Rattus norvegicus (rat): 25718
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Entry
25718 CDS
T01003
Symbol
Igf1r
Name
(RefSeq) insulin-like growth factor 1 receptor isoform 2 precursor
KO
K05087
insulin-like growth factor 1 receptor [EC:
2.7.10.1
]
Organism
rno
Rattus norvegicus (rat)
Pathway
rno01521
EGFR tyrosine kinase inhibitor resistance
rno01522
Endocrine resistance
rno04010
MAPK signaling pathway
rno04014
Ras signaling pathway
rno04015
Rap1 signaling pathway
rno04066
HIF-1 signaling pathway
rno04068
FoxO signaling pathway
rno04081
Hormone signaling
rno04114
Oocyte meiosis
rno04140
Autophagy - animal
rno04144
Endocytosis
rno04150
mTOR signaling pathway
rno04151
PI3K-Akt signaling pathway
rno04152
AMPK signaling pathway
rno04211
Longevity regulating pathway
rno04213
Longevity regulating pathway - multiple species
rno04510
Focal adhesion
rno04520
Adherens junction
rno04550
Signaling pathways regulating pluripotency of stem cells
rno04730
Long-term depression
rno04913
Ovarian steroidogenesis
rno04914
Progesterone-mediated oocyte maturation
rno05200
Pathways in cancer
rno05202
Transcriptional misregulation in cancer
rno05205
Proteoglycans in cancer
rno05214
Glioma
rno05215
Prostate cancer
rno05218
Melanoma
rno05224
Breast cancer
rno05225
Hepatocellular carcinoma
Brite
KEGG Orthology (KO) [BR:
rno00001
]
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
25718 (Igf1r)
04014 Ras signaling pathway
25718 (Igf1r)
04015 Rap1 signaling pathway
25718 (Igf1r)
04066 HIF-1 signaling pathway
25718 (Igf1r)
04068 FoxO signaling pathway
25718 (Igf1r)
04151 PI3K-Akt signaling pathway
25718 (Igf1r)
04152 AMPK signaling pathway
25718 (Igf1r)
04150 mTOR signaling pathway
25718 (Igf1r)
09133 Signaling molecules and interaction
04081 Hormone signaling
25718 (Igf1r)
09140 Cellular Processes
09141 Transport and catabolism
04144 Endocytosis
25718 (Igf1r)
04140 Autophagy - animal
25718 (Igf1r)
09143 Cell growth and death
04114 Oocyte meiosis
25718 (Igf1r)
09144 Cellular community - eukaryotes
04510 Focal adhesion
25718 (Igf1r)
04520 Adherens junction
25718 (Igf1r)
04550 Signaling pathways regulating pluripotency of stem cells
25718 (Igf1r)
09150 Organismal Systems
09152 Endocrine system
04913 Ovarian steroidogenesis
25718 (Igf1r)
04914 Progesterone-mediated oocyte maturation
25718 (Igf1r)
09156 Nervous system
04730 Long-term depression
25718 (Igf1r)
09149 Aging
04211 Longevity regulating pathway
25718 (Igf1r)
04213 Longevity regulating pathway - multiple species
25718 (Igf1r)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
25718 (Igf1r)
05202 Transcriptional misregulation in cancer
25718 (Igf1r)
05205 Proteoglycans in cancer
25718 (Igf1r)
09162 Cancer: specific types
05225 Hepatocellular carcinoma
25718 (Igf1r)
05214 Glioma
25718 (Igf1r)
05218 Melanoma
25718 (Igf1r)
05215 Prostate cancer
25718 (Igf1r)
05224 Breast cancer
25718 (Igf1r)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
25718 (Igf1r)
01522 Endocrine resistance
25718 (Igf1r)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
rno01001
]
25718 (Igf1r)
09183 Protein families: signaling and cellular processes
04090 CD molecules [BR:
rno04090
]
25718 (Igf1r)
Enzymes [BR:
