Rattus norvegicus (rat): 24680 Help Entry 24680             CDS       T01003                                  Symbol Prkca Name (RefSeq) protein kinase C alpha type   KO K02677   classical protein kinase C alpha type [EC:2.7.11.13] Organism rno  Rattus norvegicus (rat) Pathway rno01521   EGFR tyrosine kinase inhibitor resistance rno04010   MAPK signaling pathway rno04012   ErbB signaling pathway rno04014   Ras signaling pathway rno04015   Rap1 signaling pathway rno04020   Calcium signaling pathway rno04066   HIF-1 signaling pathway rno04070   Phosphatidylinositol signaling system rno04071   Sphingolipid signaling pathway rno04072   Phospholipase D signaling pathway rno04082   Neuroactive ligand signaling rno04150   mTOR signaling pathway rno04151   PI3K-Akt signaling pathway rno04261   Adrenergic signaling in cardiomyocytes rno04270   Vascular smooth muscle contraction rno04310   Wnt signaling pathway rno04360   Axon guidance rno04370   VEGF signaling pathway rno04510   Focal adhesion rno04540   Gap junction rno04613   Neutrophil extracellular trap formation rno04650   Natural killer cell mediated cytotoxicity rno04664   Fc epsilon RI signaling pathway rno04666   Fc gamma R-mediated phagocytosis rno04670   Leukocyte transendothelial migration rno04713   Circadian entrainment rno04720   Long-term potentiation rno04723   Retrograde endocannabinoid signaling rno04724   Glutamatergic synapse rno04725   Cholinergic synapse rno04726   Serotonergic synapse rno04727   GABAergic synapse rno04728   Dopaminergic synapse rno04730   Long-term depression rno04750   Inflammatory mediator regulation of TRP channels rno04911   Insulin secretion rno04912   GnRH signaling pathway rno04916   Melanogenesis rno04918   Thyroid hormone synthesis rno04919   Thyroid hormone signaling pathway rno04921   Oxytocin signaling pathway rno04925   Aldosterone synthesis and secretion rno04926   Relaxin signaling pathway rno04928   Parathyroid hormone synthesis, secretion and action rno04929   GnRH secretion rno04933   AGE-RAGE signaling pathway in diabetic complications rno04935   Growth hormone synthesis, secretion and action rno04960   Aldosterone-regulated sodium reabsorption rno04961   Endocrine and other factor-regulated calcium reabsorption rno04970   Salivary secretion rno04971   Gastric acid secretion rno04972   Pancreatic secretion rno05017   Spinocerebellar ataxia rno05022   Pathways of neurodegeneration - multiple diseases rno05031   Amphetamine addiction rno05032   Morphine addiction rno05143   African trypanosomiasis rno05146   Amoebiasis rno05161   Hepatitis B rno05163   Human cytomegalovirus infection rno05164   Influenza A rno05170   Human immunodeficiency virus 1 infection rno05171   Coronavirus disease - COVID-19 rno05200   Pathways in cancer rno05205   Proteoglycans in cancer rno05206   MicroRNAs in cancer rno05207   Chemical carcinogenesis - receptor activation rno05214   Glioma rno05223   Non-small cell lung cancer rno05225   Hepatocellular carcinoma rno05231   Choline metabolism in cancer rno05415   Diabetic cardiomyopathy rno05417   Lipid and atherosclerosis Brite KEGG Orthology (KO) [BR:rno00001]  09130 Environmental Information Processing   09132 Signal transduction    04010 MAPK signaling pathway     24680 (Prkca)    04012 ErbB signaling pathway     24680 (Prkca)    04014 Ras signaling pathway     24680 (Prkca)    04015 Rap1 signaling pathway     24680 (Prkca)    04310 Wnt signaling pathway     24680 (Prkca)    04370 VEGF signaling pathway     24680 (Prkca)    04066 HIF-1 signaling pathway     24680 (Prkca)    04020 Calcium signaling pathway     24680 (Prkca)    04070 Phosphatidylinositol signaling system     24680 (Prkca)    04072 Phospholipase D signaling pathway     24680 (Prkca)    04071 Sphingolipid signaling pathway     24680 (Prkca)    04151 PI3K-Akt signaling pathway     24680 (Prkca)    04150 mTOR signaling pathway     24680 (Prkca)   