KEGG   Rattus norvegicus (rat): 24422
Entry
24422             CDS       T01003                                 
Symbol
Gsta2
Name
(RefSeq) glutathione S-transferase alpha-1
  KO
K00799  glutathione S-transferase [EC:2.5.1.18]
Organism
rno  Rattus norvegicus (rat)
Pathway
rno00480  Glutathione metabolism
rno00980  Metabolism of xenobiotics by cytochrome P450
rno00982  Drug metabolism - cytochrome P450
rno00983  Drug metabolism - other enzymes
rno01100  Metabolic pathways
rno01524  Platinum drug resistance
rno05200  Pathways in cancer
rno05204  Chemical carcinogenesis - DNA adducts
rno05207  Chemical carcinogenesis - receptor activation
rno05208  Chemical carcinogenesis - reactive oxygen species
rno05225  Hepatocellular carcinoma
rno05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:rno00001]
 09100 Metabolism
  09106 Metabolism of other amino acids
   00480 Glutathione metabolism
    24422 (Gsta2)
  09111 Xenobiotics biodegradation and metabolism
   00980 Metabolism of xenobiotics by cytochrome P450
    24422 (Gsta2)
   00982 Drug metabolism - cytochrome P450
    24422 (Gsta2)
   00983 Drug metabolism - other enzymes
    24422 (Gsta2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    24422 (Gsta2)
   05204 Chemical carcinogenesis - DNA adducts
    24422 (Gsta2)
   05207 Chemical carcinogenesis - receptor activation
    24422 (Gsta2)
   05208 Chemical carcinogenesis - reactive oxygen species
    24422 (Gsta2)
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    24422 (Gsta2)
  09166 Cardiovascular disease
   05418 Fluid shear stress and atherosclerosis
    24422 (Gsta2)
  09176 Drug resistance: antineoplastic
   01524 Platinum drug resistance
    24422 (Gsta2)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   02000 Transporters [BR:rno02000]
    24422 (Gsta2)
Enzymes [BR:rno01000]
 2. Transferases
  2.5  Transferring alkyl or aryl groups, other than methyl groups
   2.5.1  Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
    2.5.1.18  glutathione transferase
     24422 (Gsta2)
Transporters [BR:rno02000]
 Other transporters
  Pores ion channels [TC:1]
   24422 (Gsta2)
SSDB
Motif
Pfam: GST_C GST_C_3 GST_N GST_N_2 GST_N_3
Other DBs
NCBI-GeneID: 24422
NCBI-ProteinID: NP_058709
RGD: 2754
Ensembl: ENSRNOG00000029861
UniProt: P00502 B6DYP7
Structure
LinkDB
Position
8:complement(88064829..88077168)
AA seq 222 aa
MSGKPVLHYFNARGRMECIRWLLAAAGVEFDEKFIQSPEDLEKLKKDGNLMFDQVPMVEI
DGMKLAQTRAILNYIATKYDLYGKDMKERALIDMYTEGILDLTEMIMQLVICPPDQKEAK
TALAKDRTKNRYLPAFEKVLKSHGQDYLVGNRLTRVDIHLLELLLYVEEFDASLLTSFPL
LKAFKSRISSLPNVKKFLQPGSQRKLPVDAKQIEEARKIFKF
NT seq 669 nt   +upstreamnt  +downstreamnt
atgtctgggaagccagtgcttcactacttcaatgcccggggcagaatggagtgcatccgg
tggctcctggctgcagcaggagtggagtttgatgagaagtttatacagagtccagaagac
ttggaaaagctaaagaaagacgggaatttgatgtttgaccaagtgcccatggtggagatt
gacgggatgaagctggcacagaccagagccattctcaactacatcgccaccaaatatgac
ctctatgggaaggacatgaaggagagagccctgattgacatgtacaccgaaggcatttta
gatctgactgaaatgattatgcaattggtaatatgtcccccagaccaaaaagaagccaag
accgccttggcaaaagacaggaccaaaaaccggtacttgcctgcctttgaaaaggtgttg
aagagccatggccaagactaccttgtaggtaacaggctgacccgggtagacatccacctg
ctggaacttctcctctatgttgaagagtttgatgccagccttctgacctctttccctctg
ctgaaggccttcaagagcagaatcagcagcctccccaatgtgaagaagttcctgcagcct
ggcagtcagagaaagcttcccgtggatgcaaaacaaatcgaagaagcaaggaagattttc
aagttttag

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