Rattus norvegicus (rat): 25638
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Entry
25638 CDS
T01003
Symbol
Pde4a
Name
(RefSeq) 3',5'-cyclic-AMP phosphodiesterase 4A isoform 1
KO
K13293
cAMP-specific phosphodiesterase 4 [EC:
3.1.4.53
]
Organism
rno
Rattus norvegicus (rat)
Pathway
rno00230
Purine metabolism
rno01100
Metabolic pathways
rno04024
cAMP signaling pathway
rno04928
Parathyroid hormone synthesis, secretion and action
rno05032
Morphine addiction
Brite
KEGG Orthology (KO) [BR:
rno00001
]
09100 Metabolism
09104 Nucleotide metabolism
00230 Purine metabolism
25638 (Pde4a)
09130 Environmental Information Processing
09132 Signal transduction
04024 cAMP signaling pathway
25638 (Pde4a)
09150 Organismal Systems
09152 Endocrine system
04928 Parathyroid hormone synthesis, secretion and action
25638 (Pde4a)
09160 Human Diseases
09165 Substance dependence
05032 Morphine addiction
25638 (Pde4a)
Enzymes [BR:
rno01000
]
3. Hydrolases
3.1 Acting on ester bonds
3.1.4 Phosphoric-diester hydrolases
3.1.4.53 3',5'-cyclic-AMP phosphodiesterase
25638 (Pde4a)
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GFIT
Motif
Pfam:
PDEase_I
PDE4_UCR
Motif
Other DBs
NCBI-GeneID:
25638
NCBI-ProteinID:
NP_037233
RGD:
3279
Ensembl:
ENSRNOG00000020828
UniProt:
P54748
F1M8I9
A6JNP9
Structure
PDB
PDBj
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All DBs
Position
8:27966978..28029721
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AA seq
844 aa
AA seq
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MEPPAAPSERSLSLSLPGPREGQATLKPPPQHLWRQPRTPIRIQQRGYSDSAERSETERS
PHRPIERADAVDTGDRPGLRTTRMSWPSSFHGTGTGGGSSRRLEAENGPTPSPGRSPLDS
QASPGLVLHAGATTSQRRESFLYRSDSDYDMSPKAVSRSSSVASEAHAEDLIVTPFAQVL
ASLRSVRSNFSLLTNVPIPSNKRSPLGGPPSVCKATLSEETCQQLARETLEELDWCLEQL
ETMQTYRSVSEMASHKFKRMLNRELTHLSEMSRSGNQVSEYISNTFLDKQNEVEIPSPTP
RQRAFQQPPPSVLRQSQPMSQITGLKKLVHTGSLNTNVPRFGVKTDQEDLLAQELENLSK
WGLNIFCVSEYAGGRSLSCIMYTIFQERDLLKKFHIPVDTMMMYMLTLEDHYHADVAYHN
SLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQFLINTNSELAL
MYNDESVLENHHLAVGFKLLQEENCDIFQNLSKRQRQSLRKMVIDMVLATDMSKHMTLLA
DLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTDRIMAEFF
QQGDRERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLED
NRDWYHSAIRQSPSPPLEEEPGGLGHPSLPDKFQFELTLEEEEEEDSLEVPGLPTTEETF
LAAEDARAQAVDWSKVKGPSTTVVEVAERLKQETASAYGAPQESMEAVGCSFSPGTPILP
DVRTLSSSEEAPGLLGLPSTAAEVEAPRDHLAATRACSACSGTSGDNSAIISTPGRWGSG
GDPA
NT seq
2535 nt
NT seq
+upstream
nt +downstream
nt
atggagcctccggccgccccctcggaaaggagcctgtctctctctcttccggggccccgg
gagggccaggccaccctgaagccgcccccccagcacctgtggcggcagccgaggaccccg
