Rattus norvegicus (rat): 24600 Help Entry 24600             CDS       T01003                                  Symbol Nos3 Name (RefSeq) nitric oxide synthase 3   KO K13242   nitric-oxide synthase, endothelial [EC:1.14.13.39] Organism rno  Rattus norvegicus (rat) Pathway rno00220   Arginine biosynthesis rno00330   Arginine and proline metabolism rno01100   Metabolic pathways rno04020   Calcium signaling pathway rno04022   cGMP-PKG signaling pathway rno04066   HIF-1 signaling pathway rno04071   Sphingolipid signaling pathway rno04151   PI3K-Akt signaling pathway rno04370   VEGF signaling pathway rno04371   Apelin signaling pathway rno04611   Platelet activation rno04915   Estrogen signaling pathway rno04921   Oxytocin signaling pathway rno04926   Relaxin signaling pathway rno04931   Insulin resistance rno04933   AGE-RAGE signaling pathway in diabetic complications rno05415   Diabetic cardiomyopathy rno05417   Lipid and atherosclerosis rno05418   Fluid shear stress and atherosclerosis Brite KEGG Orthology (KO) [BR:rno00001]  09100 Metabolism   09105 Amino acid metabolism    00220 Arginine biosynthesis     24600 (Nos3)    00330 Arginine and proline metabolism     24600 (Nos3)  09130 Environmental Information Processing   09132 Signal transduction    04370 VEGF signaling pathway     24600 (Nos3)    04371 Apelin signaling pathway     24600 (Nos3)    04066 HIF-1 signaling pathway     24600 (Nos3)    04020 Calcium signaling pathway     24600 (Nos3)    04071 Sphingolipid signaling pathway     24600 (Nos3)    04022 cGMP-PKG signaling pathway     24600 (Nos3)    04151 PI3K-Akt signaling pathway     24600 (Nos3)  09150 Organismal Systems   09151 Immune system    04611 Platelet activation     24600 (Nos3)   09152 Endocrine system    04915 Estrogen signaling pathway     24600 (Nos3)    04921 Oxytocin signaling pathway     24600 (Nos3)    04926 Relaxin signaling pathway     24600 (Nos3)  09160 Human Diseases   09166 Cardiovascular disease    05417 Lipid and atherosclerosis     24600 (Nos3)    05418 Fluid shear stress and atherosclerosis     24600 (Nos3)    05415 Diabetic cardiomyopathy     24600 (Nos3)   09167 Endocrine and metabolic disease    04931 Insulin resistance     24600 (Nos3)    04933 AGE-RAGE signaling pathway in diabetic complications     24600 (Nos3) Enzymes [BR:rno01000]  1. Oxidoreductases   1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen    1.14.13  With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor     1.14.13.39  nitric-oxide synthase (NADPH)      24600 (Nos3) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  NO_synthase FAD_binding_1 Flavodoxin_1 