KEGG   Rattus norvegicus (rat): 134484121
Entry
134484121         CDS       T01003                                 
Name
(RefSeq) LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like
  KO
K00922  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
Organism
rno  Rattus norvegicus (rat)
Pathway
rno00562  Inositol phosphate metabolism
rno01100  Metabolic pathways
rno01521  EGFR tyrosine kinase inhibitor resistance
rno01522  Endocrine resistance
rno01524  Platinum drug resistance
rno04012  ErbB signaling pathway
rno04014  Ras signaling pathway
rno04015  Rap1 signaling pathway
rno04024  cAMP signaling pathway
rno04062  Chemokine signaling pathway
rno04066  HIF-1 signaling pathway
rno04068  FoxO signaling pathway
rno04070  Phosphatidylinositol signaling system
rno04071  Sphingolipid signaling pathway
rno04072  Phospholipase D signaling pathway
rno04140  Autophagy - animal
rno04150  mTOR signaling pathway
rno04151  PI3K-Akt signaling pathway
rno04152  AMPK signaling pathway
rno04210  Apoptosis
rno04211  Longevity regulating pathway
rno04213  Longevity regulating pathway - multiple species
rno04218  Cellular senescence
rno04360  Axon guidance
rno04370  VEGF signaling pathway
rno04380  Osteoclast differentiation
rno04510  Focal adhesion
rno04550  Signaling pathways regulating pluripotency of stem cells
rno04611  Platelet activation
rno04613  Neutrophil extracellular trap formation
rno04620  Toll-like receptor signaling pathway
rno04625  C-type lectin receptor signaling pathway
rno04630  JAK-STAT signaling pathway
rno04650  Natural killer cell mediated cytotoxicity
rno04660  T cell receptor signaling pathway
rno04662  B cell receptor signaling pathway
rno04664  Fc epsilon RI signaling pathway
rno04666  Fc gamma R-mediated phagocytosis
rno04668  TNF signaling pathway
rno04670  Leukocyte transendothelial migration
rno04722  Neurotrophin signaling pathway
rno04725  Cholinergic synapse
rno04750  Inflammatory mediator regulation of TRP channels
rno04810  Regulation of actin cytoskeleton
rno04910  Insulin signaling pathway
rno04914  Progesterone-mediated oocyte maturation
rno04915  Estrogen signaling pathway
rno04917  Prolactin signaling pathway
rno04919  Thyroid hormone signaling pathway
rno04923  Regulation of lipolysis in adipocytes
rno04926  Relaxin signaling pathway
rno04929  GnRH secretion
rno04930  Type II diabetes mellitus
rno04931  Insulin resistance
rno04932  Non-alcoholic fatty liver disease
rno04933  AGE-RAGE signaling pathway in diabetic complications
rno04935  Growth hormone synthesis, secretion and action
rno04960  Aldosterone-regulated sodium reabsorption
rno04973  Carbohydrate digestion and absorption
rno05010  Alzheimer disease
rno05017  Spinocerebellar ataxia
rno05020  Prion disease
rno05100  Bacterial invasion of epithelial cells
rno05132  Salmonella infection
rno05135  Yersinia infection
rno05142  Chagas disease
rno05146  Amoebiasis
rno05160  Hepatitis C
rno05161  Hepatitis B
rno05162  Measles
rno05163  Human cytomegalovirus infection
rno05164  Influenza A
rno05165  Human papillomavirus infection
rno05166  Human T-cell leukemia virus 1 infection
rno05167  Kaposi sarcoma-associated herpesvirus infection
rno05168  Herpes simplex virus 1 infection
rno05169  Epstein-Barr virus infection
rno05170  Human immunodeficiency virus 1 infection
rno05171  Coronavirus disease - COVID-19
rno05200  Pathways in cancer
rno05203  Viral carcinogenesis
rno05205  Proteoglycans in cancer
rno05206  MicroRNAs in cancer
rno05207  Chemical carcinogenesis - receptor activation
rno05208  Chemical carcinogenesis - reactive oxygen species
rno05210  Colorectal cancer
rno05211  Renal cell carcinoma
rno05212  Pancreatic cancer
rno05213  Endometrial cancer
rno05214  Glioma
rno05215  Prostate cancer
rno05218  Melanoma
