KEGG   Rattus norvegicus (rat): 289950
Entry
289950            CDS       T01003                                 
Symbol
Pdhb
Name
(RefSeq) pyruvate dehydrogenase E1 component subunit beta, mitochondrial precursor
  KO
K00162  pyruvate dehydrogenase E1 component subunit beta [EC:1.2.4.1]
Organism
rno  Rattus norvegicus (rat)
Pathway
rno00010  Glycolysis / Gluconeogenesis
rno00020  Citrate cycle (TCA cycle)
rno00620  Pyruvate metabolism
rno00785  Lipoic acid metabolism
rno01100  Metabolic pathways
rno01200  Carbon metabolism
rno01210  2-Oxocarboxylic acid metabolism
rno04066  HIF-1 signaling pathway
rno04922  Glucagon signaling pathway
rno05230  Central carbon metabolism in cancer
rno05415  Diabetic cardiomyopathy
Module
rno_M00307  Pyruvate oxidation, pyruvate => acetyl-CoA
Brite
KEGG Orthology (KO) [BR:rno00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00010 Glycolysis / Gluconeogenesis
    289950 (Pdhb)
   00020 Citrate cycle (TCA cycle)
    289950 (Pdhb)
   00620 Pyruvate metabolism
    289950 (Pdhb)
  09108 Metabolism of cofactors and vitamins
   00785 Lipoic acid metabolism
    289950 (Pdhb)
 09130 Environmental Information Processing
  09132 Signal transduction
   04066 HIF-1 signaling pathway
    289950 (Pdhb)
 09150 Organismal Systems
  09152 Endocrine system
   04922 Glucagon signaling pathway
    289950 (Pdhb)
 09160 Human Diseases
  09161 Cancer: overview
   05230 Central carbon metabolism in cancer
    289950 (Pdhb)
  09166 Cardiovascular disease
   05415 Diabetic cardiomyopathy
    289950 (Pdhb)
Enzymes [BR:rno01000]
 1. Oxidoreductases
  1.2  Acting on the aldehyde or oxo group of donors
   1.2.4  With a disulfide as acceptor
    1.2.4.1  pyruvate dehydrogenase (acetyl-transferring)
     289950 (Pdhb)
SSDB
Motif
Pfam: Transket_pyr Transketolase_C
Other DBs
NCBI-GeneID: 289950
NCBI-ProteinID: NP_001007621
RGD: 1359146
Ensembl: ENSRNOG00000007895
UniProt: P49432
LinkDB
Position
15:19182789..19188731
AA seq 359 aa
MAAVAGLVRGPLRQASGLLKRRFHRSAPAAVQLTVREAINQGMDEELERDEKVFLLGEEV
AQYDGAYKVSRGLWKKYGDKRIIDTPISEMGFAGIAVGAAMAGLRPICEFMTFNFSMQAI
DQVINSAAKTYYMSAGLQPVPIVFRGPNGASAGVAAQHSQCFAAWYGHCPGLKVVSPWNS
EDAKGLIKSAIRDDNPVVMLENELMYGVAFELPTEAQSKDFLIPIGKAKIERQGTHITVV
AHSRPVGHCLEAAAVLSKEGIECEVINLRTIRPMDIEAIEASVMKTNHLVTVEGGWPQFG
VGAEICARIMEGPAFNFLDAPAVRVTGADVPMPYAKILEDNSIPQVKDIIFAIKKTLNI
NT seq 1080 nt   +upstreamnt  +downstreamnt
atggcggcggtggctggtctggtgcggggacctttgcggcaggcttccgggctgctgaag
aggcgtttccaccgctcggcgcccgcggcggtgcagttgacagttcgtgaagccattaat
caaggtatggatgaagaactagaaagagatgaaaaggtttttctgcttggggaagaagtt
gcccagtatgatggtgcatacaaggttagcagaggcctgtggaagaaatatggtgacaag
aggatcatagatactcccatatcggagatgggctttgctggaattgctgttggtgcagct
atggctgggctgcggcccatctgtgaatttatgaccttcaatttctctatgcaagctatt
gaccaggtcataaactcagctgccaagacgtactatatgtctgctggcctccagccggtg
cccatagtgttcagggggcccaacggcgcctcagcgggcgtggctgctcagcactcgcaa
tgcttcgctgcgtggtatgggcactgccccggtttgaaagtggtcagcccctggaattcc
gaggatgcgaaaggacttattaaatcggccattcgtgatgataatccagtggtgatgcta
gagaatgaactgatgtatggagttgcatttgaacttcccacagaagctcaatcaaaagat
ttcctgattcctattggaaaagccaaaattgaaaggcaagggacccacatcactgtagtt
gcccattcaagaccagtgggccactgcctagaagctgcagctgtattgtctaaggaggga
attgaatgtgaggtaataaatctgcggaccatcagaccaatggacattgaagctatagaa
gccagtgtcatgaagacaaatcatctcgtaactgtggaaggaggctggccacaatttgga
gtaggagctgagatttgtgcgagaattatggaaggccctgcattcaacttccttgatgcg
cctgctgttcgagtcactggtgctgatgtccctatgccttacgcaaagattctagaagac
aactccatacctcaggtcaaagacatcatatttgcaataaagaagactttgaatatctaa

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