Rattus norvegicus (rat): 170546 Help Entry 170546            CDS       T01003                                  Symbol Ryr3 Name (RefSeq) ryanodine receptor 3 isoform X1   KO K04963   ryanodine receptor 3 Organism rno  Rattus norvegicus (rat) Pathway rno04020   Calcium signaling pathway rno04371   Apelin signaling pathway rno04713   Circadian entrainment rno04921   Oxytocin signaling pathway rno04970   Salivary secretion rno05010   Alzheimer disease rno05012   Parkinson disease rno05020   Prion disease rno05022   Pathways of neurodegeneration - multiple diseases Brite KEGG Orthology (KO) [BR:rno00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     170546 (Ryr3)    04020 Calcium signaling pathway     170546 (Ryr3)  09150 Organismal Systems   09152 Endocrine system    04921 Oxytocin signaling pathway     170546 (Ryr3)   09154 Digestive system    04970 Salivary secretion     170546 (Ryr3)   09159 Environmental adaptation    04713 Circadian entrainment     170546 (Ryr3)  09160 Human Diseases   09164 Neurodegenerative disease    05010 Alzheimer disease     170546 (Ryr3)    05012 Parkinson disease     170546 (Ryr3)    05020 Prion disease     170546 (Ryr3)    05022 Pathways of neurodegeneration - multiple diseases     170546 (Ryr3)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:rno04040]     170546 (Ryr3) Ion channels [BR:rno04040]  Voltage-gated cation channels   Ryanodine receptor    170546 (Ryr3) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 Ins145_P3_rec MIR SPRY RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 EF-hand_8 EF-hand_5 Motif Other DBs NCBI-GeneID:  170546 NCBI-ProteinID:  XP_063141018 RGD:  68952 Ensembl:  ENSRNOG00000006645 LinkDB All DBs Position 3:complement(119886129..120433465) Genome browser AA seq 4871 aa AA seqDB search MAESGEGGEDEIQFLRTEDEVVLQCIANIHKEQRKFCLAAEGLGNRLCFLEPTSEAKYIP PDLCVCNFVLEQSLSVRALQEMLANTVENGGEGLSDLSEWAAQGGSHRTLLYGHAILLRH SFSGMYLTCLTTSRSQTDKLAFDVGLREHATGEACWWTIHPASKQRSEGEKVRIGDDLIL VSVSSERYLHLSISNGSIQVDASFMQTLWNVHPTCSGSSIEEGYLLGGHVVRLFHGHDEC LTIPSTDQNDSQHRRVFYEAGGAGTRARSLWRVEPLRISWSGSNIRWGQALRLRHLTTGH YLALTEDQGLLLQDRGKADTKSTAFSFRASKEIKEKLDSSHKRDMEGMGVPEIKYGDSVC FVQHVASGLWVTYKAQDAKTSRLGPLKRKVILHQEGHMDDGLTLQRCQQEESQAARIIRN TTALFSQFVSGNNRTAAPVALPIEEVLQTLQDLIAYFQPPEEDMQHEDKQNKLRSLKNRQ NLFKEEGMLALVLNCIDRLNIYNSVAHFAGIIREENGMAWKEILNLLYKLLAALIRGNRN NCAQFSNNLDWLISKLDRLESSSGILEVLHCILIESPEALNLIAEGHIKSIISLLDKHGR NHKVLDVLCSLCLCNGVAVRANQNLICDNLLPRRNLLLQTRLINDVTSIRPNIFLGVAEG SPQYKKWYFELIIDQVEPFLTAEPTHLRVGWASSSGYAPYPGGGEGWGGNGVGDDLYSYG FDGLHLWSGRIPRAVASINQHLLKSDDVVSCCLDLGVPSISFRINGQPVQGMFENFNTDG LFFPVMSFSAGVKVRFLMGGRHGEFKFLPPSGYAPCYEALLPKEKMRLEPVKEYKRDADG VRDLLGTTQFLSQASFIPCPIDTSQVVLPLHLEKIRDRLAENIHELWGMNKIELGWTFGK