Rattus norvegicus (rat): 29337
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Entry
29337 CDS
T01003
Symbol
Plcg2
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
KO
K05859
phosphatidylinositol phospholipase C, gamma-2 [EC:
3.1.4.11
]
Organism
rno
Rattus norvegicus (rat)
Pathway
rno00562
Inositol phosphate metabolism
rno01100
Metabolic pathways
rno01521
EGFR tyrosine kinase inhibitor resistance
rno04012
ErbB signaling pathway
rno04014
Ras signaling pathway
rno04020
Calcium signaling pathway
rno04062
Chemokine signaling pathway
rno04064
NF-kappa B signaling pathway
rno04066
HIF-1 signaling pathway
rno04070
Phosphatidylinositol signaling system
rno04072
Phospholipase D signaling pathway
rno04360
Axon guidance
rno04370
VEGF signaling pathway
rno04380
Osteoclast differentiation
rno04611
Platelet activation
rno04613
Neutrophil extracellular trap formation
rno04625
C-type lectin receptor signaling pathway
rno04650
Natural killer cell mediated cytotoxicity
rno04662
B cell receptor signaling pathway
rno04664
Fc epsilon RI signaling pathway
rno04666
Fc gamma R-mediated phagocytosis
rno04670
Leukocyte transendothelial migration
rno04722
Neurotrophin signaling pathway
rno04750
Inflammatory mediator regulation of TRP channels
rno04919
Thyroid hormone signaling pathway
rno04933
AGE-RAGE signaling pathway in diabetic complications
rno04935
Growth hormone synthesis, secretion and action
rno05167
Kaposi sarcoma-associated herpesvirus infection
rno05169
Epstein-Barr virus infection
rno05170
Human immunodeficiency virus 1 infection
rno05171
Coronavirus disease - COVID-19
rno05200
Pathways in cancer
rno05205
Proteoglycans in cancer
rno05206
MicroRNAs in cancer
rno05214
Glioma
rno05223
Non-small cell lung cancer
rno05225
Hepatocellular carcinoma
Module
rno_M00130
Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:
rno00001
]
09100 Metabolism
09101 Carbohydrate metabolism
00562 Inositol phosphate metabolism
29337 (Plcg2)
09130 Environmental Information Processing
09132 Signal transduction
04012 ErbB signaling pathway
29337 (Plcg2)
04014 Ras signaling pathway
29337 (Plcg2)
04370 VEGF signaling pathway
29337 (Plcg2)
04064 NF-kappa B signaling pathway
29337 (Plcg2)
04066 HIF-1 signaling pathway
29337 (Plcg2)
04020 Calcium signaling pathway
29337 (Plcg2)
04070 Phosphatidylinositol signaling system
29337 (Plcg2)
04072 Phospholipase D signaling pathway
29337 (Plcg2)
09150 Organismal Systems
09151 Immune system
04611 Platelet activation
29337 (Plcg2)
04613 Neutrophil extracellular trap formation
29337 (Plcg2)
04625 C-type lectin receptor signaling pathway
29337 (Plcg2)
04650 Natural killer cell mediated cytotoxicity
29337 (Plcg2)
04662 B cell receptor signaling pathway
29337 (Plcg2)
04664 Fc epsilon RI signaling pathway
29337 (Plcg2)
04666 Fc gamma R-mediated phagocytosis
29337 (Plcg2)
04670 Leukocyte transendothelial migration
29337 (Plcg2)
04062 Chemokine signaling pathway
29337 (Plcg2)
09152 Endocrine system
04935 Growth hormone synthesis, secretion and action
29337 (Plcg2)
04919 Thyroid hormone signaling pathway
29337 (Plcg2)
09156 Nervous system
04722 Neurotrophin signaling pathway
29337 (Plcg2)
09157 Sensory system
04750 Inflammatory mediator regulation of TRP channels
29337 (Plcg2)
09158 Development and regeneration
04360 Axon guidance
29337 (Plcg2)
04380 Osteoclast differentiation
29337 (Plcg2)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