NAD_binding_1 Motif Other DBs NCBI-GeneID:  24600 NCBI-ProteinID:  NP_068610 RGD:  3186 Ensembl:  ENSRNOG00000009348 UniProt:  Q62600 LinkDB All DBs Position 4:complement(11686088..11706604) Genome browser AA seq 1202 aa AA seqDB search MGNLKSVGQEPGPPCGLGLGLGLGLCGKQGPASPAPEPSQAPVPPSPTRPAPDHSPPLTR PPDGPKFPRVKNWEVGSITYDTLSAQAQQDGPCTPRRCLGSLVFPRKLQSRPTQGPSPTE QLLGQARDFINQYYNSIKRSGSQAHEQRLQEVEAEVVATGTYQLRESELVFGAKQAWRNA PRCVGRIQWGKLQVFDARDCRTAQEMFTYICNHIKYATNRGNLRSAITVFPQRYAGRGDF RIWNSQLVRYAGYRQQDGSVRGDPANVEITELCIQHGWTPGNGRFDVLPLLLQAPDEPPE LFTLPPELVLEVPLEHPTLEWFAALGLRWYALPAVSNMLLEIGGLEFPAAPFSGWYMSSE IGMRDLCDPHRYNILEDVAVCMDLDTRTTSSLWKDKAAVEINVAVLYSYQLAKVTIVDHH AATASFMKHLENEQKARGGCPADWAWIVPPISGSLTPVFHQEMVNYFLSPAFRYQPDPWK GSAAKGTGITRKKTFKEVANAVKISASLMGTVMAKRVKATILYGSETGRAQSYAQQLGRL FRKAFDPRVLCMDEYDVVSLEHEALVLVVTSTFGNGDPPENGESFAAALMEMSGPYNSSP RPEQHKSYKIRFNSVSCSDPLVSSWRRKRKESSNTDSAGALGTLRFCVFGLGSRAYPHFC AFARAVDTRLEELGGERLLQLGQGDELCGQEEAFRGWAQAAFQAACETFCVGEDAKAAAR DIFSPKRSWKRQRYRLSTQAESLQLLPGLTHVHRRKMFQATILSVENLQSSKSTRATILV RLDTGSQEGLQYQPGDHIGVCPPNRPGLVEALLSRVEDPPPSTEPVAVEQLEKGSPGGPP PGWVRDPRLPPCTLRQALTYFLDITSPPSPRLLRLLSTLAEESSEQQELEALSQDPRRYE EWKWFRCPTLLEVLEQFPSVALPAPLILTQLPLLQPRYYSVSSAPSAHPGEIHLTVAVLA YRTQDVLGPLHYGVCSTWMSQLKAGDPVPCFIRGAPSFRLPPDPNLPCILVGPGTGIAPF RGFWQDRLHDIEIKGLQPAPMTLVFGCRCSQLDHLYRDEVLDAQQRGVFGQVLTAFSRDP GSPKTYVQDLLRTELAAEVHRVLCLEQGHMFVCGDVTMATSVLQTVQRILATEGSMELDE AGDVIGVLRDQQRYHEDIFGLTLRTQEVTSRIRTQSFSLQERQLRGAVPWSFDPPTQETP GS NT seq 3609 nt NT seq  +upstreamnt  +downstreamnt atgggcaacttgaagagtgtgggccaggagcctgggccaccctgtggcctagggctcggg ctgggcctagggctatgcggcaagcagggcccagcctcaccggcaccagagcctagccag gcaccagtacccccgtccccaacccgaccagcaccagaccacagccccccgttaacccgg cccccagacggacccaagtttcctcgagtaaagaactgggaagtgggcagcatcacctac gataccctcagtgcacaggctcagcaggatgggccctgtaccccaagacgctgcttggga tccctggtatttccaaggaagttacagagccggcccacccagggcccttcacccactgag cagctattgggtcaagcccgggacttcatcaatcagtactataactcgatcaaaaggagt ggttcccaggctcatgagcagcggcttcaggaagtggaagctgaggtggtggccacgggc acctaccagctccgggagagtgagctggtgtttggggccaaacaggcctggcgcaacgct ccccgctgtgtggggcggatccagtgggggaaactgcaggtatttgatgctcgggactgc aggacagcacaggaaatgttcacctacatctgtaaccacattaagtatgcaacaaaccga ggcaatcttcgttcagccatcacggtgttcccccagcgctacgctggccggggagacttc cggatctggaacagccagctggtgcgctacgcgggctataggcagcaggacggctctgtg cgaggggaccctgccaacgtggagatcactgagctctgtattcaacatggctggacccca ggaaatggccgctttgatgtgctgcccctgctactccaggctcccgatgagcccccagaa ctcttcactctgcccccagagctggtcctcgaggtgcctctggagcaccccacgctagag tggtttgctgcccttggcctgcgctggtatgccctcccagctgtgtccaatatgctgcta gaaatcgggggcctggagtttccggctgcccctttcagcggctggtacatgagttcagag