Rattus norvegicus (rat): 338458 Help Entry 338458            CDS       T01003                                  Symbol Obscn Name (RefSeq) obscurin isoform X3   KO K17531   obscurin-RhoGEF [EC:2.7.11.1] Organism rno  Rattus norvegicus (rat) Pathway rno04820   Cytoskeleton in muscle cells Brite KEGG Orthology (KO) [BR:rno00001]  09140 Cellular Processes   09142 Cell motility    04820 Cytoskeleton in muscle cells     338458 (Obscn)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:rno01001]     338458 (Obscn)   09182 Protein families: genetic information processing    04131 Membrane trafficking [BR:rno04131]     338458 (Obscn) Enzymes [BR:rno01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.11  Protein-serine/threonine kinases     2.7.11.1  non-specific serine/threonine protein kinase      338458 (Obscn) Protein kinases [BR:rno01001]  Serine/threonine kinases: CAMK group   Trio family [OT]    338458 (Obscn) Membrane trafficking [BR:rno04131]  Others   Rho GTPase associated proteins    Rho guanine nucleotide exchange factors (GEFs)     338458 (Obscn) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  I-set Ig_3 ig Ig_2 V-set Pkinase Ig_4 Ig_5 PK_Tyr_Ser-Thr Izumo-Ig SOS1_NGEF_PH fn3 C2-set_2 RhoGEF PH Ig_DSCAM-DSCAML_C IQ ABC1 Motif Other DBs NCBI-GeneID:  338458 NCBI-ProteinID:  XP_038943147 RGD:  631335 Ensembl:  ENSRNOG00000058068 LinkDB All DBs Position 10:complement(44273686..44419275) Genome browser AA seq 9211 aa AA seqDB search MDHSFSGAPRFLTRPKAFVVSVGKDATLSCQIVGNPTPHVSWEKDRQPVEAGARFRLAQD GDVYRLTILDLALGDSGQYVCRARNAIGEAFAAVGLRVDSEGTCAEQAPHFLLRPTSIRV REGADATFRCRVGGSPQPAVSWSKDGRRLGAPDAPHVRVEDRGEASALRIRSARPRDGGT YEVRAENPLGSASAAAALVVDSDAEAAGPPGTSVATLLAHLQQRREAMRAEGVPPSPPGA GTRTCTVTEGKHARLSCFVTGEPKPETVWKKDGQLVNEGRRHVVYEDEQENFVLKILFCK QSDRGLYTCTASNLVGQTYSSVLVVVREPAVPFKKRLQDLEVREKESATFQCEVAQPATE AAWFKEETRLWASAKYDIEEEGTERRLTVRNVSADDDAVYICETTEGSRTVAELSVKGNL TRKLPRKTAVRTGDTAIFWVELAVPEGPVQWLRNQEEMVAGGRIAITAEGTCHTLTIFQC TLEDMGEVAFVAGGCRTTTQFCVSAPRRPPLYPPADPVVKAKTESSVTLSWSPPPHGDRP VTIDGYVVEKRKLGAYAWSRCHEAEWLATTEFTIAGVAEEGDFQFRVSAINHFGHSPYLE FPGTMHLVPTLAVKTPLKAVEAMEGGEVTFSVDLTVASSGEWFLDGKALKESSTYVIRCD RTRHMLTIREVPASLHGAQLKFVANGIETSIQMVVRGALGLPSNKLPAVAAREVLAQLHE EAQLLAELSDQAAAVTWLKDGRELSLGPKYEMQVSAGKQALLVRDVAQDDAGLYECVSRG SRITYQLLVQEANLMFAKKQQARSEVKAEVGASATLSCEVAQAQTEVTWFKDGKKLSSSS KVRMEASGCSRRLVVQQVGKADAGEYSCEAGGQKVSFRLDVTEPKVVFAKGQQSHSKVKA EAGANATLSCEVAQAQTEVTWFKDGKKLSSSSKVCVEASGCSRRLVVQQAGKADAGEYSC EAGGQKVSFCLDVAEPKVVFAKEQQARSEVKAEAGASATLSCEVAQAQTEVSWFKDGKKL SSSSKVRMEASGCSRRLVVQQAGKADAGEYSCEAGGQKVSFRLDVTEPKVVFAKEQQARS EVKAEAGANATLSCEVAEAQTEVSWFKDGKKLSSSSKLRVEASGCSRRLVVQQAGKADAG EYSCEAGGQKVSFRLDVTEPKVVFAKEQQARSEVKAEAGASATLSCEVAQAQTEVTWFKD GKKLSSSSKVRVEASGCSRRLVVQQAGKADAGEYSCEAGGQKVSFRLDVAEPKVVFAKEQ QARSEVKAEAGASATLSCEVAQAQTEVTWFKDGKKLSSSSKVRVEASGCSRRLVVQQAGK ADAGEYSCEAGGQKVSFRLDVAEPKVVFAKEQQARSEVKAEAGASATLSCEVAQAQTEVM WFKDGKKLSSSSKVRVEASGCSRRLVVQQAGKADAGEYSCEAGGQKVSFRLDVTEPKLVF AKEQQACSEVKAEAGASATLSCEVAQAQTEVTWFKDGKKLSSSSKVRVEASGCSRRLVVQ QAGKADAGEYSCEAGGQKVSFRLDVTEPKVVFAKEQQARSEVKAEAGASATLSCEVAQAQ TEVTWFKDGKKLSSSSKVCVEASGCSRRLVVQQAGKADAGEYSCEAGGQKVSFRLDVAEP KLVFAKEQQARSEVKAEAGASATLSCEVAQAQTEVTWFKDGKKLSSSSKVRVEASGCSRR LVVQQAGKADAGEYSCEAGGQKVSFRLDVPEPKVVFAKEQQARSEVKAEAGASATLSCEV AQAQTEVTWFKDGKKLSSSSKVRVEASGCSRRLVVQQAGKADAGEYSCEAGGQKVSFRLD VTEPKLVFAKEQQARSEVKAEAGASATLSCEVAQAQTEVTWFKDGKKLSSSSKVRVEASG CSRRLVVQQAGKADAGEYSCEAGGQKVSFRLDVTEPKVVFAKEQQARSEVKAEAGASATL SCEVAQAQTEVSWFKDGKKLSSSSKVRVEASGCSRRLVVQQAGKADAGEYSCEAGGQKVS FRLDVAEPKVVFAKEQQACSEVKAEAGASATLSCEVAQAQTEVIWFKDGKKLSSSSKVRV EASGCSRRLVVQQVGKADAGEYSCEAGGQKVSFRLDVPDTKLMFAKEQQACSEVKAEAGA SATLSCEVAQAQTEVTWFKDGKKLSSSSKVRVEASGCSRRLVVQQAGKADAGEYSCEAGG QKVSFRLDVAEPEPESQTPQRPSRREPLVIKEHETIVLSATIAAPSVAAVTWLKDGVEIR RSKRHETTSVGDTHTLTVRGAQVLDSAIYSCRVGKEGQDFPVQVEEVATKFSKPLEPVEG ELGGTVTLVCELSPEQAEVVWRCGSTQLRAGKRFQMTAEGSRRTLTVSGLREDDAEEYVC ESRDDRTSARLTVKVPRVVKFTSGLSAMAAEEGQEATFQCVVSPSDAAVMWYKDGTQLQP SEKFVMVQSGASRSLTILGLTLEDAGHVTVEAEGASSSAALRVREAPVLFKKKLEPQTVE ERTPVTLEVELTRPWPEVKWTRNAAVLVPSENVEIHAEGARHRLVLRSVGFADRGFFGCE TPDDKTQAKLNVEMRQVRLVRGLQEVEAKEQGTASMDVELSHADVEGSWTRDGLRLQPGP KCHLAVQGPVHILTLSALQPQDSGLVAFRAEGVHTSARLIVTELPVSFTRLLQDVVATQK EKVTLECELSRPVDVRWLKDGVELRAGKAIGIVAQGTCRSLVIYRCETGDQGVYVCDALD AQTSASLRVQGRSVQIMKPLEDVEVMEKEGATFSCEVSHDEVPGIWFREATKLRPSDNVR IRQEGRTYTLIFRRVLAEDAGEIKFVAENAESRAHLRVKELPVTLLRPLRDKIAMEKHRG VLECQVSRASAQVRWFKGKVELQPGPKYEVVSDGLYRKLVINDVQPEDEDTYTCDAGDVK TSAQFFVEEQSITIVRGLKDMTVMEPAPAWFECETSIPSVRPPKWLLGKTVLQAGGNVGL EQDGTVHRLTLHKTCSTMTGPVHFTIGKSRSTAQLVVSDIPVVLTRPLEPKAGRELQSVV LSCDFRPAPKAVQWYKEDTPLSPSEKFKMVLEGQMAELRILRLTPADAGVYRCQAGSAQS SAEVTVEAREVTVIQPLQDVEAMEEGRVCFSCELSHKDEDIEWSLNGTPLYSDSFHEISH EGCLHTLVLKSVRQADTGTVCATSPKVSVSARLVVKAKPVVFLKALDDVSAEERGTLTLQ CEVSDPEARVVWRKDGVELGPSDKYDFLHKAGVRSLTVHDMSHEDAGLYTCQVGSKETQS RVSVHDLHVGITKRLKTVEVLEGESCSFECVLSHESPSDPAVWTVGGKIVRSSDHFQAVR QGRKYTLTVKDAALSDAGEVVFSVLGLTSKASLIIREKPVDITKPLEDQHTTPGEDVMLS