Rattus norvegicus (rat): 360243
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Entry
360243 CDS
T01003
Symbol
Top2a
Name
(RefSeq) DNA topoisomerase 2-alpha
KO
K03164
DNA topoisomerase II [EC:
5.6.2.2
]
Organism
rno
Rattus norvegicus (rat)
Pathway
rno01524
Platinum drug resistance
Brite
KEGG Orthology (KO) [BR:
rno00001
]
09160 Human Diseases
09176 Drug resistance: antineoplastic
01524 Platinum drug resistance
360243 (Top2a)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
03032 DNA replication proteins [BR:
rno03032
]
360243 (Top2a)
03036 Chromosome and associated proteins [BR:
rno03036
]
360243 (Top2a)
Enzymes [BR:
rno01000
]
5. Isomerases
5.6 Isomerases altering macromolecular conformation
5.6.2 Enzymes altering nucleic acid conformation
5.6.2.2 DNA topoisomerase (ATP-hydrolysing)
360243 (Top2a)
DNA replication proteins [BR:
rno03032
]
Eukaryotic type
DNA Topoisomerases
360243 (Top2a)
Chromosome and associated proteins [BR:
rno03036
]
Eukaryotic type
Chromosome condensation proteins
Other regulators of chromosome condensation
360243 (Top2a)
Centrosome formation proteins
Centriole proteins
360243 (Top2a)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
DNA_topoisoIV
TOPRIM_C
DNA_gyraseB
DTHCT
HATPase_c
Toprim
Microp_apicomplexa_20
Motif
Other DBs
NCBI-GeneID:
360243
NCBI-ProteinID:
NP_001380697
RGD:
62048
Ensembl:
ENSRNOG00000053047
UniProt:
A6HIW1
A0A0G2JWP8
LinkDB
All DBs
Position
10:complement(84441954..84473093)
Genome browser
AA seq
1528 aa
AA seq
DB search
MELSPLQPVNENMLLNKKKNEDGKKRLSVERIYQKKTQLEHILLRPDTYIGSVELVTQQM
WVYDEDVGINYREVTFVPGLYKIFDEILVNAADNKQRDPKMSCIRVTIDAENNLISIWNN
GKGIPVVEHKVEKMYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVET
ASREYKKMFKQTWMDNMGRAGDMELKPFSGEDYTCITFQPDLSKFKMQSLDKDIVALMVR
RAYDIAGSTKDVKVFLNGNRLPVKGFRSYVDMYLKDKVDETGNALKVVHEQVNPRWEVCL
TMSEKGFQQISFVNSIATSKGGRHVDYVADQIVSKLVDVVKKKNKGGVAVKAHQVKNHMW
IFVNALIENPTFDSQTKENMTLQAKSFGSTCQLSEKFIKAAIGCGIVESILNWVKFKAQI
QLNKKCSAVKHNRIKGIPKLDDANDAGSRNSAECTLILTEGDSAKTLAVSGLGVVGRDKY
GVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKKNYEDEDSLKTLRYGKIMIMTD
QDQDGSHIKGLLINFIHHNWPSLLRHRFLEEFITPIVKVSKNKQEIAFYSLPEFEEWKSA
NPNHKKWKVKYYKGLGTSTSKEAKEYFANMKRHRIQFKYSGPEDDAAISLAFSKKQVDDR
KEWLTNFMEDRRQRKLLGLPEDYLYGQTTMYLTYNDFINKELILFSNSDNERSIPSMVDG
LKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEMSSYHHGEMSLMMTIINLAQNFVGSNNL
NLLQPIGQFGTRLHGGKDSASPRYIFTMLSPLARLLFPSKDDHTLRFLYDDNQRVEPEWY
IPIIPMVLINGAEGIGTGWSCKIPNFDVREVVNNIRRLLDGEEPLPMLPSYKNYKGTIEE
LASNQYVINGEVAILNSTTIEITELPIRTWTQTYKEQVLEPMLNGTEKTPPLITDYREYH
TDTTVKFVIKMTEEKLAEAERVGLHKVFKLQTSLTCNSMVLFDHVGCLKKYDTVLDILRD