rno05220  Chronic myeloid leukemia
rno05221  Acute myeloid leukemia
rno05222  Small cell lung cancer
rno05223  Non-small cell lung cancer
rno05224  Breast cancer
rno05225  Hepatocellular carcinoma
rno05226  Gastric cancer
rno05230  Central carbon metabolism in cancer
rno05231  Choline metabolism in cancer
rno05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
rno05415  Diabetic cardiomyopathy
rno05417  Lipid and atherosclerosis
rno05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:rno00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    134484121
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    134484121
   04014 Ras signaling pathway
    134484121
   04015 Rap1 signaling pathway
    134484121
   04370 VEGF signaling pathway
    134484121
   04630 JAK-STAT signaling pathway
    134484121
   04668 TNF signaling pathway
    134484121
   04066 HIF-1 signaling pathway
    134484121
   04068 FoxO signaling pathway
    134484121
   04070 Phosphatidylinositol signaling system
    134484121
   04072 Phospholipase D signaling pathway
    134484121
   04071 Sphingolipid signaling pathway
    134484121
   04024 cAMP signaling pathway
    134484121
   04151 PI3K-Akt signaling pathway
    134484121
   04152 AMPK signaling pathway
    134484121
   04150 mTOR signaling pathway
    134484121
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    134484121
  09143 Cell growth and death
   04210 Apoptosis
    134484121
   04218 Cellular senescence
    134484121
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    134484121
   04550 Signaling pathways regulating pluripotency of stem cells
    134484121
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    134484121
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    134484121
   04613 Neutrophil extracellular trap formation
    134484121
   04620 Toll-like receptor signaling pathway
    134484121
   04625 C-type lectin receptor signaling pathway
    134484121
   04650 Natural killer cell mediated cytotoxicity
    134484121
   04660 T cell receptor signaling pathway
    134484121
   04662 B cell receptor signaling pathway
    134484121
   04664 Fc epsilon RI signaling pathway
    134484121
   04666 Fc gamma R-mediated phagocytosis
    134484121
   04670 Leukocyte transendothelial migration
    134484121
   04062 Chemokine signaling pathway
    134484121
  09152 Endocrine system
   04910 Insulin signaling pathway
    134484121
   04923 Regulation of lipolysis in adipocytes
    134484121
   04929 GnRH secretion
    134484121
   04915 Estrogen signaling pathway
    134484121
   04914 Progesterone-mediated oocyte maturation
    134484121
   04917 Prolactin signaling pathway
    134484121
   04926 Relaxin signaling pathway
    134484121
   04935 Growth hormone synthesis, secretion and action
    134484121
   04919 Thyroid hormone signaling pathway
    134484121
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    134484121
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    134484121
  09156 Nervous system
   04725 Cholinergic synapse
    134484121
   04722 Neurotrophin signaling pathway
    134484121
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    134484121
  09158 Development and regeneration
   04360 Axon guidance
    134484121
   04380 Osteoclast differentiation
    134484121
  09149 Aging
   04211 Longevity regulating pathway
    134484121
   04213 Longevity regulating pathway - multiple species
    134484121
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    134484121
   05206 MicroRNAs in cancer
    134484121
   05205 Proteoglycans in cancer
    134484121
   05207 Chemical carcinogenesis - receptor activation
    134484121
   05208 Chemical carcinogenesis - reactive oxygen species
    134484121
