Rattus norvegicus (rat): 100364062 Help Entry 100364062         CDS       T01003                                  Definition (RefSeq) pyruvate kinase PKM   KO K00873   pyruvate kinase [EC:2.7.1.40] Organism rno  Rattus norvegicus (rat) Pathway rno00010   Glycolysis / Gluconeogenesis rno00230   Purine metabolism rno00620   Pyruvate metabolism rno01100   Metabolic pathways rno01200   Carbon metabolism rno01230   Biosynthesis of amino acids rno01240   Biosynthesis of cofactors rno04922   Glucagon signaling pathway rno04930   Type II diabetes mellitus rno05165   Human papillomavirus infection rno05203   Viral carcinogenesis rno05230   Central carbon metabolism in cancer Module rno_M00001   Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate rno_M00002   Glycolysis, core module involving three-carbon compounds rno_M00049   Adenine ribonucleotide biosynthesis, IMP => ADP,ATP rno_M00050   Guanine ribonucleotide biosynthesis, IMP => GDP,GTP Brite KEGG Orthology (KO) [BR:rno00001]  09100 Metabolism   09101 Carbohydrate metabolism    00010 Glycolysis / Gluconeogenesis     100364062    00620 Pyruvate metabolism     100364062   09104 Nucleotide metabolism    00230 Purine metabolism     100364062  09150 Organismal Systems   09152 Endocrine system    04922 Glucagon signaling pathway     100364062  09160 Human Diseases   09161 Cancer: overview    05203 Viral carcinogenesis     100364062    05230 Central carbon metabolism in cancer     100364062   09172 Infectious disease: viral    05165 Human papillomavirus infection     100364062   09167 Endocrine and metabolic disease    04930 Type II diabetes mellitus     100364062  09180 Brite Hierarchies   09182 Protein families: genetic information processing    04131 Membrane trafficking [BR:rno04131]     100364062   09183 Protein families: signaling and cellular processes    04147 Exosome [BR:rno04147]     100364062 Enzymes [BR:rno01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.1  Phosphotransferases with an alcohol group as acceptor     2.7.1.40  pyruvate kinase      100364062 Membrane trafficking [BR:rno04131]  Autophagy   Chaperone mediated autophagy (CMA)    Selective cargos     100364062 Exosome [BR:rno04147]  Exosomal proteins   Proteins found in most exosomes    100364062 BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  PK PK_C HpcH_HpaI IMPDH Motif Other DBs NCBI-GeneID:  100364062 NCBI-ProteinID:  XP_003752000 RGD:  2321795 LinkDB All DBs Position 20 AA seq 532 aa AA seqDB search MPKPDSEAGTAFIQTQQLHAAMADTFLEHMCRLDIDSAPITARNTGIICTIGPASRSVEM LKEMIKSGMNVARLNFSHGTHEYHAETIKNVRAATESFASDPILYRPVAVALDTKGPEIR TGLIKGSGTAEVELKKGATLKITLDNAYMEKCDENILWLDYKNICKVVEVGSKIYVDDGL ISLQVKEKGADYLVTEVENGGSLGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMV FASFIRKAADVHEVRKVLGEKGKNIKIISKIENHEGVRRFDEILEASDGIMVARGDLGIE