Rattus norvegicus (rat): 24592 Help Entry 24592             CDS       T01003                                  Symbol Nf1 Name (RefSeq) neurofibromin   KO K08052   neurofibromin 1 Organism rno  Rattus norvegicus (rat) Pathway rno01521   EGFR tyrosine kinase inhibitor resistance rno04010   MAPK signaling pathway rno04014   Ras signaling pathway Brite KEGG Orthology (KO) [BR:rno00001]  09130 Environmental Information Processing   09132 Signal transduction    04010 MAPK signaling pathway     24592 (Nf1)    04014 Ras signaling pathway     24592 (Nf1)  09160 Human Diseases   09176 Drug resistance: antineoplastic    01521 EGFR tyrosine kinase inhibitor resistance     24592 (Nf1) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  PH_NF1 RasGAP CRAL_TRIO_2 CRAL_TRIO MIF4G_like_2 Motif Other DBs NCBI-GeneID:  24592 NCBI-ProteinID:  NP_036741 RGD:  3168 Ensembl:  ENSRNOG00000013780 UniProt:  P97526 LinkDB All DBs Position 10:64803986..65037086 Genome browser AA seq 2820 aa AA seqDB search MAAHRPVEWVQAVVSRFDEQLPIKTGQQNTHTKVSTEHNKECLINISKYKFSLVISGLTT ILKNVNNMRIFGEAAEKNLYLSQLIILDTLEKCLAGQPKDTMRLDETMLVKQLLPEICHF LHTCREGNQHAAELRNSASGVLFSLSCNNFNAVFSRISTRLQELTVCSEDNVDVHDIELL QYINVDCAKLKRLLKETAFKFKALKKVAQLAVINSLEKAFWNWVENYPDEFTKLYQIPQT DMAECAGKLFDLVDGFAESTKRKAAVWPLQIILLILCPEIIQDISRDVVDENNTNKKLFL DSLRKALAGHGGSRQLTESAAIACVKLCKASTYINWEDNSVIFLLVQSMVVDLKNLLFNP SKPFSRGSQPADVDLMIDCLVSCFRISPHNNQHFKICLAQNSPSTFHYVLVNSLHRIITN SAWDWWPKIDAVYCHSVELRNMFGETLHKAVQGCGAHPALRMAPSLTFKEKVTSLKFKEK PTDLEARSYKYLLLSMVKLIHADPKLLLCNPRKQGPETQGSTAELITGLVQLVPQSHMPE VAQEAMEALLVLHQLDSIDLWNPDAPVETFWEISSQMLFYICKKLTSHQMLSSTEILKWL REILICRNKFLLKNKQADRSSCHSLYLYGVGCDLPASGNVTQMSVDHEESLRTCAPGASL RKGRGNSSMDSTAGCSGTPPICRQAQTKLEVALYMFLWSPDTEVVLVAMSCFRHLCEEAD IRCGVDEVSVHNFLPNYNTFMEFASVSNMLSTGRAALQKRVMALLRRIEHPTAGNTEAWE DTHAKWEQATKLILNYPKAKMEDGQAAESLHKTIVKRRMSHVSGGGSIDLSDTDSLQEWI NMTGFLCALGGVCLQQRSSSGLATYSPPMGPVSERKGSMISVMSSEGNVDSPVSRFMDRL LSLMVCNHEKVGLQIRTNVKDLVGLELSPALYPMLFNKLKSAISKFFDSQGQVLLTDSNT QFVEQTIAIMKNLLDNHTEGSSEHLGQASIETMMLNLVRYVRVLGNMVHAIQIKTKLCQL VEVMMARRDDLSFCQEMKFRNKMVEYLTDWVMGTSNQAADDDVKCLTRDLDQASMEAVVS LLAGLPLQPEEGDGVELMEAKSQLFLKYFTLFMNLLNDCSEVEDENAQTGGRKRGMSRRL ASLRHCTVLAMSNLLNANVDSGLMHSIGLGYHKDLQTRATFMEVLTKILQQGTEFDTLAE TVLADRFERLVELVTMMGDQGELPIAMALANVVPCSQWDELARVLVTLFDSRHLLYQLLW NMFSKEVELADSMQTLFRGNSLASKIMTFCFKVYGATYLQKLLDPLLRIIITSSDWQHVS FEVDPTRLEPSESLEENQRNLLQMTEKFFHAIISSSSEFPSQLRSVCHCLYQVVSQRFPQ NSIGAVGSAMFLRFINPAIVSPYEAGILDKKPPPRIERGLKLMSKVLQSIANHVLFTKEE HMRPFNDFVKSNFDLARRFFLDIASDCPTSDAVNHSLSFISDGNVLALHRLLWNNQEKIG