Rattus norvegicus (rat): 100361294
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Entry
100361294 CDS
T01003
Symbol
Tyk2
Name
(RefSeq) non-receptor tyrosine-protein kinase TYK2
KO
K11219
non-receptor tyrosine-protein kinase TYK2 [EC:
2.7.10.2
]
Organism
rno
Rattus norvegicus (rat)
Pathway
rno04217
Necroptosis
rno04380
Osteoclast differentiation
rno04620
Toll-like receptor signaling pathway
rno04621
NOD-like receptor signaling pathway
rno04630
JAK-STAT signaling pathway
rno04658
Th1 and Th2 cell differentiation
rno04659
Th17 cell differentiation
rno05145
Toxoplasmosis
rno05160
Hepatitis C
rno05161
Hepatitis B
rno05162
Measles
rno05164
Influenza A
rno05165
Human papillomavirus infection
rno05167
Kaposi sarcoma-associated herpesvirus infection
rno05168
Herpes simplex virus 1 infection
rno05169
Epstein-Barr virus infection
rno05171
Coronavirus disease - COVID-19
Brite
KEGG Orthology (KO) [BR:
rno00001
]
09130 Environmental Information Processing
09132 Signal transduction
04630 JAK-STAT signaling pathway
100361294 (Tyk2)
09140 Cellular Processes
09143 Cell growth and death
04217 Necroptosis
100361294 (Tyk2)
09150 Organismal Systems
09151 Immune system
04620 Toll-like receptor signaling pathway
100361294 (Tyk2)
04621 NOD-like receptor signaling pathway
100361294 (Tyk2)
04658 Th1 and Th2 cell differentiation
100361294 (Tyk2)
04659 Th17 cell differentiation
100361294 (Tyk2)
09158 Development and regeneration
04380 Osteoclast differentiation
100361294 (Tyk2)
09160 Human Diseases
09172 Infectious disease: viral
05161 Hepatitis B
100361294 (Tyk2)
05160 Hepatitis C
100361294 (Tyk2)
05171 Coronavirus disease - COVID-19
100361294 (Tyk2)
05164 Influenza A
100361294 (Tyk2)
05162 Measles
100361294 (Tyk2)
05168 Herpes simplex virus 1 infection
100361294 (Tyk2)
05167 Kaposi sarcoma-associated herpesvirus infection
100361294 (Tyk2)
05169 Epstein-Barr virus infection
100361294 (Tyk2)
05165 Human papillomavirus infection
100361294 (Tyk2)
09174 Infectious disease: parasitic
05145 Toxoplasmosis
100361294 (Tyk2)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
rno01001
]
100361294 (Tyk2)
Enzymes [BR:
rno01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.10 Protein-tyrosine kinases
2.7.10.2 non-specific protein-tyrosine kinase
100361294 (Tyk2)
Protein kinases [BR:
rno01001
]
Non-receptor tyrosine kinases
JAK family [OT]
100361294 (Tyk2)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
PK_Tyr_Ser-Thr
Pkinase
Jak1_Phl
FERM_F2
FERM_F1
SH2_1
Kinase-like
Kdo
ABC1
Motif
Other DBs
NCBI-GeneID:
100361294
NCBI-ProteinID:
