHUK)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    308507894 (CHUK)
   05135 Yersinia infection
    308507894 (CHUK)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    308507894 (CHUK)
   05142 Chagas disease
    308507894 (CHUK)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    308507894 (CHUK)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    308507894 (CHUK)
   05418 Fluid shear stress and atherosclerosis
    308507894 (CHUK)
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    308507894 (CHUK)
  09176 Drug resistance: antineoplastic
   01523 Antifolate resistance
    308507894 (CHUK)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:rhii01001]
    308507894 (CHUK)
Enzymes [BR:rhii01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.10  IkappaB kinase
     308507894 (CHUK)
Protein kinases [BR:rhii01001]
 Serine/threonine kinases: Other
  IKK family [OT]
   308507894 (CHUK)
SSDB
Motif
Pfam: IKBKB_SDD Pkinase UBL_IKK PK_Tyr_Ser-Thr Pkinase_fungal Kdo TBK1_ULD M1AP_N YrbL-PhoP_reg
Other DBs
NCBI-GeneID: 308507894
NCBI-ProteinID: XP_080929987
LinkDB
Position
15:24229581..24259555
AA seq 759 aa
MERPPGLRPGAGGPWEMRERLGTGGFGNVCLYQHRELDLKIAIKSCRLELSTKNRERWCH
EIQIMKKLNHSNVVKACDVPEELNFLINDVPLLAMEYCSGGDLRKLLNKPENCCGLKESQ
ILSLLSDIGSGIRYLHENKIIHRDLKPENIVLQDVGGKTIHKIIDLGYAKDVDQGSLCTS
FVGTLQYLAPELFENKPYTATVDYWSFGTMVFECIAGYRPFLHHLQPFTWHEKIKKKDPK
CIFACEEMTGEVRFSSHLPQPNSLCSLIVEPMENWLQLMLNWDPQQRGGPVDPTLKQPRC
FVSMDHILNLKIVHILNMTSAKIISFLLPPDESLHSLQSRIERETGINTASQELLSETGI
SLDPRKPASQCVLDGVRGCDSYMVYLFDKSKTVYEGPFASRSLSDCVNYIVQDSKIQLPI
IQLRKVWAEAVHYVSGLKEDYSRLFQGQRAAMLSLLRYNANLTKMKNTLISASQQLKAKL
EFFQKSIQLDLERYSEQMTYGISSEKMLKAWKEMEEKAIHYAEVGVIGYLEDQIMSLHTE
IMELQKSPYGRRQGDLMESLEQRAIDLYKQLKHRPSDHSYSDSTEMVKVIVHTVQSQDRV
LKELFGHLSKLLGCKQKIIDLLPKVEMALSSIKEADNTVMFMQGKRQKEIWHLLKIACTQ
SSARSLVGSSLEGAVTPPQASAWLPPTSAGREHPLSCVVTPQDGIRCATARASGSLLACV
LLLFSQLTETSTAAAFPWKLCPQLVLQMCSHVPSLLRRS
NT seq 2280 nt   +upstreamnt  +downstreamnt
atggagcggcccccggggctgcggccgggcgcgggcgggccctgggagatgcgggagcgg
ctgggcaccggcggcttcgggaacgtctgcctgtaccaacatcgggaactagatctcaaa
atagcaattaagtcttgtcgcctagagctaagtaccaaaaacagagaacggtggtgtcat
gaaatccagatcatgaaaaagttgaaccactcaaatgttgtaaaggcctgtgatgttcct
gaggaattgaattttttgattaatgatgtgcctcttctagcaatggaatactgttctgga
ggagatctccggaagctactcaacaaaccagaaaattgctgtggacttaaagaaagccag
atactttctttactgagcgatatagggtctgggattcgatatttgcatgaaaacaaaatt
atacatcgtgatctaaaacctgaaaacatagttcttcaggatgttggtggaaagactata
cataaaataattgatctgggatatgccaaagacgttgaccaaggaagtctgtgtacatct
tttgtgggaacattgcagtatctggccccagagctctttgagaataagccttacacagcc
actgttgattattggagctttgggaccatggtgtttgaatgtattgctggctataggcct
tttttgcatcacctgcaaccatttacctggcatgagaaaattaagaagaaggatccaaag
tgtatatttgcatgtgaagagatgacaggagaagttcggttcagtagtcatttacctcaa
ccaaatagcctttgtagtttaattgtagaacctatggaaaactggctacaattgatgctg
aactgggatcctcagcagagaggaggacctgttgatcctactttgaagcagccaagatgt
tttgtgtcaatggatcacattctgaatttgaagatagtacacatcctaaatatgacttct
gcaaagataatttcttttttgttaccacctgatgaaagtcttcattcactgcagtctcgt
attgagcgtgaaactggaataaatactgcttctcaagagcttctttcagagacgggaatt
tctctggatcctcggaaaccagcctctcaatgtgttctagatggagtaagaggctgtgat
agctatatggtttatttgtttgataaaagtaagactgtatatgaaggaccgtttgcttcc
agaagtttatctgactgtgtaaattatattgtacaggacagcaaaatacagcttccaatt
atacagctgcgtaaagtatgggctgaagcagtgcactatgtgtctgggctaaaagaagac
tacagcaggctctttcagggacaaagagcagctatgctaagtcttcttagatataatgct
aacttgacaaaaatgaagaacactttgatctcagcatctcagcaactgaaagctaaactg
gagttctttcaaaaaagtattcagcttgacttggaaagatatagtgaacagatgacttac
ggaatatcctcagaaaaaatgttaaaagcatggaaggaaatggaagaaaaggctatccat
tatgctgaggtgggtgtcattggatatctggaggatcagatcatgtccctgcacactgaa
atcatggagctacagaagagcccctatggaagacgtcagggagacttgatggaatctctg
gaacagcgtgccattgatctgtataagcagttaaaacatagaccatcagatcactcgtac
agcgacagcacagagatggtgaaggtcattgtgcacactgtgcagagtcaggaccgggtt
ctcaaggagctgtttggtcatctcagcaagttgttgggctgcaagcagaagattattgat
ttactgcccaaggtggaaatggccctcagtagcatcaaagaagctgacaatacggtcatg
tttatgcagggaaagaggcagaaagaaatatggcatctccttaaaattgcctgtacacag
agttcagcccggtccctggtaggatccagtctagaaggtgcagtgactccccctcaggca
tcagcatggctgcccccgacttcagcaggacgtgaacatcctctgtcatgtgtggtaact
cctcaagatggcattagatgtgccacagccagagccagtggctctttgctagcttgtgtg
ttgttgcttttctcacaactcacggagacttctacagcagcagcatttccctggaagctc
tgcccacaattagttttgcagatgtgcagccatgttccatcactgctcaggaggtcatga

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