IPAEKVFLAQKMMIGRCNRAGKPVICANQMLESMIKKPRPTRAEGSDVANAVLDGADCIM LSGVTAKGDYPLEAVRMQHLIAREAEAAIYHLQLFEELRRLAPITSDPTEAAAVGAVEAS FKCCSGAIIVLTKSGRSAHQVARYLPRAPIIAVTRNPQTARQAHLYRGIFPVLCKDAVLD AWAEDVDLRVNLAMNVGKARGFFKKGDVVIVLTGWRPGSGFTNTMRVVPVPR NT seq 1599 nt NT seq  +upstreamnt  +downstreamnt atgcccaagccagacagcgaagcagggactgccttcattcagacccagcagctccatgca gccatggctgacaccttcctggaacacatgtgccgcctggacattgactccgcacccatc acggcccgcaacactgggatcatctgtaccattggccctgcttcccgatctgtggagatg ctgaaggagatgattaagtctgggatgaatgtggctcggctgaatttctctcatggaacc catgagtaccatgcagagactatcaagaatgtccgtgcagccacagaaagctttgcatct gatcccattctctaccgacccgttgcggtggctctggatacaaagggacctgagatccgg actggactcatcaagggcagcggcaccgcagaggtggagctgaagaagggagccacactg aagatcaccctggacaacgcctacatggagaagtgcgacgagaacatcctgtggctggac tataagaacatctgcaaggtggtggaggtgggcagcaagatctacgtggacgatgggctc atctccctgcaggtgaaggagaaaggtgctgactacctggtgacagaagtggaaaatggt ggctccttgggcagcaagaagggcgtgaacctgcctggtgctgctgtggacctccctgct gtgtcagaaaaggacatccaggacctgaagtttggggtggagcaggacgtggacatggtg tttgcgtctttcatccgcaaggcggctgacgtgcatgaggttaggaaggtcctgggagag aagggcaagaacatcaagatcatcagcaaaatcgagaaccatgaaggtgtccgcaggttt gatgagattttggaggccagcgatggaatcatggtagctcgtggtgacctgggcattgag attccggcagagaaggtcttcctagctcagaagatgatgattggacgatgcaaccgagct gggaagccggtcatctgtgccaaccagatgctggagagcatgatcaagaagccacgcccc acccgtgctgaaggcagtgacgtggccaatgcagtcctagatggagctgactgcatcatg ctgtccggagtaacagccaaaggggactaccctctggaggctgttcgcatgcagcacctg attgcccgagaggcagaggctgccatctaccacttgcagttattcgaggaactccgccgc ctggcgcccattaccagcgaccccacagaagctgccgccgtgggtgccgtggaggcctcc ttcaagtgctgcagtggggccattatcgtgctcaccaagtctggcaggagtgctcaccaa gtggcccggtacctcccaagggctcctatcattgctgtgacacgcaatccccagacagcc cgccaggcccatctgtaccgtggcatcttccctgtgctgtgtaaggatgccgtactggat gcctgggctgaggacgttgatcttcgtgtgaacttggccatgaatgttggcaaggcccga ggcttcttcaagaagggagatgtggtcattgtgctgaccggatggcgccctggctctggc ttcaccaacaccatgcgtgtagtgcctgtaccacgatga

Rattus norvegicus (rat): 24651 Help Entry 24651             CDS       T01003                                  Gene name Pklr Definition (RefSeq) pyruvate kinase PKLR   KO K12406   pyruvate kinase isozymes R/L [EC:2.7.1.40] Organism rno  Rattus norvegicus (rat) Pathway rno00010   Glycolysis / Gluconeogenesis rno00230   Purine metabolism rno00620   Pyruvate metabolism rno01100   Metabolic pathways rno01200   Carbon metabolism rno01230   Biosynthesis of amino acids rno01240   Biosynthesis of cofactors rno04910   Insulin signaling pathway rno04930   Type II diabetes mellitus rno04932   Non-alcoholic fatty liver disease rno04950   Maturity onset diabetes of the young Module rno_M00001   Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate rno_M00002   Glycolysis, core module involving three-carbon compounds rno_M00049   Adenine ribonucleotide biosynthesis, IMP => ADP,ATP rno_M00050   