CELSRAGSSVRWLKDGKAIRKSQKYDLLIEGTQAVLVVRKASLKDSGEYTCETEASRSTA RLCVEEKTNRFTEELADLQVEEKGRAVFTCKTEQPASIVTWRKGLLELRASGKHVPSQEG LTLTLTINALERTDSDTYTCDIGQARTQARLLVHGQKVRVIEDLEDTAVQEGSSAKFCCR ISPADYGPVHWFLDKTPLHSNELNEITVQSGGYHVLTLRQLTLKDSGTVYFEAGDQRTSA ALRVTEKPSIFSRPLTDVTVTEGEDLTLVCETTTPDSSVRWTKDGKTLRPSARCQLNREG CQAQLVITGTTLQDGGRYKCEVGGASSSSIVRVHARPVRFRESLKDMEVPEGKAATLRCV LSSVAAPVEWRHGDDVLKSSNKYSLRQEGAVLELVIRDLKPQDSGQYSCSFGDQTTSATL TVKTSSAQFIGKLRNKEATEGTMATLRCELTKEAPVEWKKGTETLRNGDKYSLKQDGAVC ELQICNLLVADAGEYLCVCGQEKTSATLTVKAVPVHFIRRLRNKEATEGDTVTLQCELSK AAPVEWRKGTETLRDGDRYSLKQDGAVCELQIRSLAVADAGEYLCMCGQEKTSATLTIRA LPAKFIESLKNEGATEGTTATLSCKLSKAVPVTWKRGTKTLRDGDKYGLRQDGAVCELQI RGLTTADAGEYSCVCGQEKTSAALTVKGLPAKFIEDLRSQEAMEGATAILRCELSKAAPV EWRKGSKILEDGDRYTLRQDGAVCELQIRGLAVVDTGTYSCVCGQEKTSATLNINALPAK FTEGLRNEESMEGTMVTLRCQMSKVTPVEWRKGSETLRDGGRYSLRQDGAVCELQIRGLI LEDAGEYSCVCGQEKTSATLSVKALPPRFIEDLRSQEAMEGTMVTLRCQMNKAAPVEWRK GSETLRDGGRYSLRQDGAGCELQIHRLALEDAGEYSCVCGQEKTSATLSVKALPPRFIED LRSQEATEGTMVTLRCQMNKAPSSTVEWRKGSESLRDGGRYSLRQDGAVCELQIRGLTLE DAGEYSCVFGQERTSATLSVKALPPRFIEDLGSQEAMEGTMVTLRCQMSKTAPVEWRKGS ETLRDGGRYSLRQDGALCELQIHRLALEDAGEYSCVCGQEKTSATLSVKALPPRFIEDLR SQKATEGTMVTLRCQMSKVAPVEWRKGSESLRDGDRYSLRQDGAMCELQICGLAVEDSGE YSCVCGQERTSATLTVDALPPKFTEGLKKEEATEGNMATLRCQMSKAAPVEWRKGSETLR DGGRYSLRQDGAACELQIRGLALEDAGEYSCLCGQEKTSATLSVKALPPRFIEDLRSQEA TEGNMVTLRCQMSKVTPVEWRKGSETLRDGGRYSLRQDGAVCELQIHRLALEDAGEYSCL CGQEKTSATLSVKALPPRFTEDLRSQKATEGTMVTLRCQMSKAAPVEWRKGSETLRDGGR YSLRQDGAVYELQIRGLALEDAGEYSCVCGQEKTSATLSVKALPARFIEDLRSQEVPESS TVTMRCELSKKAPVVWRKGSETLKNGARYSLRQDGAVCELEIRDLTVEDAGEYSCTCGKE RTSATLSIMAPQVVFQKLLENLQAEEGSTASLRCELSVPNTAVVWSKGGLELQADTCRET RQQGCVAELLLRDVRREDAGEYSCTCGSQTTSATLMVTAAPVRFLQELQAQDVDEGTTAR LRCELSREAASVEWRKGSLQLFPCAKYQMVQEGTTAELLVHGVEQEDAGEYTCDAGHMQS IARLSVRAPKPKFKTGLQSKEQEAGGTARLCCQLSEAESGTPVQWLKEGVELHVSSKYEM RCQGAMCELLIHKLEAKDTGEYACVVGGQKTLASLRVKEPEVTIVQGLVDMEVQADEDVE FTCKVSQAGATDVQWHLQGLPLQSNEVTEVAVLGDGCTHVLQLKGVTLDDAGTVSFHVGS HSSSAQLIVRVPEVTVLEPLKDVQLSEGQDAHFQCRLSRASGQEARWALGGVPLQCNEMN DITVEQGTLYSLTLHKVTLEDAGTITLQVGSCSSEAQLKVTEAALCLVRGLQNVDVFAGE VATFSCEVSRAGGPEARWWLDGTLLQNSPESAMTVREGTVHSLTLSGLGVADSGTITFRT GPLVSTAKLLVKDPTVEVVSAMQDLVVEEGGSAELLCQYSRPVQAMWKMNEREVCADGHR VIIEQDWTVARLTLRPALPCDSGIYSCEAAGTRVVALLQVQAKNTVVRGLENVDALEGGE ALFECQLSQPEVAAHTWLLDDEPVHTSANVEVVYFENGLRHLLLLKNLKPQDSCRVTFLA GDVVTSAFLTVRGWRLEVLEPPQDASVKAGTQVCFTCILSEALPVGEATWYINGAAIQPD DADWIVTADGSHHALTLSNAQPQHAGEVTFAARDAVASARLSVLALPGPPEDAEVVGRSD HSVTLSWVAPVSDGGGGLCGYRVEMKEASTGQWQLCHELVPGPECVVDGLVSGKTYRFRV AAVGPAGAGEPVHLPQMVKIAEPMEPKPAPAPAPALAPTPAPIPTPAPAPAPAPTPAPTP TPAPAPAPAPAPATRRAVVGEDVCLELEVAADAGEVVWHKGTERIHPSGHFEVLSQGQRQ MLVIKGFRTEDQGEYRCGPIQGLPSSGASTFNVVVTSGSEDEVPAQPSLPPEAAQEGDLH LLWEALARKRRMSREPTLDSISELPEEDSRVQHLRQEAEEAAPDLSEGYSTADELARTGE ADLSHTSSDDESRAGTPSLITYLKKAGGPGISPLASKHEAQVATSVKPQKQQERVVPTCP LPGDLNAADLKDPSLDKAAVKIQAAFKGYKVRKEMKQQGGPVFSRTFGDTEAQVGDALRL ECVVSTKADVRACWLKDGVELTDGRHYHIDQLKDGTCSLLVTGLGPTDSGRYTCQVSTKF GSVSHSACVMVSGTESEAESSSGGELDDAFRRAARRLHRLFRTKSPAELSEEELFLSADE GPMEPEEPADWQTYREDENFVCIRFESLAEAHRAVTCFRDMFATMGIGVEISLGEQGPRG VEMRIGKVAPTVIPAVPLAKTPGLQTSDAAPVFLTELQNQDVQDGYPMSFDCVVTGQPVP SVRWFKDGKLLEEDDHYMINEDQQGGHQLIITAVVPADMGVYRCLAENSMGVSSTKAELR VELTSTDYDTAADATETSSYFSAQGYLSSREQEGTESDEGQLPQVLEELKDLQVAPGTRL AKFQLKVKGYPAPKLYWFKDGQPLTTSDHIRMTDKKTLHTLEIVSITREDSGQYAAYISN AVGAAYSSARLLVRGPSEPEEKPQPDVHERLVPPRILEKFTPKKVKRGSSITFSVKVEGH PAPSVHWLKEEAEKGVLWIGPDTPGYTMASSSKQHSLVLLDVGRQHQGTYTCIATNAAGQ ALCSASLHISGLAKEEEQERVKEALISSFLQGTSQAVSAQMSESASFADLVGQRKGESLV AEEAHSHLSLSEVGTEEFLQKLTSQITEMVSAKISQAKLQVPGGDSDEESKTPSASPRHG RSRPSSSVQESSSESEDGDSRGEIFDIYVVTADYLPLGAEQDAIILREGQYVEVLDSAHP LRWLVRTKPTKSSPSRQGWVSPAYLDKRLKLSPEWGPTEAPEFPGEAVSEDEYRTRLSSV IQELLSSEQAFVGELQFLESHHIKHLDRSPRVPAAVASQKTVIFRNVQDISHFHSSFLKE LQSCGTDDDVAMCFIKNQEAFEKYLEFLVGRVQAESVVVSTPVQEFYKKYAEEMLSAKDP TQPPPPPLQHYLEQPVERVQKYQALLKELIRNKARNRQNCALLEQAYAVVSALPQRAENK LHVSLMENYPGTLEALGEPIRQGHFIVWEGAPGARMPWKGHNRHVFLFRNHLVICKPRRD SRTDTFSYVFRNMMKLNSIDLNDQVEGDDRAFEVWHEREDSVRKYLLQARTVIIKNSWVK EICGIQQRLAQPVWRPPEFEEELADCTAELGETVKLACRVTGTPKPIVSWYKDGKPVEVD PHHILIEDPDGSCTLILDNLTGIDSGQYMCFAASAAGNASTLGKILVQVPPRFVNKVRAT PFVEGEDAQITCTVEGAPYPQIRWYKDGALLTLGNRYRMVNEPRSGMLVLVIQAASKEDL GHYECELVNRLGSTRCGGELYMQSPALRAWDQHHREQLVAAVEDASMEDSAHPTQEGADQ QAASVLWRLLGSEALSPSPGGFPNTRQSEPPTSEEAAPQIPGTTSGTPGKLPEASRPGTY KGLEQGMTTTSGSQERNVPIRVEGTAWPGGGTGQLLLDVHSQVIMETTQRTYVCQAPDTG VTRAPSMQVTIEDLQVQVGDMAQFDAVIEGNPPPTVTWYKDSNQLVNGTRLRQQQGGTTY SLVLMDVTPHDAGVYTCVAQNAGGQVLCKAELLVYGGDKSDAEKQAYRRKLHSFYEVQEE IGRGVFGFVKRVQHKGNKMSCAAKFIPLRSKTRAQAYQERDILATLSHPLVTGLLDQFET QKTLILILELCSSEELLDRLFKKAVVTEAEVKVYIQQLVEGLHYLHSHDILHLDIKPPNI LMVHPAREDIKICDFGFAQKITPSEPQYSKYGSPEFVSPEIIEQSPVSEGSDIWAMGVIS YLSLTCSSPFAGESDRATLLNVLEGRVSWSSPMAAHLSEDAKDFIKATLQKTPRARPSAS QCLAHPWFLKSMPAEEAHFINTKQLKFLLARSRWQRSLMSYKSILVMRSIPELLQGPPDS PSLGVARHLRGEASGSSSSSSSSDNELAPFARAKSLPPSPVTHSPLLHPRGFLRPSASLP EETEASMSTADAAMPAPPQSAGPPASPGCVPRHSVISSLFYQQAGEGAERGSKALGAKRH