VRDDNKRQHPCLVEFSKLPETEKNYNLQMSTETLKTLLALGCHIAHVNPAAEEDLKKVKL PKNYMMSNGYKPAPLDLSDVKLLPPQEILVDKLAENAHNVWAKDRIKQGWTYGIQQDLKN KRNPRLVPYALLDERTKKSNRDSLREAVRTFVGYGYNIEPSDQELVADPTVEKVSIDKIR FFRVERSYAVKSGKWYFEFEVVTGGDMRVGWARPGCRPDIELGADDQAFVFEGSRGQRWH QGSGYFGRTWQPGDVVGCMINLDDASMVFTLNGELLITNKGSELAFADYEIENGFVPICS LGLSQIGRMNLGTDASTFKFYTMCGLQEGFEPFAVNMNRDVAVWFSKRLPTFVNVPKDHP HIEVVRIDGTMDSPPCLKVTHKTFGTQNSNANMIYCRLSMPVECHSSFSHSPCLDSEAFQ KRKQMQEILSHTTTQCYYAIRIFAGQDPSCVWVGWVTPDYHLYSEKFDLNKNCTVTVTLG DERGRVHESVKRSNCYMVWGGDIVASSQRSSRSNVDLEIGCLLDLAMGMLSFSANGKELG TCYQVEPNTKVFPAVFLQPTSTSLFQFELGKLKNAMPLSAAIFKSEEKNPIPQCPPRLDV QTIQPVLWSRMPSSFLKVETERVSERHGWVVQCLEPLQMMALHIPEENRCVDILELCEQE DLMQFHYHTLRLYSAVCALGNSRVASALCSHVDLSQLFYAIDNKYLPGLLRSGFYDLLIS IHLANAKERKLMMKNEYIIPITSSTRNIRLYPDESKRHGLPGVGLRTCLKPGFRFSTPCF VVTNEDHQKQSPEIPLQILKTKALSMLTEAVHCSGAHIRDPVGGSVEFQFVPVLKLIGTL LVMGVFDDDDVRQILLLIDPSVFGEHSGETEEGVEKEVTHVEEKAVEAGEKASKEAPVKG LLQTRLPESVKLQMCELLSYLCDCELQHRVEAIVAFGDIYVSKLQANQKFRYNELMQALN MSAALTARKTREFRSPPQEQINMLLNFHLGENCPCPEEIREELYDFHEDLLVHCGVPLEE EEEEEEDTSWTGKLCALVYKIKGQPKPEKEPPTEEEEPYPTTLKELVSQTMIRWAQENQI QDAELVRMMFNLLRRQYDSIGELLQALRKTYTISQASVNDTINLLAALGQIRSLLSVRMG REEELLMINGLGDIMNNKVFYQHPNLMRVLGMHETVMEVMVNVLGTEKSQIAFPKMVASC CRFLCYFCRISRQNQKAMFEHLSYLLENSSVGLASPSMRGSTPLDVAASSVMDNNELALG LEEPDLEKVVTYLAGCGLQSCPMLLAKGYPDIGWNPIEGERYLSFLRFAVFVNSESVEEN ASVVVKLLIRRPECFGPALRGEGGNGLLAAMQGAIKISESPALDLPSQGYKTEVTQDDEE EEEIVHMGNAIMSFYSALIDLLGRCAPEMHLIQTGKGEAIRIRSILRSLVPTEDLVGIIS IPLKLPSLNKDGSVSEPDMAANFCPDHKAPMVLFLDRVYGIKDQTFLLHLLEVGFLPDLR ASASLDTVSLSTTEAALALNRYLCSAVLPLLTRCAPLFSGTEHCTSLIDSTLQTIYRLSK GRSLTKAQRDTIEECLLAICNHLRPSMLQQLLRRLVFDVPQLSEYCKMPLKLLTNHYEQC WKYYCLPSGWGSYGLAVEEELHLTEKLFWGIFDSLSHKKYDPDLFRMALPCLSAIAGALP PDYLDTRITATLEKQVSVDADGNFDPKPINTMNFSLPEKLEYIVTKYAEHSHDKWACDKS HSGWKYGISLDENVKTHPLIRPFKTLTEKEKEIYRWPARESLKTMLAVGWTVERTKEGEA LVQQRENEKLRCVSQSNQGNSYSPAPLDLSNVVLSRELQGMVEVVAENYHNIWAKKKKLE LESKGGGSHPLLVPYDTLTAKEKLRDREKAQDLFKFLQVNGILVSRGVKDMELDASSMEK RFAYKFLRKILKYVDSAQEFIAHLEAIVSSGKTEKSPHDQEIKFFAKVLLPLVDQYFTNH RLYFLSSPLKPLSSSGYASHKEKEMVASLFCKLAALVRHRISLFGSDSTTMVSCLHILAQ TLDTRTVMKSGSELVKAGLRAFFENAAEDLEKTSENLKLGKFTHSRTQIKGVSQNINYTT VALLPILTSIFEHIAQHQFGVDLLLSDVQISCYHILCSLYSLGTGKNIYVERQRPALGEC LASLAAAIPVAFLEPSLNRYNPLSVFNTKTPRERSILGMPDKVEDMCPDVPQLEGLMKEI NGLAESGARYTEMPHVIEVILPMLCNYLSYWWERGPENLPPSIGPCCTKVTSEHLSLILG NILKIINNNLGIDEASWMKRIAVYAQPIISKARPDLLRSHFIPTLEKLKKKAVKIVQEEE QLKTDGKGDTQEAELLILDEFAVLCRDLYAFYPMLIRYVDNNRSNWLKSPDTDSDQLFRM VAEVFILWCKSHNFKREEQNFVIQNEINNLAFLTGDSKSKMSKSGGQDQERKKTKRRGDL YSIQTSLIVAALKKMLPIGLNMCTPGDQELISLAKSRYSCRDTDEEVKEHLRNNLHLQEK SDDPAVKWQLNLYKDVLRNEEPSNPEKTVERVQRISAALFHLEQVEQPLRSKKAVWHKLL SKQRKRAVVACFRMAPLYNLPRHKINNFFLITFQRVWLEKVNEKTQYDRLIPILMKSPRV EDEEEEETEKQPDPLHQIILHFSRNALTERSKLEDDPLYTSYSSMMAKSCQSGEDEEEEE