Rattus norvegicus (rat): 24598 Help Entry 24598             CDS       T01003                                  Symbol Nos1 Name (RefSeq) nitric oxide synthase 1   KO K13240   nitric-oxide synthase, brain [EC:1.14.13.39] Organism rno  Rattus norvegicus (rat) Pathway rno00220   Arginine biosynthesis rno00330   Arginine and proline metabolism rno01100   Metabolic pathways rno04020   Calcium signaling pathway rno04081   Hormone signaling rno04145   Phagosome rno04371   Apelin signaling pathway rno04713   Circadian entrainment rno04730   Long-term depression rno04926   Relaxin signaling pathway rno04970   Salivary secretion rno05010   Alzheimer disease rno05014   Amyotrophic lateral sclerosis rno05022   Pathways of neurodegeneration - multiple diseases rno05410   Hypertrophic cardiomyopathy rno05412   Arrhythmogenic right ventricular cardiomyopathy rno05414   Dilated cardiomyopathy rno05416   Viral myocarditis Brite KEGG Orthology (KO) [BR:rno00001]  09100 Metabolism   09105 Amino acid metabolism    00220 Arginine biosynthesis     24598 (Nos1)    00330 Arginine and proline metabolism     24598 (Nos1)  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     24598 (Nos1)    04020 Calcium signaling pathway     24598 (Nos1)   09133 Signaling molecules and interaction    04081 Hormone signaling     24598 (Nos1)  09140 Cellular Processes   09141 Transport and catabolism    04145 Phagosome     24598 (Nos1)  09150 Organismal Systems   09152 Endocrine system    04926 Relaxin signaling pathway     24598 (Nos1)   09154 Digestive system    04970 Salivary secretion     24598 (Nos1)   09156 Nervous system    04730 Long-term depression     24598 (Nos1)   09159 Environmental adaptation    04713 Circadian entrainment     24598 (Nos1)  09160 Human Diseases   09164 Neurodegenerative disease    05010 Alzheimer disease     24598 (Nos1)    05014 Amyotrophic lateral sclerosis     24598 (Nos1)    05022 Pathways of neurodegeneration - multiple diseases     24598 (Nos1)   09166 Cardiovascular disease    05410 Hypertrophic cardiomyopathy     24598 (Nos1)    05412 Arrhythmogenic right ventricular cardiomyopathy     24598 (Nos1)    05414 Dilated cardiomyopathy     24598 (Nos1)    05416 Viral myocarditis     24598 (Nos1) Enzymes [BR:rno01000]  1. Oxidoreductases   1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen    1.14.13  With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor     1.14.13.39  nitric-oxide synthase (NADPH)      24598 (Nos1) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  NO_synthase FAD_binding_1 Flavodoxin_1 NAD_binding_1 PDZ PDZ_6 PDZ_2 Motif Other DBs NCBI-GeneID:  24598 NCBI-ProteinID:  NP_434686 RGD:  3184 Ensembl:  ENSRNOG00000001130 UniProt:  P29476 D3ZEW7 Structure PDBPDBj LinkDB All DBs Position 12:complement(44276011..44456371) Genome browser AA seq 1463 aa AA seqDB search MEENTFGVQQIQPNVISVRLFKRKVGGLGFLVKERVSKPPVIISDLIRGGAAEQSGLIQA GDIILAVNDRPLVDLSYDSALEVLRGIASETHVVLILRGPEGFTTHLETTFTGDGTPKTI