KEGG   Cupriavidus metallidurans: Rmet_6110
Entry
Rmet_6110         CDS       T00351                                 
Symbol
copS1
Name
(GenBank) CopS sensor from the two components sensor/regulator family involved in Cu(II)/Cu(I) resistance
  KO
K07644  two-component system, OmpR family, heavy metal sensor histidine kinase CusS [EC:2.7.13.3]
Organism
rme  Cupriavidus metallidurans
Pathway
rme02020  Two-component system
Brite
KEGG Orthology (KO) [BR:rme00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   02020 Two-component system
    Rmet_6110 (copS1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:rme01001]
    Rmet_6110 (copS1)
  09183 Protein families: signaling and cellular processes
   02022 Two-component system [BR:rme02022]
    Rmet_6110 (copS1)
   01504 Antimicrobial resistance genes [BR:rme01504]
    Rmet_6110 (copS1)
Enzymes [BR:rme01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.13  Protein-histidine kinases
    2.7.13.3  histidine kinase
     Rmet_6110 (copS1)
Protein kinases [BR:rme01001]
 Histidine kinases
  OmpR family
   Rmet_6110 (copS1)
Two-component system [BR:rme02022]
 OmpR family
  CusS-CusR (copper tolerance)
   Rmet_6110 (copS1)
Antimicrobial resistance genes [BR:rme01504]
 Gene sets
  beta-Lactam resistance modules
   Imipenem resistance, repression of porin OprD [MD:M00745]
    Rmet_6110 (copS1)
SSDB
Motif
Pfam: CusS HATPase_c HisKA HAMP HATPase_c_5 ZW10_C2
Other DBs
NCBI-ProteinID: ABF12969
UniProt: Q58AD4
LinkDB
Position
pMOL30:192086..193477
AA seq 463 aa
MRHRLSLTVRLTILFSLSSAVVLLGLGVLIWLAMDRHFANEDFVVLGDNIRLIERVADET
PVERLPARLQELVEHHPGFVARVQTAQGKTIFATRDFDFRPAESATNEGPNSEGTFVWQQ
ETKHYRGMRAEVPVLGSDVGALKVVVGMDTEIHAHFMHAFRRSLAFYTTLAAFASGLLGW
WAARRGLAPLRMMASRAKDVTANRLDARMPVAAVPVEMADLAATLNAMLERLQNDFQRLS
EFSSDLAHELRTPITNLMTQTHVVLSQPRDAAKYRDVLTSNAEELQRLGRMVSDMLYLAK
MEHGITLPNEESIDIADEVLALFDFYDALAEDKGVNLQLQGNAKLAGDRLMMRRALSNLL
SNALRYTAEGRQILVSVREHGTDAMIVVENEGEEIRPDLLPYIFDRFFRADKSRTRLDSD
SVGLGLSITKAIVVAHGGKIAADCSGGKTRFTMTFPHGRLGLT
NT seq 1392 nt   +upstreamnt  +downstreamnt
atgaggcaccgtctgtccctgactgttcggctgaccatcctgttctcgctttcctccgca
gtggtcctgctcggacttggcgtgcttatctggctggcgatggaccggcacttcgccaac
gaagattttgtggtgctgggggacaacatccgtctgattgaacgcgtcgcggatgaaact
cctgtggaacgtctgcctgcgcgcctgcaggagttggtggagcaccatcccggctttgtc
gcacgggtgcagaccgcgcaaggcaagacgatttttgccacgcgggatttcgatttcagg
ccggcggagagcgctacgaacgaggggccgaactccgaaggcaccttcgtgtggcagcag
gaaaccaagcactaccgcggcatgcgagcggaggtgcccgttttaggctcggatgtgggc
gccttgaaagtggtcgtcggaatggacacggagattcatgcacactttatgcatgccttc
cgccggtccttggctttctatacaacgctcgctgctttcgctagcggcttgctgggctgg
tgggctgcgcgccgcggtctggcgccactgcgcatgatggcatcgcgcgctaaagatgtg
acggcgaaccgattggatgcgcgcatgccggtggccgcggtgccagtcgagatggcggat
ctcgcggcgacattgaacgcgatgctcgagcgtctgcagaacgattttcaacggttgtcg
gaattttcgtcagatctggcgcacgagttgcgcaccccgattaccaacctcatgacgcag
acacatgtcgttctgtcccagccgcgtgacgccgcaaagtatcgcgatgtgctgacctca
aacgccgaggaattgcagcgtcttggacggatggtctcggatatgctgtatctggcaaaa
atggagcacggcatcacgctgcccaatgaggagtcgatcgatattgccgatgaagtgctg
gcactcttcgacttctacgacgcgctggccgaggacaagggggtcaacctgcaactgcag
gggaacgccaaattagcgggcgaccgtctgatgatgcgtcgggcgctcagcaacctctta
tccaatgcgctgcgttacaccgcggagggtcgtcagatcctggtgtctgtacgggagcac
ggaactgatgccatgatcgtggtggagaatgagggcgaggaaatccggccggatctgctt
ccttacatttttgatcggttttttcgggcagataagtccaggacgcgactggattcggac
agtgtcggactgggactgtcgatcaccaaggcgatcgtggttgcgcatggcggaaaaatt
gccgcggactgttccggcggaaaaacccgtttcaccatgacgttcccgcatggtcgcctc
ggactgacctga

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