DKEKTFEEKEMEKQKTLYQQARLHERGAAEMVLQMISASKGEMSPMVVETLKLGIAILNG GNAGVQQKMLDYLKEKKDAGFFQSLSGLMQSCSVLDLNAFERQNKAEGLGMVTEEGTLIV RERGEKVLQNDEFTQDLFRFLQLLCEGHNSDFQNFLRTQMGNTTTVNIIISTVDYLLRLQ ESISDFYWYYSGKDIIDESGQHNFSKALAVTKQIFNSLTEYIQGPCIGNQQSLAHSRLWD AVVGFLHVFANMQMKLSQDSSQIELLKELLDLLQDMVVMLLSLLEGNVVNGTIGKQMVDT LVESSTNVEMILKFFDMFLKLKDLTSSDTFKEYDPDGKGIISRKEFQKAMEGLKQYTQSE IDFLLSCTEADENDMFNYVDFVERFHEPAKDIGFNVAVLLTNLSEHMPNDSRLKCLLDPA ESVLNYFEPYLGRIEIMGGAKKIERVYFEISESSRTQWEKPQVKESKRQFIFDVVNEGGE QEKMELFVNFCEDTIFEMQLASQISESDSTDRPEEEEEEDEDSYSVEIEGEEEDKSFESA SAFAMACASAKRNVTKFLKKATLKNLRKQYRNVKKMSAKELVRVLSSFFWMLVVGLFQLL FSILGGIFHILWNTVFGGGLVEGAKNIRVTKILGDMPDPTQFGIHDDVMEIDRAEVTEPG ITTELVHFVKGEAGDTDVMSDLFGIHSKKEGGSKQGPEVGLGDLSEITGKDEPPTLESTV RKKRKAQAAEMKAVHEAEGRTESEKADMEDREKEDKIKEEGQAEYLWADTTVKKTRRRGQ KAEKPVAFMANFFKGLEIYQTKLLHYLARNFYNLRFLALFVAFAINFILLFYKVTEEPLE EETEDVANLWNSFNEDDEEEAMVFFVLQESTGYMAPTLRALAIVHTVISLVCVVGYYCLK VPLVVFKREKEIARKLEFDGLYITEQPSEDDIKGQWDRLVINTPSFPNNYWDKFVKRKVI NKYGDLYGAERIAELLGLDKNALDFSPVEEAKAEAASLVSWLSSIDMKYHIWKLGVVFTD NSFLYLAWYTTMSVLGHYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAV VVYLYTVVAFNFFRKFYNKSEDDDEPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIEDPAG DPYEMYRIVFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVREDMETKCFICGIGND YFDTTPHGFETHTLQEHNLANYLFFLMYLINKDETEHTGQESYVWKMYQERCWDFFPAGD CFRKQYEDQLG NT seq 14616 nt NT seq  +upstreamnt  +downstreamnt atggctgaatcgggagaaggaggcgaggatgagatccagttcctgcggactgaggatgag gttgtactccagtgcatcgcaaacattcacaaggagcagcggaagttctgcctggcagct gagggacttgggaatcgcctgtgcttcttggaacctacctcagaagcaaagtacattcct ccagatctctgtgtctgcaatttcgtgctggaacagtccttatctgtcagagcactgcaa gaaatgcttgccaacaccgttgaaaatggtggagaagggctcagtgacctctcggaatgg gcagcacaaggcggtagccacaggaccctgctctacgggcatgcaattctcctgcggcac tccttcagtggaatgtatctaacgtgcttgaccacgtcaagatcccagacggataaactt gcctttgatgtaggtctgcgggaacatgccacaggagaagcctgttggtggaccatacat cctgcttcgaaacaaaggtctgaaggagagaaagtacgaattggtgatgaccttatcctt gtcagtgtgtcctccgaaagatatctccatctctcaatctcaaatggtagcatccaagtg gatgcctcctttatgcaaacactctggaatgtacatcctacatgttcaggaagtagcatc gaagaaggatacctactcggtggccacgtagttcgacttttccacggtcatgatgaatgt ttgacgataccatctacggatcagaatgactctcagcacaggagggtgttctatgaagct ggaggagctgggaccagagccaggtctctatggagagtggaaccccttcggataagctgg agtggcagtaacatcaggtggggccaggctctccgactccggcatctcaccacaggccac tacctggccttgaccgaagaccaaggccttcttcttcaagaccgtggaaaagccgacacc aagtccacagccttctccttccgagcatcaaaggaaatcaaggagaaactagattccagt cacaaaagagatatggaaggcatgggagttccagaaatcaagtatggggattctgtctgc tttgttcagcatgtagccagtggcctctgggtcacctacaaagcacaagatgccaagact tcccgcctgggacctctgaaaaggaaggtcatactccatcaggaaggccacatggatgat ggattaacactgcagcgatgccagcaggaagagtcccaggctgctcgcatcatccggaac