Rattus norvegicus (rat): 313845 Help Entry 313845            CDS       T01003                                  Symbol Sos1 Name (RefSeq) son of sevenless homolog 1   KO K03099   son of sevenless Organism rno  Rattus norvegicus (rat) Pathway rno01521   EGFR tyrosine kinase inhibitor resistance rno01522   Endocrine resistance rno04010   MAPK signaling pathway rno04012   ErbB signaling pathway rno04014   Ras signaling pathway rno04062   Chemokine signaling pathway rno04068   FoxO signaling pathway rno04072   Phospholipase D signaling pathway rno04150   mTOR signaling pathway rno04151   PI3K-Akt signaling pathway rno04510   Focal adhesion rno04540   Gap junction rno04630   JAK-STAT signaling pathway rno04650   Natural killer cell mediated cytotoxicity rno04660   T cell receptor signaling pathway rno04662   B cell receptor signaling pathway rno04664   Fc epsilon RI signaling pathway rno04714   Thermogenesis rno04722   Neurotrophin signaling pathway rno04810   Regulation of actin cytoskeleton rno04910   Insulin signaling pathway rno04912   GnRH signaling pathway rno04915   Estrogen signaling pathway rno04917   Prolactin signaling pathway rno04926   Relaxin signaling pathway rno04935   Growth hormone synthesis, secretion and action rno05034   Alcoholism rno05160   Hepatitis C rno05161   Hepatitis B rno05163   Human cytomegalovirus infection rno05165   Human papillomavirus infection rno05200   Pathways in cancer rno05205   Proteoglycans in cancer rno05206   MicroRNAs in cancer rno05207   Chemical carcinogenesis - receptor activation rno05208   Chemical carcinogenesis - reactive oxygen species rno05210   Colorectal cancer rno05211   Renal cell carcinoma rno05213   Endometrial cancer rno05214   Glioma rno05215   Prostate cancer rno05220   Chronic myeloid leukemia rno05221   Acute myeloid leukemia rno05223   Non-small cell lung cancer rno05224   Breast cancer rno05225   Hepatocellular carcinoma rno05226   Gastric cancer rno05231   Choline metabolism in cancer Brite KEGG Orthology (KO) [BR:rno00001]  09130 Environmental Information Processing   09132 Signal transduction    04014 Ras signaling pathway     313845 (Sos1)    04630 JAK-STAT signaling pathway     313845 (Sos1)    04068 FoxO signaling pathway     313845 (Sos1)    04072 Phospholipase D signaling pathway     313845 (Sos1)    04151 PI3K-Akt signaling pathway     313845 (Sos1)    04150 mTOR signaling pathway     313845 (Sos1)  09150 Organismal Systems   09151 Immune system    04650 Natural killer cell mediated cytotoxicity     313845 (Sos1)    04660 T cell receptor signaling pathway     313845 (Sos1)    04662 B cell receptor signaling pathway     313845 (Sos1)    04664 Fc epsilon RI signaling pathway     313845 (Sos1)    04062 Chemokine signaling pathway     313845 (Sos1)   09152 Endocrine system    04915 Estrogen signaling pathway     313845 (Sos1)    04917 Prolactin signaling pathway     313845 (Sos1)    04926 Relaxin signaling pathway     313845 (Sos1)    04935 Growth hormone synthesis, secretion and action     313845 (Sos1)   09156 Nervous system    04722 Neurotrophin signaling pathway     313845 (Sos1)   09159 Environmental adaptation    04714 Thermogenesis     313845 (Sos1)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     313845 (Sos1)    05206 MicroRNAs in cancer     313845 (Sos1)    05205 Proteoglycans in cancer     313845 (Sos1)    05207 Chemical carcinogenesis - receptor activation     313845 (Sos1)    05208 Chemical carcinogenesis - reactive oxygen