rno01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.10 Protein-tyrosine kinases
2.7.10.1 receptor protein-tyrosine kinase
25718 (Igf1r)
Protein kinases [BR:
rno01001
]
Receptor tyrosine kinases (RTK)
INSR family [OT]
25718 (Igf1r)
CD molecules [BR:
rno04090
]
Proteins
25718 (Igf1r)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
PK_Tyr_Ser-Thr
Recep_L_domain
Pkinase
Furin-like
fn3
Ig_DSCAM-DSCAML_C
Kinase-like
Insulin_TMD
B2
Motif
Other DBs
NCBI-GeneID:
25718
NCBI-ProteinID:
NP_434694
RGD:
2869
Ensembl:
ENSRNOG00000014187
UniProt:
P24062
LinkDB
All DBs
Position
1:130959787..131248664
Genome browser
AA seq
1370 aa
AA seq
DB search
MKSGSGGGSPTSLWGLVFLSAALSLWPTSGEICGPGIDIRNDYQQLKRLENCTVIEGFLH
ILLISKAEDYRSYRFPKLTVITEYLLLFRVAGLESLGDLFPNLTVIRGWKLFYNYALVIF
EMTNLKDIGLYNLRNITRGAIRIEKNADLCYLSTIDWSLILDAVSNNYIVGNKPPKECGD
LCPGTLEEKPMCEKTTINNEYNYRCWTTNRCQKMCPSVCGKRACTENNECCHPECLGSCH
TPDDNTTCVACRHYYYKGVCVPACPPGTYRFEGWRCVDRDFCANIPNAESSDSDGFVIHD
GECMQECPSGFIRNSTQSMYCIPCEGPCPKVCGDEEKKTKTIDSVTSAQMLQGCTILKGN
LLINIRRGNNIASELENFMGLIEVVTGYVKIRHSHALVSLSFLKNLRLILGEEQLEGNYS
FYVLDNQNLQQLWDWNHRNLTVRSGKMYFAFNPKLCVSEIYRMEEVTGTKGRQSKGDINT
RNNGERASCESDVLRFTSTTTWKNRIIITWHRYRPPDYRDLISFTVYYKEAPFKNVTEYD
GQDACGSNSWNMVDVDLPPNKEGEPGILLHGLKPWTQYAVYVKAVTLTMVENDHIRGAKS
EILYIRTNASVPSIPLDVLSASNSSSQLIVKWNPPTLPNGNLSYYIVRWQRQPQDGYLFR
HNYCSKDKIPIRKYADGTIDVEEVTENPKTEVCGGDKGPCCACPKTEAEKQAEKEEAEYR
KVFENFLHNSIFVPRPERRRRDVLQVANTTMSSRSRNTTVADTYNITDPEEFETEYPFFE
SRVDNKERTVISNLRPFTLYRIDIHSCNHEAEKLGCSASNFVFARTMPAEGADDIPGPVT
WEPRPENSIFLKWPEPENPNGLILMYEIKYGSQVEDQRECVSRQEYRKYGGAKLNRLNPG
NYTARIQATSLSGNGSWTDPVFFYVPAKTTYENFMHLIIALPVAILLIVGGLVIMLYVFH
RKRNNSRLGNGVLYASVNPEYFSAADVYVPDEWEVAREKITMNRELGQGSFGMVYEGVAK
GVVKDEPETRVAIKTVNEAASMRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLVIM
ELMTRGDLKSYLRSLRPEVENNLVLIPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAAR
NCMVAEDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTHSDVWSFG
VVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSF
LEIIGSIKDEMEPSFQEVSFYYSEENKPPEPEELEMELELEPENMESVPLDPSASSASLP
LPERHSGHKAENGPGVLVLRASFDERQPYAHMNGGRANERALPLPQSSTC
NT seq
4113 nt
NT seq
+upstream
nt +downstream
nt
atgaagtctggctccggaggagggtccccgacctcgctgtgggggctcgtgtttctctcc
gccgcgctctcgctctggccgacgagtggagaaatttgtgggcccggcattgacatccgc
aacgactatcagcagctgaagcgcctggaaaactgcacggtgatcgagggcttcctccac
atcctgctcatctccaaggccgaggactaccgaagctaccgcttccccaagctcacggtc
atcaccgagtacttgctgctgtttcgagtggccggcctcgagagcctgggagacctcttc
ccgaacctcacagtcatccgtggctggaaactcttctacaattacgcactggtcatcttc
gagatgaccaatctcaaggatattgggctttataatctgaggaacattactcggggggcc
atcaggattgagaaaaacgctgacctctgttacctctccaccatagactggtctctcatc
ttggatgcggtgtccaataactacattgtggggaacaagcccccaaaggaatgtggggac
ctgtgtccagggaccttggaggagaagcccatgtgtgagaagaccaccatcaacaatgag
tacaactaccgctgctggaccacaaatcgctgccagaaaatgtgcccaagtgtgtgtggg
aagcgagcctgcaccgagaacaatgagtgctgccacccggagtgcctaggcagctgccac
acaccggacgacaacacaacctgcgtggcctgccgacactactactacaaaggcgtgtgc
gtgcctgcctgcccgcctggcacctacaggttcgagggctggcgctgtgtggaccgggat
ttctgcgccaacatccccaacgccgagagcagtgactcagatggcttcgtcatccacgat
ggcgagtgcatgcaggagtgtccatcaggcttcatccgcaacagcacccagagcatgtac
tgtatcccctgtgaaggcccctgccccaaggtctgcggcgatgaagaaaagaaaacgaaa
accatcgattctgtgacgtctgcccagatgctccaagggtgcaccattttgaagggcaat
