Rattus norvegicus (rat): 60581 Help Entry 60581             CDS       T01003                                  Symbol Acaca Name (RefSeq) acetyl-CoA carboxylase 1   KO K11262   acetyl-CoA carboxylase / biotin carboxylase 1 [EC:6.4.1.2 6.3.4.14 2.1.3.15] Organism rno  Rattus norvegicus (rat) Pathway rno00061   Fatty acid biosynthesis rno00620   Pyruvate metabolism rno00640   Propanoate metabolism rno01100   Metabolic pathways rno01212   Fatty acid metabolism rno04152   AMPK signaling pathway rno04910   Insulin signaling pathway rno04922   Glucagon signaling pathway rno04936   Alcoholic liver disease Module rno_M00082   Fatty acid biosynthesis, initiation Brite KEGG Orthology (KO) [BR:rno00001]  09100 Metabolism   09101 Carbohydrate metabolism    00620 Pyruvate metabolism     60581 (Acaca)    00640 Propanoate metabolism     60581 (Acaca)   09103 Lipid metabolism    00061 Fatty acid biosynthesis     60581 (Acaca)   09110 Biosynthesis of other secondary metabolites    00254 Aflatoxin biosynthesis     60581 (Acaca)  09130 Environmental Information Processing   09132 Signal transduction    04152 AMPK signaling pathway     60581 (Acaca)  09150 Organismal Systems   09152 Endocrine system    04910 Insulin signaling pathway     60581 (Acaca)    04922 Glucagon signaling pathway     60581 (Acaca)  09160 Human Diseases   09167 Endocrine and metabolic disease    04936 Alcoholic liver disease     60581 (Acaca) Enzymes [BR:rno01000]  2. Transferases   2.1  Transferring one-carbon groups    2.1.3  Carboxy- and carbamoyltransferases     2.1.3.15  acetyl-CoA carboxytransferase      60581 (Acaca)  6. Ligases   6.3  Forming carbon-nitrogen bonds    6.3.4  Other carbon-nitrogen ligases     6.3.4.14  biotin carboxylase      60581 (Acaca)   6.4  Forming carbon-carbon bonds    6.4.1  Ligases that form carbon-carbon bonds (only sub-subclass identified to date)     6.4.1.2  acetyl-CoA carboxylase      60581 (Acaca) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  ACC_central Carboxyl_trans CPSase_L_D2 ACCA_BT Biotin_carb_N Biotin_carb_C Biotin_lipoyl ATP-grasp Dala_Dala_lig_C ATP-grasp_3 MetallophosN Motif Other DBs NCBI-GeneID:  60581 NCBI-ProteinID:  NP_071529 RGD:  621248 Ensembl:  ENSRNOG00000034013 UniProt:  