PARRRHLLKGGYIARALPGLREPLMEFSVLEEEAANEEQASLMTKTPSFETALRLPSSNV REVPGRSRSLDNPPGTASPSPEAYKEQYLSPPSSGLTHETTAKGMGHKEGFLQESVPFSP TSGDLRPVKQEGSSQDSCRGKPASSCHSELGSGPQEGCGSPSSQLCGSLPPQSSKKELSK PCGPLFSEQPQAAPFPAQASPLLGSQKEPQDSYLPEKPCPVPSSSPGSASQVDASLDTEG LSEAGDTCDFTPPLQRPQEQATTRKFSLESRGGYAGVAGYGTFAFGGDAGGMLGQGPLWA RMAWAVSQSSEEQDEAATESPQPLDSSGPIAEASGVPLRTSPSLTPWEEVEQVSLVQIRD LSGDAEAADTISLDISEVDPAYLNLSDLYDIKYLPFEFMIFRRVPKPVEQPESPGSETEE GQGLAEFLEEAVWPWPGELGLRAGLEITEEPQEPGDLEALLGEAAVGRKRKWSPSRGLFQ FPGRCLSGEEPVELGLRQRVKASMAHISRILKGKPEGPEKEGPPRKKAGLASFRLSGLKG RDQAPSFLRELSDEAVVLGQSVTLACQVLAQPTAQATWSKDGALLESSGHLLISSTLKNF QLLTILVVTEEDLGTYTCCVSNPLGTAVTTGVLRKAERPSSSPRPEVGELYTDAVLLVWK PVESYGPVTYIVQCCIEGGSWTTLASDISDCCYLTGKLPRGGMYTFRTACVSKAGMGPYS SPSEQVLLGGPNHLASEEESSRGRPAQLLPSTKTFAFQTQIRRGRFSVVRQCREKASGRA LAAKIVPYQPEDKTTVLREYEALKRLHHPHLAQLHAAYLSPRHLVLILELCSGPELLPSL AERDSYSESDVKDYLWQMLSATQYLHAQHILHLDLRSENMMVTEYNLLKVIDLGNAQSLS QEKVPPPENFKDYLETMAPELLEGQGAVPQTDIWAIGVTAFIMLSGEYPVSSEGTRDLQK GLRKGLIQLSRCYAGLSGGAVAFLQSSLCARPWGRPCASTCLQCGWLTEEGPTGSRPTPV TFPTARLRAFVREREKRRALLYKKHNLAQVR NT seq 27636 nt NT seq  +upstreamnt  +downstreamnt atggaccactccttcagcggagcaccccgcttcctgacgcggccaaaggcttttgtggta tctgttggcaaggatgccacgctgagctgccagatcgtgggcaaccccacgccacacgtg agctgggagaaggaccggcagccagtggaggcaggagcacgcttccgcctggcccaggac ggggatgtgtaccgcctcaccatcctcgatctggctctaggtgacagcgggcagtacgtg tgtcgagcgaggaacgccataggggaggccttcgccgctgtaggtttgcgagtggactcg gagggcacgtgtgccgagcaggcgccccactttctgctgcggcccacctccattcgtgtg cgcgagggcgcagacgccaccttccgatgtcgcgtcggcggctcaccgcaacctgctgtg agctggtccaaagatgggcggcgcctaggtgcaccagatgccccccacgtgcgcgtggaa gatcgcggagaggcgagcgcgcttcgcatccggtcggcaaggcctcgcgatggtggcacc tacgaagttcgagcagagaacccactgggctccgccagcgctgccgccgctctcgtggtg gactcggatgccgaggctgccggaccacccggaacctccgttgccacgctcctggcgcac ctgcagcagcggcgcgaggccatgcgcgcagagggcgtccctccttctccacctggtgct ggcacgcgcacctgcacggtgaccgaaggcaaacacgcgcgcctcagctgctttgtgacc ggcgagcccaagcccgagacagtgtggaagaaggacgggcagctggtgaacgagggccgg agacacgtagtatatgaggatgagcaagagaacttcgtccttaagattcttttttgcaag cagtctgatcgcggcctctacacttgcacagcatccaacctcgtgggccagacctacagc tcggtgctggtggtcgtgagagagcctgcggtgcccttcaagaagcggctgcaggacctg gaggtgcgagagaaagagtctgccacattccagtgtgaggtggctcagccagccaccgag gcggcgtggttcaaggaggagacccggctatgggccagcgccaagtacgacatcgaggag gagggcaccgagcgccggctgactgtgcgcaacgtctcggcagacgacgacgcggtgtac atctgcgagaccacagagggcagccgcacggtggcagagctctcagttaaaggaaacttg accagaaagctgcctcggaaaacagcagtgaggactggagacacagccatcttttgggtg gagctggctgtccccgaaggccctgtccagtggctacggaaccaggaggagatggtggca gggggcaggattgccatcactgcagaaggcacttgccacacactgaccatcttccagtgc accttggaggacatgggtgaggtggccttcgtggctggtggctgcagaacgactacccag ttctgtgtatcagcacccaggaggccacccctgtaccctcctgctgaccctgttgtgaag gccaagacagagagttctgtgacccttagctggtccccaccaccccatggggaccgccct gtcactattgatggttatgtggtggagaagaggaagctgggtgcctatgcctggagcagg tgtcatgaagcagaatggctggccacaactgagtttactattgctggcgtggctgaggaa ggggacttccagttccgagtgtcagccatcaatcactttggccacagtccttaccttgag tttccagggaccatgcacttggtccccacgctggctgtaaagacacctctgaaggcggtg gaggccatggagggtggtgaggtcactttctccgtggacctcacggtggcgtcttcgggt gagtggttcctggacgggaaggccttgaaagagagcagtacatacgtgatccgttgtgac cgtacccggcacatgctcaccatcagagaggtgcctgccagcttgcacggggcacagctg aagtttgtggctaatggcattgaaaccagcatccaaatggtggtccgaggggctctgggg ctgcccagcaacaagcttcctgccgtggctgcccgggaggtgctggcccagctgcatgag gaggcacagctgctggctgagctgtcagaccaggctgcggctgtgacttggctaaaggat ggtcgtgagctgtccctaggacccaagtatgagatgcaggtgtcggctgggaagcaagca ctgctggtgcgggatgtggcacaggatgacgctgggctctatgagtgtgttagtcgtggg agccgcatcacctaccagctgttggtgcaagaggccaatttgatgtttgccaagaagcag caggcacgcagcgaggtgaaggcagaggttggggccagtgccacactgagctgcgaggtg gcccaggcccagactgaggtgacatggttcaaggacgggaagaagctgagctccagctcg aaggtgcgcatggaggcctcgggctgctccaggaggctggtggtgcagcaggtgggcaag gcagatgctggggagtacagctgtgaggccgggggacagaaggtctccttccgcctggac gtcacagagcccaaggtggtgtttgccaaggggcagcagtcacacagcaaggtgaaggca gaggcaggggccaatgccacactgagctgcgaggtggcccaggcccagactgaggtgaca tggttcaaggacgggaagaagctgagctccagctccaaggtgtgtgtggaggcctcgggc tgctccaggaggctggtggtgcagcaggcgggcaaggcggatgctggggagtacagctgc gaggccgggggacagaaggtctccttctgcctggacgtggcagagcccaaggtggtgttt gccaaggagcagcaggcacgcagtgaggtgaaggcagaggcaggagccagtgccacactg agctgcgaggtggcccaggcccagactgaggtgtcatggttcaaggacgggaagaagctg agctccagctcgaaggtgcgcatggaggcctcgggctgctccaggaggctggtggtgcag caggcgggcaaggcggatgctggggagtacagctgcgaggccgggggacagaaggtctcc ttccgcctggacgtcacagaacccaaggtggtgtttgccaaggagcagcaggcacgcagc gaggtgaaggcagaggccggggccaatgccacactgagctgcgaggtggccgaggcccag actgaggtgtcatggttcaaggacgggaagaagctgagctccagctccaagctgcgtgtg gaggcctcgggctgctccaggaggctggtggtgcagcaggcgggcaaggcagatgctggg gagtacagctgtgaggccgggggacagaaggtctccttccgcctggacgtcacagaaccc aaggtggtgtttgccaaggagcagcaggcacgcagcgaggtgaaggcagaggccggggcc agtgccacactgagctgcgaggtggcccaggcccagactgaggtgacatggttcaaggat gggaagaagctgagctccagctccaaggtgcgcgtggaggcctcgggctgctccaggagg ctggtggtgcagcaggcgggcaaggcagatgctggggagtacagctgcgaggccggggga