   05203 Viral carcinogenesis
    134484121
   05230 Central carbon metabolism in cancer
    134484121
   05231 Choline metabolism in cancer
    134484121
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    134484121
  09162 Cancer: specific types
   05210 Colorectal cancer
    134484121
   05212 Pancreatic cancer
    134484121
   05225 Hepatocellular carcinoma
    134484121
   05226 Gastric cancer
    134484121
   05214 Glioma
    134484121
   05221 Acute myeloid leukemia
    134484121
   05220 Chronic myeloid leukemia
    134484121
   05218 Melanoma
    134484121
   05211 Renal cell carcinoma
    134484121
   05215 Prostate cancer
    134484121
   05213 Endometrial cancer
    134484121
   05224 Breast cancer
    134484121
   05222 Small cell lung cancer
    134484121
   05223 Non-small cell lung cancer
    134484121
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    134484121
   05170 Human immunodeficiency virus 1 infection
    134484121
   05161 Hepatitis B
    134484121
   05160 Hepatitis C
    134484121
   05171 Coronavirus disease - COVID-19
    134484121
   05164 Influenza A
    134484121
   05162 Measles
    134484121
   05168 Herpes simplex virus 1 infection
    134484121
   05163 Human cytomegalovirus infection
    134484121
   05167 Kaposi sarcoma-associated herpesvirus infection
    134484121
   05169 Epstein-Barr virus infection
    134484121
   05165 Human papillomavirus infection
    134484121
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    134484121
   05135 Yersinia infection
    134484121
   05100 Bacterial invasion of epithelial cells
    134484121
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    134484121
   05142 Chagas disease
    134484121
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    134484121
   05017 Spinocerebellar ataxia
    134484121
   05020 Prion disease
    134484121
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    134484121
   05418 Fluid shear stress and atherosclerosis
    134484121
   05415 Diabetic cardiomyopathy
    134484121
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    134484121
   04932 Non-alcoholic fatty liver disease
    134484121
   04931 Insulin resistance
    134484121
   04933 AGE-RAGE signaling pathway in diabetic complications
    134484121
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    134484121
   01524 Platinum drug resistance
    134484121
   01522 Endocrine resistance
    134484121
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:rno04131]
    134484121
Enzymes [BR:rno01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     134484121
Membrane trafficking [BR:rno04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    134484121
SSDB
Motif
Pfam: PI3Ka PI3_PI4_kinase PI3K_C2 PI3K_p85B PI3K_rbd DUF2321 ABC1 Retrotran_gag_4
Other DBs
NCBI-GeneID: 134484121
NCBI-ProteinID: XP_063136586
LinkDB
Position
X:complement(25064123..25121918)
AA seq 1107 aa
MISSNSQGPPNWQESLEEWRISSENTRSSQRVRTIPPRPSSGELWGIHLMPPRILVECLL
PNGMIVTLECLREATLVTIKHELFKEARKYPLHQLLQDESSYIFVSVTQEAEREEFFDET
RRLCDLRLFQPFLKVIEPVGNREEKILNREIGFVIGMPVCEFDMVKDLEVQDFRXNILNV
CKEAVGLRDLNSPHSRAMYVYPPNVESSPELPKHIYNKLDKGQIIVVIWVIVSPNNDKQK
YTLKINHDCVPEQVIAEAIRKKTRSMLLSSEQLKLCVLEYQGKYILKVCGCDEYFLEKYP
LSQYKERRPLCEYIRSCIMLGRMPNLMLMAKESLHSQLPIDSFTMPSYSRRISTATPYMN
GETATKSLWVINSALRIKILCATYVNVNIRDIDKIYVRTGIYHGGESLCDNVNTQRVPCS
NPRWNEWLNYDIYIPDLPRAARLCLSICSVKGRKGAKEEHCPLAWGNINLFDYTDTLVSG
KMALNLWPVPHGLEDLLNPIGVTGSNPNKETPCLELEFDWFSSVVKFPDMSVIEEHANWS
VSREAGFSYSHTGLSNRLARDNELRENDKEQLXALCTRDPLSEITEQEKDFLWSHRHYCV
TIPEILPKLLLSVKWNSRDEVAQMYCLVKDWPPIKPEQAMELLDCNYPDPMVRSFAVRCL
EKYLTDDKLSQYLIQLVQVLKYEQYLDNLLVRFLLKKALTNQRIGHFFFWHLKSEMHNKT
VSQRFSLLLESYCRACGMYLKHLNRQVEAMEKLINLTDILKQEKKDETQKVQMKFLVEQM
RQPDFMDALQGFLSPLNPAHQLGNLRLEECRIMSSAKRPLWLNWENPDIMSELLFQNNEI