accacagccttattcagccagtttgtcagtggaaacaatcgcacagctgcccctgtggcc ttgccaatagaagaggtcctacagaccctacaagacttgatagcctacttccaaccacca gaggaggacatgcaacatgaagacaaacagaataagctccgctctctaaaaaacagacag aatcttttcaaggaagaggggatgctggcccttgtattgaactgcatcgatcgattaaac atctacaacagtgtagcacactttgcagggatcatcagggaagagaacggcatggcctgg aaagagattctgaacctgctatacaaattactagctgctctcattcgtggaaacagaaac aactgtgctcaattctccaataaccttgattggttaattagtaagttggacagattagaa tcttcctcaggtatcttggaggtcttgcactgcatcttgattgaaagcccagaagcctta aacctaatagcagagggccacatcaagtccatcatctccctactggataagcacgggcgg aatcacaaggttcttgatgtcctgtgctccctctgtctctgcaatggggttgcagtaaga gccaaccagaatctgatctgtgacaacctactaccccgaaggaacctgcttctgcagaca cggctaattaatgatgtcaccagtatccgaccaaacatcttcctgggagttgctgaaggt tcaccccagtacaagaagtggtactttgagttaattatcgaccaagtggagcctttccta acagcagagcccactcatctgcgggtgggctgggcctcctcttcaggctatgccccatac cctggaggtggagaaggatggggaggcaacggtgttggtgatgacctgtactcctatggc tttgatgggcttcatctctggtcaggccggatacccagagctgtggcctccatcaaccag catctgctgaagtcagatgatgtggtgagctgctgccttgaccttggagtacccagcatt tctttccgaatcaatggacaacctgtgcagggaatgtttgagaatttcaacacagatgga ctctttttccccgtgatgagtttttcggctggtgtcaaagtacgcttcctgatgggtggt cggcatggggaatttaagttcctgcctccttctggctatgccccttgctatgaagcctta cttccgaaggagaagatgagattggagcctgtcaaagaatataagcgtgatgctgatggt gttagagatctgttgggtaccactcagtttctctcccaagcctctttcatcccatgtccc atagataccagtcaggttgttttgccacttcacctagagaagatcagagacagactggcc gagaatatccatgagctttggggaatgaataaaatagaactcggctggacttttggcaaa gtgcgggatgacaacaaaagacaacatccctgccttgtggagttttcaaagctccctgaa actgagaagaattataacctgcagatgtcaactgaaaccttgaaaaccttgctggctctg ggctgccacattgctcatgttaacccagctgcagaagaggatctaaagaaagtgaaactg cccaaaaactatatgatgtccaatggctataagccagcccctttggatttatctgatgtg aagctattaccacctcaagaaattttagtagataagcttgcagaaaatgcacacaatgtt tgggcaaaggacagaataaaacaaggatggacctacggcattcaacaggatttgaagaat aaaagaaatccccgcctggtgccatatgcgttactagatgagcgaaccaagaaatcaaac agggacagcctacgggaagctgtacggacatttgttggttatggatataacattgaacca tcagaccaagaactagtagctgaccctactgtcgagaaggtcagcatagacaagatccga tttttccgggtagagcggtcatatgcagtaaaatctggaaagtggtactttgaattcgaa gtagtaacaggaggagacatgcgcgttggctgggccaggccaggctgtcgtcctgacatt gagctcggagctgacgaccaagccttcgtgtttgaaggcagcaggggtcagcgttggcat caaggcagtgggtattttggacgaacttggcagccaggagatgtggtcgggtgcatgatt aacctggacgacgcctctatggtcttcacactgaatggggagctgctcatcaccaacaaa ggctctgaacttgccttcgcagactatgagatcgagaacggttttgtgcccatttgctct ctggggctgtcccagattggccgcatgaatcttgggacagatgccagtaccttcaagttt tataccatgtgtggactccaggagggctttgagccttttgcggtaaatatgaaccgagat gttgctgtgtggtttagcaagcgcctcccaacatttgtgaatgtgcccaaggatcatccc cacatagaggttgtgagaattgatggcaccatggacagtcctccatgcctcaaggtgacc cacaagaccttcggcacacagaacagcaatgccaacatgatctactgccgcctgagcatg cccgttgaatgccattcttcattcagccacagtccctgcctagacagtgaagccttccaa