species     313845 (Sos1)    05231 Choline metabolism in cancer     313845 (Sos1)   09162 Cancer: specific types    05210 Colorectal cancer     313845 (Sos1)    05225 Hepatocellular carcinoma     313845 (Sos1)    05226 Gastric cancer     313845 (Sos1)    05214 Glioma     313845 (Sos1)    05221 Acute myeloid leukemia     313845 (Sos1)    05220 Chronic myeloid leukemia     313845 (Sos1)    05211 Renal cell carcinoma     313845 (Sos1)    05215 Prostate cancer     313845 (Sos1)    05213 Endometrial cancer     313845 (Sos1)    05224 Breast cancer     313845 (Sos1)    05223 Non-small cell lung cancer     313845 (Sos1)   09172 Infectious disease: viral    05161 Hepatitis B     313845 (Sos1)    05160 Hepatitis C     313845 (Sos1)    05163 Human cytomegalovirus infection     313845 (Sos1)    05165 Human papillomavirus infection     313845 (Sos1)   09165 Substance dependence    05034 Alcoholism     313845 (Sos1)   09176 Drug resistance: antineoplastic    01521 EGFR tyrosine kinase inhibitor resistance     313845 (Sos1)    01522 Endocrine resistance     313845 (Sos1) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RasGEF RasGEF_N RhoGEF SOS1_NGEF_PH PH PH_19 PH_10 IQ_SEC7_PH RHG20_PH DUF6018 Takusan Motif Other DBs NCBI-GeneID:  313845 NCBI-ProteinID:  NP_001094186 RGD:  1310949 Ensembl:  ENSRNOG00000007106 UniProt:  D4A3T0 A6H9Q3 LinkDB All DBs Position 6:20286117..20363350 Genome browser AA seq 1319 aa AA seqDB search MQAQQLPYEFFSEENAPKWRGLLVPALKKVQGQVHPTLESNEDALQYVEELILQLLNMLC QAQPRSASDVEERVQKSFPHPIDKWAIADAQSAIEKRKRRNPLSLPAERIHHLLREVLGY KIDHQVSVYIVAVLEYISADILKLVGNYVRNIRHYEITKQDIKVAMCADKVLMDMFHQDV EDINILSLTDEEPSTSGEQTYYDLVKAFMAEIRQYIRELNLIIKVFREPFVSNSKLFSSY DVENIFSRIVDIHELSVKLLGHIEDTVEMTDEGSPHPLVGSCFEDLAEELAFDPYESYAR DVLRPGFHERFLSQLSKPGAALYLQSIGEGFKEAVQYVLPRLLLAPVYHCLHYFELLKQL EEKSEDQEDKECMKQAITALLNVQSGMEKICSKNLAKRRLSESACRFYSQQMKGKQLAIK KMNEIQKNIDGWEGKDIGQCCNEFIMEGTLTRVGAKHERHIFLFDGLMICCKSNHGQPRL PGASNAEYRLKEKFFMRKVQINDKDDTSEYKHAFEIILKDGNSVIFSAKSAEEKNNWMAA LISLQYRSTLERMLDVTMLQEEKEEHMRLPSADVYRFAEPDSEENILFEENVQPKAGIPI IKAGTVVKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLNLLIERFEIPEPEPTEADR IAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDVDLLQRMEEFIGT VRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQNSPPTVEWHISRPGHIETFDLLTLH PIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIV ETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKI LEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLRRHGKELINFSK RRRVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRN PKPLPRFPKKYSYPLKSPGVRPSNPRPGTMRHPTPLQQEPRKISYSRIPESETESTASAP NSPRTPLTPPPASSASSNTDVCSVFDSDHSASPFHSRSASVSSISLSKGTEEVPVPPPVP PRRRPESAPAESSPSKIMSKHLDSPPAIPPRQPTSKAYSPRYSISDRTSISDPPESPPLL PPREPVRTPDVFSSSPLHLQPPPLGKKSDHGNAFFPNSPSPFTPPPPQTPSPHGTRRHLP SPPLTQEVDLHSIAGPPVPPRQSTSQLIPKLPPKTYKREHTHPSMHRDGPPLLENAHSS NT seq 3960 nt NT seq  +upstreamnt  +downstreamnt atgcaggcgcagcagctgccctacgagtttttcagcgaggagaacgcgcccaagtggcgg gggctgctggtgcctgcgctgaaaaaggttcaggggcaagttcaccctactcttgagtct aatgaggatgctcttcagtatgttgaagaattaattttgcaattactaaatatgctatgc caagctcagccccggagtgcttcagatgtggaggaacgtgttcaaaaaagtttccctcat ccaattgataagtgggcaatagctgatgcccaatcagctattgaaaagaggaagagaagg aaccctttatccctgccagcagaaagaattcatcatttattaagggaggtcctgggttat aaaattgaccaccaggtttctgtttacatagtagcagtattagaatacatttctgcagat attttaaagctggtggggaattatgtaagaaatatacggcattatgaaattacaaaacaa gacattaaagtggcaatgtgtgctgataaggtattgatggatatgtttcatcaagatgta gaagatataaatatcttatctttaactgatgaagaaccttccacctcaggagaacaaact