29337 (Plcg2)
05206 MicroRNAs in cancer
29337 (Plcg2)
05205 Proteoglycans in cancer
29337 (Plcg2)
09162 Cancer: specific types
05225 Hepatocellular carcinoma
29337 (Plcg2)
05214 Glioma
29337 (Plcg2)
05223 Non-small cell lung cancer
29337 (Plcg2)
09172 Infectious disease: viral
05170 Human immunodeficiency virus 1 infection
29337 (Plcg2)
05171 Coronavirus disease - COVID-19
29337 (Plcg2)
05167 Kaposi sarcoma-associated herpesvirus infection
29337 (Plcg2)
05169 Epstein-Barr virus infection
29337 (Plcg2)
09167 Endocrine and metabolic disease
04933 AGE-RAGE signaling pathway in diabetic complications
29337 (Plcg2)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
29337 (Plcg2)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:
rno04131
]
29337 (Plcg2)
Enzymes [BR:
rno01000
]
3. Hydrolases
3.1 Acting on ester bonds
3.1.4 Phosphoric-diester hydrolases
3.1.4.11 phosphoinositide phospholipase C
29337 (Plcg2)
Membrane trafficking [BR:
rno04131
]
Exocytosis
Calcium ion-dependent exocytosis
Phospholipases
29337 (Plcg2)
Endocytosis
Macropinocytosis
Phospholipase C
29337 (Plcg2)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
PI-PLC-X
SH2
PI-PLC-Y
EF-hand_PLCG2
SH3_1
C2
SH3_9
PH
PH_12
EF-hand_PLCG1
SH2_1
SH3_2
PH_14
GDPD
EF-hand_like
Motif
Other DBs
NCBI-GeneID:
29337
NCBI-ProteinID:
NP_058864
RGD:
3348
Ensembl:
ENSRNOG00000051986
UniProt:
P24135
Structure
PDB
PDBj
LinkDB
All DBs
Position
19:62456196..62592684
Genome browser
AA seq
1265 aa
AA seq
DB search
MTTMVNVDTLPEYEKSQIKRALELGTVMTVFSARKSTPERRTVQMIMETRQVAWSKTADK
IEGFLDIMEIKEIRPGKNSKDFERAKAVRHKADCCFTIFYGTQFVLSTLSLATDSKEDAV
KWLSGLKILHQEAMNASTPTMIESWLRKQIYSVDQTRRNSISLRELKTILPLVNFKVSGI
KFLKDKLVEIGAQKDELSFEQFHLFYKKLMFEQQKSILDEFKKDSSVFILGNTDRPDASA
VYLQDFQRFLLHEQQELWAQDLNKVRERMTKFIDDTMRETAEPFLFVDEFLTYLFSRENS
IWDEKYDAVDMQDMNNPLSHYWISSSHNTYLTGDQLRSESSTEAYIRCLRAGCRCIELDC
WDGPDGKPIIYHGWTRTTKIKFDDVVQAIRDHAFVTSSFPVILSIEEHCSVEQQRHMAKV
FKEVLGDLLLTKPTEASADQLPSPSQLREKIIIKHKKLGPRGDVDVNVEDKKDEHKTQGE
LYMWDSIDQKWTRHYCAIADAKLSFSDDIEQTVEEDPVQDTPPTELHFGEKWFHKKVESR
TSAEKLLQEYCAETGAKDGTFLVRESETFPNDYTLSFWRSGRVQHCRIRSTMEGGVMKYY
LTDNLTFNSIYALIQHYREAHLRCAEFELRLTDPVPNPNPHESKPWYYDRLSRGEAEDML
MRIPRDGAFLIRKREGTDSYAITFRARGKVKHCRINRDGRHFVLGTSAYFESLVELVSYY
EKHALYRKMRLRYPVTPELLERYNMERDINSLYDVSRMYVDPSEINPSMPQRTVKALYDY
KAKRSDELTFCRGALIHNVSKEPGGWWKGDYGTRIQQYFPSNYVEDISAGDAEEMEKQII
EDNPLGSLCRGILDLNTYNVVKAPQGKNQKAFVFILEPKKQGDPPVEFATDRVEELFEWF
QSIREITWKIDTKENNMKYWERNQSIAIELSDLVVYCKPTSKTKDHLENPDFREIRSFVE
TKADSIVRQKPVDLLRYNQKGLTRVYPKGQRVDSSNYDPFRLWLCGSQMVALNFQTPDKY
MQMNHALFSLNGRTGYVLQPESMRSEKYDPMPPESQRKILMTLTVKVLGARHLPKLGRSI
ACPFVEVEICGAEYDSNKFKTTVVNDNGLSPVWAPTQEKVTFEIYDPNLAFLRFLVYEED
MFSDPNFLAHATYPIKGIKSGFRSVPLKNGYSEDIELASLLVFCEMRPVLESEEELYSSC
RQLRRRQEELNNQLFLYDTHQNLRGANRDALVKEFNVNENQLRLYQEKCNRRLREKRVSN
SRFYS
NT seq
3798 nt
NT seq
+upstream
nt +downstream
nt
atgaccaccatggtcaacgtggacacccttccagaatatgagaagagtcagatcaagaga
gccctggagctagggacggtgatgaccgtattcagtgcccgcaaatccaccccagagcgg
aggacagtacagatgatcatggagacccggcaggtggcatggagcaagacagcagataag
atcgaaggcttcttggacatcatggaaataaaggaaatccggccagggaagaactccaag
gactttgagcgagccaaggctgtccgtcacaaggcagactgctgcttcaccatcttctac
ggcacccagttcgtgctcagcactctcagtctggcaaccgactcaaaggaggatgcagtg
aagtggctctctggcttgaagatcttacaccaggaagcgatgaacgcatccactcccaca
atgattgagagttggctgcggaaacagatttattcagtagatcaaacccgaagaaacagc
atcagcctccgggagctgaagaccatcttgcccctggtcaacttcaaagtgagcggcatc