aaaaggaaacagatgcaagaaatactctctcacacaacaacacaatgctactatgctatc cgcatttttgctgggcaggacccatcatgtgtctgggttggatgggtgactccagactac catttatacagtgaaaagtttgacctgaataaaaactgcaccgtgactgtcaccctggga gatgaaaggggccgggttcatgaaagtgtgaaacgtagcaactgctatatggtctggggt ggggacattgtagccagttcccagagatcaagccggagcaatgtggacctggagattggc tgccttctagatctggcaatgggcatgttgtccttctctgcgaatgggaaggaacttggc acctgctaccaggtggagcctaacaccaaagtattcccagcagtcttcctccagcctaca agcacctccttgtttcagtttgaacttggaaaactgaagaatgcaatgcctctgtcagca gccatatttaagagtgaagagaagaaccccatcccacagtgcccacctaggctggatgtc caaaccatccagcctgtgctctggagccgcatgcccagcagcttcctcaaagtggagacc gagcgagtgagcgagcgccacggctgggtggtgcagtgcctagaacccctgcaaatgatg gcactccacatccctgaggagaacaggtgtgtggacatcctcgagctctgtgagcaggag gacctgatgcagttccattaccacacactgagactttacagcgctgtgtgcgctctggga aatagccgagttgcttctgccctgtgcagccatgtggacctctcacagctcttctatgcc attgacaacaagtacctgcctggcctcctccgatctggtttctatgacctgcttattagc atccacctggccaatgctaaggagaggaagctgatgatgaagaatgagtacatcatccct atcaccagcagtaccaggaatatccgcctatacccagatgagtccaagaggcatggtttg cctggggtgggcctgaggacatgcctcaagccaggcttcaggttctctaccccttgcttt gtggtgactaatgaggaccatcagaaacagagccctgagattcccttgcagattctcaag acaaaggccctgagcatgctgaccgaggcggtacattgtagtggggcccacatcagagac cctgttgggggttctgtggagttccagtttgtgcctgtgctgaaactcattgggaccttg ttagtcatgggagtttttgacgacgatgatgttcgccagattctcctcctgatagatccc tctgtgtttggggagcacagtggtgagacagaagagggagtggagaaagaagtgacccac gtagaggaaaaggcggtggaggctggagaaaaggctagcaaggaggctccagtcaaaggc ttgctgcagacccgattacctgagtctgtcaagctgcagatgtgcgaactcctcagctac ctctgtgactgtgaactacagcaccgagtagaggctattgtggcatttggtgacatttac gtgtccaagctgcaggcaaatcagaagttccgctacaatgagctcatgcaggccctgaat atgtctgcagccctaactgcccggaagacaagagagttccgctcaccaccccaggagcag atcaacatgctcctcaactttcacctgggagagaactgcccctgcccagaggagatccga gaggagctgtacgacttccatgaggaccttctggttcactgtggggtccccttggaggaa gaggaggaagaggaggaggacacttcatggacaggaaaactgtgtgctctggtgtataaa atcaaggggcaacccaagcctgagaaggagccaccaacagaggaagaggaaccgtaccct acaacactgaaggaactagtctcacagacaatgatccgttgggcccaggagaaccaaatc caggatgcagagctggtgaggatgatgttcaacctcctccggagacagtatgacagcatc ggggagttgctacaggctctgcggaagacctacaccatcagccaggcctctgtgaacgac accatcaacctgctggctgccctgggccagattcggtccctgcttagtgtcaggatgggg agagaagaggagctcctcatgatcaacgggctaggggacataatgaacaacaaggtgttt taccagcatcccaaccttatgagagtcctcggcatgcatgagacagtgatggaagtgatg gtgaatgtgttgggtacagaaaagtcacagattgccttcccaaagatggttgctagctgc tgccgcttcctttgctatttctgtcgaattagccggcaaaatcagaaggccatgtttgag catctgagttacctgctggagaacagtagtgtgggcctagcatccccatcaatgaggggg tccaccccactggatgtggcagcctcctctgtgatggacaataacgaattagcactgggc ttagaagaaccggatcttgagaaggttgtaacctacttggcaggttgtggtcttcagagc tgccccatgcttctggccaaaggataccctgacatcggttggaaccccattgaaggagag cgttacctgtccttcctgaggtttgccgtcttcgtgaacagtgaaagtgtggaggaaaat