tactatgatttggtaaaagcattcatggcagaaattcgacaatatataagagaattaaat ctaattataaaggtttttcgagaaccctttgtctctaattccaagttgttttcatcttat gatgtagaaaacatatttagtcgtatagtggatatccatgaacttagtgtaaagttactg ggccatatagaagacactgtagagatgacagatgaaggcagtccccacccgttagtcgga agctgttttgaagacttagcagaagaactggcctttgacccatatgagtcctatgctcgg gatgttctgcggcccggattccatgagcgttttctcagtcagctatcaaagcctggggca gcactttatctgcagtccataggtgaaggcttcaaagaggccgttcagtatgtcctgccc cggctgctgctcgcccctgtgtaccactgtctgcattactttgaacttctgaagcagtta gaagaaaagagcgaagatcaagaagataaggagtgtatgaaacaagcaataacagccctg cttaatgtccaaagtggcatggaaaaaatttgctccaaaaatcttgcaaaacgaagactg agtgagtctgcatgtcggttttacagccagcaaatgaaggggaaacaactggccatcaag aagatgaatgagattcagaagaacattgatggttgggaggggaaagacattggacaatgc tgcaatgagtttataatggaaggaactcttacacgtgtaggagccaaacacgagagacac atatttctcttcgatggcttaatgatttgctgtaaatcaaatcatgggcagccaagactt cctggtgctagcaatgcagaatatcggcttaaagaaaagttttttatgcgaaaggtacag attaacgataaggatgacaccagtgaatacaagcacgctttcgaaataattctgaaggat ggaaatagtgttatattttctgccaagtcagctgaagagaagaataactggatggcagcc ctgatatccctgcagtaccgcagcacgctggagagaatgctggacgttacaatgctgcag gaggagaaggaggagcacatgaggctgccgagtgctgacgtgtacaggtttgcagagccc gactctgaggagaacattctgtttgaagagaacgtgcagcccaaggctggcatccccatc atcaaggcagggacagtggttaagctgattgagaggctcacgtaccacatgtacgcagat ccaaattttgttcggacatttcttacaacatacagatcattttgcaaacctcaagaacta ctgaatcttctaatagaaagatttgaaattccagagcctgagccaacagaagctgatcgc atagctatagagaatggagatcagcccctgagcgcagagctgaaaaggtttagaaaggag tatatccagcctgtacagctgagggtgttaaacgtgtgtcggcactgggtggagcaccat ttctatgactttgaaagagatgtagaccttttacagagaatggaggaatttattggaaca gtaagaggtaaagcaatgaaaaaatgggtcgaatccatcactaagataatccaaaggaaa aaaattgcaagagacaatggcccaggtcataatattacatttcagaattcacctcccaca gttgagtggcacataagcagacctgggcatatagagacttttgacttgctcaccctacac ccaatagaaattgctcgacaactcactttacttgaatcagatctataccgagctgtgcag ccatcagaattagttggaagtgtgtggacaaaagaagataaagaaattaactctcctaac cttctgaaaatgattcggcacaccaccaacctcactctgtggtttgagaaatgtattgta gaaacagagaacttagaagaaagagtagcagtagtgagtcgaataattgagattctacaa gtctttcaagagctgaacaacttcaatggtgtcctggaagttgttagtgctatgaactcg tcacctgtttacagactggaccacacatttgagcaaataccaagtagacaaaagaaaatt ttagaagaagctcatgagttgagtgaagatcactataagaaatatttggcaaaactcagg tctattaatccaccatgtgtgcctttctttggaatttatctcacaaatatcttgaaaaca gaagaaggcaaccctgaggtcctaagaagacatggaaaagagcttatcaacttcagcaag aggaggagagtggccgagataacaggagagatccagcagtaccaaaaccagccttactgc ttacgggtagagtcagacatcaagagattctttgaaaacttgaatccaatgggaaatagc atggagaaggaatttacagactatctattcaacaaatccctagaaatagaaccacggaac cctaagcctcttccaagatttccaaaaaaatacagctatcccctaaaatctcctggtgtt cgtccatcaaatccaagaccaggaaccatgaggcaccctacacctctgcagcaggagcca aggaaaatcagctacagtcggattcctgagagcgagacagaaagtacagcgtcggcacca aactccccgagaacaccgctgacgccgcctcctgcgtccagcgcctccagtaacacagac gtctgcagcgtgttcgattccgaccactccgcaagcccttttcactcaagatctgcttca gtctcatctataagtttatccaagggcaccgaggaagtgcctgtccctcctcctgtcccc cctcgaagacgaccagagtctgccccagcggaatcctccccatccaagattatgtctaag cacttggatagccccccagcgattcctcctaggcagcccacatcgaaagcctattcacca cgatactcaatatcagatcggacctctatatcagatcctcccgagagccctcccttgtta ccaccacgagaacctgtgaggacacccgatgttttctcaagctcgccattacatctccaa cctcccccgttgggcaaaaagagtgaccatggcaatgccttcttcccaaacagcccatcc ccctttacaccgccacctcctcaaaccccgtctcctcacggcacgagaaggcatctgcca tcaccaccactgacacaggaagtggacctccattccattgctgggcctcccgttcctcca cggcaaagcacttctcaacttatccccaaactccctccaaaaacttacaaaagggagcac acacacccatccatgcacagagatggaccgccactgctggagaatgcccattcttcctga

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