RVTQPLGPPTKAVDLSHQPSASKDQSLAVDRVTGLGNGPQHAQGHGQGAGSVSQANGVAI DPTMKSTKANLQDIGEHDELLKEIEPVLSILNSGSKATNRGGPAKAEMKDTGIQVDRDLD GKSHKAPPLGGDNDRVFNDLWGKDNVPVVLNNPYSEKEQSPTSGKQSPTKNGSPSRCPRF LKVKNWETDVVLTDTLHLKSTLETGCTEHICMGSIMLPSQHTRKPEDVRTKDQLFPLAKE FLDQYYSSIKRFGSKAHMDRLEEVNKEIESTSTYQLKDTELIYGAKHAWRNASRCVGRIQ WSKLQVFDARDCTTAHGMFNYICNHVKYATNKGNLRSAITIFPQRTDGKHDFRVWNSQLI RYAGYKQPDGSTLGDPANVQFTEICIQQGWKAPRGRFDVLPLLLQANGNDPELFQIPPEL VLEVPIRHPKFDWFKDLGLKWYGLPAVSNMLLEIGGLEFSACPFSGWYMGTEIGVRDYCD NSRYNILEEVAKKMDLDMRKTSSLWKDQALVEINIAVLYSFQSDKVTIVDHHSATESFIK HMENEYRCRGGCPADWVWIVPPMSGSITPVFHQEMLNYRLTPSFEYQPDPWNTHVWKGTN GTPTKRRAIGFKKLAEAVKFSAKLMGQAMAKRVKATILYATETGKSQAYAKTLCEIFKHA FDAKAMSMEEYDIVHLEHEALVLVVTSTFGNGDPPENGEKFGCALMEMRHPNSVQEERKY PEPLRFFPRKGPSLSHVDSEAHSLVAARDSQHRSYKVRFNSVSSYSDSRKSSGDGPDLRD NFESTGPLANVRFSVFGLGSRAYPHFCAFGHAVDTLLEELGGERILKMREGDELCGQEEA FRTWAKKVFKAACDVFCVGDDVNIEKANNSLISNDRSWKRNKFRLTYVAEAPDLTQGLSN VHKKRVSAARLLSRQNLQSPKSSRSTIFVRLHTNGNQELQYQPGDHLGVFPGNHEDLVNA LIERLEDAPPANHVVKVEMLEERNTALGVISNWKDESRLPPCTIFQAFKYYLDITTPPTP LQLQQFASLATNEKEKQRLLVLSKGLQEYEEWKWGKNPTMVEVLEEFPSIQMPATLLLTQ LSLLQPRYYSISSSPDMYPDEVHLTVAIVSYHTRDGEGPVHHGVCSSWLNRIQADDVVPC FVRGAPSFHLPRNPQVPCILVGPGTGIAPFRSFWQQRQFDIQHKGMNPCPMVLVFGCRQS KIDHIYREETLQAKNKGVFRELYTAYSREPDRPKKYVQDVLQEQLAESVYRALKEQGGHI YVCGDVTMAADVLKAIQRIMTQQGKLSEEDAGVFISRLRDDNRYHEDIFGVTLRTYEVTN RLRSESIAFIEESKKDADEVFSS NT seq 4392 nt NT seq  +upstreamnt  +downstreamnt atggaagagaacacgtttggggttcagcagatccaacccaatgtaatttctgttcgtctc ttcaaacgcaaagtgggaggtctgggcttcctggtgaaggaacgggtcagcaagcctccc gtgatcatctcagacctgattcgaggaggtgctgcggagcagagcggccttatccaagct ggagacatcattctcgcagtcaacgatcggcccttggtagacctcagctatgacagtgcc ctggaggttctcaggggcattgcctctgagacccacgtggtcctcattctgaggggccct gagggcttcactacacatctggagaccaccttcacaggggatggaacccccaagaccatc cgggtgacccagcccctcggtcctcccaccaaagccgtcgatctgtctcaccagccttca gccagcaaagaccagtcattagcagtagacagagtcacaggtctgggtaatggccctcag catgcccaaggccatgggcagggagctggctcagtctcccaagctaatggtgtggccatt gaccccacgatgaaaagcaccaaggccaacctccaggacatcggggaacatgatgaactg ctcaaagagatagaacctgtgctgagcatcctcaacagtgggagcaaagccaccaacaga gggggaccagccaaagcagagatgaaagacacaggaatccaggtggacagagacctcgat ggcaaatcgcacaaagctccgcccctgggcggggacaatgaccgcgtcttcaatgacctg tgggggaaggacaacgttcctgtggtccttaacaacccgtattcagagaaggaacagtcc cctacctcggggaaacagtctcccaccaagaacggcagcccttccaggtgcccccgtttc ctcaaggtcaagaactgggagacggacgtggtcctcaccgacaccctgcacctgaagagc acactggaaacggggtgcacagagcacatctgcatgggctcgatcatgctgccttcccag cacacgcggaagccagaagatgtccgcacaaaggaccagctcttccctctagccaaagaa tttctcgaccaatactactcatccattaagagatttggctccaaggcccacatggacagg ctggaggaggtgaacaaggagattgaaagcaccagcacctaccagctcaaggacaccgag ctcatctatggcgccaagcatgcctggcggaacgcctctcgatgtgtgggcaggatccag tggtccaagctgcaggtgttcgatgcccgagactgcaccacagcccacggcatgttcaac tacatctgtaaccatgtcaagtatgccaccaacaaagggaatctcaggtcggccatcacg atattccctcagaggactgacggcaaacatgacttccgagtgtggaactcgcagctcatc cgctacgcgggctacaagcagccagatggctctaccttgggggatccagccaatgtgcag