cagaaggtctccttccgtctggatgtggcagaacccaaggtggtgtttgccaaggagcag caggcacgcagtgaggtgaaggcagaggcgggggccagtgccacactgagctgcgaggtg gcccaggcccagactgaggtgacgtggttcaaggacgggaagaagttgagctctagctcc aaggtgcgcgtggaggcctcgggctgctccaggaggctggtggtgcagcaggcgggcaag gcggatgctggggagtacagctgtgaggccgggggacagaaggtctccttccgcctggac gtggcagagcccaaggtggtgtttgccaaggagcagcaggctcgcagcgaggtgaaggca gaggcgggggccagtgccacactgagctgcgaggtggcccaggcccagactgaagtgatg tggttcaaggacgggaagaagctgagctccagctccaaggtgcgcgtggaggcctcgggc tgctccaggaggctggtggtgcagcaggcgggcaaggcggatgctggggagtacagctgt gaggccgggggacagaaggtctccttccgcctggacgtcacagagcccaagctggtgttt gccaaggagcagcaggcatgcagtgaggtgaaggcagaggccggggccagcgccacactg agctgcgaggtggcccaggcccagactgaggtgacgtggttcaaggacgggaagaagttg agctctagctccaaggtgcgcgtggaggcctcgggctgctccaggaggctggtggtgcag caggcgggcaaggcagatgctggggagtacagctgtgaggccgggggacagaaggtctcc ttccgcctggacgtcacagagcccaaggtggtgtttgccaaggagcagcaggcacgcagc gaggtgaaggcagaggccggggccagtgccacactgagctgcgaggtggcccaggcccag actgaggtgacatggttcaaggacgggaagaagctgagctctagctcgaaggtgtgcgtg gaggcctcgggctgctccaggaggctggtggtgcagcaggcgggcaaggcggatgctggg gagtacagctgcgaggccgggggacagaaggtctccttccgtctggacgtagcagagccc aagctggtgtttgccaaggagcagcaggcacgcagcgaggtgaaggcagaggccggggcc agtgccacactgagctgcgaggtggcccaggcccagactgaggtgacgtggttcaaggac gggaagaagttgagctctagctccaaggtgcgcgtggaggcctcgggctgctccaggagg ctggtggtgcagcaagcgggcaaggcagatgctggagagtacagctgtgaggccggggga cagaaggtctccttccgcctggatgtgccagagcccaaggtggtgtttgccaaggagcag caggcacgcagcgaggtgaaggcagaggccggggccagtgccacactgagctgcgaggtg gcccaggcccagactgaggtgacatggttcaaggacgggaagaagctgagctccagctcc aaggtgcgagtggaggcctcgggctgctccaggaggctggtggtgcagcaggcgggcaag gcggatgctggggagtacagctgcgaggccgggggacagaaggtctccttccgtctggac gtcacagagcccaagctggtatttgccaaggagcagcaggcacgcagcgaggtgaaggca gaggctggggccagtgccacactgagctgcgaggtggcccaggcccagactgaggtgaca tggttcaaggatgggaagaagctgagctccagctcgaaggtgcgcgtggaggcctcaggc tgctccaggaggctggtggtgcagcaggcgggcaaggcggatgctggggagtacagctgt gaggccgggggacagaaggtctccttccgcctggacgtcacagagcccaaggtggtgttt gccaaggagcagcaggcacgcagtgaggtgaaggcagaggcaggggccagtgccacactg agctgcgaggtggcccaggcccagactgaggtgtcgtggttcaaggacgggaagaagctg agctccagctcgaaggtgcgcgtggaggcctcaggctgctccaggaggctggtggtgcag caggcgggcaaggcggatgctggggagtacagctgcgaggccgggggacagaaggtctcc ttccgcctggacgtggcagagcccaaggtggtgtttgccaaggagcagcaggcatgcagc gaggtgaaggcagaggcaggggccagtgccacactgagctgcgaggtggcccaggcccag actgaggtgatatggttcaaggatgggaagaagctgagctccagctcgaaggtgcgcgtg gaggcctcaggctgctccaggaggctggtggtgcagcaggtgggcaaggcggatgctggg gagtacagctgcgaggccgggggacagaaggtctccttccgtctggatgtgccagacacc aaacttatgtttgccaaggagcagcaggcatgcagcgaggtgaaggcagaggccggggcc agtgccacactgagctgtgaggtggcccaggcccagactgaggtgacatggttcaaggat gggaagaagctgagctccagctcgaaggtgcgcgtggaggcctcgggctgctccaggagg ctggtggtgcagcaggcgggcaaggcggatgctggggagtacagctgcgaggccggggga cagaaggtctccttccgcctggacgtggcagaaccagagcctgagtcccaaactccacag aggcctagccgcagggagcctctggttatcaaggaacatgagaccattgtcctgagtgcc acgatagctgcaccctctgtggctgctgtgacctggctcaaagacggcgtggagatccgc cgcagcaagcggcatgagaccaccagtgtgggtgatactcataccctgactgtgagaggt gcacaggttctggacagtgccatctacagctgccgtgtcggcaaggaaggtcaggacttc ccggtgcaggtagaagaggtggccaccaagttctccaaacccctggagcctgtggaaggg gaattgggtggcactgtgacgctggtctgtgagctgagcccggaacaggctgaggttgtg tggcgctgtgggagcacacagctgcgggcgggcaagcgcttccagatgacagctgagggg tctaggcgcacactgaccgtgtctggccttcgagaggacgacgcagaggagtatgtgtgt gagagccgggatgaccgcaccagtgcacggctcactgtcaaagttccccgagtggtcaag tttacatccggattgagtgccatggcggcagaggagggccaagaggccacctttcagtgt gtcgtgtcccccagcgatgcagcagtcatgtggtacaaggacggcacgcagctgcagcct agcgagaagtttgttatggtgcagagtggggccagccgaagcttgactatcttgggcctg accctggaggatgctgggcatgtcactgtggaggctgagggtgcttcatcatctgctgcc ctccgggtccgagaggcaccagtcctcttcaaaaagaagcttgagccacagacggtggag gagaggacccctgtgaccctggaagtagagctgactcgcccctggcccgaggtgaagtgg acgcggaatgctgccgtcctggtacccagcgagaacgtggaaatccacgctgagggtgcc cggcaccgtctggtgctgcgaagcgtgggcttcgctgaccgtggcttctttggctgtgag acaccagatgacaagactcaggccaagctcaacgtagaaatgcggcaggtccggctggtt cgaggtttgcaggaggtggaggctaaggaacagggcacagcctcgatggatgtggaattg tcccatgctgacgtggaaggcagctggactcgagatggcctgcgacttcagccggggccc aaatgccacctggccgtacaaggccctgtccacatcctcacactctcagcgctgcagcca caggacagcgggttggtggccttcagggctgagggcgtgcacacgtctgcacggctcata gtcactgagttgcccgtgagcttcaccagactgctacaggatgtggtggccactcagaag gagaaggtgaccctggagtgtgagttgtcacggcccgtcgatgtgcgctggctgaaggat ggtgtggagctgcgggcaggcaaggccataggcatagtggctcagggaacctgcaggagt ctcgttatctaccggtgtgagactggggaccagggcgtctatgtatgtgatgctctggat gctcagacctctgcctctctgagggtgcagggacgcagtgttcagattatgaagccccta gaggatgtggaggtgatggagaaggagggtgccacattctcctgtgaggtgtcccatgat gaggttcctggcatatggttccgagaagccactaagctacggcccagtgacaatgtgcgc atccggcaggaagggaggacatatactctcatcttccggagggtactggcagaagatgcg ggggagatcaagtttgtagctgaaaatgcagaatcaagggctcacctccgagtgaaagaa ctgcctgtgaccctcctgcgcccactacgggacaagattgccatggaaaaacaccgtggc gtgcttgagtgccaggtgtcccgggctagtgcccaggtgcggtggttcaagggcaaagtc