Guanine ribonucleotide biosynthesis, IMP => GDP,GTP Brite KEGG Orthology (KO) [BR:rno00001]  09100 Metabolism   09101 Carbohydrate metabolism    00010 Glycolysis / Gluconeogenesis     24651 (Pklr)    00620 Pyruvate metabolism     24651 (Pklr)   09104 Nucleotide metabolism    00230 Purine metabolism     24651 (Pklr)  09150 Organismal Systems   09152 Endocrine system    04910 Insulin signaling pathway     24651 (Pklr)  09160 Human Diseases   09167 Endocrine and metabolic disease    04930 Type II diabetes mellitus     24651 (Pklr)    04950 Maturity onset diabetes of the young     24651 (Pklr)    04932 Non-alcoholic fatty liver disease     24651 (Pklr)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04147 Exosome [BR:rno04147]     24651 (Pklr) Enzymes [BR:rno01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.1  Phosphotransferases with an alcohol group as acceptor     2.7.1.40  pyruvate kinase      24651 (Pklr) Exosome [BR:rno04147]  Exosomal proteins   Exosomal proteins of other body fluids (saliva and urine)    24651 (Pklr) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  PK PK_C IMPDH HpcH_HpaI Motif Other DBs NCBI-GeneID:  24651 NCBI-ProteinID:  NP_036756 RGD:  3336 Ensembl:  ENSRNOG00000020420 UniProt:  P12928 B1WBN9 LinkDB All DBs Position 2 AA seq 543 aa AA seqDB search MEGPAGYLRRASVAQLTQELGTAFFQQQQLPAAMADTFLEHLCLLDIDSQPVAARSTSII ATIGPASRSVDRLKEMIKAGMNIARLNFSHGSHEYHAESIANIREATESFATSPLSYRPV AIALDTKGPEIRTGVLQGGPESEVEIVKGSQVLVTVDPKFQTRGDAKTVWVDYHNITRVV AVGGRIYIDDGLISLVVQKIGPEGLVTEVEHGGILGSRKGVNLPNTEVDLPGLSEQDLLD LRFGVQHNVDIIFASFVRKASDVLAVRDALGPEGQNIKIISKIENHEGVKKFDEILEVSD GIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKARPTRAETSDV ANAVLDGADCIMLSGETAKGSFPVEAVMMQHAIAREAEAAVYHRQLFEELRRAAPLSRDP TEVTAIGAVEASFKCCAAAIIVLTKTGRSAQLLSQYRPRAAVIAVTRSAQAARQVHLSRG VFPLLYREPPEAIWADDVDRRVQFGIESGKLRGFLRVGDLVIVVTGWRPGSGYTNIMRVL SVS NT seq 1632 nt NT seq  +upstreamnt  +downstreamnt atggaagggccagcgggataccttcgacgtgcgagtgtggctcaactgacccaggagctg ggcactgccttcttccagcagcagcaactgcccgcagctatggcggacaccttcctggaa cacctctgccttctggatatcgactcacagcctgtggctgctcgtagcaccagcatcatt gccaccattgggccagcatcccgctctgtggaccgcctcaaggagatgatcaaagcaggg atgaacattgcacgactcaacttctcccatggctcccatgagtaccatgcagaatccatc gccaacatccgggaggcaactgagagttttgcaacctccccactcagctacagacctgtg gccatcgccctggacaccaagggacctgagatacgaaccggagtcttgcaggggggtccg gagtcggaggtggaaattgtgaagggctcacaggtgctggtgacggtggacccgaagttc cagacaaggggcgatgcaaagacagtgtgggtggactaccacaatatcacccgggtcgtt gcagtggggggccgcatctacattgacgacgggctcatctccttagtggtacagaaaatc ggcccagagggactggtgacagaagtggagcacggtggtatcttgggcagcaggaagggt gtgaacttgccaaacactgaggtggacctgcccgggctgtctgagcaagaccttttggat ctgcgcttcggggtgcagcataatgtggacatcatctttgcctcctttgtgcggaaagcc agtgacgtgttagcagtccgggatgccctggggccagaaggacagaacatcaaaattatc