ttcacggagatctgtatacagcagggctggaaagccccaagaggccgcttcgacgtgctg cctctcctgcttcaggccaatggcaatgaccctgagctcttccagatccccccagagctg gtgctggaagtgcccatcaggcaccccaagttcgactggtttaaggacctggggctcaaa tggtatggcctccccgctgtgtccaacatgctgctggagatcgggggcctggagttcagc gcctgtcccttcagcggctggtacatgggcacagagatcggcgtccgtgactactgtgac aactctcgatacaacatcctggaggaagtagccaagaagatggatttggacatgaggaag acctcgtccctctggaaggaccaagcactggtggagatcaacattgctgttctatatagc ttccagagtgacaaggtgaccatcgttgaccaccactctgccacggagtccttcatcaaa cacatggagaatgaataccgctgcagagggggctgccccgccgactgggtgtggattgtg cctcccatgtcgggcagcatcacccctgtcttccaccaggagatgctcaactatagactc accccgtcctttgaataccagcctgatccatggaacacccacgtgtggaagggcaccaac gggacccccacgaagcggcgagctatcggctttaagaaattggcagaggccgtcaagttc tcagccaagctaatggggcaggccatggccaagagggtcaaggcgaccattctctacgcc acagagacaggcaaatcacaagcctatgccaagaccctgtgtgagatcttcaagcacgcc ttcgatgccaaggcaatgtccatggaggagtatgacatcgtgcacctggagcacgaagcc ctggtcttggtggtcaccagcacctttggcaatggagacccccctgagaacggggagaaa ttcggctgtgctttaatggagatgaggcaccccaactctgtgcaggaggagagaaagtac ccggaacccttgcgtttctttccccgtaaagggccttccctctcccatgttgactctgaa gcccacagtctggttgctgcccgtgacagccaacacaggagctacaaggtccgattcaac agcgtctcctcctattctgactcccgaaagtcatcgggcgacggacccgacctcagagac aactttgaaagtactggacccctggccaatgtgaggttctcagtgttcggcctcggctct cgggcgtacccccacttctgtgcctttgggcatgcggtggacaccctcctggaggaactg ggaggggagaggattctgaagatgagggagggggatgagctttgcggacaggaagaagct ttcaggacctgggccaagaaagtcttcaaggcagcctgtgatgtgttctgcgtgggggat gacgtcaacatcgagaaggcgaacaactccctcattagcaatgaccgaagctggaagagg aacaagttccgcctcacgtatgtggcggaagctccagatctgacccaaggtctttccaat gttcacaaaaaacgagtctcggctgctcgactcctcagccgccaaaacctgcaaagccct aagtccagccgatcgaccatcttcgtgcgtctccacaccaacgggaatcaggagctgcag taccagccaggggaccacctgggtgtcttccccggcaaccacgaggacctcgtgaatgca ctcattgaacggctggaggatgcaccgcctgccaaccacgtggtgaaggtggagatgctg gaggagaggaacactgctctgggtgtcatcagtaattggaaggatgaatctcgcctccca ccctgcaccatcttccaggccttcaagtactacctggacatcaccacgccgcccacgccc ctgcagctgcagcagttcgcctctctggccactaatgagaaagagaagcagcggttgctg gtcctcagcaaggggctccaggaatatgaggagtggaagtggggcaagaaccccacaatg gtggaggtgctggaggagttcccgtccatccagatgccggctacacttctcctcactcag ctgtcgctgctgcagcctcgctactactccatcagctcctctccagacatgtaccccgac gaggtgcacctcaccgtggccatcgtctcctaccacacccgagacggagaaggaccggtc caccacggggtgtgctcctcctggctcaacagaatacaggctgacgatgtagtcccctgc ttcgtgagaggtgcccctagcttccacctgcctcgaaacccccaggtgccttgcatcctg gttggcccaggcactggcatcgcacccttccgaagcttctggcaacagcgacaatttgac atccaacacaaaggaatgaatccgtgccccatggttctggtctttgggtgtcgacaatcc aagatagatcatatctacagagaggagaccctgcaggccaagaacaagggcgtcttcaga gagctgtacactgcctattcccgggaaccggacaggccaaagaaatatgtacaggacgtg ctgcaggaacagctggctgagtctgtgtaccgcgccctgaaggagcaaggaggccacatt tatgtctgtggggacgttaccatggccgccgatgtcctcaaagccatccagcgcataatg acccagcaggggaaactctcagaggaggacgctggtgtattcatcagcaggctgagggat gacaaccggtaccacgaggacatctttggagtcaccctcagaacgtatgaagtgaccaac cgccttagatctgagtccatcgccttcatcgaagagagcaaaaaagacgcagatgaggtt ttcagctcctaa

DBGET integrated database retrieval system