aagttcctcaaggacaagctggtggaaattggcgcccagaaagatgagctcagttttgaa
cagttccatctcttctataaaaaactcatgtttgagcagcagaagtcgatacttgacgaa
ttcaaaaaagactcctccgtgttcatcctagggaacacagaccggcctgatgcctcagcc
gtctacctgcaagacttccagaggtttcttttacatgaacagcaggagctatgggctcag
gatctgaacaaagtccgggagcggatgaccaagtttatcgatgacacaatgagggagacc
gcagagcccttcttgtttgtggatgagttcctcacgtatctgttctcacgggagaacagc
atctgggacgagaagtacgatgccgtggacatgcaggacatgaacaaccccttgtcccat
tactggatctcctcttcccacaacacgtacctcactggagaccagctgcgtagcgagtcc
tccacggaagcgtatatccgctgtctgcgtgctggttgtcgctgcatcgagttggattgc
tgggatgggcctgacgggaaacccataatctatcacggttggacacggaccaccaagatc
aagtttgatgatgttgttcaggccatccgggatcatgcctttgttacctccagctttccc
gtgattctgtctatcgaggagcactgcagtgtggagcagcaacgtcacatggccaaggtc
ttcaaggaagtgttaggagacctgctgttgacgaagcccacggaggccagtgctgaccag
ctgccctcacccagccagcttcgtgagaagatcattatcaagcataagaagctgggcccc
cgaggtgatgtcgatgtcaatgtggaggacaagaaagatgagcacaagacccagggcgag
ctgtatatgtgggactccatcgaccagaaatggactcgccactactgtgctattgcggac
gccaagctgtccttcagtgacgacattgaacagactgtggaagaggatccggtccaggac
actccccccacggagctacattttggggagaaatggttccataagaaggtggagagcagg
accagtgcggagaagctgctgcaggagtactgtgccgagactggggccaaggatggcacc
ttcctggtgcgggagagcgagaccttccccaacgactacacactctccttctggcggtct
ggccgggtgcagcactgccgaatccggtctaccatggagggtggggtcatgaagtactac
ctgactgacaacctcacgttcaacagcatctacgccctcatccagcactaccgggaggca
cacctgcgctgtgcggagttcgagctgcggctcacagacccggtgcccaaccccaaccca
catgagtccaagccgtggtactatgacaggctgagcaggggggaagcagaggacatgttg
atgcggattccccgagatggagccttcctcattcggaagcgggaggggaccgactcttac
gccatcaccttcagggccaggggcaaggtgaaacattgccgtatcaaccgggacggacgt
cactttgtgctggggacctctgcctactttgagagcctggtggagctcgtcagctactat
gagaagcacgcactctaccgcaagatgaggcttcgctaccccgtgaccccggagctcctg
gaacgatataatatggaaagagacatcaactctctctatgacgtcagcaggatgtatgtg
gacccaagtgagatcaacccttccatgcctcagaggactgtgaaagcactctatgactac
aaagccaagcgcagcgatgagctgaccttctgccgaggtgccctcatccacaacgtctcc
aaggagccgggaggatggtggaaaggggactatgggacccggatccagcagtatttccca
tctaactacgttgaagatatctcggcaggcgatgctgaggagatggaaaagcagattatt
gaagacaaccccctcgggtctctctgcagaggcatattggatcttaatacctacaatgtg
gtgaaggccccccaggggaaaaaccagaaagccttcgtctttatcctggagcctaagaaa
cagggggaccctcctgtggagttcgcgactgaccgtgtggaggaactgtttgagtggttt
cagagtatacgagagatcacttggaagatcgacaccaaggagaacaacatgaagtactgg
gagaggaatcagtccattgctattgagctctctgacttggttgtgtactgcaagccgact
agcaaaaccaaggaccatttggaaaatcctgacttccgggaaattcgctcttttgtggag
acaaaggcagacagcattgtcaggcaaaagcccgtggatctattgcggtacaaccagaag
ggcctgacccgtgtctaccccaagggacagagagttgactcttccaactacgaccccttc
cgtctgtggctgtgtggctcccagatggtggcgctcaatttccagactccagacaagtac
atgcagatgaaccatgcattgttttcgctcaatgggcggacaggttacgtcctgcagccc
gagagcatgcggtctgagaagtatgacccgatgcccccggagtcccagaggaagatcctg
atgacactcactgtcaaggttcttggtgcacgccacctccctaaactagggcggagtatc
gcctgtccctttgtagaggtggaaatctgtggggccgagtatgacagcaacaaattcaag
acgacggttgtgaatgacaacggtctcagccctgtctgggctccaactcaggagaaggtg
acatttgaaatttatgacccaaaccttgcgttcctacgctttctggtctacgaagaagac
atgttcagtgaccccaacttcctggctcatgccacataccccattaaaggcatcaaatca
ggatttagatcagtccctctgaagaacgggtacagtgaagacatcgagctggcatccctc
ctggttttctgtgagatgcggccagtcctggagagtgaagaagaactctattcctcctgt
cgccagctgcggaggcggcaggaagagctcaacaaccagctcttcctgtatgacacacac
cagaacctgcgaggagccaaccgggatgccctggtgaaggagttcaatgttaacgagaat
cagctgcggctgtaccaggagaagtgtaaccggaggctgagagagaagagagtgagtaac
agcaggttctactcctag
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integrated database retrieval system