NP_001244276
RGD:
2320469
Ensembl:
ENSRNOG00000032948
UniProt:
D3ZD03
LinkDB
All DBs
Position
8:complement(27918054..27943319)
Genome browser
AA seq
1186 aa
AA seq
DB search
MVTSMPLCGRRAASEDSKADGTEAQPLVPTGRLMVLLHWPGPEGGEPWVTFSQPSLTAEE
MCIHIAHKVGITPPCLNLFALYDAQAKVWLPPNHVLDTSQDATLRLYFRMRFYFRNWHGM
NPQEPAVYRCGFPGAETSSDHAEQGVQLLDSASFEYLFEQGKHEFMNDVVSLRDLSSEEE
IHHFKNESLGMAFLHLCHLALNRGVPLEEMAREISFKNCIPHSFRQHIRQHNVLTRLRLR
RVFRRFLQAFQPGHLSQQVVMVKYLATLERLAPRFGSEHIPVCHLEVLAQPERDPCYIQN
SGQTTGDPGPELASGPATHEVLVTGTGGIQWRPLQTQDSERGHSRGNPQGSQSGKKPKAP
ESGEHLAGSPQEPPWTYFCDFQDISHVVLKERRVHIHLQDNKCLLLCLCSQAEALSFVAL
VDGYFRLTADSSHYLCHEVAPPRLVTSIQNGIHGPLMDPFVQAKLWPEDGLYLIQWSTSH
LHRLILTVAHRNPASRNGPRGLRLRKFPITQQPGAFVLDGWGRSFDSLGDLRQALQGCSL
RAGDDCFPLHHCCLPRPREISNLVIMRGSRAHTRPLNLSQLSFHRVHQDEITQLSHLGQG
TRTNVYEGLLSVGGPNEGKVDSGCPSGPDRGSGQQLRVVLKVLDPSHHDIALAFYETASL
MSQVSHMHLAFLHGVCVRGSENIIVAEFVEHGPLDVWLRRQRGRVPMPWKMVVAQQLASA
LSYLEDKNLVHGNVCGRNILLARLGLEEGTNPFIKLSDPGVGQGALSREERVERIPWTAP
ECLSGGANSLGTATDMWGFGATLLEICFDGEAPLQGRGPSEKERFYTKKHQLPEPSCPEL
ATLTRQCLSYEPAQRPSFRTILRDLTRLQPQNLVGTSTVNSDSPASDPTVFHKRYLKRIR
DLGEGHFGKVSLYCYDPNNDGTGEMVAVKALKEGCGPQLRSGWQREIEILRTLYHEHIVK
YKGCCEDQGEKSVQLVMEYVPLGSLRDYLPRHSVGLAQLLLFAQQICEGMAYLHAQHYIH
RDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKECKFYYA
SDVWSFGVTLYELLTYCDSSQSPPTKFIELIGVTQGQMTVLRLTELLERGERLPRPDRCP
CEIYHLMKNCWESEASFRPTFQNLVPILKTAQEKYQGQVPSVFSVC
NT seq
3561 nt
NT seq
+upstream
nt +downstream
nt
atggtgacaagcatgcctctgtgtgggcggagagccgcctcggaagacagcaaggcagat
ggcacagaagctcagcccctggtgcccacaggacggttgatggtgctgctgcactggccc
gggcctgagggcggggagccctgggtcaccttcagccagccatctctgactgcagaggag
atgtgcatccacatcgcacacaaagtcggcatcactccaccctgcctgaatctcttcgca
ctctacgatgcacaggccaaggtctggctgcccccaaaccacgttctggacacatcccaa
gacgcaaccctgaggctctattttcgaatgaggttttacttccggaactggcatggcatg
aatccccaagagcctgctgtataccgatgtggtttcccaggggcagagacttcctcagac
catgcagagcaaggtgtacagctcttggactctgcctcatttgaatacctttttgagcag
ggaaaacatgaattcatgaacgatgtggtatctctgcgggacctgtctagcgaggaagag
atccaccactttaagaatgagagcctgggcatggcctttctgcacctctgccatcttgct
ctcaaccgtggcgtccccctggaggagatggccagagagatcagcttcaagaactgtatc
cctcactccttccgtcagcacatccgccagcacaatgtgcttacgcgcctgcgtctccgc
agagtcttccgccgcttcctgcaggccttccagcctggccacctctcccaacaggttgtg
atggttaagtacttggccaccctggagcggctggctcctcgttttggctcagagcacata
cctgtgtgtcatctggaagttctggcccagcctgagagggacccctgctacatccagaac
agtgggcagaccactggggacccaggcccagagctggcttctgggccagccacccatgag
gtactggtgacaggcaccggaggtatccagtggcgtccactacagacccaggactctgag
agaggtcacagcagagggaatccccaaggcagccagtctgggaagaaacccaaggcccct
