KEGG   Rattus norvegicus (rat): 366508
Entry
366508            CDS       T01003                                 
Symbol
Pik3cd
Name
(RefSeq) phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
  KO
K00922  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
Organism
rno  Rattus norvegicus (rat)
Pathway
rno00562  Inositol phosphate metabolism
rno01100  Metabolic pathways
rno01521  EGFR tyrosine kinase inhibitor resistance
rno01522  Endocrine resistance
rno01524  Platinum drug resistance
rno04012  ErbB signaling pathway
rno04014  Ras signaling pathway
rno04015  Rap1 signaling pathway
rno04024  cAMP signaling pathway
rno04062  Chemokine signaling pathway
rno04066  HIF-1 signaling pathway
rno04068  FoxO signaling pathway
rno04070  Phosphatidylinositol signaling system
rno04071  Sphingolipid signaling pathway
rno04072  Phospholipase D signaling pathway
rno04081  Hormone signaling
rno04140  Autophagy - animal
rno04150  mTOR signaling pathway
rno04151  PI3K-Akt signaling pathway
rno04152  AMPK signaling pathway
rno04210  Apoptosis
rno04211  Longevity regulating pathway
rno04213  Longevity regulating pathway - multiple species
rno04218  Cellular senescence
rno04360  Axon guidance
rno04370  VEGF signaling pathway
rno04380  Osteoclast differentiation
rno04510  Focal adhesion
rno04550  Signaling pathways regulating pluripotency of stem cells
rno04611  Platelet activation
rno04613  Neutrophil extracellular trap formation
rno04620  Toll-like receptor signaling pathway
rno04625  C-type lectin receptor signaling pathway
rno04630  JAK-STAT signaling pathway
rno04650  Natural killer cell mediated cytotoxicity
rno04660  T cell receptor signaling pathway
rno04662  B cell receptor signaling pathway
rno04664  Fc epsilon RI signaling pathway
rno04666  Fc gamma R-mediated phagocytosis
rno04668  TNF signaling pathway
rno04670  Leukocyte transendothelial migration
rno04722  Neurotrophin signaling pathway
rno04725  Cholinergic synapse
rno04750  Inflammatory mediator regulation of TRP channels
rno04810  Regulation of actin cytoskeleton
rno04910  Insulin signaling pathway
rno04914  Progesterone-mediated oocyte maturation
rno04915  Estrogen signaling pathway
rno04917  Prolactin signaling pathway
rno04919  Thyroid hormone signaling pathway
rno04923  Regulation of lipolysis in adipocytes
rno04926  Relaxin signaling pathway
rno04929  GnRH secretion
rno04930  Type II diabetes mellitus
rno04931  Insulin resistance
rno04932  Non-alcoholic fatty liver disease
rno04933  AGE-RAGE signaling pathway in diabetic complications
rno04935  Growth hormone synthesis, secretion and action
rno04960  Aldosterone-regulated sodium reabsorption
rno04973  Carbohydrate digestion and absorption
rno05010  Alzheimer disease
rno05017  Spinocerebellar ataxia
rno05020  Prion disease
rno05100  Bacterial invasion of epithelial cells
rno05132  Salmonella infection
rno05135  Yersinia infection
rno05142  Chagas disease
rno05146  Amoebiasis
rno05160  Hepatitis C
rno05161  Hepatitis B
rno05162  Measles
rno05163  Human cytomegalovirus infection
rno05164  Influenza A
rno05165  Human papillomavirus infection
rno05166  Human T-cell leukemia virus 1 infection
rno05167  Kaposi sarcoma-associated herpesvirus infection
rno05168  Herpes simplex virus 1 infection
rno05169  Epstein-Barr virus infection
rno05170  Human immunodeficiency virus 1 infection
rno05171  Coronavirus disease - COVID-19
rno05200  Pathways in cancer
rno05203  Viral carcinogenesis
rno05205  Proteoglycans in cancer
rno05206  MicroRNAs in cancer
rno05207  Chemical carcinogenesis - receptor activation
rno05208  Chemical carcinogenesis - reactive oxygen species
rno05210  Colorectal cancer
rno05211  Renal cell carcinoma
rno05212  Pancreatic cancer
rno05213  Endometrial cancer
rno05214  Glioma
rno05215  Prostate cancer
rno05218  Melanoma