gccagtgttgtggtcaagttgctcatcagacgtcccgagtgctttggtccagctctgagg ggtgaaggagggaacggactgctggcagctatgcagggtgccattaagatctcagagagc cctgccctcgaccttccttcccagggttacaagacggaagtcacacaggacgatgaagag gaggaagagattgtgcacatgggcaatgcaattatgtcattttattcagcgcttatcgat ctattaggccgatgtgctcctgaaatgcatctcatccaaacaggcaaaggggaagccatc cggatccggtccatcctgcgctccctggtccccacagaagacctggttggaatcatcagc attcccctgaagctgccctccctaaacaaagatgggtccgtcagcgagccagacatggcg gccaacttctgtcctgaccacaaagcacccatggtgctgttcttggaccgtgtttatggc attaaagatcaaacttttctgctccacttgctggaagttgggtttttacccgatttacga gcttctgcatctctagatacagtgtccctcagcaccacagaggccgcgctggcactgaat aggtatttatgttcggctgtgctcccgctccttactagatgcgcccctctcttttctggg acagagcactgtacttctctgatcgactctacactgcagacaatatacagactttccaaa ggacggtccctcaccaaggcacagagggacaccatagaagaatgtttgctagccatttgc aatcacttgagaccttccatgttacagcaactcctgcggcgtctggtctttgacgtgcca cagctcagcgagtactgcaaaatgccactcaagctcctgacaaatcactatgagcagtgc tggaagtattactgcctgccttcgggatgggggagctatgggctagcagtggaggaggag ctgcacctcacggagaagctcttctgggggatttttgactccctctcgcacaagaaatac gacccggaccttttccgaatggccctgccttgtctcagtgctattgctggagccttgcca ccggactatttagatactagaatcacggccacactggagaagcaggtctcagtggatgca gatggaaactttgaccccaaacctatcaacaccatgaatttttccttgcctgaaaaattg gaatacattgtcaccaagtacgctgagcattctcatgataaatgggcttgcgacaagagt cacagtggatggaaatatgggatttctctggatgaaaatgtgaagacccacccactaata cggcctttcaagaccttaacagagaaggagaaggaaatttatcgctggcctgccagagag tccctgaaaaccatgctggctgtgggctggacagtggaaaggaccaaagaaggagaagct ttggttcaacaaagagagaatgagaagcttcgatgtgtgtcccagtccaatcagggcaac agctacagccctgcccctctggatctctcaaatgttgtgctgtccagggagcttcaggga atggtggaggtggtggctgaaaactatcacaatatctgggccaagaagaagaagctggag ctggaaagcaaaggtggtggcagtcaccctcttttggtaccatatgacaccttgactgcc aaggaaaagctcagggatcgagaaaaggcacaggacctgttcaaattcctccaggtgaat ggcattctagtttctagaggcgtgaaggacatggagctggatgcctcctccatggaaaag agatttgcctacaagtttttgaggaagatcctgaagtacgttgactctgctcaagagttt attgcccacttggaagccattgtcagcagtgggaaaacggaaaagtctccccatgaccag gagatcaaattctttgccaaagttctcctcccactggttgaccagtacttcaccaaccac cgcctttatttcctgtcatctcctttgaagccgcttagcagcagtgggtatgcttcccat aaagagaaagaaatggtggccagcctattctgcaagctggccgctcttgtgagacacagg atttccctctttgggagtgattcaactacaatggtgagctgtcttcatatcttagctcag acacttgacacaaggacagtgatgaagtcaggctcagagctggtgaaagccgggctgcga gcgttctttgaaaatgctgcggaagaccttgagaagacctcagaaaacctgaagctgggg aagtttacccattccagaacgcagatcaaaggtgtttctcagaatattaactacaccaca gtggctctgcttcccatcctgacatccatctttgagcacatcgctcagcatcagtttggg gtggatctactcttgagtgacgtgcagatttcatgctaccacattctgtgcagcctctat tcccttgggactgggaaaaatatctatgttgaaaggcaacgtcctgctcttggagaatgt ctggcttccctagcagctgctatccctgtggcatttctggaacccagccttaaccgctat aatcccctctcagtcttcaacaccaaaacacccagggagcggtctattctggggatgcca