IFKNGDDLRQDMLTLXRIMENIWQNQGLDLRMLPYACLSIGDCVGLIEVVRNSHTIMQIQ
CKGGLKGALQFNRHTLHQWLKDKNKGKIYDAAIDLFTWSCAGYCVATFILGIGDRHNSNI
MVKDDGQLFHIDFGHFLDHKKKKFGYKRERVPFVLTQDFLIVISKGAQEYTKTREFERFQ
EMCYKAYLAIRQHANLFINLFSMMLGSGMPELQSFDDIAYIRKTLALDKTEQEALEYFTK
QMNDAHHGGWTTKMDWIFHTIKQHALN
NT seq 3324 nt   +upstreamnt  +downstreamnt
atgatcagtagcaacagccagggtcctcccaactggcaggagtccctggaagaatggaga
atcagcagtgagaatacaagaagttctcagagggtcagaacaattcctccacgaccatct
tcgggtgaactgtggggcatccacttgatgcccccacgaatcctagtggaatgtttactc
ccaaatggaatgatagtgactttagaatgcctccgtgaggccacactagtcaccatcaag
catgaactgttcaaagaggccaggaaataccctctccatcagcttctgcaagatgaatca
tcttacattttcgtaagtgttacccaagaagcagaaagggaagaatttttcgatgaaaca
agacggctttgtgaccttcggctttttcaaccctttttaaaagtaattgagccagtaggc
aaccgtgaagaaaagatcctcaaccgagaaattggttttgttattggcatgccagtgtgt
gaatttgatatggttaaagatctagaagtccaagacttccganagaacattctgaatgtt
tgcaaagaagccgtgggcctgcgggatctcaactcgcctcatagcagagcaatgtatgtc
taccctccaaatgtcgagtcttccccagaactgccaaagcacatctacaacaagttagat
aaaggacaaatcatagtggtgatttgggtgatagtctctccaaacaacgacaagcagaag
tacactctgaagatcaaccatgactgcgtgccagagcaagtcattgctgaggccatcagg
aagaagacccggagcatgttgctgtcctcggagcagctgaaactctgtgtcttagaatac
cagggcaagtacattctcaaagtgtgtggctgtgatgagtacttcctagagaagtaccct
ctgagtcagtacaaggagagaagacccttgtgcgaatacataagaagctgtataatgctg
gggaggatgcccaacttgatgctgatggccaaggagagcctgcactctcagctgccgatc
gatagcttcacaatgccatcctactccaggcgcatttccacagcgacaccctatatgaac
ggggagactgctacgaaatctctctgggttataaatagcgcgctcagaataaaaattctg
tgtgcaacctatgtaaatgtaaatattcgagacattgataagatctatgttcgaacaggt
atctaccatggaggagaatccttatgtgacaatgtgaatactcaaagagtcccttgttcc
aatcctaggtggaatgaatggctgaattatgatatatacattcctgatcttcctcgtgct
gcccgcctttgcctttcaatctgctctgttaaaggccgaaagggtgctaaggaggagcac
tgtccgttggcctggggaaacataaacttgtttgattatacagacaccctagtgtccggg
aaaatggctttgaatctctggcctgtaccacatgggttggaagatctgctgaaccctatt
ggtgttactgggtcaaatccaaataaagaaactccatgcttagagttggagtttgattgg
ttcagcagtgtggtgaagtttccagatatgtctgtgatcgaagagcatgccaattggtct
gtgtcccgagaagccggattcagttactctcatacaggactgagtaacagactagccaga
gacaatgagttaagagaaaatgacaaggaacagctctgagcactttgtacccgggaccca
ctgtctgaaatcactgaacaagagaaagacttcctatggagccacagacactactgtgta
actattcctgaaatcctacccaaattgcttctgtctgtcaagtggaattccagagatgaa
gtggcccagatgtactgcttagtaaaagattggcctccaatcaaaccagagcaagccatg
gagctcctggactgtaactacccagaccccatggttcggagctttgctgtccggtgcttg
gaaaaatacttaacagatgacaaactttctcagtacctcatccagcttgtacaggtctta
aaatatgaacagtatttggataacctgcttgtgagatttttactcaagaaagcactgaca
aatcaaaggattggccattttttcttttggcatttaaaatctgagatgcacaataagact
gtcagtcagaggttcagcctgctgttggagtcctactgccgtgcctgtgggatgtatctg
aagcacctgaacagacaggtagaggccatggagaagctcatcaatctaactgacatcctc
aagcaagagaagaaggatgagacacagaaggtacagatgaagttcttggttgaacagatg
agacagccagatttcatggatgctttgcagggttttctgtcccctctaaatcctgctcat
caactaggaaacctcaggcttgaagagtgtcgaattatgtcctctgcaaaaaggccactg
tggttgaattgggagaacccagacatcatgtcagagctactgtttcagaacaatgagatc
atctttaaaaatggcgatgacttacggcaagacatgttaacccttnncagaatcatggag
aacatctggcaaaaccaaggccttgaccttcgcatgctaccttatgcctgtctatccatt
ggggactgtgtgggtctcatcgaggtggtgagaaactctcacaccatcatgcagattcag
tgcaaaggaggcctgaagggggcactgcagttcaacaggcacacgctgcatcagtggctc
aaggacaagaacaagggcaagatatatgacgcagccattgacctgttcacttggtcctgc
gctgggtactgcgtggcaacctttatcttgggaattggagaccggcacaacagcaacatc
atggtgaaagatgacggacagctgtttcatatagattttgggcactttttggatcacaag
aagaaaaaatttggctataaacgggaacgcgtgccgtttgttttgacgcaggatttctta
atagtgattagtaaaggagcacaagagtacacaaagaccagagagtttgagaggtttcag
gagatgtgttacaaggcgtacctagcaattcggcagcatgccaatctcttcatcaacctt
ttctccatgatgcttggctccggaatgccagaactgcagtcttttgatgatattgcatat
attcgaaagactctagccttagacaaaactgagcaagaggctctggagtatttcacaaag
caaatgaatgacgcacatcatggtggctggacaacaaaaatggactggatcttccacacc
atcaagcagcatgcattgaactga

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