Rattus norvegicus (rat): 24651 Help Entry 24651             CDS       T01003                                  Symbol Pklr Name (RefSeq) pyruvate kinase PKLR   KO K12406   pyruvate kinase isozymes R/L [EC:2.7.1.40] Organism rno  Rattus norvegicus (rat) Pathway rno00010   Glycolysis / Gluconeogenesis rno00620   Pyruvate metabolism rno01100   Metabolic pathways rno01200   Carbon metabolism rno01230   Biosynthesis of amino acids rno04910   Insulin signaling pathway rno04930   Type II diabetes mellitus rno04932   Non-alcoholic fatty liver disease rno04950   Maturity onset diabetes of the young Module rno_M00001   Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate rno_M00002   Glycolysis, core module involving three-carbon compounds Brite KEGG Orthology (KO) [BR:rno00001]  09100 Metabolism   09101 Carbohydrate metabolism    00010 Glycolysis / Gluconeogenesis     24651 (Pklr)    00620 Pyruvate metabolism     24651 (Pklr)  09150 Organismal Systems   09152 Endocrine system    04910 Insulin signaling pathway     24651 (Pklr)  09160 Human Diseases   09167 Endocrine and metabolic disease    04930 Type II diabetes mellitus     24651 (Pklr)    04950 Maturity onset diabetes of the young     24651 (Pklr)    04932 Non-alcoholic fatty liver disease     24651 (Pklr)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04147 Exosome [BR:rno04147]     24651 (Pklr) Enzymes [BR:rno01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.1  Phosphotransferases with an alcohol group as acceptor     2.7.1.40  pyruvate kinase      24651 (Pklr) Exosome [BR:rno04147]  Exosomal proteins   Exosomal proteins of other body fluids (saliva and urine)    24651 (Pklr) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  PK PK_C IMPDH HpcH_HpaI Motif Other DBs NCBI-GeneID:  24651 NCBI-ProteinID:  NP_036756 RGD:  3336 Ensembl:  ENSRNOG00000020420 UniProt:  P12928 B1WBN9 Structure PDBPDBj LinkDB All DBs Position 2:176840779..176849637 Genome browser AA seq 543 aa AA seqDB search MEGPAGYLRRASVAQLTQELGTAFFQQQQLPAAMADTFLEHLCLLDIDSQPVAARSTSII ATIGPASRSVDRLKEMIKAGMNIARLNFSHGSHEYHAESIANIREATESFATSPLSYRPV AIALDTKGPEIRTGVLQGGPESEVEIVKGSQVLVTVDPKFQTRGDAKTVWVDYHNITRVV AVGGRIYIDDGLISLVVQKIGPEGLVTEVEHGGILGSRKGVNLPNTEVDLPGLSEQDLLD LRFGVQHNVDIIFASFVRKASDVLAVRDALGPEGQNIKIISKIENHEGVKKFDEILEVSD GIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKARPTRAETSDV ANAVLDGADCIMLSGETAKGSFPVEAVMMQHAIAREAEAAVYHRQLFEELRRAAPLSRDP TEVTAIGAVEASFKCCAAAIIVLTKTGRSAQLLSQYRPRAAVIAVTRSAQAARQVHLSRG VFPLLYREPPEAIWADDVDRRVQFGIESGKLRGFLRVGDLVIVVTGWRPGSGYTNIMRVL SVS NT seq 1632 nt NT seq  +upstreamnt  +downstreamnt atggaagggccagcgggataccttcgacgtgcgagtgtggctcaactgacccaggagctg ggcactgccttcttccagcagcagcaactgcccgcagctatggcggacaccttcctggaa cacctctgccttctggatatcgactcacagcctgtggctgctcgtagcaccagcatcatt gccaccattgggccagcatcccgctctgtggaccgcctcaaggagatgatcaaagcaggg atgaacattgcacgactcaacttctcccatggctcccatgagtaccatgcagaatccatc gccaacatccgggaggcaactgagagttttgcaacctccccactcagctacagacctgtg gccatcgccctggacaccaagggacctgagatacgaaccggagtcttgcaggggggtccg gagtcggaggtggaaattgtgaagggctcacaggtgctggtgacggtggacccgaagttc cagacaaggggcgatgcaaagacagtgtgggtggactaccacaatatcacccgggtcgtt gcagtggggggccgcatctacattgacgacgggctcatctccttagtggtacagaaaatc ggcccagagggactggtgacagaagtggagcacggtggtatcttgggcagcaggaagggt gtgaacttgccaaacactgaggtggacctgcccgggctgtctgagcaagaccttttggat ctgcgcttcggggtgcagcataatgtggacatcatctttgcctcctttgtgcggaaagcc agtgacgtgttagcagtccgggatgccctggggccagaaggacagaacatcaaaattatc agcaaaatcgagaaccatgaaggcgtgaagaagtttgatgaaattctagaagtgagcgat ggcatcatggtggcacggggtgacctgggcattgagatccctgcggagaaggttttcttg gctcagaagatgatgattggacgctgcaacctggccggcaagcctgtcgtttgtgccaca cagatgctggagagcatgatcactaaggctcgaccaactcgggcggagacaagcgatgtg gccaatgccgtgctggatggggctgactgtatcatgctgtccggagagaccgccaagggc agttttcctgtggaagctgtaatgatgcaacatgcgattgcgcgggaggcagaggccgct gtgtaccaccgccagttgtttgaggagctacgccgggcagcgccgctgagccgtgaccca actgaggtcactgcgattggagccgtggaggcttccttcaagtgctgtgcagcagccatc atcgtgctgacgaagactggccgttcagcccagcttctatctcaataccgacctcgggcg gctgtcattgctgtgactcgatctgcccaggctgcccgacaggtccacctgtcccgagga gtcttccccttgctctaccgtgagcctccagaggccatctgggcagatgatgtggatcga agggtccaatttggcattgaaagtggaaagctccgtggtttcctccgtgtgggtgatctg gtgattgtggtgacaggttggcggcctggctctggctataccaacatcatgcgggtgctg agcgtatcctga

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