gagctgcagcctgggcccaagtatgaggtggtcagcgacggcctttaccgcaaactggtc atcaatgatgtgcagcccgaggacgaagatacttacacctgtgatgctggcgatgtgaag accagtgcccagttcttcgtggaagagcaatccatcactattgtgcgggggctgaaggac atgacagttatggagcctgcccctgcctggtttgaatgtgagacctccattccttctgtg aggccacccaagtggctccttggtaagactgtgctacaggcaggggggaacgtggggctg gagcaagacggtactgtgcaccgactgacacttcacaagacctgctctaccatgaccggg cctgtgcacttcaccatcggcaagtcccgctccactgcccagcttgttgtctcagacatt cctgtggtattgacaaggcctctggagcccaaagcagggcgcgagctgcagtcggtcgtc ctgtcctgtgacttcaggccagcccccaaggctgtgcagtggtacaaggaggatacacct ctgtccccgtcagaaaagttcaagatggtgctggagggccagatggcagagctgcgtata ctccggcttactccagctgatgctggggtctaccggtgccaggcgggtagtgcccagagc agtgccgaggttactgtggaagctcgggaggtgacagtgatccagccactgcaggatgtg gaagccatggaggaaggccgggtctgcttctcctgtgagctatctcataaggacgaggat atcgaatggtcactcaatggtacacccctgtactcggacagcttccacgagatcagccat gagggctgtctccacacgctggtgctgaagagtgtccggcaggctgacacgggcaccgtg tgtgccacctctcccaaggtgtcagtttctgcccggctggtggttaaagcaaagccagtg gtgttcctaaaagcactggatgacgtatctgcagaagagcggggcacgctgaccctgcag tgcgaggtctccgacccggaggcgcgtgtggtttggcgcaaagatggtgtggagttgggt cccagcgacaagtatgacttcctacacaaggcaggtgttcggagccttacggtccatgac atgagccacgaggatgctggactgtacacctgccaggtgggcagtaaggagacccagtcc agggtcagcgtgcatgaccttcatgtgggcatcaccaagaggttaaagacggtggaggtg ctggagggagagagctgcagctttgagtgtgtcctctcccatgagagtcccagtgaccca gcagtgtggacagttggtgggaagatagtgcgtagttctgaccacttccaggccgtacgg cagggccgcaaatacactctgacagtcaaagatgctgccctcagtgatgcaggagaggtg gtcttctcagtgctgggcctcacatccaaggcctcgctcatcatcagagagaagccagtg gacatcacaaagcccctggaggaccagcacactacgcctggggaagatgtgatgctaagc tgcgagctctctagggcaggctcctccgtgcgctggctgaaagacgggaaggccatccgg aagagtcagaagtatgacctgctcattgaaggcacacaggctgtgttggttgtccgaaag gcctcgctcaaggattctggagaatacacctgtgagacagaagcctccagaagcactgcc aggctgtgtgtggaagaaaagacaaaccggttcacggaggagctggctgacctgcaggta gaagagaagggcagagctgtgttcacatgcaagacagagcaaccggcatctattgtgacc tggcgcaaaggcctcctggagctgcgcgcctcagggaagcatgtccccagccaggagggt ttgaccctgacgcttactatcaatgccctggagaggacagacagtgacacttacacctgt gacattggccaagcccggacccaggcccggctcctcgtccatggccagaaagtacgagtc attgaggacctagaggacaccgctgtccaggagggctcctctgccaagttttgctgccgc atctcccctgctgactacggccctgtgcactggttcctggataagacccctttgcacagc aacgagctgaacgagatcactgtccagtccggaggctaccacgtgctcaccctgcggcag ctgacgctcaaggattcaggcacggtctacttcgaggcgggtgaccagcggacctcagct gccctgcgggtgactgagaagccgagcatcttctctcggccactcacagatgtcacagtc acagaaggcgaggacctgactctcgtctgtgaaaccaccaccccggatagctctgtgcgc tggaccaaagatgggaagacactgaggccatctgcacgatgccagctgaaccgcgaaggc tgtcaggcccagctggtcatcactggcactaccctacaggatggcgggcggtacaaatgt gaggtgggcggagcctccagcagctccattgtcagggttcacgctcggccagtgcggttc agggagtccctgaaggacatggaggtgccagagggcaaggctgccacactacgctgtgtg ctgtcatccgtggctgcacctgtggagtggcgtcacggagatgatgtcctgaaatccagc aacaagtatagcctgcgccaagagggtgctgtgctggaactggtcatccgagacctgaag ccccaggacagcgggcagtactcatgctcctttggggaccagacaacttcagccacactc acagtgaaaacctcgtctgcccagttcataggaaaactgagaaacaaggaggccacagaa gggaccatggccacacttcggtgtgagctgaccaaagaggcccccgtggaatggaagaag ggaacagagaccctgagaaatggggacaaatacagtctgaagcaggatggagctgtgtgt gaactgcagatctgtaacctgcttgtggcagacgcgggggagtacttgtgtgtatgcggg caggagaagacttcagccacgctgactgtcaaggccgttcctgtccactttatcagaagg ctcaggaacaaggaggccacagaaggggacacggtcacactgcagtgtgaactgagcaag gcggcccccgtggagtggaggaagggaacagagaccctgagagatggggacagatacagc ctgaagcaggatggggccgtgtgtgagctgcagatccgcagcctggctgtagcagatgct ggagagtacttgtgcatgtgtggacaggaaaagacctcagccacactgaccatcagggcc cttccggctaagttcatagaaagtctgaagaatgaaggggccacagaaggaaccacagcc acgctgagctgcaaactgagcaaggcggttccggtgacgtggaagagaggaacaaagacc ttgcgagacggagacaaatatggcctgaggcaggacggagctgtgtgtgagctgcagatc cgtggcctgaccacagccgatgctggggagtactcatgtgtgtgtgggcaggagaagaca tcagctgctctgactgtcaagggcttgcctgccaagtttatagaagatctaagaagccaa gaggccatggaaggggccacggcaatcttaagatgtgagctgagcaaggcggcccctgtg gagtggaggaaggggtccaagatcctggaagatggggacagatacaccctgaggcaggac ggggccgtgtgtgaactgcagatccgtggtctggctgtggtggatactgggacgtactca tgtgtgtgtgggcaggagaagacctcggccacactgaatattaatgccctgcctgccaag ttcacagagggtctgaggaatgaagagtccatggaaggcaccatggtgactctgaggtgc cagatgagcaaggtgacccctgtggagtggaggaaggggtcagagaccctgagagatggg ggcagatacagcctgaggcaggatggggccgtgtgtgagctgcagatccgtggcctgatt ctggaagatgctggggagtactcatgcgtgtgtgggcaggagaagacgtcagccacactg agtgtcaaggccctgccccccagattcatagaagacttgagaagccaagaggccatggaa ggcaccatggtgactctgaggtgccagatgaacaaggcagcccctgtggagtggaggaag gggtcagagaccctgagagatgggggcagatacagcctgaggcaggatggggccgggtgt gagctgcagatccatcgcctggctctggaagatgctggggagtactcatgcgtgtgtggg caggagaagacgtcagccacactgagtgtcaaggccctgccccccagattcatagaagac ttgagaagccaagaggctacggaaggcaccatggtgactctgaggtgccagatgaacaag gcaccttcctccactgtagagtggaggaaggggtctgagagtctgagagatgggggcaga tacagcctgaggcaggatggggctgtgtgtgagctgcagatccgaggcctgactctagaa gatgctggggagtactcatgcgtgtttgggcaggagagaacgtcagccacactgagtgtc aaggccctgcctcccagattcatagaagacttgggaagccaagaggccatggaaggcacc atggtgactctaagatgccagatgagcaagacagcccctgtggagtggaggaaggggtca