QYLSSNRDHKAVGRRPFDKMATLLAYLGPPEHKPVADTHWSSLNLTSSKFEEFMTRHQVH EKEEFKALKTLSIFYQAGTSKAGNPIFYYVARRFKTGQINGDLLIYHVLLTLKPYYAKPY EIVVDLTHTGPSNRFKTDFLSKWFVVFPGFAYDNVSAVYIYNCNSWVREYTKYHERLLTG LKGSKRLIFIDCPGKLAEHIEHEQQKLPAATLALEEDLKVFHNALKLAHKDTKVSIKVGS TAVQVTSAERTKVLGQSVFLNDIYYASEIEEICLVDENQFTLTIANQGTPLTFMHQECEA IVQSIIHIRTRWELSQPDSIPQHTKIRPKDVPGTLLNIALLNLGSSDPSLRSAAYNLLCA LTCTFNLKIEGQLLETSGLCIPANNTLFIVSISKTLAANEPHLTLEFLEECISGFSKSSI ELKHLCLEYMTPWLSNLVRFCKHNDDAKRQRVTAILDKLITMTINEKQMYPSIQAKIWGS LGQITDLLDVVLDSFIKTSATGGLGSIKAEVMADTAVALASGNVKLVSSKVIGRMCKIID KTCLSPTPTLEQHLMWDDIAILARYMLMLSFNNSLDVAAHLPYLFHVVTFLVATGPLSLR ASTHGLVINIIHSLCTCSQLHFSEETKQVLRLSLTEFSLPKFYLLFGISKVKSAAVIAFR SSYRDRSFSPGSYERETFALTSLETVTEALLEIMEACMRDIPTCKWLDQWTELAQRFAFQ YNPSLQPRALVVFGCISKRVSHGQIKQIIRILSKALESCLKGPDTYNSQVLIEATVIALT KLQPLLNKDSPLHKALFWVAVAVLQLDEVNLYSAGTALLEQNLHTLDSLRIFNDKSPEEV FMAIRNPLEWHCKQMDHFVGLNFNSNFNFALVGHLLKGYRHPSPAIVARTVRILHTLLTL VNKHRNCDKFEVNTQSVAYLAALLTVSEEVRSRCSLKHRKSLLLTDISMENVPMDTYPIH HGDPSSRTLKETQPWSSPRGSEGYLAATYPAVGQTSPRARKSMSLDMGQPSQANTKKLLG TRKSFDHLISDTKAPKRQEMESGITTPPKMRRVAETDYEMETQRISSSQQHPHLRKVSVS ESNVLLDEEVLTDPKIQALLLTVLATLVKYTTDEFDQRILYEYLAEASVVFPKVFPLVHN LLDSKINTLLSLCQDPNLLNPIHGIVQSVVYHEESPPQYQTSYLQSFGFNGLWRFAGPFS KQTQIPDYAELIVKFLDALIDTYLPGIDEETSEESLLTPTSPYPPALQSQLSITANLNLS NSMTSLATSQHSPGIDKENVELSPTTGHCNSGRTRHGSASQVQKQRSAGSFKRNSIKKIV NT seq 8463 nt NT seq  +upstreamnt  +downstreamnt atggccgcacacaggccggtggaatgggtccaggccgtggtcagccgcttcgacgagcag cttccaataaaaacaggacagcagaacacacataccaaagtcagcacggagcacaacaag gagtgtctgatcaacatttccaagtacaagttttctttggtcatcagtggactcaccacc attctaaagaatgttaacaatatgaggatatttggagaagctgctgaaaaaaatttgtat ctctctcagttgatcatattggatacactggaaaaatgtcttgctgggcaaccaaaggac acaatgagattagatgaaacaatgctggtcaaacagttgctaccagaaatctgccatttt cttcacacctgccgtgaaggaaaccaacatgcagccgaacttcggaattctgcttctggg gttttattttctctcagctgcaacaacttcaatgcagtctttagtcgaatttctacaagg ttacaggagttgactgtctgttcagaagacaatgttgatgttcatgatatagaattgtta cagtatatcaatgtggattgtgcaaaattaaaacgactcctgaaggaaacagcatttaaa tttaaagccctgaagaaggtggcacaattggcagttataaatagcctagaaaaggctttt tggaactgggtggaaaattatccagatgaatttacaaagctataccaaattccacagaca gatatggctgagtgtgcaggaaagctgtttgacttggtggatggttttgcagaaagcacc aaacgtaaagcagcagtttggccactacagatcattctcctcattctgtgtccagaaata atccaggacatatccagggatgtggtcgatgagaacaacacaaacaagaaactgtttctg gacagtttacggaaagcacttgctggccatggcggaagcagacagctgactgaaagtgct gccatcgcttgtgtcaagttgtgtaaagcaagtacttacatcaactgggaagacaactct gtcattttcctactggttcagtccatggtggttgatctgaagaacctgctttttaatcca