Rattus norvegicus (rat): 24514 Help Entry 24514             CDS       T01003                                  Symbol Jak2 Name (RefSeq) tyrosine-protein kinase JAK2   KO K04447   Janus kinase 2 [EC:2.7.10.2] Organism rno  Rattus norvegicus (rat) Pathway rno01521   EGFR tyrosine kinase inhibitor resistance rno04062   Chemokine signaling pathway rno04151   PI3K-Akt signaling pathway rno04217   Necroptosis rno04550   Signaling pathways regulating pluripotency of stem cells rno04630   JAK-STAT signaling pathway rno04658   Th1 and Th2 cell differentiation rno04659   Th17 cell differentiation rno04725   Cholinergic synapse rno04917   Prolactin signaling pathway rno04920   Adipocytokine signaling pathway rno04933   AGE-RAGE signaling pathway in diabetic complications rno04935   Growth hormone synthesis, secretion and action rno05140   Leishmaniasis rno05145   Toxoplasmosis rno05152   Tuberculosis rno05161   Hepatitis B rno05164   Influenza A rno05167   Kaposi sarcoma-associated herpesvirus infection rno05168   Herpes simplex virus 1 infection rno05200   Pathways in cancer rno05207   Chemical carcinogenesis - receptor activation rno05235   PD-L1 expression and PD-1 checkpoint pathway in cancer rno05417   Lipid and atherosclerosis Brite KEGG Orthology (KO) [BR:rno00001]  09130 Environmental Information Processing   09132 Signal transduction    04630 JAK-STAT signaling pathway     24514 (Jak2)    04151 PI3K-Akt signaling pathway     24514 (Jak2)  09140 Cellular Processes   09143 Cell growth and death    04217 Necroptosis     24514 (Jak2)   09144 Cellular community - eukaryotes    04550 Signaling pathways regulating pluripotency of stem cells     24514 (Jak2)  09150 Organismal Systems   09151 Immune system    04658 Th1 and Th2 cell differentiation     24514 (Jak2)    04659 Th17 cell differentiation     24514 (Jak2)    04062 Chemokine signaling pathway     24514 (Jak2)   09152 Endocrine system    04920 Adipocytokine signaling pathway     24514 (Jak2)    04917 Prolactin signaling pathway     24514 (Jak2)    04935 Growth hormone synthesis, secretion and action     24514 (Jak2)   09156 Nervous system    04725 Cholinergic synapse     24514 (Jak2)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     24514 (Jak2)    05207 Chemical carcinogenesis - receptor activation     24514 (Jak2)    05235 PD-L1 expression and PD-1 checkpoint pathway in cancer     24514 (Jak2)   09172 Infectious disease: viral    05161 Hepatitis B     24514 (Jak2)    05164 Influenza A     24514 (Jak2)    05168 Herpes simplex virus 1 infection     24514 (Jak2)    05167 Kaposi sarcoma-associated herpesvirus infection     24514 (Jak2)   09171 Infectious disease: bacterial    05152 Tuberculosis     24514 (Jak2)   09174 Infectious disease: parasitic    05145 Toxoplasmosis     24514 (Jak2)    05140 Leishmaniasis     24514 (Jak2)   09166 Cardiovascular disease    05417 Lipid and atherosclerosis     24514 (Jak2)   09167 Endocrine and metabolic disease    04933 AGE-RAGE signaling pathway in diabetic complications     24514 (Jak2)   09176 Drug resistance: antineoplastic    01521 EGFR tyrosine kinase inhibitor resistance     24514 (Jak2)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:rno01001]     24514 (Jak2) Enzymes [BR:rno01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.10  Protein-tyrosine kinases     2.7.10.2  non-specific protein-tyrosine kinase      24514 (Jak2) Protein kinases [BR:rno01001]  Non-receptor tyrosine kinases   JAK family [OT]    24514 (Jak2) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  PK_Tyr_Ser-Thr Pkinase FERM_F2 FERM_F1 Jak1_Phl SH2 ABC1 Kinase-like RIO1 APH Motif Other DBs NCBI-GeneID:  24514 NCBI-ProteinID:  NP_113702 RGD:  2939 Ensembl:  ENSRNOG00000059968 UniProt:  Q62689 LinkDB All DBs Position 1:226995334..227054381 Genome browser AA seq 1132 aa AA seqDB search MGMACLTMTEMEGTSTSPAHQNGDIPGNANSVKQTEPVLQVYLYHSLGQAEGDYLKFPNG EYVAEEICVAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNILYRIRFYF PHWYCSGSNRTYRYGVSRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLG MAVLDMMRIAKEKDQTPLAVYNSISYKTFLPKCVRAKIQDYHILTRKRIRYRFRRFIQQF SQCKATARNLKLKYLINLETLQSAFYTEQFEVKESARGPSGEEIFATIIITGNGGIQWSR GKHKESETLTEQDLQLYCDFPDIIDVSIKQANQECSTESRVVTVHKQDGKVLEIELSSLK EALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIHSNCHGPISMDFAISKLKKAGNQT GLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENGEYNLSGTKRNFSSLKDLLNC YQMETVRSDSIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVQLSPTLQRHNNVNQMVFHKI RNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASM MSQLSHKHLVLNYGVCVCGEENILVQEFVKFGSLDTYLKKNKNSINILWKLGVAKQLAWA MHFLEEKSLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVP PECIENPKNLTLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDKHQLPAPKWTEL ANLINTCMDYEPDFRPAFRAVIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRD PTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIE ILKSLQHDNIVKYKGVCYSAGRRNLRLIMEYLPYGSLRDYLQKHKERIDHKKLLQYTSQI CKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFW YAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPVEFMRMIGNDKQGQMIVFHLIE LLKNNGRLPRPEGCPDEIYVIMTECWNNNVNQRPSFRDLSLRVDQIRDSMAA NT seq 3399 nt NT seq  +upstreamnt  +downstreamnt atgggaatggcttgccttacaatgacagaaatggagggaacctccacatctcctgcacat cagaatggtgatattcctggaaatgctaactctgtgaagcagacagagccagtccttcaa gtgtacctgtaccattctcttgggcaagctgaaggagactatctgaagtttccaaatgga gagtatgttgccgaagaaatttgtgtggctgcttctaaagcatgtggtattacgcctgtg tatcataatatgtttgctttaatgagtgaaacagaaaggatctggtatccacccaatcat gtcttccacatagatgagtcaaccaggcataatatactctacagaataaggttttacttt cctcattggtactgcagtggcagcaacagaacctataggtacggagtatctcgtggggct gaagctcctctccttgacgactttgtcatgtcttacctttttgctcagtggcggcatgat tttgttcatgggtggataaaagtacctgtgactcacgaaactcaggaagaatgtcttggc atggcagtgttagacatgatgagaatagctaaggagaaggaccagactcccctggctgtc tataactccatcagctacaagacgttcttaccgaagtgcgtgcgagcgaagatccaggac tatcacattttaactcggaagcggataaggtacagattccgcaggttcattcagcagttc agtcagtgcaaagccactgccaggaacctaaaacttaagtatctcataaacctggagacc ctgcagtctgccttctacacagaacagtttgaagtaaaagaatctgcaagaggtccttca ggtgaggagatttttgcaaccattataataactggaaacggtggaattcagtggtcaaga gggaaacataaggaaagtgagacactgacagaacaggatttacagttgtattgtgatttt cctgatattattgatgtcagtattaagcaagcaaatcaggaatgctcaactgaaagtaga gttgtgaccgtccacaagcaggacgggaaggtcttggaaatagaacttagctcattaaaa gaagccttgtcatttgtgtcgttaattgacgggtattacagactaactgcggatgcacac cattacctctgtaaagaggtggctcctccagccgtgcttgaaaacatacacagcaactgt cacggcccaatttcaatggattttgccatcagcaaactaaagaaggcaggaaaccagact ggactgtatgtacttcgatgtagccctaaggacttcaacaaatacttcctgacctttgcc gttgagcgagaaaatgttattgaatataaacactgtttgattacaaagaatgagaatgga gagtacaacctcagtgggactaagaggaacttcagtagtcttaaggaccttttgaattgc taccagatggaaactgtgcgctcagacagtatcatcttccagttcaccaaatgctgtcct ccaaagccgaaagataaatcaaaccttcttgtcttcagaacaaatggtgtttctgatgtt cagctctcaccaacattacagaggcataataatgtgaatcaaatggtgtttcacaaaatc aggaatgaagatttgatatttaatgaaagccttggccaaggcacttttacaaaaatattt aaaggtgtaagaagagaagttggagattatggtcagctgcacgaaaccgaagttcttttg aaagtcctagataaagcacatagaaactattcagagtctttctttgaagcagcaagcatg atgagtcagctttctcacaagcatttggttttgaattatggagtatgtgtctgtggagag gagaacattttggttcaagagtttgtaaaatttggatccctggatacatacctgaaaaaa aacaaaaattccataaatatactatggaaacttggagtggccaaacagttggcatgggcc atgcacttcctcgaagaaaaatcccttattcatgggaatgtgtgtgccaaaaatatcctg cttatcagagaagaagacaggaaaacagggaatccacctttcatcaaacttagtgatcct gggattagcatcacagttctaccaaaggacattcttcaggagagaataccatgggtacca cctgagtgcattgaaaaccctaaaaatctaactttggcaacagacaagtggagctttggc accactctgtgggagatctgcagtggaggagacaagcctctgagtgctctggactctcaa agaaagctgcagttctatgaagataagcaccagctcccagcacccaagtggacagagttg gcaaaccttataaatacttgcatggattatgagccagacttcaggcctgccttcagagct gtcatccgtgatctgaacagcctgtttactccagattatgaactgctgacagaaaatgac atgctacccaacatgagaataggtgccctaggattttctggtgcttttgaagacagggac cctacacagtttgaagagagacacttgaaatttctacagcaacttggcaagggtaacttt gggagtgtggagatgtgccgctatgacccgctgcaggacaacactggagaggtggtagct gttaagaagctccagcacagcacggaagagcatctccgagactttgaaagggaaattgaa atcctgaaatccttgcagcatgacaacatcgtgaagtacaagggagtgtgctacagtgct ggtcggcgcaacctaagattaattatggaatatttgccgtatggaagtttacgagactat ctccaaaaacataaagaacggatagatcacaaaaaacttctgcagtatacatcccagata tgcaagggcatggagtatcttggtacaaaaaggtatatccaccgggatctggcaacaagg aatatattggtagaaaatgagaacagagttaaaataggagattttggattaaccaaagtc ttgccacaggacaaagaatactacaaagtaaaggaaccaggtgaaagtcccatattctgg tatgctcccgaatccttgacagagagcaagttttctgtggcctcagatgtgtggagcttt ggtgtggttctgtacgaacttttcacgtatatcgagaagagcaaaagcccacctgtggaa tttatgcgaatgatcggcaatgataaacaagggcagatgatcgtattccatttgatagag ctactgaagaacaacggaagactgccgagaccagaagggtgcccagacgagatttatgtg atcatgacagaatgctggaacaacaatgtcaaccaacgtccctctttcagggacctttcc cttcgggtggatcaaatccgggacagtatggctgcatga

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