gagaccctgagagatgggggcagatacagcctgaggcaggatggggccttgtgtgagctg cagatccatcgcctggctctggaagatgctggggagtactcatgcgtgtgtgggcaggag aagacgtcagccacactgagtgtcaaggccctgcctcccagattcatagaagacttgaga agccaaaaggccacagaaggcaccatggtgactctgaggtgccagatgagcaaggtggcc cctgtggagtggaggaaggggtctgagagcctgagagatggggacagatacagcctgagg caggatggggccatgtgtgagctgcagatctgtggcctggctgtagaagacagtggggag tactcgtgcgtgtgtgggcaggagaggacatcagccacactgactgtagatgcactgccc cccaagttcacagagggtctgaaaaaggaagaggccacagaagggaacatggcgactctg aggtgccagatgagcaaggcggcccctgtggagtggaggaaggggtcagagaccctgaga gatgggggcagatacagcctgaggcaggatggggccgcgtgtgagctgcagatccgtggt ctggctctggaagatgctggggagtactcatgcctgtgtgggcaggagaagacgtcagcc acactgagtgtcaaggccctgccccccagattcatagaagacttgagaagccaagaggcc acagaagggaacatggtgactctaaggtgccagatgagcaaggtgacccctgtggagtgg aggaaggggtcagagaccctgagagatgggggcagatacagcctgaggcaggatggggcc gtgtgtgagctgcagatccatcgcctggctctggaagatgctggggagtactcatgcctg tgtgggcaggagaagacgtcagccacactgagtgtcaaggccctgccccccagattcaca gaagacttgagaagccaaaaagccacggaaggcaccatggtgactttaaggtgccagatg agcaaggcagcccctgtggagtggaggaaggggtctgagaccctgagagatgggggcaga tacagcctgaggcaggatggggccgtgtatgagctgcagatccgaggcttggctctggaa gatgctggggagtactcatgtgtgtgtgggcaggagaagacctcagccacactgagtgtc aaggcccttccagccagattcatagaagatttgagaagccaagaggtcccggaaagttca acagtcacaatgcggtgtgagctaagcaagaaggcccctgtggtgtggaggaaagggtct gagaccctgaaaaatggggccaggtacagcctgagacaggatggtgctgtgtgtgagctg gagatccgtgacctgactgtggaagatgctggagagtactcatgcacatgtgggaaggag aggacctcagccacactgagcattatggctccacaggtggtgttccagaagttactggag aatctgcaagcagaagaaggctccacagccagcctgcggtgtgagctgtcagtccccaac actgctgtggtctggagcaagggcggcctggagctgcaggctgacacatgccgagagaca cggcagcagggctgcgttgcagaactgctgcttagggacgtgcgccgtgaggacgcgggc gagtacagctgtacctgtggttcccagaccacaagtgccacactcatggtcacagctgct cctgtgaggttcctccaggagctacaggcccaggacgtagatgaagggaccaccgcacgc ctgcgctgtgagctgagccgggaggctgcgagtgtggaatggcgcaagggctccttgcag ctttttccttgtgctaagtatcagatggtgcaggagggcacaactgcagagctgctagtc catggggtggagcaggaggatgcaggggaatacacctgcgatgcaggacacatgcagagc attgccaggctctccgtccgagcccccaagcccaagttcaagaccggcctacagagcaaa gagcaagaagcaggtggcacagcacggctgtgttgtcaactgagcgaagctgagtcgggg actccagtacaatggctcaaagagggggtggagctgcatgtcagctccaagtacgagatg cggtgccaaggggctatgtgtgagttgctgatccacaagctggaggccaaggacactggt gaatatgcctgcgtggtgggtggccagaagaccttggcctccctcagagtcaaagagcct gaggtgaccattgtgcagggactggtggacatggaggtgcaggctgatgaggatgtggag ttcacttgcaaggtgtcacaggcaggagccacagatgtgcagtggcatctccaaggtctg ccactgcagagcaatgaagtgacagaggtggctgttcttggagacggctgtacccatgtg ctccagttgaagggtgtgacactggatgatgctggtactgtctccttccacgtgggcagc cattcatcttctgctcagctcatagtccgagtccccgaggtgaccgttctggagcccctg aaggatgtgcagctcagcgagggccaggatgcccatttccagtgccggctgtccagggct tcgggccaggaggctcgctgggctttgggaggagttcccttgcagtgcaatgagatgaat gacatcactgtggagcagggcacactctactcgctcactctgcacaaggtgaccctcgag gatgccggaaccatcactctccaagtgggctcatgctcctcagaggcccagctgaaggtc acagaggcagcactgtgcctggtacgaggcttgcagaatgtggatgtcttcgcgggggag gtggccacgttctcctgtgaggtatctcgagcaggtgggccagaggcccgctggtggctg gatggcaccctgcttcagaacagccctgagagtgccatgactgtacgagagggtactgtt cactccctcacgctctcgggcctgggggtggctgactcaggcaccatcaccttccgcacg gggcccctggtctccacagccaagttattggtcaaagatcccacagtggaggtggtgagt gccatgcaggacctggtggtggaggagggtggctcggccgagctcctctgccagtactcg cggcccgtgcaggccatgtggaagatgaacgagcgggaggtgtgcgcggatgggcaccgt gtcatcatagagcaggactggaccgtagccaggctgaccctcaggccggccctgccctgt gacagtggcatctattcttgtgaggctgcgggcactcgagttgtggcactgctccaagtg caagccaagaacacagtggtgcgtggcctggagaatgtggatgcactggagggcggcgaa gctctgttcgagtgtcagctgtcccagccggaagtggctgcccacacctggttactagac gatgagcctgtgcacacatcagcaaacgtggaggtggtctactttgagaacggactgcgc cacttgcttttgctcaaaaacctgaagccacaggacagctgccgagtgaccttcctggca ggggacgtggtcacgtctgccttcctcactgtgagaggctggcgcttggaggtcctggag cccccacaagacgcatctgtgaaagctggtacgcaggtctgcttcacttgcatactaagt gaggccctgcctgtgggcgaggctacttggtacatcaacggggctgccatccaacctgat gacgctgactggatagtcaccgcagatggcagccaccatgccctgacgctgagcaacgcc cagccccagcacgcaggagaggtcacatttgcagcacgtgacgccgtggcctctgcacgc ctctctgtgttggctctccctggtccccctgaagatgctgaagtagtgggtcgaagtgac cactctgtgaccctatcctgggtggctcccgtgagtgacggcggcggcggtctatgtggt tatcgtgtggagatgaaggaggcatccacaggccagtggcagttgtgccatgagttggta cctggcccagagtgtgtggtggacggcctggtctctgggaagacctaccgcttccgagtg gcagccgtgggtccggcaggagctggggagcctgtacatctgccccagatggtcaagata gcagagccaatggaacctaaaccagccccagccccagcccctgccctagccccaacccca gctccaatcccaaccccagccccagccccagccccagccccaaccccagccccaacccca accccagccccagccccagcccctgccccagccccagcaacacggcgagcagtggttggt gaagatgtgtgtctggagctggaagtggcagctgatgctggcgaggtcgtctggcacaag ggaacagagcgcatccatcccagtgggcactttgaggtcctctctcagggtcagcggcag atgctggtgatcaagggctttaggaccgaagaccagggggagtaccgctgtggtcccatc cagggcctgccctcctcaggagcttctactttcaatgtggtcgtgacctcgggctcggag gatgaggtccctgcacagcccagcctgcctcccgaggcagcccaggagggtgacctgcat ctgctttgggaggcccttgctcggaagcgtcgcatgagccgggagcccacgctggactcc atcagtgagctgcccgaggaagacagccgtgtgcagcatctgcggcaggaggcagaagag