09133 Signaling molecules and interaction    04082 Neuroactive ligand signaling     24680 (Prkca)  09140 Cellular Processes   09144 Cellular community - eukaryotes    04510 Focal adhesion     24680 (Prkca)    04540 Gap junction     24680 (Prkca)  09150 Organismal Systems   09151 Immune system    04613 Neutrophil extracellular trap formation     24680 (Prkca)    04650 Natural killer cell mediated cytotoxicity     24680 (Prkca)    04664 Fc epsilon RI signaling pathway     24680 (Prkca)    04666 Fc gamma R-mediated phagocytosis     24680 (Prkca)    04670 Leukocyte transendothelial migration     24680 (Prkca)   09152 Endocrine system    04911 Insulin secretion     24680 (Prkca)    04929 GnRH secretion     24680 (Prkca)    04912 GnRH signaling pathway     24680 (Prkca)    04921 Oxytocin signaling pathway     24680 (Prkca)    04926 Relaxin signaling pathway     24680 (Prkca)    04935 Growth hormone synthesis, secretion and action     24680 (Prkca)    04918 Thyroid hormone synthesis     24680 (Prkca)    04919 Thyroid hormone signaling pathway     24680 (Prkca)    04928 Parathyroid hormone synthesis, secretion and action     24680 (Prkca)    04916 Melanogenesis     24680 (Prkca)    04925 Aldosterone synthesis and secretion     24680 (Prkca)   09153 Circulatory system    04261 Adrenergic signaling in cardiomyocytes     24680 (Prkca)    04270 Vascular smooth muscle contraction     24680 (Prkca)   09154 Digestive system    04970 Salivary secretion     24680 (Prkca)    04971 Gastric acid secretion     24680 (Prkca)    04972 Pancreatic secretion     24680 (Prkca)   09155 Excretory system    04960 Aldosterone-regulated sodium reabsorption     24680 (Prkca)    04961 Endocrine and other factor-regulated calcium reabsorption     24680 (Prkca)   09156 Nervous system    04724 Glutamatergic synapse     24680 (Prkca)    04727 GABAergic synapse     24680 (Prkca)    04725 Cholinergic synapse     24680 (Prkca)    04728 Dopaminergic synapse     24680 (Prkca)    04726 Serotonergic synapse     24680 (Prkca)    04720 Long-term potentiation     24680 (Prkca)    04730 Long-term depression     24680 (Prkca)    04723 Retrograde endocannabinoid signaling     24680 (Prkca)   09157 Sensory system    04750 Inflammatory mediator regulation of TRP channels     24680 (Prkca)   09158 Development and regeneration    04360 Axon guidance     24680 (Prkca)   09159 Environmental adaptation    04713 Circadian entrainment     24680 (Prkca)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     24680 (Prkca)    05206 MicroRNAs in cancer     24680 (Prkca)    05205 Proteoglycans in cancer     24680 (Prkca)    05207 Chemical carcinogenesis - receptor activation     24680 (Prkca)    05231 Choline metabolism in cancer     24680 (Prkca)   09162 Cancer: specific types    05225 Hepatocellular carcinoma     24680 (Prkca)    05214 Glioma     24680 (Prkca)    05223 Non-small cell lung cancer     24680 (Prkca)   09172 Infectious disease: viral    05170 Human immunodeficiency virus 1 infection     24680 (Prkca)    05161 Hepatitis B     24680 (Prkca)    05171 Coronavirus disease - COVID-19     24680 (Prkca)    05164 Influenza A     24680 (Prkca)    05163 Human cytomegalovirus infection     24680 (Prkca)   09174 Infectious disease: parasitic    05146 Amoebiasis     24680 (Prkca)    05143 African trypanosomiasis     24680 (Prkca)   09164 Neurodegenerative disease    05017 Spinocerebellar ataxia     24680 (Prkca)    05022 Pathways of neurodegeneration - multiple diseases     24680 (Prkca)   09165 Substance dependence    05031 Amphetamine addiction     24680 (Prkca)    05032 Morphine addiction     24680 (Prkca)   09166 Cardiovascular disease    05417 Lipid and atherosclerosis     24680 (Prkca)    05415 Diabetic cardiomyopathy     24680 (Prkca)   09167 Endocrine and metabolic disease    04933 AGE-RAGE signaling pathway in diabetic complications     24680 (Prkca)   09176 Drug resistance: antineoplastic    