FFELRLKYYGLRKEWLLGMLGAESSKLNNQARFILEKIDGKIVIENKPKKELIKVLIQRG
YDSDPVKAWKEAQQKVPEEEENEENEESESESSSPAAESGPTFNYLLDMPLWYLTKEKKD
ELCKQRDEKEQELNTLKKKTPSDLWKEDLAAFVEELEVVEAKEKQDEQVGLPGKGVKAKG
KKAQISEVLPSPVGKRVIPQVTMEMRAEAEKKIRRKIKSENVEGTPAEDGAEPGGLRQRL
EKRQKREPGTRAKKQTTLPFKPIKKGKKKNPWSDSESDMSSNESNFDVPPREKEPRIAAT
KAKFTADLDSDDDFSGLDEKDEDEDFFPLDDTPPKTKMPPKNTKKALKPQKSSTSVDLES
DGKDSVPASPGASAADVPAETEPSKPSSKQTVGVKRTITKGQSLTSTAGTKKRAVPKETK
SDSALNAHVSKKPAPAKAKNSRKRKPSSSDSSDSEFEKAISKGATSKKPKGEERDFHVDL
DDTVAPRAKSGRARKPIKYLEESDDDLF
NT seq
4587 nt
NT seq
+upstream
nt +downstream
nt
atggagttgtcaccgctgcagcctgtaaatgaaaatatgctactcaacaaaaagaagaat
gaagatggcaagaaaagactgtccgttgaaagaatctatcagaaaaaaacccaactggaa
catatactgctccgcccagatacctacatcggctctgtggagttagtgacccagcaaatg
tgggtttacgatgaagatgttggtattaactacagggaagtcacttttgttcctggtttg
tataaaatctttgatgaaattctagttaatgctgctgataacaaacaaagggacccaaaa
atgtcttgcattagagtcacaattgatgcagaaaataatttaattagtatatggaataat
ggaaaaggaattcctgttgttgaacacaaagtggagaaaatgtatgtcccagctctcata
tttggacagctcctgacctccagtaactacgatgatgatgagaagaaagtgacaggtggt
cgaaatggctatggagctaaactgtgtaacatattcagcaccaaatttactgtggaaaca
gccagtagggaatacaagaaaatgttcaaacagacatggatggataacatggggagagct
ggtgacatggagctcaagccctttagcggagaggattacacgtgtattaccttccagcct
gacttatctaagtttaaaatgcaaagcctggacaaagatattgtcgcactgatggtcaga
agagcatacgatattgctggttccaccaaagatgtaaaagtctttcttaatggaaacagg
ctgccagtcaaagggttccgtagttacgtggatatgtatttgaaggataaggttgatgaa
actgggaacgcactgaaggtggtgcatgaacaagtaaatccccggtgggaagtgtgctta
acaatgagcgagaaaggctttcagcagattagcttcgtcaacagcatcgctacttctaag
ggtggcagacatgtcgattatgtagccgatcagattgtgagtaaactcgttgatgtggtg
aaaaagaagaacaagggaggtgttgcagtgaaggcccatcaggtgaagaatcacatgtgg
atttttgtaaatgccttaattgaaaacccaacctttgactctcaaacaaaagaaaacatg
actttacaagccaagagctttggatcaacttgtcaattaagtgaaaaattcatcaaagct
gcaattggttgtggtattgtcgaaagcatactaaactgggtgaagtttaaggcccaaatc
caattaaacaagaagtgttcagctgtaaaacataacaggatcaagggaatccccaaactt
gacgacgccaatgacgcagggagccgaaactctgctgaatgcacacttatcctgactgaa
ggggactcagccaaaactctggcagtctcaggacttggagtggttggaagagacaaatat
ggggtgttccctctcagaggaaaaatactcaatgtgcgagaagcttctcataaacagatc
atggaaaatgctgaaattaacaatatcatcaagattgtggggcttcagtacaagaaaaac
tatgaggatgaagattcattgaaaactcttcgttatgggaagatcatgattatgacagat
caggaccaagatggttcccacatcaaaggcttgctgatcaattttatccatcacaattgg
ccatctcttctgcgacatcgttttctagaagaatttatcactcctattgtaaaggtgtct
aaaaacaagcaagaaatagcattctacagtcttcccgagtttgaagaatggaagagtgca
aatccaaatcacaaaaaatggaaagtcaagtactacaaaggtttgggcacgagcacatca
aaggaagctaaggagtattttgcaaatatgaaacgacatcgtattcagttcaaatactct
ggccctgaagacgatgctgcgatcagcctggcctttagtaaaaaacaggtcgatgatcga
aaggaatggttaactaatttcatggaagatagaagacagcggaagttacttggccttcct
