Roseburia hominis: RHOM_02230
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Entry
RHOM_02230 CDS
T01621
Name
(GenBank) UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanyl ligase
KO
K01929
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase [EC:
6.3.2.10
]
Organism
rho
Roseburia hominis
Pathway
rho00300
Lysine biosynthesis
rho00550
Peptidoglycan biosynthesis
rho01100
Metabolic pathways
rho01502
Vancomycin resistance
Brite
KEGG Orthology (KO) [BR:
rho00001
]
09100 Metabolism
09105 Amino acid metabolism
00300 Lysine biosynthesis
RHOM_02230
09107 Glycan biosynthesis and metabolism
00550 Peptidoglycan biosynthesis
RHOM_02230
09160 Human Diseases
09175 Drug resistance: antimicrobial
01502 Vancomycin resistance
RHOM_02230
Enzymes [BR:
rho01000
]
6. Ligases
6.3 Forming carbon-nitrogen bonds
6.3.2 Acid-D-amino-acid ligases (peptide synthases)
6.3.2.10 UDP-N-acetylmuramoyl-tripeptide---D-alanyl-D-alanine ligase
RHOM_02230
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Motif
Pfam:
Mur_ligase_M
Mur_ligase_C
Mur_ligase
Motif
Other DBs
NCBI-ProteinID:
AEN95568
UniProt:
G2T1S4
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Position
483480..484910
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AA seq
476 aa
AA seq
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MGAIMKNMTLEHIAQACGGTYIGEECDRKKEIQGAVIDSRLVGEGYLFIPIRGARVDGHD
FIPAVFEKGALAVLSEQRLEHPAGPYILVDSTEEAMKKIAAFYRRSLDIKVVGITGSVGK
TSTKEMIASVLSEKYRVLKTEGNLNNEIGLPLTIFKIREEHQVAVLEMGISEFGEMHRLA
EMAQPDICVITNIGLCHLENLITRDGILKAKTESFEHLAPDGIAVLNGDDDKLCDKKMVN
GRPAVFYGIGQEAKTAETETGSKRLAEKEVYATDVEAIGLEGTKAVIHTPEQQFEVVIPI
AGEHNVYNALAAVCVARRLGLDAEEMKLGIEHAHTIGGRSNLIRKNGITIIDDCYNANPV
SMMASIDVLSQAKGRKIAVLGDMGELGSEEKKLHGMVGTHFAGKKIDALFVTGTLAGEIA
EEARRVAPETRVYAEPDKEALEEALLEYRRPGDTILVKASHFMGFSEIVKKLEQPQ
NT seq
1431 nt
NT seq
+upstream
nt +downstream
nt
atgggagccattatgaaaaatatgacattggagcatatcgcgcaggcgtgcggcggtaca
tacatcggggaagaatgcgaccgcaaaaaggagattcagggggcggtgattgacagccgt
ctggtcggggagggatatctgtttattcccatccgcggagcgcgcgtcgacggacatgat
ttcattccggcggtttttgaaaagggagcgcttgccgtgctctccgagcagcggctcgag
catccggcaggaccgtatattctggttgactctacggaggaagccatgaagaagatcgcg
gcgttctaccgccgctcactcgacatcaaagtcgtggggatcacaggaagcgttggaaag
accagcacaaaagagatgattgcgtcggtgctctccgagaaataccgcgtgttaaagacc
gaggggaatctgaacaatgagattggacttccgctgacgatctttaagatccgggaggaa
catcaggtggcggtgctcgagatgggaatctctgagttcggtgagatgcaccgtcttgca
gagatggcacagccggatatctgcgtcattaccaatatcggcttatgtcatttggagaac
ctcatcacaagagacggcattttaaaggcgaagacggagagctttgagcatctggcaccg
gacgggatcgccgtattaaacggggatgacgataagctctgtgacaaaaagatggtgaat
ggcagaccggcggtgttctatggaatcggacaggaagcaaagacggcagagacagagacc
ggcagcaaacggctcgcggaaaaggaagtgtacgcgaccgatgtggaggcgatcggcctt
gagggaacgaaggcggtcattcacacgccggagcagcagtttgaggtggtgatcccgatt
gctggtgagcacaatgtatacaacgcgcttgcagcagtctgcgtggcaagacggctggga
cttgatgcggaggagatgaagcttggaattgagcatgcgcacacgattggcgggcggagt
aatctgatccggaaaaacggcatcacaattatcgacgactgctacaatgcgaatccggtg
tccatgatggcttccatagacgtgctgtcccaggcgaagggacgaaagattgccgtgctc
ggcgatatgggagaactcggcagtgaggaaaagaagctgcacggaatggtcggcacacac
tttgcggggaagaagatcgatgcgctgtttgtgaccggaacacttgcaggggagattgcg
gaggaggcgcggcgtgtagcgccggagaccagggtctatgcggaaccggacaaagaggcg
ctggaggaggcgctgctggagtaccgcagaccgggggataccattctggtaaaggcgtcc
cattttatgggattttcggagattgtgaaaaaattggaacagccacagtga
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