gacaaggtggaggacatgtgtcctgacgtcccgcagctggaaggcctgatgaaggaaatc aatggcttggccgagtcaggtgcccggtataccgagatgccccatgtcattgaagtgatc ttgcccatgctctgcaactacctgtcctactggtgggagcggggacctgagaacctgccc ccaagcataggaccctgctgcaccaaggtcacatctgaacacctcagcctcatcctgggc aacatactgaaaatcatcaacaacaacctgggcattgatgaggcctcctggatgaagcgt atcgcagtgtatgcccagccaatcatcagcaaagccaggcctgacctgcttcgaagccac ttcatccccaccctggagaagctgaagaagaaggcggtgaagattgtgcaggaggaggag cagctgaagactgatggcaagggggatacccaggaggctgagctcctcatcctagacgag tttgctgtcctctgcagggacctgtatgccttctaccccatgctgatccgctatgtggac aacaacagatctaactggctcaaaagcccggatactgattctgaccagctcttccgaatg gtggccgaggtcttcattctgtggtgtaaatctcacaacttcaagagggaagagcaaaat ttcgtgattcaaaatgaaattaataacttggcatttttaactggagacagcaaaagcaag atgtcaaaatctggaggacaggaccaggaacggaagaagacaaagaggcgaggagacttg tattccatccagacgtccctcatcgtggctgcactcaagaaaatgctgcccattggtctg aacatgtgtactccaggcgaccaggagctcatctcgcttgcgaaatcacgatacagctgt agagacactgatgaagaagtcaaggaacatcttcggaataacctgcacctgcaggagaag tctgatgaccccgctgtgaaatggcaactgaacctctacaaagacgttctgaggaatgaa gagccttctaatccagaaaagacggtggagcgggtgcagaggatttcagcggctctgttc cacctggagcaggtggaacagcctttgaggtccaaaaaggctgtgtggcataaattgttg tcaaagcaacggaaacgggcagtggtggcctgtttcaggatggctccactctacaatctg cccagacacaaaattaacaatttcttcctgatcacctttcaacgtgtttggctggaaaag gttaatgaaaaaactcagtatgacagactaatacccattttaatgaaatctcccagggtt gaagatgaggaagaagaggagaccgaaaagcaacctgacccccttcaccagatcattcta cattttagccgcaatgcgctcactgagaggagcaaattggaagatgacccactgtacact tcctattccagcatgatggccaagagctgtcagagtggtgaggatgaagaagaagaggaa gacaaggaaaaaacattcgaagagaaggagatggagaagcaaaagacactatatcagcaa gcacgactacacgagcgtggtgctgcagagatggtccttcagatgataagtgccagcaaa ggtgagatgagccccatggtggttgagaccctgaagctggggattgccattctgaacgga ggcaatgctggtgtgcaacagaaaatgctagattacttaaaggagaaaaaagatgctgga ttctttcaaagcctttctggtcttatgcagtcttgcagtgtccttgatttgaatgcattt gagaggcagaataaagctgaaggcctggggatggttacagaagaaggcaccctcattgtc cgtgagcgtggtgaaaaggtactccagaatgatgaattcacacaagatctctttagattt ctacagttgctttgtgaaggacataacagtgactttcagaacttcctgagaactcagatg ggcaacaccactactgtgaacatcattattagcaccgtggactaccttctgcgtctgcag gagtcaatcagcgatttctattggtactattcaggaaaggacatcattgatgaatctgga cagcacaatttctctaaagctctggcagtcaccaagcaaatctttaattctcttacagag tacatccagggcccttgcatcgggaaccagcagagcctggctcacagtaggctgtgggat gcagtggttggattcctccatgtatttgctaacatgcagatgaagctctctcaggattcc agtcagatcgagctgctgaaggaactcttggatctccttcaggacatggtggtgatgctt ctgtccctcctggaaggaaatgtggtaaatgggactattggaaagcagatggttgacacg ctggtagaatcgtctactaatgtagagatgatcttgaaattctttgacatgttcttgaaa cttaaagacttaaccagctcagacaccttcaaagaatatgacccagatggtaaagggatc atctcccgaaaagaattccagaaggccatggaaggtctaaagcaatatacacagtcagag attgattttcttctttcgtgtacagaggctgatgagaatgacatgtttaattatgtggat tttgtagagaggttccacgagccagccaaggacatagggttcaatgtggcggtgttattg