gaggattatttgtatggacaaaccactatgtacctgacctataatgatttcattaacaag
gaacttatcctcttttcaaactctgataatgaaagatctatcccatctatggtagatggt
ttgaaaccaggtcagagaaaggttttgtttacttgtttcaaacggaatgacaagcgagag
gtgaaagttgcccagttagctgggtcagtggcagaaatgtcctcttatcaccatggtgag
atgtcgctgatgatgaccattatcaatttggctcagaattttgtgggtagcaataatttg
aaccttctacagcctattggtcagtttggtaccaggctgcatggtggcaaggactcagcc
agccctaggtacatctttacaatgctcagccctttggctcggttgttatttccatcaaaa
gatgatcacacgttacggtttctgtatgacgacaaccagcgtgttgagcctgaatggtac
atccctattatacccatggtgctgataaatggtgctgagggaattggtactgggtggtcc
tgcaaaatccccaactttgatgttcgtgaagtcgtaaataatatcaggcggctgttggat
ggagaagagcctctgcccatgctcccaagttataagaattacaaaggtactattgaagaa
ctggcttcaaatcagtatgtgattaatggagaagtagctattctgaattccacaaccatt
gagatcactgagcttcccatcagaacatggacccagacatataaggaacaggttctagaa
cctatgttgaatggcaccgagaagacaccccctctaataacagactatagggaataccac
acagataccactgtgaagtttgtcataaagatgactgaagaaaaattggcagaggcagag
agagtgggactacacaaagtcttcaaactccagactagtctcacttgcaactctatggta
ctttttgaccatgttggttgtttaaagaaatatgacactgtgttggatattctaagagac
ttctttgagctcaggcttaaatattatggattaagaaaagaatggcttctaggaatgctt
ggtgcagaatcttctaaactgaataatcaagctcgctttatattagagaaaatagatggc
aaaatagtcattgaaaataaacctaagaaagaattaattaaagttctgattcagagaggc
tatgactccgaccctgtgaaagcctggaaagaagctcagcagaaggtcccagaagaagag
gaaaatgaagagaatgaagagagcgagagtgaaagcagcagccctgcagcggagtctgga
ccgaccttcaactaccttcttgatatgcccctgtggtatctaaccaaggagaagaaggac
gagctgtgcaagcaaagggacgagaaggaacaagagctcaacacgttaaagaaaaagact
ccatcggatttgtggaaggaagacctggctgcttttgtggaagaactggaggttgttgaa
gccaaggaaaaacaggatgaacaagtaggacttcctggaaagggggtgaaagcgaagggg
aagaaagcgcagatatctgaagtcctgccttctcctgtggggaaaagggtcatcccgcag
gtgactatggagatgagagctgaggcagagaagaaaatcaggaggaaaattaagagcgag
aatgttgagggcacccctgctgaggatggtgctgagccaggaggcctccggcagagacta
gagaagaggcagaagagagagccaggtaccagggcaaagaagcaaactacattgccattt
aagcctatcaaaaaagggaaaaagaaaaacccttggtctgattctgaatcagatatgagc
agtaacgaaagtaattttgatgtccctccacgagagaaagagccaagaattgctgcaaca
aaagccaaattcacggcggatttagactctgatgacgatttctcaggcttggatgagaag
gatgaggatgaagatttcttcccattagatgatactccacctaagaccaaaatgccccca
aaaaatactaaaaaagcactgaagccacagaagagctccacatcagttgatcttgaaagt
gatgggaaagacagtgtgccagcttctccaggcgcttctgctgctgacgtcccagctgag
actgaaccctccaagccgtcctccaaacagacagtgggagtgaagaggacaataaccaaa
ggtcagtctttaacctccactgctggcaccaaaaagagagctgtaccaaaggagaccaag
tcagattcagccttgaatgctcatgtctccaaaaagcctgctcctgccaaagccaagaac
agtcgcaagaggaagccatcttcttctgacagctcggactctgagtttgagaaggcgatt
tctaaaggtgccacaagcaagaaacccaagggagaggagcgggatttccatgtggactta
gatgacactgtggctcctcgagcaaaatccggacgagcaaggaagccgattaagtacctg
gaggagtcggatgacgacctcttctaa
DBGET
integrated database retrieval system