attggcatgagggacctgtgtgaccctcaccgatacaacatacttgaggatgtggctgtc tgcatggatctagacacccggacaacctcatcactgtggaaagacaaggcagcagtggaa attaacgtggctgtgctgtacagttaccagctggccaaagtgaccattgtggaccaccat gccgccacagcctccttcatgaagcacttggaaaatgagcagaaggccagagggggctgc cccgctgactgggcctggatcgtgccccccatctcaggcagcctcacccctgtcttccat caagagatggtcaactatttcctgtcccctgccttccgctaccagcctgacccctggaaa ggaagtgcagcaaaaggcacaggcatcaccaggaagaagacttttaaggaagtagccaat gcagtgaagatctctgcctcactcatgggcacggtgatggcgaagcgtgtgaaggcgact atcctgtatggctctgagactggccgcgcccagagctacgcacagcagctggggaggctc tttcggaaggcgtttgacccccgggtcctgtgcatggatgaatacgatgtggtatcccta gagcatgaggccttggtattggtggtgaccagcacatttggcaatggggatcccccggag aatggagagagctttgcagcagcgctgatggaaatgtcgggcccctacaacagctcccct cggcctgagcagcacaagagttacaaaatccgattcaacagtgtctcctgctcggaccca ctggtatcctcttggcggcgcaaaaggaaggaatccagtaacacagacagtgcaggggcc ctgggcaccctcaggttctgtgtgtttgggctgggctccagagcatacccgcacttctgt gcctttgctcgagcggtggacacaaggctggaggagctgggcggggagcgactgttgcag ctgggccagggtgatgagctctgcggccaggaggaggctttccgaggctgggcccaggca gccttccaggctgcctgtgaaactttctgtgtgggagaagatgccaaggctgctgcccga gatatcttcagtcccaagcgcagctggaaacgccagaggtaccggctgagtacccaagct gagagcctgcaattactgccagggctgactcacgtgcacagacggaagatgttccaggct acaattctttctgtggagaacctacagagcagcaaatccacccgagccacaatcctggtg cgtctggacactggaagccaggagggactgcagtaccagccaggggaccacataggtgtg tgcccacccaaccggcctggcctagtggaggcgctgctgagccgagtggaggaccctccg ccatccacagagcctgtggccgtggaacaactggaaaaaggcagccctggtggccctccc cccggctgggtacgggacccccggcttcccccatgtacgctgcgccaggctctcacttac ttcctggacatcacttccccgcccagccctcgccttcttcgactgctgagcaccctggca gaggagtccagcgaacagcaggagctagaggctcttagccaggacccccggcgctacgaa gaatggaagtggttccgctgccccacactgctagaggtgctggaacaatttccatccgtg gcactgcctgccccgctgatcctcacccagctgcccctgctccagccccggtactactct gtcagctcagcacccagcgcccacccaggagagatccacctcactgtagctgtgctggca tacagaacccaggatgtgctgggccctctgcactatggggtctgttccacatggatgagc caactcaaggcaggagacccggtgccctgcttcatcaggggggctccctccttccggctg ccacctgatcctaacttgccttgcatcctggtgggcccagggactggtattgcacccttc cggggattctggcaagaccgattacacgacattgagatcaaaggactgcagcctgccccc atgactttggtgtttggctgccgatgctcccaactggaccatctctaccgggacgaggta ctggacgcccagcagcgtggagtgtttggacaagtcctcaccgccttttccagggatcct ggcagccctaagacctatgtgcaagacctcctgaggacagagctggccgcggaggttcac cgcgtgctgtgcctcgagcaaggacacatgtttgtctgcggtgatgtcactatggcaacc agcgtcctgcaaaccgtgcagcgaattctggcaacagagggcagcatggagctggatgaa gccggtgacgtcatcggcgtgctgcgggatcagcaacgctaccacgaggacattttcgga ctcacattgcgcacccaggaggtgacgagccgcatccgcacccagagtttttctttgcag gagcgacagctgaggggtgcagtgccctggtcctttgacccgcctacccaagaaacacct ggttcctga

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