rno05220  Chronic myeloid leukemia
rno05221  Acute myeloid leukemia
rno05222  Small cell lung cancer
rno05223  Non-small cell lung cancer
rno05224  Breast cancer
rno05225  Hepatocellular carcinoma
rno05226  Gastric cancer
rno05230  Central carbon metabolism in cancer
rno05231  Choline metabolism in cancer
rno05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
rno05415  Diabetic cardiomyopathy
rno05417  Lipid and atherosclerosis
rno05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:rno00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    366508 (Pik3cd)
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    366508 (Pik3cd)
   04014 Ras signaling pathway
    366508 (Pik3cd)
   04015 Rap1 signaling pathway
    366508 (Pik3cd)
   04370 VEGF signaling pathway
    366508 (Pik3cd)
   04630 JAK-STAT signaling pathway
    366508 (Pik3cd)
   04668 TNF signaling pathway
    366508 (Pik3cd)
   04066 HIF-1 signaling pathway
    366508 (Pik3cd)
   04068 FoxO signaling pathway
    366508 (Pik3cd)
   04070 Phosphatidylinositol signaling system
    366508 (Pik3cd)
   04072 Phospholipase D signaling pathway
    366508 (Pik3cd)
   04071 Sphingolipid signaling pathway
    366508 (Pik3cd)
   04024 cAMP signaling pathway
    366508 (Pik3cd)
   04151 PI3K-Akt signaling pathway
    366508 (Pik3cd)
   04152 AMPK signaling pathway
    366508 (Pik3cd)
   04150 mTOR signaling pathway
    366508 (Pik3cd)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    366508 (Pik3cd)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    366508 (Pik3cd)
  09143 Cell growth and death
   04210 Apoptosis
    366508 (Pik3cd)
   04218 Cellular senescence
    366508 (Pik3cd)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    366508 (Pik3cd)
   04550 Signaling pathways regulating pluripotency of stem cells
    366508 (Pik3cd)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    366508 (Pik3cd)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    366508 (Pik3cd)
   04613 Neutrophil extracellular trap formation
    366508 (Pik3cd)
   04620 Toll-like receptor signaling pathway
    366508 (Pik3cd)
   04625 C-type lectin receptor signaling pathway
    366508 (Pik3cd)
   04650 Natural killer cell mediated cytotoxicity
    366508 (Pik3cd)
   04660 T cell receptor signaling pathway
    366508 (Pik3cd)
   04662 B cell receptor signaling pathway
    366508 (Pik3cd)
   04664 Fc epsilon RI signaling pathway
    366508 (Pik3cd)
   04666 Fc gamma R-mediated phagocytosis
    366508 (Pik3cd)
   04670 Leukocyte transendothelial migration
    366508 (Pik3cd)
   04062 Chemokine signaling pathway
    366508 (Pik3cd)
  09152 Endocrine system
   04910 Insulin signaling pathway
    366508 (Pik3cd)
   04923 Regulation of lipolysis in adipocytes
    366508 (Pik3cd)
   04929 GnRH secretion
    366508 (Pik3cd)
   04915 Estrogen signaling pathway
    366508 (Pik3cd)
   04914 Progesterone-mediated oocyte maturation
    366508 (Pik3cd)
   04917 Prolactin signaling pathway
    366508 (Pik3cd)
   04926 Relaxin signaling pathway
    366508 (Pik3cd)
   04935 Growth hormone synthesis, secretion and action
    366508 (Pik3cd)
   04919 Thyroid hormone signaling pathway
    366508 (Pik3cd)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    366508 (Pik3cd)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    366508 (Pik3cd)
  09156 Nervous system
   04725 Cholinergic synapse
    366508 (Pik3cd)
   04722 Neurotrophin signaling pathway
    366508 (Pik3cd)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    366508 (Pik3cd)
  09158 Development and regeneration
   04360 Axon guidance
    366508 (Pik3cd)
   04380 Osteoclast differentiation
    366508 (Pik3cd)
  09149 Aging
   04211 Longevity regulating pathway
    366508 (Pik3cd)
   04213 Longevity regulating pathway - multiple species