agtaaaccattctctagaggcagtcagcctgcagatgtggacctcatgattgactgtctt gtctcttgctttcggatcagccctcacaacaaccaacactttaagatctgtctggctcag aattcaccttctacatttcactatgtgttggtaaactcactccaccgcattatcaccaat tctgcatgggattggtggcctaagattgacgctgtatattgtcactcagttgaacttcga aatatgtttggtgaaacccttcataaagcagtgcaaggctgtggagcacacccagcatta cggatggcaccaagtcttacctttaaggaaaaggtaacaagccttaagtttaaagaaaag cctacggacctagaggcaaggagctacaagtatcttcttttgtctatggtgaaactgatt catgcagacccaaagcttttgctttgtaatccaagaaaacagggccctgaaactcaaggt agtacagcagaactgattacagggctcgtacagctggttcctcagtcacacatgccagag gtcgctcaggaggctatggaggctttgttggttcttcatcagttagacagcattgatctg tggaatcctgatgctcctgtagaaacgttttgggaaattagttcacaaatgcttttttac atctgcaagaaattaactagtcatcaaatgcttagtagcacagaaattctcaagtggtta cgggaaattctgatctgcaggaataaatttcttcttaaaaataagcaggcagatagaagt tcctgtcattctctctacctttatggagtaggatgtgacctgcctgctagtggaaatgtc actcagatgtcagttgatcatgaggagtcactacgtacctgtgctcctggagcctctctg cggaaaggaagagggaattcctccatggatagcacagcagggtgcagtggaaccccacct atatgccgacaagcccagaccaagctagaagtggccttgtacatgtttctgtggagtcct gacacggaagttgttctggttgctatgtcctgtttccgccacctctgtgaagaagcagac atccgatgtggtgtggatgaagtgtcagtacacaacttcttgcccaactacaacacattc atggaatttgcctcagtcagcaatatgttgtcaacaggaagagcggcacttcagaaaaga gtgatggccctgctaaggcgcattgagcaccctactgcaggaaacactgaggcctgggaa gatacacatgcaaagtgggaacaggctacaaaactaatccttaactacccaaaggccaaa atggaagatggccaggctgcagaaagtcttcataagaccattgttaagagacggatgtcc catgtcagtggaggaggatccatagacttgtctgacacagactccctgcaggaatggatc aacatgactggcttcctctgtgcccttggtggggtgtgcctgcaacagagaagcagctct ggcctagcaacatacagcccacctatgggccctgtcagtgaacgcaaagggtctatgatt tctgtaatgtcttctgaagggaatgttgattcacctgtcagcagatttatggaccggctt ctgtccttgatggtgtgtaaccatgagaaagtggggcttcagatacggaccaatgttaag gacctggtgggtctggagctgagtcctgctctgtatccaatgctgttcaacaaactgaag agtgccatcagcaagttttttgactctcaaggacaggtattattaactgacagcaatact cagtttgtagagcaaaccatagctataatgaagaacctactggataatcatactgaaggc agctctgagcatctgggacaagctagcattgagacaatgatgctaaatctggtcagatat gttcgtgttcttgggaatatggttcatgcaattcaaataaaaacgaaattgtgtcagtta gttgaagtcatgatggcaagaagagacgacctctcgttttgtcaagagatgaaatttcgg aataagatggtggagtacctaacagactgggttatgggcacttcaaaccaagccgcagat gatgatgtaaagtgtctcacaagagatctagaccaagcaagcatggaggcagtagtctcg ctcctcgctggtcttccactgcagcctgaagaaggagacggagtggagctgatggaggcc aagtcacagctattccttaagtacttcacattatttatgaaccttttgaatgactgtagt gaagttgaagatgaaaatgcacaaacaggtggcaggaaacgtggcatgtctcggaggctg gcatccctgaggcactgtacagtgcttgcaatgtcaaacttactcaatgctaatgtggac agtggactcatgcactccataggcttaggttatcataaagatcttcagacaagagctaca tttatggaagttctgacaaaaatccttcaacaaggaacagaatttgatacacttgctgaa