agcaaaatcgagaaccatgaaggcgtgaagaagtttgatgaaattctagaagtgagcgat ggcatcatggtggcacggggtgacctgggcattgagatccctgcggagaaggttttcttg gctcagaagatgatgattggacgctgcaacctggccggcaagcctgtcgtttgtgccaca cagatgctggagagcatgatcactaaggctcgaccaactcgggcggagacaagcgatgtg gccaatgccgtgctggatggggctgactgtatcatgctgtccggagagaccgccaagggc agttttcctgtggaagctgtaatgatgcaacatgcgattgcgcgggaggcagaggccgct gtgtaccaccgccagttgtttgaggagctacgccgggcagcgccgctgagccgtgaccca actgaggtcactgcgattggagccgtggaggcttccttcaagtgctgtgcagcagccatc atcgtgctgacgaagactggccgttcagcccagcttctatctcaataccgacctcgggcg gctgtcattgctgtgactcgatctgcccaggctgcccgacaggtccacctgtcccgagga gtcttccccttgctctaccgtgagcctccagaggccatctgggcagatgatgtggatcga agggtccaatttggcattgaaagtggaaagctccgtggtttcctccgtgtgggtgatctg gtgattgtggtgacaggttggcggcctggctctggctataccaacatcatgcgggtgctg agcgtatcctga

Rattus norvegicus (rat): 25630 Help Entry 25630             CDS       T01003                                  Gene name Pkm Definition (RefSeq) pyruvate kinase PKM   KO K00873   pyruvate kinase [EC:2.7.1.40] Organism rno  Rattus norvegicus (rat) Pathway rno00010   Glycolysis / Gluconeogenesis rno00230   Purine metabolism rno00620   Pyruvate metabolism rno01100   Metabolic pathways rno01200   Carbon metabolism rno01230   Biosynthesis of amino acids rno01240   Biosynthesis of cofactors rno04922   Glucagon signaling pathway rno04930   Type II diabetes mellitus rno05165   Human papillomavirus infection rno05203   Viral carcinogenesis rno05230   Central carbon metabolism in cancer Module rno_M00001   Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate rno_M00002   Glycolysis, core module involving three-carbon compounds rno_M00049   Adenine ribonucleotide biosynthesis, IMP => ADP,ATP rno_M00050   Guanine ribonucleotide biosynthesis, IMP => GDP,GTP Brite KEGG Orthology (KO) [BR:rno00001]  09100 Metabolism   09101 Carbohydrate metabolism    00010 Glycolysis / Gluconeogenesis     25630 (Pkm)    00620 Pyruvate metabolism     25630 (Pkm)   09104 Nucleotide metabolism    00230 Purine metabolism     25630 (Pkm)  09150 Organismal Systems   09152 Endocrine system    04922 Glucagon signaling pathway     25630 (Pkm)  09160 Human Diseases   09161 Cancer: overview    05203 Viral carcinogenesis     25630 (Pkm)    05230 Central carbon metabolism in cancer     25630 (Pkm)   09172 Infectious disease: viral    05165 Human papillomavirus infection     25630 (Pkm)   09167 Endocrine and metabolic disease    04930 Type II diabetes mellitus     25630 (Pkm)  09180 Brite Hierarchies   09182 Protein families: genetic information processing    04131 Membrane trafficking [BR:rno04131]     25630 (Pkm)   09183 Protein families: signaling and cellular processes    04147 Exosome [BR:rno04147]     25630 (Pkm) Enzymes [BR:rno01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.1  Phosphotransferases with an alcohol