    366508 (Pik3cd)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    366508 (Pik3cd)
   05206 MicroRNAs in cancer
    366508 (Pik3cd)
   05205 Proteoglycans in cancer
    366508 (Pik3cd)
   05207 Chemical carcinogenesis - receptor activation
    366508 (Pik3cd)
   05208 Chemical carcinogenesis - reactive oxygen species
    366508 (Pik3cd)
   05203 Viral carcinogenesis
    366508 (Pik3cd)
   05230 Central carbon metabolism in cancer
    366508 (Pik3cd)
   05231 Choline metabolism in cancer
    366508 (Pik3cd)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    366508 (Pik3cd)
  09162 Cancer: specific types
   05210 Colorectal cancer
    366508 (Pik3cd)
   05212 Pancreatic cancer
    366508 (Pik3cd)
   05225 Hepatocellular carcinoma
    366508 (Pik3cd)
   05226 Gastric cancer
    366508 (Pik3cd)
   05214 Glioma
    366508 (Pik3cd)
   05221 Acute myeloid leukemia
    366508 (Pik3cd)
   05220 Chronic myeloid leukemia
    366508 (Pik3cd)
   05218 Melanoma
    366508 (Pik3cd)
   05211 Renal cell carcinoma
    366508 (Pik3cd)
   05215 Prostate cancer
    366508 (Pik3cd)
   05213 Endometrial cancer
    366508 (Pik3cd)
   05224 Breast cancer
    366508 (Pik3cd)
   05222 Small cell lung cancer
    366508 (Pik3cd)
   05223 Non-small cell lung cancer
    366508 (Pik3cd)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    366508 (Pik3cd)
   05170 Human immunodeficiency virus 1 infection
    366508 (Pik3cd)
   05161 Hepatitis B
    366508 (Pik3cd)
   05160 Hepatitis C
    366508 (Pik3cd)
   05171 Coronavirus disease - COVID-19
    366508 (Pik3cd)
   05164 Influenza A
    366508 (Pik3cd)
   05162 Measles
    366508 (Pik3cd)
   05168 Herpes simplex virus 1 infection
    366508 (Pik3cd)
   05163 Human cytomegalovirus infection
    366508 (Pik3cd)
   05167 Kaposi sarcoma-associated herpesvirus infection
    366508 (Pik3cd)
   05169 Epstein-Barr virus infection
    366508 (Pik3cd)
   05165 Human papillomavirus infection
    366508 (Pik3cd)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    366508 (Pik3cd)
   05135 Yersinia infection
    366508 (Pik3cd)
   05100 Bacterial invasion of epithelial cells
    366508 (Pik3cd)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    366508 (Pik3cd)
   05142 Chagas disease
    366508 (Pik3cd)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    366508 (Pik3cd)
   05017 Spinocerebellar ataxia
    366508 (Pik3cd)
   05020 Prion disease
    366508 (Pik3cd)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    366508 (Pik3cd)
   05418 Fluid shear stress and atherosclerosis
    366508 (Pik3cd)
   05415 Diabetic cardiomyopathy
    366508 (Pik3cd)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    366508 (Pik3cd)
   04932 Non-alcoholic fatty liver disease
    366508 (Pik3cd)
   04931 Insulin resistance
    366508 (Pik3cd)
   04933 AGE-RAGE signaling pathway in diabetic complications
    366508 (Pik3cd)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    366508 (Pik3cd)
   01524 Platinum drug resistance
    366508 (Pik3cd)
   01522 Endocrine resistance
    366508 (Pik3cd)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:rno04131]
    366508 (Pik3cd)
Enzymes [BR:rno01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     366508 (Pik3cd)
Membrane trafficking [BR:rno04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    366508 (Pik3cd)
SSDB
Motif
Pfam: PI3_PI4_kinase PI3Ka PI3K_p85B PI3K_rbd PI3K_C2
Other DBs
NCBI-GeneID: 366508
NCBI-ProteinID: NP_001102448
RGD: 1310990
Ensembl: ENSRNOG00000016846
UniProt: A6IUB9 D4A5Q1
LinkDB
Position
5:complement(165377994..165426620)
AA seq 944 aa
MPPGVDCPMEFWTKEESQSVAVDFLLPTGVYLNFPVSRNANLSTIKQVLWHRAQYEPFFH
MLSDPEAYVFTCVNQTAEQQELEDEQRRLCDIQPFLPVLRLVAREGDRVKKLINSQISLL
IGKGLHEFDSLRDPEVNDFRTKMRQFCEEAAAHRQQLGWVEWLQYSFPLQLEPSARGWRA
GLLHVSNRPLLVNVKFEGSEESFTFQVSTKDMPLALMACALRKKATVFRQPLVERPEEYA
LQVNGRHEYLYGSYPLCHFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPR
VKPPPIPAKKPSSVSLWSLEQPFCIELIEGRKVNADERMKLVVQAGLFHGNEMLCKTVSS
SEVNVCSEPVWKQRLEFDISICDLPRMARLCFALYAVVEKAKKARSTKKKSKKADCPIAW
ANLMLFDYKDQLKTGERCLYMWPSVPDEKGELMNPAGTVRGNPNTESAAALVIYLPEVAP
HPVYFPALEKILELGRHGERGRITEEEMLYLLCSWPELPVLSALELLDFSFPDCYVGSFA
IKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLGRALANRKIGHFLFWHLRSEMH
VPSVALRFGLIMEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKASSQKTTKPQTKEMMH
MCMRQETYMEALSHLQSPLDPSTLLEEVCVEQCTFMDSKMKPLWIMYSSEKAGGAGSVGI
IFKNGDDLRQDMLTLQMIQLMDFLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLHSDTIAN
IQLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHS
DNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERF
RGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQTLWH
NT seq 2835 nt   +upstreamnt  +downstreamnt
atgccccctggggtagactgccccatggagttctggaccaaagaggagagccagagcgtg
gccgttgacttcttgctgcccacaggagtctacttgaacttccctgtgtcccgcaatgcc
aacctcagcaccatcaagcaggtgctgtggcatcgtgcacagtatgagccgttcttccac
atgctcagtgaccccgaggcttatgtgttcacctgtgtgaaccagacagcggagcagcag
gagttggaggatgagcagcggaggctgtgtgacatccagcccttcctgcccgtgctgcgc
ctggtggcccgagagggggaccgcgtgaagaagctcatcaactcacagatcagcctcctc
atcggcaaaggtctccatgagtttgattccctgcgggacccggaagtaaacgacttccgc
actaagatgcgccagttttgcgaagaggccgcggctcaccgccagcagctgggctgggtg
gaatggctgcagtatagcttccccctgcagctggagccctcagccagaggttggcgggct
ggcttattgcatgtcagcaaccgacccctgctggtcaatgtgaagttcgagggcagtgag
gagagcttcaccttccaggtatccaccaaggacatgcccctcgcactgatggcctgtgcc
ctccgaaaaaaggccaccgtgttccggcagcctctggtggagaggcctgaggagtatgcc
ctgcaggtgaacgggaggcacgagtacctctacggcagctaccccctctgccactttcag
tacatctgtagctgcctgcacagcggactgactccccatctgaccatggtccactcctcc
tccatcctcgccatgagggatgagcagagcaaccctgccccccaggtgcagaagccacga
gtcaaacctcccccgatccctgccaagaagccctcctctgtgtccctgtggtccctggaa
cagccattctgcattgagctgattgagggccgcaaggtgaatgcggatgaaaggatgaag
ctggttgtgcaggccgggctcttccacggcaatgagatgctgtgcaagactgtgtcgagc
tcagaggtgaatgtgtgctcagagcccgtgtggaagcagcgactagaattcgacatcagc
atctgtgacctcccccgaatggcccggctctgctttgcactctatgctgtcgtggagaag
gctaagaaggcgcgctccacaaagaagaagtccaagaaggcggactgtcccatcgcttgg
gccaacctcatgctattcgactacaaagatcagctcaagacgggcgaacggtgcctctac
atgtggccctctgtcccagatgagaaaggggaactgatgaatcctgcgggtacagtacgt
ggtaaccccaacacagagagtgccgctgccctggtcatctacctacctgaggtggctccc
caccctgtgtacttccctgctctggagaagatcctggagctggggcgtcacggggagcgt
gggcgcatcacagaggaggagatgctctatttgctgtgctcctggcccgagcttcctgtg
ctgagcgccctggagcttctggactttagttttcctgactgctacgtgggttccttcgcc
atcaagtccctacggaagctgacggatgacgagcttttccagtaccttctgcagctggta
caagtactcaaatatgagtcctacctggactgcgagttgaccaaattcttgttgggccga
gccctggctaaccgcaagatcgggcacttcctgttctggcacctccgctctgagatgcat
gtaccgtccgtggccctgcgttttggcctcatcatggaagcctactgcagaggcagcacc
caccacatgaaggtgctgatgaagcagggggaggcactgagcaagcttaaggccctgaat
gactttgtgaaggcgagctcgcagaagaccaccaagccccagaccaaggagatgatgcat
atgtgtatgcgccaggagacttacatggaggcgctgtcccacctgcagtctcccctcgac
cccagcaccctgctggaggaagtctgtgtggagcagtgcaccttcatggactccaaaatg
aagccattgtggatcatgtacagcagcgagaaggcaggcggtgccggcagcgtgggcatc
atctttaagaacggggatgacctccgccaggacatgctgactctgcagatgatccagctc
atggacttcctatggaagcaggagggcctggacctgaggatgaccccctatggctgcctc
cccaccggagatcgcacaggcctcattgaggtggtcctccactcggacaccatcgccaac
atccagctgaataaaagcaacatggcagccacggctgcgttcaacaaggacgctctgctc
aactggctcaagtctaagaaccctggggaggctctggatcgggccattgaggaattcacc
ctctcctgtgctggctactgtgtggccacatatgtgctgggcatcggtgaccggcacagc
gataacatcatgatcagagagagtgggcagcttttccacattgactttggccactttctg
gggaacttcaagaccaagttcgggatcaaccgggagcgtgtccccttcattctcacctac
gactttgtccacgtgatccagcaggggaagactaacaacagtgagaaatttgaaaggttc
cgaggctactgtgaacgagcctacaccatcctgcggcgtcacgggctgcttttccttcat
ctcttcgccctcatgcgcgcagcaggtctgcctgagcttagctgctccaaagacatccag
actctctggcactag

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