gcggctcctgacctctctgagggctactccacagccgatgagctcgcacgcacaggagaa gctgacctctcacacaccagctctgatgacgagtctcgggctggcaccccttccctaatt acctacctcaagaaggccgggggtcctgggatctcacccttggccagcaagcatgaggcc caggtggccacgtctgtgaagccacaaaagcagcaggagcgggttgtgcccacatgccca ctgccgggagatttgaacgcagcagatttgaaggatccatccctggacaaggccgctgtg aagatccaggctgcctttaagggctacaaagtgaggaaggagatgaagcagcagggaggc cccgtgttctcacggacatttggggacacagaggcacaggttggggatgcgctgcggctg gagtgtgtggtgtccaccaaggctgacgtgcgggcctgctggttgaaggatggcgtagag ttaacagatgggcgccattaccacatagaccagctcaaggacggtacctgctctctgctg gtcactggcctgggccccactgactctggtcgctacacctgtcaggtgagcaccaagttt ggaagcgtgagccacagtgcctgcgtaatggtcagtgggacagaaagtgaggctgagagc tcctcaggaggtgagctggacgatgccttccgccgggcagcacgacgcctgcatcgtctc ttccgaaccaagagcccagctgagctttcagaagaggagctcttcctcagtgctgacgaa ggccccatggagccagaggagcctgcagactggcaaacataccgagaggatgaaaacttt gtgtgcatccgttttgagtcacttgcagaggcccaccgggcagtcacctgcttccgtgac atgtttgccaccatgggcatcggggtggagatcagcctaggggagcaggggccccgggga gtggagatgcgcattggcaaggtggcccccactgtcatccctgcggtgccacttgcaaag acacctggcctgcagacttcagatgctgccccagtgttcctgacggagctgcagaaccaa gacgtgcaggacggataccccatgagcttcgactgcgtggtaacaggccagcctgtgccc agtgtgcgctggttcaaggacgggaagttgctagaagaggatgaccactacatgatcaac gaggaccaacaggggggtcaccagctcatcatcacagccgtggtgccggcagacatggga gtgtaccgctgcctggcggagaacagcatgggcgtctcctccaccaaggctgagcttcgt gtggaattgaccagcacagactatgacactgctgctgatgctaccgagacctcatcctac ttcagcgcccagggatacctgtccagccgggagcaagaggggacggagtcagatgagggg cagcttccccaggtgctggaggaactgaaagacctccaggtggcccctggcacacgcctg gccaagttccagctcaaggtgaaaggttatccagctcccaaactgtactggttcaaagat ggccagcccctgaccacatctgaccacatccgcatgactgacaaaaagaccctgcacacc ctggagattgtctccatcacccgagaggacagcggccagtacgcggcctacatcagcaat gctgtgggtgccgcctattcgtcagcccggctgctggtccgaggtcccagtgaaccagaa gagaagccacaaccagatgttcatgagaggctggtgccaccccgaatcctggagaagttc acccccaagaaagtgaagaggggctccagcatcaccttttcagtgaaggtggaaggacac ccggcccccagtgtgcattggctcaaggaggaggcagagaagggagtcctgtggattggc cctgatacccctggctacacgatggccagttcttccaagcaacatagcctggtcctgctg gacgtaggccgacagcaccagggcacctacacgtgcattgccaccaatgctgctggccag gcgctctgctctgccagtctgcacatctctggcttggccaaagaagaggagcaggagaga gtgaaggaggctctcatttcctccttcctgcaagggacgagccaagctgtctcagcccag atgtcagaatctgcaagttttgctgatcttgtcgggcaaaggaaaggtgagtccctggtg gctgaggaggcccacagtcacctgtccctttctgaggtgggcacagaagagttcctgcag aaactcacctcacagatcaccgagatggtatcagccaagatctcgcaggccaaactccag gtgcctggaggtgacagtgatgaggagtctaagacaccatctgcttctcctcggcacggc cggtcacgtccttcctccagtgttcaagagtcttcctcagagtcagaggatggagactcc cgtggtgagatctttgacatctacgtggtcacagctgattatctgcccctgggagctgag caggatgccatcatcctgagagaaggccagtatgtggaggtcctggactcagcccatccc ctgcgctggcttgtacgcaccaagcccaccaaatccagcccttccaggcagggctgggtg tcacctgcctacctggacaagaggctcaagctatctcctgagtgggggcccactgaggcc cctgagttccctggcgaggctgtgtctgaggatgagtatagaacgaggctgagctctgtc atccaggagttgctgagttcagagcaggcttttgtgggtgagttacagttcttggagagc caccacatcaagcacctggaccgatctccccgtgtacccgcagctgtggccagccagaag acggtcatctttcgtaatgtgcaggacatcagccatttccacagcagcttcttgaaggag ctgcagagctgtggcaccgacgatgatgtagccatgtgcttcatcaagaaccaggaggcc tttgagaagtaccttgagttcctggtgggccgggtgcaagcggaatcagtggtcgtcagc accccagtccaggagttctacaagaaatatgcagaagagatgctgtcagccaaggacccc acacagccacccccacctcctcttcagcactacttggagcagccagtggaacgggtgcag aaataccaggccttgctgaaggagctaatccgcaacaaggctcgcaaccggcagaactgt gcgctgctggagcaggcctacgctgtggtgtctgccctgcctcagcgtgctgagaacaag ctgcacgtttctctcatggagaactacccgggaaccctggaggccctgggagaacctatc cgccagggtcacttcatagtgtgggagggggctccaggagcccggatgccttggaagggc cacaaccggcatgtcttcctcttccgaaaccacctggtgatctgcaagccccggagagac tctcgaacggacaccttcagctacgtgttccggaacatgatgaagctgaatagcatcgac ctgaatgaccaggtagagggggatgaccgtgcctttgaggtgtggcacgagcgggaagac tctgtccgcaagtacctgctgcaggcgcggacagtgatcatcaaaaactcatgggtgaag gagatctgtggcatccagcagcgccttgcccagcccgtgtggcgtccccctgagtttgaa gaagaactagctgactgcacagccgagctgggtgaaacagtcaagctagcatgccgagtg actggcacacctaagcctattgtcagctggtacaaagatgggaagcccgtggaggtggac ccacaccacatcctcattgaagaccctgatggctcctgtaccctcatcttggacaacctt actggcatagactctggccagtacatgtgttttgcggccagtgctgctggcaatgccagc accttggggaagattctagtacaagtgcccccacgatttgtgaacaaggtccgagccaca ccctttgtggagggagaggacgcgcagatcacctgcacagtggaaggagctccgtaccct cagatcaggtggtacaaggacggtgccctgctaaccctgggcaacaggtaccggatggtg aatgagccccgcagtggtatgctggtgctggtgatccaggcagccagcaaggaggacctg ggacactatgaatgtgagttggtgaaccggttgggctcaacacgttgtggcggagaatta tacatgcagagtcccgcactgcgtgcctgggaccagcaccaccgggaacagcttgtggct gctgtggaagacgcctccatggaggactctgcccaccccactcaggagggagctgaccaa caagccgcttctgtcctttggaggctgctgggctcagaagccctcagcccctccccaggg ggtttccccaacaccagacaaagtgagccacccacatcagaagaggctgctccccagatc ccaggcacaacttcaggaacacctggcaaactcccagaggcttcacggcccggcacatac aaaggcctggagcaggggatgacaacaacttctggatcccaggaacggaatgtacccatt cgggtggagggcacggcctggccaggcggaggcactgggcagctgctcttggatgtgcac agccaagtcatcatggagaccacacagaggacctatgtgtgccaagctcctgacacaggt gtcacaagggccccatccatgcaggtcactatcgaggacctacaagtacaagtgggtgac