atccgcatccagcaacgcggctactcggacagtgccgagcgctcagagacagagcgctca
ccgcaccggcccatagagcgcgccgacgccgtggacactggcgaccggccaggcctgcgg
actacccgcatgtcctggccctcgtccttccacggcaccggtaccggcggaggcagcagt
aggcgcttggaggcagaaaatgggccaacgccatcccctggccgcagccccctggactcg
caggcgagcccggggcttgtgctgcatgctggggccaccaccagccagcgccgcgagtcc
ttcctctaccgctcagacagcgactatgacatgtcaccgaaggctgtgtccaggagctcg
tctgtcgccagcgaagcgcacgctgaggacctcattgtgacaccatttgcccaggtgctg
gccagtctccgcagcgttcgaagcaacttctcactcttaaccaatgtgcccatccccagc
aacaagaggtctccactgggtggcccaccctctgtctgcaaggccacactgtcagaggag
acgtgccagcagctggcccgggagaccctggaagagctggattggtgcctggagcagctg
gagaccatgcagacctaccgctctgtcagcgagatggcctcacacaagttcaaaaggatg
ctgaaccgtgagctcacacacctgtcggaaatgagcaggtcaggaaaccaggtctcagag
tacatttccaacacattcctggacaagcagaatgaagtggagatcccctcacccacacct
cggcagagagccttccagcagcccccgccgtcagtgctgcgacagtcccagcccatgtct
cagatcacagggctgaaaaagctggtacacactggaagcttgaacaccaacgtcccacgg
tttggagtcaagacagatcaagaggacctcttagcacaagaactggagaacttgagcaaa
tggggcctgaacatcttttgtgtgtcggagtacgctggaggccgctcactcagctgtatc
atgtatacgatattccaggagcgggacctactgaagaaattccacatccctgtggacacc
atgatgatgtacatgctgaccctggaggaccactaccatgccgacgtggcctaccacaac
agcctgcacgcagcggatgtgctgcagtccacacacgtgctgctggccacgcccgcactg
gacgctgtgttcacagacctggagattcttgctgccctcttcgctgctgccatccacgat
gtggaccaccctggcgtctccaaccagttcctaatcaacaccaattcggagctggcgttg
atgtacaacgatgagtctgtgcttgagaaccaccacctggctgtgggattcaagctgctg
caagaagagaactgcgacatcttccagaacctcagcaagcgccagcggcagagcctgcgc
aagatggtcatcgacatggtgctggccacagacatgtccaaacacatgaccctcctggct
gacctgaagactatggtggagacgaagaaagtgaccagctccggagttctcttgctggac
aactactctgaccgtatccaggtcctcaggaacatggtgcactgtgcagacctcagcaat
cccaccaagcccctggagctgtaccgacagtggaccgaccgcatcatggctgagttcttc
cagcagggcgaccgagaacgggagcgtggaatggagatcagccccatgtgcgacaagcac
acagcctctgtggagaagtctcaggtgggcttcatcgactacattgttcatccattgtgg
gagacatgggcagatctcgtccacccggatgcccaagacatcctggacacgctggaagac
aaccgggactggtaccacagtgccattcggcagagtccttccccacccctggaagaggag
ccaggggggcttggccatccgtccctgcctgacaagttccaatttgagctcaccttggag
gaagaggaggaagaggattccttggaggttccaggattgcctaccactgaggaaaccttc
ctggctgcagaggatgccagagctcaagctgtggactggtcaaaggtcaaaggcccgagc
actacagtggtggaagtggcagagcgcttgaagcaggagaccgcctcagcatatggtgct
cctcaggagtccatggaggctgtaggctgttccttcagccctgggacccctattctgcct
gacgtgaggaccctatcctcctcagaggaggccccaggcctcctgggcctcccctccacg
gcggcagaggtggaggccccaagagaccatctggctgccacgagggcttgttctgcctgc
tctgggacctcaggagacaattctgccatcatctctactccaggcaggtgggggtcaggc
ggagaccctgcctga
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