gagtctggagagcacctggcagggagtccccaggaaccaccttggacctacttctgtgac
ttccaggacatttcccatgtggtactaaaggagcgtcgagtgcacatccaccttcaagac
aacaagtgcttgttgctgtgcctctgctcccaggccgaggccctgtcctttgtggccctg
gtcgatggctatttccgcttgactgctgactccagccactacctgtgccatgaggtagca
cccccgaggctggtgactagcatccagaatggcatccacgggcccctgatggacccattt
gtacaggctaagctgtggccagaggatggcctctacctgatccagtggagcaccagccac
ctgcaccgactgatcctcaccgtagcccatcgaaacccggcttccagaaacggccctagg
ggcctacgcctccgaaagttccccatcacccagcagcctggagcctttgtgcttgatggt
tggggccgctcctttgacagcttgggggaccttcggcaggccttgcagggctgctcattg
cgagctggtgatgactgtttcccgttgcaccactgctgcctgccccgaccaagagaaatc
tccaaccttgtcatcatgcgggggtctagggcccacacccggccactcaacctcagtcag
cttagcttccacagggttcaccaggatgaaatcacccagctgtcccacttgggccaaggc
acaaggaccaatgtgtatgagggcctgctaagtgtgggaggccccaatgagggcaaagtg
gacagtggatgcccctctgggcctgataggggcagtgggcagcagcttcgagtggtgctc
aaagtcctcgaccctagtcaccatgatatcgccttggccttctatgagactgccagcctc
atgagccaggtgtcacacatgcacctggctttcctgcatggtgtctgcgtgcgtggctca
gagaatatcattgtagcggaattcgtagagcacggtcccctggatgtgtggttacggaga
cagagaggccgagtgcccatgccctggaagatggtcgtggctcagcagctggccagcgcc
ctgagctacctggaggacaagaatctggttcacgggaacgtatgtggccggaacatcctg
ctggcccgcctggggctggaggagggtaccaaccccttcatcaagctcagtgaccctggc
gtgggccaaggcgccctctccagggaagagcgggtggagcgaatcccctggacagctccg
gagtgcctgtccggaggggccaacagcttgggcactgccacggacatgtggggctttggt
gccaccctccttgagatctgttttgatggagaggcacctctgcagggccgtggtccctcc
gagaaagaacggttctacacaaagaaacatcagctgccagagccctcatgcccggagctg
gccacactcacccgtcagtgcctgagctatgaacccgcacagaggccatcgttccgcacc
attttgcgggacctcacaagactgcagccacagaatctagtgggaacttcgactgtgaac
tcggactcaccagcatcggaccccaccgtttttcacaagcgttacttgaaaaggatccgg
gatttgggtgagggtcactttggcaaggtcagcctgtactgctatgacccgaacaatgac
ggcactggcgagatggtggctgtgaaagccctgaaggagggatgtggtccccagctccgc
tcaggctggcagcgggagatcgaaatccttcggacgctgtaccacgagcacattgtcaag
tacaaaggctgctgtgaagaccaaggggagaagtctgtacagctggtcatggaatacgtc
cctctgggcagcctccgagactacctgccaaggcacagcgtggggctggctcagctcctg
ttgtttgcccagcagatctgcgagggcatggcttacctgcacgctcagcactacattcac
cgagacctcgctgcgcgaaacgtgctgctggacaacgaccggctggtcaagattggagac
tttggcctagccaaggctgtacctgaaggccacgagtactaccgagtgcgcgaggacggg
gacagcccagtattctggtatgccccagaatgcctaaaggagtgcaagttttactatgca
tctgatgtctggtccttcggggtgaccctttatgagctgttgacatactgtgactctagc
cagagtccccccacgaaattcatcgagctcatcggcgtaacccagggccagatgactgtg
ctgaggctcacagagctgctggagcgaggggagaggctgccgcggcctgacagatgtccc
tgtgagatctatcacctcatgaagaactgctgggagtcagaggcctccttccggcccacg
ttccagaatcttgtgcccatccttaagacagcacaggagaagtaccaaggccaggtgcct
tcagtgttcagcgtgtgctga
DBGET
integrated database retrieval system