acaaatctctctgagcatatgccaaatgattctcgtctcaagtgtctcttggacccagca gaaagtgtgctaaattactttgaaccatacctgggtcgaatcgagatcatgggtggggcc aagaagattgagcgtgtttattttgagatcagtgaatccagtcgaactcagtgggaaaag cctcaagtgaaggaatctaagcgacagttcatctttgatgttgtcaatgaaggcggggag caagagaagatggaactgtttgtgaacttctgtgaagatacaatattcgagatgcaatta gcatctcagatctcagaatctgactcaactgacaggccagaagaggaagaggaagaggat gaagattcctattcggtagaaattgagggggaggaagaagataaatcttttgagtctgcc tctgcatttgccatggcctgtgcctcagcaaagagaaatgtcaccaagtttctgaagaag gcaaccttgaagaacctcaggaaacagtacaggaatgtgaaaaagatgagcgcaaaggag ctggtcagggtgctctcctccttcttctggatgctggttgtgggcctctttcagttgctc ttctctatcttgggaggaatctttcacatactctggaacacagtatttggagggggcctt gtagaaggggcaaagaacatcagagtgactaagatcctaggtgacatgcccgaccccacc cagtttgggatccatgatgatgtaatggagattgacagggcggaagtgactgagccaggt atcaccaccgagctggtccactttgtaaagggtgaggccggagacacagacgtcatgtca gacctctttggaatccactcaaagaaagaaggtggttcaaagcaagggcctgaagtggga ttaggtgacctctctgaaattaccggcaaagacgaacccccgacattagagagtactgta cggaagaaaaggaaagcacaggcagcagagatgaaggcagtgcatgaagctgaaggaaga actgaatctgagaaggccgacatggaagacagagaaaaggaagacaaaatcaaggaggag ggacaagcagagtacctgtgggcagacacaacagtaaagaagacgcgacggcgtggtcag aaggccgagaagccagtagccttcatggccaacttcttcaaagggctggagatttatcag accaagttactgcactacctggccaggaatttctacaacctgaggttcctcgctctattt gtagccttcgctatcaacttcatcctgcttttctataaggtcacggaagagcctttagag gaagaaacagaggatgttgcaaacctgtggaactcattcaatgaggatgatgaggaagaa gcgatggtgttctttgttcttcaggagagcactgggtatatggcaccaacactgcgtgcc ctggccattgtccacactgtcatctctctggtctgtgtggtgggctattactgcctgaag gtacctttggtggtattcaaaagggagaaggaaattgccaggaagctggagtttgatggt ctgtatatcactgagcagccatctgaggatgacatcaaagggcagtgggatcgcttggtg atcaacacgccatcttttcctaataactactgggacaagtttgtgaagagaaaggtgatc aacaagtatggagatctctatggagcagagcgcatcgctgaactcctgggtttggacaaa aatgccctggactttagcccagtagaagaggccaaagcagaggcggcgtctctggtgtca tggctaagttccatcgacatgaagtaccatatttggaagctaggggtggttttcactgac aactcctttctctaccttgcctggtacacaaccatgtctgtcctgggccactacaacaac ttcttctttgctgctcatctgttggatattgccatgggctttaagaccttgaggacgatc ctgtcatctgtgactcacaatggcaaacagctggttctgactgttggcctcctggctgta gttgtttacctctatactgtggtggctttcaacttcttccgcaagttctacaacaaaagc gaagatgatgatgagccggatatgaagtgtgatgacatgatgacgtgctacctcttccac atgtatgtgggcgtaagagcaggtggcggcattggtgacgaaattgaagatcccgctggt gacccttatgaaatgtatcgcatcgtctttgatattaccttcttcttctttgtcattgtc atcttgctggccatcattcaaggtcttattattgatgcttttggagagctgagggaccag caggaacaagtacgggaagacatggagactaaatgcttcatctgtggcattggcaatgac tactttgacacgacccctcatggttttgaaacgcatacattgcaagagcacaacttagcc aattatctattcttccttatgtatttgattaacaaggatgaaacagaacacacgggtcag gaatcctatgtgtggaagatgtaccaggaaaggtgttgggacttcttcccagctggagac tgcttccgtaagcaatatgaagatcagctcgggtaa

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