ctgcttattaacatccggcgaggcaataacattgcctcggaattggagaacttcatgggg
ctcatcgaggtggtgactggctacgtgaagatccgccattcccatgccttggtctccttg
tccttcctgaagaaccttcgtctcatcttaggagaggagcagctagaagggaactactcc
ttctatgtcctggacaaccagaacttgcagcagctgtgggactggaaccaccggaacctg
accgtcaggtcagggaaaatgtacttcgctttcaatcccaagctgtgtgtctctgaaatt
taccggatggaggaggtgacaggaacaaagggacggcagagcaaaggagacataaacacc
aggaacaacggagagcgagcttcctgtgaaagtgatgttctccgtttcacctccaccacc
acctggaagaaccgcatcatcataacgtggcaccggtaccggccgccggactaccgggat
ctcatcagtttcacagtctactacaaggaggcaccctttaaaaacgtcacggaatacgac
gggcaggatgcctgtggctccaacagctggaacatggtggacgtggacctgcctccgaac
aaggagggggagcctggcattttgctgcatgggctgaagccctggacccagtatgcagtc
tatgtcaaggctgtgaccctcaccatggtggaaaacgaccacatccgtggggccaaaagt
gaaatcttgtacattcgcaccaacgcttcagttccttccattcctctagatgtcctctcg
gcatcaaactcctcctctcagctgatcgtgaagtggaaccccccaactctgcccaatggt
aacttgagttactacattgtgaggtggcagcggcagccgcaggatggctatctgttccgg
cacaactactgctccaaagacaaaatacccatcagaaagtacgccgatggtaccatcgat
gtggaggaggtgacagaaaatcccaagacagaagtgtgcggtggtgataaagggccgtgc
tgtgcctgtcctaaaaccgaagctgagaagcaggctgagaaggaggaggctgagtaccgt
aaagtctttgagaatttccttcacaactccatctttgtgcccagacctgagaggaggcgg
agagatgtcctgcaggtggctaacaccaccatgtccagccgaagcaggaacaccacggta
gctgacacctacaatatcacagacccggaagagttcgagacagaataccctttctttgag
agcagagtggataacaaggagaggactgtcatttccaacctccggcctttcactctgtac
cgtatcgatatccacagctgcaaccacgaggctgagaagctgggctgcagcgcctccaac
tttgtctttgcaagaaccatgccagcagaaggagcagatgacattcctggcccagtgacc
tgggagccaagacctgaaaactccatctttttaaagtggccagaacccgagaaccccaac
ggattgattctaatgtatgaaataaaatacggatcgcaagtcgaggatcagcgggaatgt
gtgtccagacaggagtacaggaagtatggaggggccaaacttaaccgtctaaacccaggg
aactatacggcccggattcaggctacctccctctctgggaatgggtcgtggacagatcct
gtgttcttctatgtcccagccaaaacaacgtatgagaatttcatgcatctgatcattgct
ctgccggttgccatcctgctgattgtggggggcctggtaatcatgctgtatgtcttccat
agaaagaggaataacagcagattgggcaacggggtgctgtacgcctctgtgaaccccgag
tatttcagcgcagctgatgtgtacgtgcctgatgaatgggaggtagctcgggagaagatc
accatgaaccgggagctcggacaagggtccttcgggatggtctatgaaggagtggccaag
ggcgtggtcaaggacgagcctgaaaccagagtggccatcaagacagtgaatgaggctgca
agtatgcgtgagagaattgagtttctcaacgaggcctcagtgatgaaggagttcaactgt
caccatgtggtccggttgctgggtgtagtatcccaaggccagcccaccctggtcatcatg
gaactaatgacacgtggcgatctcaaaagttatctccggtctctaaggccagaggtggag
aataatctagtcctgattcctccgagcttaagcaagatgatccagatggctggagagatt
gcagatggcatggcctacctcaatgccaacaagttcgtccacagagacctggctgctcgg
aactgcatggtagctgaagatttcacagtcaaaattggagattttggtatgacacgagac
atctacgagacggactactaccggaaaggcgggaagggcttgctgcctgtgcgctggatg
tctcccgagtccctcaaggatggcgtcttcaccactcattccgatgtctggtcctttggg
gtcgtcctctgggagatcgccactctggctgagcagccgtaccagggcctgtccaacgag
caagttcttcgtttcgtcatggagggcggccttctggacaagccggataactgccccgat
atgctgtttgaacttatgcgcatgtgctggcagtacaaccccaagatgcggccctccttc
ctggagatcatcggaagcatcaaggatgagatggagcccagtttccaggaggtctccttc
tactacagcgaggagaacaagcctccagagccggaggagctggagatggagctggagctg
gagcccgagaacatggagagcgtcccgctggacccttcggcctcctcagcctccctgcct
ctgcctgaaagacactcaggacacaaggctgagaacggccctggcgtgctggttctccgt
gccagttttgatgagagacagccttacgctcacatgaatgggggacgcgccaacgagagg
gccttgcctctgccccagtcctcaacctgctga
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integrated database retrieval system