atggcacagtttgatgctgtcattgaaggcaacccaccgccaacagtgacctggtacaag gacagcaaccagctggtgaacggtacccggctgaggcagcagcaaggtggaactacatat tccttggtgttgatggacgtgactccacacgatgccggtgtctacacctgtgttgcccag aatgcaggtggacaggtgctgtgcaaggcagagctgctggtctatgggggggacaagtca gatgctgaaaagcaagcctatcggaggaaactgcattccttctatgaagttcaagaagag attgggaggggtgtgtttggttttgtgaaaagagttcagcataaaggaaacaagatgtcc tgtgctgccaagttcatccccctgcggagcaaaactcgggcccaggcataccaggaacga gacatcttggctaccctcagccacccactggtcactgggctcctggatcaatttgagacc cagaagactctcatccttatcttggaactgtgctcatccgaggagctgctggatcgcctc ttcaagaaggctgtagtgaccgaagctgaggtcaaggtctatatccagcagctggtggaa ggcctacactacctgcacagccatgatatcctccatctggacataaagccccccaacatc ctgatggtccacccagctcgggaagacattaagatctgtgactttggctttgcccaaaag atcaccccgtcagagccacagtacagcaagtatggctcacctgaattcgtgtccccagag atcatcgagcagagtcctgtgagtgagggctcagacatctgggccatgggcgtcatctcc tacctcagcctcacctgttcatccccattcgctggagagagtgaccgtgccaccctgctc aatgttttggaggggcgggtctcttggagcagtcccatggctgcccatctgagtgaggat gccaaggacttcatcaaggccacactgcaaaagacccccagggcccggcctagtgcttcc cagtgccttgctcacccctggttcctgaagtccatgcctgctgaggaggcccacttcatc aacaccaaacagctcaagttccttcttgctcgcagtcgctggcagcgttccttgatgagc tacaagtctatcctggtgatgcgctccatccctgagctgctccagggtcctccagacagt ccatctctaggagtggcccggcacctacgaggggaagccagcggatcctctagctcatcg tcttcctcggacaatgagcttgccccatttgccagggctaagtcactgccaccttcccct gtcactcactcgccactgctgcaccctcggggctttctgcggccttcagccagcctcccg gaggagacagaggccagcatgtccactgctgatgcagccatgccggcacccccccagagt gctgggcctccagcaagcccaggttgtgtgccccggcacagcgtcatcagcagcttgttc taccagcaagctggtgagggtgcagagcgtgggagcaaagcgttgggcgccaagaggcac ccagctcggagacgccacctgctaaagggcgggtacattgcaagggccctgcccgggcta cgagagccgctgatggagtttagtgtgttggaggaagaggctgctaatgaggagcaggcc tctctgatgaccaagacaccctcctttgagaccgctctgcgactacctagttccaatgtc agagaggtcccaggccgaagccgctccctggacaacccaccaggcacagccagcccctct cctgaggcatacaaggaacaatacctgtccccaccctcctcggggttgactcatgaaacc accgccaagggcatgggacacaaagaagggttcttgcaggagtctgtccccttttcacct accagtggtgacctgaggcctgttaagcaagaggggtcatcccaggatagctgtagaggg aaaccagcctcttcctgtcactctgaactgggttctggtccgcaggagggctgtggctct ccatcatcacaattgtgtggctccttacctccacagtcatcgaagaaagagctctcaaaa ccctgtggcccactcttttcagaacagcctcaggcagccccattcccagcgcaagcaagc ccccttctgggttctcagaaggaacctcaggatagctatctacctgaaaagccatgtcca gttccctccagttctccagggtcagcctcccaagtagatgcatccctggataccgaaggc ttgtcggaagctggggacacatgtgacttcacgcctcctctccagcggcctcaggagcag gccaccacccggaagttctctctggaatcccgtgggggctatgcaggggtggcaggatat ggcaccttcgcctttggtggggatgcaggggggatgttagggcagggtcccctttgggcc aggatggcctgggctgtgtcccagtcctcagaagagcaagatgaagcagcgactgagagc cctcaacctctggacagctcagggcccattgctgaggccagtggggttcccctaaggacc tcgccaagcctcaccccatgggaggaagttgagcaggtttccctggtacagatccgggat ctgtctggtgatgcagaagcagccgacaccatctccttggacatttcagaggtagatcct gcctacctcaacctctccgatctatatgacatcaagtatctcccgtttgagttcatgatc ttcaggagggtccccaaacctgtagagcagccagagtcacctggctctgaaactgaagag gggcaagggctggcggagttcctggaggaggctgtgtggccctggccaggcgagctggga ctgcgtgctggtctggagattacagaggagccacaggagccaggggacctggaagcactg ctgggcgaggctgctgtgggcaggaagcgcaagtggtccccctcccgtggcctcttccaa ttccctgggaggtgcctgtcaggggaggagcccgtggagcttgggctgcgccagagggtg aaggcttccatggctcacatctccaggatcctgaagggcaagccggaaggtcctgagaag gaagggcctcccagaaagaaggcaggcctagcttctttccggctatcaggcctgaagggc agggaccaagcgccatccttcctaagagaactctctgatgaggctgtggtcctgggccaa tcagtgacactggcctgccaggtgttggcccagccaactgcccaggctacctggagcaaa gatggggcccttctggagagcagcggccacctcctcatctcttccaccctgaagaacttc cagctgctgaccattctggtggtgacggaggaggatctgggcacatatacctgctgtgtg agcaacccactagggacagcagtcaccacaggtgtcctccggaaagcagagcgcccttca tcttctccacgcccggaggtgggggaactatacacggatgcagtgttgctggtctggaag cctgtggaatcctatggcccagtgacctacattgtgcagtgctgtatagaaggaggcagc tggacaaccctggcctctgacatctccgactgctgctacctcactggcaagctgccccgg ggtggcatgtataccttccggacagcatgtgtcagcaaagcaggaatgggcccctacagt agcccctcagaacaggtcctccttggaggacccaaccacctggcttctgaggaggaaagc agccgggggagaccagcccagcttcttcccagcacaaagacttttgccttccagacacag atccggaggggccgcttcagtgtggtgaggcagtgtagggagaaagcaagtgggcgggcc ctggctgctaagatcgttccctaccagcctgaggacaagacaactgtactaagagaatat gaggcactaaagagactgcaccacccacatctggcccaactccatgctgcctacctcagt ccccggcacctggtgctcatcctagagctgtgctctggccctgagctgctaccctctctg gcggagagggactcgtactcagagtctgatgtgaaggactacctgtggcagatgctcagt gccacccagtacctgcatgcccaacacatcctgcacctggacctgaggtcggagaacatg atggtcaccgagtacaacctgcttaaggttatagacctgggtaacgcccagagtctcagc caagagaaggtcccacctcctgaaaacttcaaagactacctagagaccatggctccagaa cttctggaaggccaaggggcggttccacagacagacatctgggctattggtgtaacagcc ttcattatgctgagtggcgagtacccagtgagcagcgaggggactcgcgacctgcagaaa ggcctgcgcaagggactcattcaattgagtcgctgctatgcaggattatcagggggtgcg gtagccttcctgcagagttcattgtgcgctcggccctggggtcgcccgtgcgcttccacc tgcttgcagtgcgggtggctgacggaggagggccccaccggttcccggcccacgcccgtg accttccccaccgcgcgattgcgtgcctttgtgcgcgagcgcgagaagcgccgggcgcta ctctacaagaagcacaacctggctcaggtgcgctga

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