accgtgttggcagatcggttcgagagacttgtggaactggtcacaatgatgggagaccag ggagagctccctatagctatggctctggccaatgtggtcccttgttctcagtgggatgag ctggctcgagttctggtcacgctgtttgattctcggcatttgctctaccagctgctctgg aacatgttttctaaggaggtagagttggcagactccatgcagactctctttcgaggcaac agcttggccagtaagataatgacgttctgcttcaaggtgtacggtgctacttacctacaa aagctcttggaccccttgttacgaatcattatcacatcctccgattggcagcatgttagc tttgaagtggatcctaccaggttagagccctctgagagccttgaggagaaccagaggaac ctccttcagatgacagagaagttcttccatgccatcatcagttcttcctcagagttcccc tcgcagcttcgaagtgtctgccattgtttgtaccaggtggttagccagcgcttccctcag aacagcatcggtgccgtcggaagtgccatgttcctgaggttcatcaaccctgccattgtc tcaccgtatgaagcagggattttagataaaaagccaccacctagaattgaaaggggcttg aagttaatgtcaaaggtccttcagagcattgccaatcatgtactgttcacaaaggaagag cacatgaggccttttaatgattttgtgaaaagcaacttcgacttggcacggaggtttttc ttagatatagcatcagattgtcccacaagtgacgcagtaaaccatagtctttccttcatc agtgatggcaatgtgctcgctttacatcggctgctttggaataatcaggagaaaattggc cagtatctttccagcaacagggatcataaagctgttggaagacgacctttcgataagatg gccacacttcttgcatatctgggtcctccggagcacaagcctgtggcagatacacactgg tccagccttaaccttaccagttcaaagtttgaggaatttatgaccaggcatcaggttcat gagaaggaagagttcaaggccttgaaaacattaagcatcttctaccaagctggcacatcc aaagctgggaatcctattttctattatgttgcacggaggttcaaaactggccaaatcaat ggggatttgctgatataccatgtcttgctgactttaaagccatattatgcaaagccatat gaaattgtagtggaccttacccatactgggcctagcaatcgctttaaaacagacttcctc tctaagtggtttgttgtttttcctggctttgcttatgacaacgtgtctgcagtctatatc tataactgtaactcctgggtcagggagtacaccaaataccatgagcggctgctgactggc ctcaagggcagcaaaaggctcattttcatcgactgtcctgggaagctggctgagcacata gagcacgagcaacagaagctccctgctgctaccttggcactggaagaggatctaaaggtt ttccacaatgcgctcaagctagctcacaaggacaccaaagtttctattaaggttggttct actgctgttcaggtaacctcagcagaaagaacaaaagtattggggcaatccgtctttcta aatgatatctactatgcttctgaaatcgaagagatctgcctagttgatgagaaccagttc actttaaccattgcaaaccaaggcacaccgctgacctttatgcaccaagagtgtgaagcc attgttcagtctatcattcatatcaggacccgatgggaactgtcacagcctgactccatc cctcagcataccaagattcgaccaaaagatgtccctggaacactgcttaatatcgcatta ctgaatttgggcagttcagaccctagtttacggtctgctgcctataacctcctgtgtgcc ttaacttgtacctttaatttaaagatcgaaggtcagttactagagacatcagggttatgc atccctgccaacaacaccctcttcattgtctctatcagtaaaacgcttgcagccaacgag ccacacctcaccttagagtttttggaagagtgtatttctggatttagcaaatctagtatt gaattgaaacacctttgtttggaatatatgaccccatggctgtcaaacctagtccgtttt tgtaagcataacgatgacgccaaacgacaaagggttactgccatccttgataaactcata acaatgaccataaatgaaaagcagatgtacccttctattcaagcaaaaatatgggggagc cttgggcagatcacagacctgctagatgttgtgcttgacagtttcatcaaaaccagtgct accggagggttggggtctatcaaagctgaggtgatggcagacacagctgtggctttagct