group as acceptor     2.7.1.40  pyruvate kinase      25630 (Pkm) Membrane trafficking [BR:rno04131]  Autophagy   Chaperone mediated autophagy (CMA)    Selective cargos     25630 (Pkm) Exosome [BR:rno04147]  Exosomal proteins   Proteins found in most exosomes    25630 (Pkm) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  PK PK_C HpcH_HpaI Motif Other DBs NCBI-GeneID:  25630 NCBI-ProteinID:  NP_445749 RGD:  3337 Ensembl:  ENSRNOG00000011329 UniProt:  P11980 LinkDB All DBs Position 8 AA seq 531 aa AA seqDB search MPKPDSEAGTAFIQTQQLHAAMADTFLEHMCRLDIDSAPITARNTGIICTIGPASRSVEM LKEMIKSGMNVARLNFSHGTHEYHAETIKNVRAATESFASDPILYRPVAVALDTKGPEIR TGLIKGSGTAEVELKKGATLKITLDNAYMEKCDENILWLDYKNICKVVEVGSKIYVDDGL ISLQVKEKGADYLVTEVENGGSLGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMV FASFIRKAADVHEVRKVLGEKGKNIKIISKIENHEGVRRFDEILEASDGIMVARGDLGIE IPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIM LSGETAKGDYPLEAVRMQHLIAREAEAAVFHRLLFEELARASSQSTDPLEAMAMGSVEAS YKCLAAALIVLTESGRSAHQVARYRPRAPIIAVTRNPQTARQAHLYRGIFPVLCKDAVLD AWAEDVDLRVNLAMNVGKARGFFKKGDVVIVLTGWRPGSGFTNTMRVVPVP NT seq 1596 nt NT seq  +upstreamnt  +downstreamnt atgcccaagccagacagcgaagcagggactgccttcattcagacccagcagctccatgca gccatggctgacaccttcctggaacacatgtgccgcctggacattgactccgcacccatc acggcccgcaacactgggatcatctgtaccattggccctgcttcccgatctgtggagatg ctgaaggagatgattaagtctgggatgaatgtggctcggctgaatttctctcatggaacc catgagtaccatgcagagactatcaagaatgtccgtgcagccacagaaagctttgcatct gatcccattctctaccgacctgttgcggtggctctggatacaaagggacctgagatccgg actggactcatcaagggcagcggcaccgcagaggtggagctgaagaagggagccacactg aagatcaccctggacaacgcctacatggagaagtgcgatgagaacatcctgtggctggac tataagaacatctgcaaggtggtggaggtgggcagcaagatctacgtggacgatgggctc atctccctgcaggtgaaggagaaaggtgctgactacctggtgacagaagtggaaaatggt ggctccttgggcagcaagaagggcgtgaacctgcctggtgctgctgtggacctccctgct gtgtcagaaaaggacatccaggacctgaagtttggggtggagcaggacgtggacatggtg tttgcgtctttcatccgcaaggcggctgacgtgcatgaggttaggaaggtcctgggagag aagggcaagaacatcaagatcatcagcaaaatcgagaaccatgaaggtgtccgcaggttt gatgagattttggaggccagcgatggaatcatggtagctcgtggtgacctgggcattgag attccggcagagaaggtcttcctagctcagaagatgatgattggacgatgcaaccgagct gggaagccagtcatctgcgccacccagatgctggagagcatgatcaagaagccacgcccc acccgtgctgaaggcagtgacgtggccaatgcagtcctagatggagctgactgcatcatg ctgtccggagaaacagccaaaggggactaccctctggaggctgttcgcatgcagcacctg atagctcgagaggctgaggcagccgtgttccaccgcctgctgtttgaagagcttgcgcga gcctccagtcaatccacagaccccctggaggccatggccatgggcagcgtggaggcctct tataaatgtttagcagcagctttgatagttctgacggagtccggcaggagtgctcaccaa gtggcccggtaccgcccaagggctcctatcattgctgtgacacgcaatccccagacagcc cgccaggcccatctgtaccgtggcatcttccctgtgctgtgtaaggatgccgtactggat gcctgggctgaggacgttgatcttcgtgtgaacttggccatgaatgttggcaaggcccga ggcttcttcaagaagggagatgtggtcattgtgctgactggatggcgccctggctctggc ttcaccaacaccatgcgtgtagtgcctgtaccatga

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