01521 EGFR tyrosine kinase inhibitor resistance     24680 (Prkca)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:rno01001]     24680 (Prkca)   09182 Protein families: genetic information processing    04131 Membrane trafficking [BR:rno04131]     24680 (Prkca) Enzymes [BR:rno01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.11  Protein-serine/threonine kinases     2.7.11.13  protein kinase C      24680 (Prkca) Protein kinases [BR:rno01001]  Serine/threonine kinases: AGC group   PKC family [OT]    24680 (Prkca) Membrane trafficking [BR:rno04131]  Endocytosis   Lipid raft mediated endocytosis    Caveolin-mediated endocytosis     24680 (Prkca) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  Pkinase PK_Tyr_Ser-Thr C1_1 C2 Pkinase_C C1_2 ABC1 Motif Other DBs NCBI-GeneID:  24680 NCBI-ProteinID:  NP_001386228 RGD:  3395 Ensembl:  ENSRNOG00000003491 UniProt:  P05696 B5DFC4 Structure PDBPDBj LinkDB All DBs Position 10:complement(93388991..93787617) Genome browser AA seq 672 aa AA seqDB search MADVYPANDSTASQDVANRFARKGALRQKNVHEVKDHKFIARFFKQPTFCSHCTDFIWGF GKQGFQCQVCCFVVHKRCHEFVTFSCPGADKGPDTDDPRSKHKFKIHTYGSPTFCDHCGS LLYGLIHQGMKCDTCDMNVHKQCVINVPSLCGMDHTEKRGRIYLKAEVTDEKLHVTVRDA KNLIPMDPNGLSDPYVKLKLIPDPKNESKQKTKTIRSTLNPQWNESFTFKLKPSDKDRRL SVEIWDWDRTTRNDFMGSLSFGVSELMKMPASGWYKLLNQEEGEYYNVPIPEGDEEGNVE LRQKFEKAKLGPAGNKVISPSEDRKQPSNNLDRVKLTDFNFLMVLGKGSFGKVMLADRKG TEELYAIKILKKDVVIQDDDVECTMVEKRVLALLDKPPFLTQLHSCFQTVDRLYFVMEYV NGGDLMYHIQQVGKFKEPQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLDSEGHIKIA DFGMCKEHMMDGVTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAYGVLLYEMLAGQPPFDG EDEDELFQSIMEHNVSYPKSLSKEAVSICKGLMTKHPAKRLGCGPEGERDVREHAFFRRI DWEKLENREIQPPFKPKVCGKGAENFDKFFTRGQPVLTPPDQLVIANIDQSDFEGFSYVN PQFVHPILQSAV NT seq 2019 nt NT seq  +upstreamnt  +downstreamnt atggctgacgtttacccggccaacgactccacggcgtctcaggacgtggccaaccgcttc gcccgcaaaggggcgctgaggcagaagaacgtgcatgaggtgaaagaccacaaattcatc gcccgcttcttcaagcaacccaccttctgcagccactgcaccgacttcatctgggggttt ggaaaacaaggcttccagtgccaagtttgctgttttgtggttcacaagaggtgccatgag tttgttactttctcttgtccgggtgcggataagggacctgacactgatgaccccagaagc aagcacaagttcaaaatccacacctatggaagccctaccttctgtgatcactgtgggtcc ctgctctacggacttatccaccaagggatgaaatgcgacacctgcgacatgaatgttcac aagcagtgcgtgatcaatgtccccagcctctgcggaatggatcacacagagaagaggggg cggatttacctgaaggcagaggtcacagatgaaaagctgcacgtcaccgtacgagatgca aaaaatctaatccctatggatccaaatgggctttcggatccttacgtgaagctgaaactt attcctgaccccaagaatgagagcaaacagaaaaccaaaaccatccgatccacactgaac cctcagtggaatgagtccttcacgttcaaattaaaaccttcagacaaagaccggcgactg tccgtagaaatctgggactgggatcggacgacacggaatgacttcatgggctccctttcc ttcggcgtctcagagctgatgaagatgccagccagtggatggtacaagttgctcaaccaa gaggagggtgaatactacaatgtgcccattccagaaggagatgaagaaggcaacgtggaa ctcaggcagaagttcgagaaagccaagctgggccccgctggaaacaaagtcatcagccct tcagaagacaggaagcagccatctaacaacctggacagggtgaaactcacagacttcaac ttcctcatggtgctggggaaggggagttttggaaaggtgatgcttgctgacaggaaggga acagaggaactgtacgccatcaaaatcctgaagaaggacgtggtgatccaggatgacgac gtggagtgcaccatggtggagaagcgggttctggccctgctcgacaagcccccgttcctg acacagctgcactcctgcttccagacagtggaccggctgtacttcgtcatggaatacgtc aacggtggggacctcatgtaccacattcagcaagtcggaaaatttaaggagccacaagca gtattctatgcagccgagatctccatcggactgttctttcttcacaaaagaggaatcatt tacagggatctgaagctggacaacgtcatgctggactcagaagggcatatcaaaatcgcc gacttcgggatgtgcaaggaacacatgatggacggggtcacgaccaggaccttctgtggg actccggattacattgccccagagataatcgcttaccagccatatggaaagtctgtggac tggtgggcgtacggcgtgctcctgtatgagatgctagctgggcagcctccgttcgatggc gaagacgaagatgaactgtttcagtctataatggagcacaatgtgtcctaccccaaatcc ttgtccaaggaagctgtctccatctgcaaagggcttatgaccaaacaccctgccaagcgg ctgggctgcgggcccgagggggaaagggatgtcagagagcatgccttctttaggaggatc gactgggagaagttggagaacagggagatccaaccgccattcaagcccaaagtgtgcggc aaaggagcagaaaactttgacaagttcttcacacgagggcagcctgtcttaacaccacca gatcagctggtcatcgctaacatagaccagtctgattttgaagggttctcgtatgtcaac ccccagtttgtgcacccaatcttgcaaagtgcagtatga

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