tctggaaatgtgaaactggtgtcaagtaaggttattggaaggatgtgtaaaataattgac aagacttgcttatctccaactccaactttagaacagcatcttatgtgggacgacattgcc attttagcccgctatatgctgatgctgtccttcaacaactccctggatgtggccgctcat ctcccctatctcttccatgttgtcaccttcttagtagccacaggtcctttgtcccttcgc gcttccacccacggattggtcattaatatcattcactctctgtgcacttgctcacagctt cattttagtgaagagaccaagcaagttttgaggctcagtctgacagagttctcgttaccc aaattttacttactgtttggcatcagcaaagtcaagtcagctgctgtcattgccttccgt tccagctaccgggaccggtcgttctctcctggctcctatgaaagggagacttttgctttg acgtccctggaaacagtcacagaagctttgttggagatcatggaggcatgtatgagagat attccaacatgcaagtggctggatcagtggacggaactggctcaaagatttgcatttcag tacaacccatccctgcagccaagagctcttgtggtgtttggctgtattagcaaacgtgtg tctcacgggcagataaagcagattatccgaatccttagcaaggcacttgaaagttgttta aagggacctgacacttacaacagtcaagttctgatagaagccacagtgattgcactgacc aaactacagccacttcttaataaggactcaccactgcacaaagccctcttctgggttgct gtggctgtgctgcagctagatgaagtcaacttgtactcagctggcactgcacttctggaa cagaatctgcataccttggatagtctccggatattcaatgacaagagtccggaagaggta tttatggcaatccggaatcctctggaatggcactgcaagcaaatggatcactttgttgga ctcaatttcaactctaattttaactttgcactagttggacacctcttaaaagggtacaga catccttcacctgccattgttgcaagaacagtcagaattttgcatacactactaactctt gttaacaaacatagaaattgtgacaaatttgaggtgaatacacagagtgtggcttactta gcagctctactcacagtgtctgaagaggttcgaagtcgctgtagcctcaagcataggaag tcccttcttcttactgatatctcaatggaaaatgttcctatggatacatatcccattcat cacggtgatcccagctctaggacactaaaggagactcagccatggtcctctcccagaggt tcagaaggataccttgcagccacctacccagctgtaggccaaactagtccccgagccagg aaatccatgagcttggacatgggacagccttctcaggccaacacaaaaaaattgcttgga acaaggaaaagttttgatcacttgatatcagacacaaaggctcctaaaagacaagaaatg gaatcagggattacaacacccccaaaaatgagaagagtggcagagaccgactatgaaatg gaaacccaaaggatttcctcctcgcagcagcacccacatttacggaaagtctcagtgtct gaatctaatgttctattggacgaagaagtacttactgacccaaagatccaagcactgctt cttactgttctggctacactggtaaaatataccacagatgaatttgatcagcgaattctt tatgaatatctagcagaggccagtgttgtgtttcccaaagtgtttcctcttgtgcacaat ttgttggactctaagatcaataccctcttgtctttgtgccaagatccaaatttgttaaat ccgatccatggaatcgtgcagagtgtggtgtaccatgaggaatcccctccacagtaccaa acatcatacctgcaaagtttcggttttaatggcttatggcggtttgcaggacccttttca aagcaaacacaaatcccagactatgctgagctcattgttaaatttcttgatgccttgatt gacacgtacttgcctggaattgatgaagaaaccagtgaggagtccctcctgacacccaca tctccttaccctcctgcactgcagagccagcttagtatcactgccaaccttaacctctct aattctatgacctcacttgcaacttcccagcattccccaggaatcgacaaggagaacgtt gaactctcccccaccactggccactgtaacagtggacggactcgccatggatccgcaagc caagtgcagaagcaaaggagtgctggcagtttcaaacgtaatagcattaagaagatcgtg tga

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