Rattus norvegicus (rat): 309757
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Entry
309757 CDS
T01003
Symbol
Sirt1
Name
(RefSeq) NAD-dependent protein deacetylase sirtuin-1
KO
K11411
NAD-dependent protein deacetylase sirtuin 1 [EC:
2.3.1.286
]
Organism
rno
Rattus norvegicus (rat)
Pathway
rno00760
Nicotinate and nicotinamide metabolism
rno01100
Metabolic pathways
rno04068
FoxO signaling pathway
rno04148
Efferocytosis
rno04152
AMPK signaling pathway
rno04211
Longevity regulating pathway
rno04213
Longevity regulating pathway - multiple species
rno04218
Cellular senescence
rno04310
Wnt signaling pathway
rno04922
Glucagon signaling pathway
rno04936
Alcoholic liver disease
rno05031
Amphetamine addiction
rno05206
MicroRNAs in cancer
Brite
KEGG Orthology (KO) [BR:
rno00001
]
09100 Metabolism
09108 Metabolism of cofactors and vitamins
00760 Nicotinate and nicotinamide metabolism
309757 (Sirt1)
09130 Environmental Information Processing
09132 Signal transduction
04310 Wnt signaling pathway
309757 (Sirt1)
04068 FoxO signaling pathway
309757 (Sirt1)
04152 AMPK signaling pathway
309757 (Sirt1)
09140 Cellular Processes
09141 Transport and catabolism
04148 Efferocytosis
309757 (Sirt1)
09143 Cell growth and death
04218 Cellular senescence
309757 (Sirt1)
09150 Organismal Systems
09152 Endocrine system
04922 Glucagon signaling pathway
309757 (Sirt1)
09149 Aging
04211 Longevity regulating pathway
309757 (Sirt1)
04213 Longevity regulating pathway - multiple species
309757 (Sirt1)
09160 Human Diseases
09161 Cancer: overview
05206 MicroRNAs in cancer
309757 (Sirt1)
09165 Substance dependence
05031 Amphetamine addiction
309757 (Sirt1)
09167 Endocrine and metabolic disease
04936 Alcoholic liver disease
309757 (Sirt1)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
03036 Chromosome and associated proteins [BR:
rno03036
]
309757 (Sirt1)
03029 Mitochondrial biogenesis [BR:
rno03029
]
309757 (Sirt1)
Enzymes [BR:
rno01000
]
2. Transferases
2.3 Acyltransferases
2.3.1 Transferring groups other than aminoacyl groups
2.3.1.286 protein acetyllysine N-acetyltransferase
309757 (Sirt1)
Chromosome and associated proteins [BR:
rno03036
]
Eukaryotic type
Histone modification proteins
HDACs (histone deacetylases)
SIRTs (sirtuins, class III HDACs)
309757 (Sirt1)
Mitochondrial biogenesis [BR:
rno03029
]
Mitochondrial quality control factors
Regulator of mitochondrial biogenesis
Other regulator of mitochondrial biogenesis
309757 (Sirt1)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
SIR2
Motif
Other DBs
NCBI-GeneID:
309757
NCBI-ProteinID:
NP_001359019
RGD:
1308542
Ensembl:
ENSRNOG00000051592
UniProt:
A0A8I6B0Z5
LinkDB
All DBs
Position
20:25305953..25328000
Genome browser
AA seq
444 aa
AA seq
DB search
MCLCSGRKAILEIYPGQFQPSLCHKFIALSDKEGKLLRNYTQNIDTLEQVAGIQRIIQCH
GSFATASCLICKYKVDCEAVRGDIFNQVVPRCPRCPADEPLAIMKPEIVFFGENLPEQFH
RAMKYDKDEVDLLIVIGSSLKVRPVALIPSSIPHEVPQILINREPLPHLHFDVELLGDCD
VIINELCHRLGGEYAKLCCNPVKLSEITEKPPRTQKELVHLSELPPTPLHISEDSSSPER
TVPQDSSVIATLVDQTIKNKVDDLEVSEPKSCVEEKSQEVQTYRNVESINVENPDFKAVG
SSTGDKNERTSVAETVRKCWPNRLAKEQISKRLDGNQYLFVPPNRYIFHGAEVYSDSEDD
ALSSSSCGSNSDSGTCQSPSLEEPLEDESEIEEFYNGLEDDADRPECAGGSGADGGDQEA
VNEAIAMKQELTDVNCTPDKSEHY
NT seq
1335 nt
NT seq
+upstream
nt +downstream
nt
atgtgcctgtgcagtggaaggaaagcaattttggaaatatatcccggacagttccagcca
tctctgtgtcacaaattcatagctttgtcagataaggaaggaaaactacttcgaaattat
actcaaaatatagataccttggagcaggttgcaggaatccaaaggatcattcagtgtcat
ggttcctttgcaacagcatcttgcctgatttgtaaatacaaagttgattgtgaagctgtt
cgtggagatatttttaatcaggtagttcctcggtgtcctaggtgcccagctgatgagcca
cttgccatcatgaagccagagattgtcttctttggtgaaaacttaccagaacagtttcat
agagccatgaagtatgacaaagatgaagttgacctcctcattgttattgggtcttctctg
aaagtaagaccagtagcactaattccaagttctataccccatgaagtgcctcaaatatta
ataaatagggaacctctgcctcatctacattttgatgtagagcttcttggagactgcgat
gtcataattaatgagttgtgtcataggttaggtggcgagtatgccaaactttgttgtaac
cctgtaaagctttcagaaattactgaaaaacctccacgaacacaaaaggaattggttcat
ttatcagagttgccaccaacacctcttcatatttcagaagactcaagttcacctgaaaga
actgtaccacaagactcttctgtgattgctacacttgtagaccaaacaataaagaacaaa
gttgacgatttagaagtatctgaaccaaaaagttgtgtggaagaaaaatcacaggaagta
cagacttataggaatgttgagagcattaatgtggaaaacccagatttcaaggctgttggt
tccagtactggagacaaaaatgaaagaacttctgttgcagaaacagtgagaaaatgctgg
cctaatagacttgcaaaggagcagattagtaagcgtcttgacggtaatcaatacttgttt
gtaccaccaaatcgttacatatttcatggtgctgaggtatactcagactctgaagatgac
gccttatcctctagttcctgtggcagtaacagtgacagtggcacatgccagagtccaagt
ttagaagaacccttggaagatgaaagtgaaattgaagagttctacaatggcttggaagat
gatgctgacagaccggagtgtgctggaggatctggagctgacggaggggatcaagaggca
gttaatgaagctatagccatgaaacaggaattaacagatgtaaactgtacaccagacaaa
tcagagcactattga
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