P11497 D3ZRA3 LinkDB All DBs Position 10:69511627..69773888 Genome browser AA seq 2345 aa AA seqDB search MDEPSPLAKTLELNQHSRFIIGSVSEDNSEDEISNLVKLDLEEKEGSLSPASVSSDTLSD LGISALQDGLAFHMRSSMSGLHLVKQGRDRKKIDSQRDFTVASPAEFVTRFGGNKVIEKV LIANNGIAAVKCMRSIRRWSYEMFRNERAIRFVVMVTPEDLKANAEYIKMADHYVPVPGG ANNNNYANVELILDIAKRIPVQAVWAGWGHASENPKLPELLLKNGIAFMGPPSQAMWALG DKIASSIVAQTAGIPTLPWSGSGLRVDWQENDFSKRILNVPQDLYEKGYVKDVDDGLKAA EEVGYPVMIKASEGGGGKGIRKVNNADDFPNLFRQVQAEVPGSPIFVMRLAKQSRHLEVQ ILADQYGNAISLFGRDCSVQRRHQKIIEEAPAAIATPAVFEHMEQCAVKLAKMVGYVSAG TVEYLYSQDGSFYFLELNPRLQVEHPCTEMVADVNLPAAQLQIAMGIPLFRIKDIRMMYG VSPWGDAPIDFENSAHVPCPRGHVIAARITSENPDEGFKPSSGTVQELNFRSNKNVWGYF SVAAAGGLHEFADSQFGHCFSWGENREEAISNMVVALKELSIRGDFRTTVEYLIKLLETE SFQLNRIDTGWLDRLIAEKVQAERPDTMLGVVCGALHVADVNLRNSISNFLHSLERGQVL PAHTLLNTVDVELIYEGIKYVLKVTRQSPNSYVVIMNGSCVEVDVHRLSDGGLLLSYDGS SYTTYMKEEVDRYRITIGNKTCVFEKENDPSVMRSPSAGKLIQYIVEDGGHVFAGQCYAE IEVMKMVMTLTAVESGCIHYVKRPGAALDPGCVIAKMQLDNPSKVQQAELHTGSLPQIQS TALRGEKLHRVFHYVLDNLVNVMNGYCLPDPFFSSKVKDWVERLMKTLRDPSLPLLELQD IMTSVSGRIPLNVEKSIKKEMAQYASNITSVLCQFPSQQIANILDSHAATLNRKSEREVF FMNTQSIVQLVQRYRSGIRGHMKAVVMDLLRQYLRVETQFQNGHYDKCVFALREENKSDM NTVLNYIFSHAQVTKKNLLVTMLIDQLCGRDPTLTDELLNILTELTQLSKTTNAKVALRA RQVLIASHLPSYELRHNQVESIFLSAIDMYGHQFCIENLQKLILSETSIFDVLPNFFYHS NQVVRMAALEVYVRRAYIAYELNSVQHRQLKDNTCVVEFQFMLPTSHPNRGNIPTLNRMS FASNLNHYGMTHVASVSDVLLDNAFTPPCQRMGGMVSFRTFEDFVRIFDEVMGCFCDSPP QSPTFPESGHTSLYDEDKVPRDEPIHILNVAIKTDGDIEDDRLAAMFREFTQQNKATLVE HGIRRLTFLVAQKDFRKQVNCEVDQRFHREFPKFFTFRARDKFEEDRIYRHLEPALAFQL ELNRMRNFDLTAIPCANHKMHLYLGAAKVEVGTEVTDYRFFVRAIIRHSDLVTKEASFEY LQNEGERLLLEAMDELEVAFNNTNVRTDCNHIFLNFVPTVIMDPSKIEESVRSMVMRYGS RLWKLRVLQAELKINIRLTTTGKAIPIRLFLTNESGYYLDISLYKEVTDSRTAQIMFQAY GDKQGPLHGMLINTPYVTKDLLQSKRFQAQSLGTTYIYDIPEMFRQSLIKLWESMSTQAF LPSPPLPSDILTYTELVLDDQGQLVHMNRLPGGNEIGMVAWKMSLKSPEYPDGRDVIVIG NDITYRIGSFGPQEDLLFLRASELARAEGIPRIYVAANSGARIGLAEEIRHMFHVAWVDS EDPYKGYKYLYLTPQDYKRVSALNSVHCEHVEDEGESRYKITDIIGKEEGLGAENLRGSG MIAGESSLAYDEIITISLVTCRAIGIGAYLVRLGQRTIQVENSHLILTGAGALNKVLGRE VYTSNNQLGGIQIMHNNGVTHCTVCDDFEGVFTVLHWLSYMPKNVHSSVPLLNSKDPIDR IIEFVPTKAPYDPRWMLAGRPHPTQKGQWLSGFFDYGSFSEIMQPWAQTVVVGRARLGGI PVGVVAVETRTVELSVPADPANLDSEAKIIQQAGQVWFPDSAFKTYQAIKDFNREGLPLM VFANWRGFSGGMKDMYDQVLKFGAYIVDGLRECSQPVMVYIPPQAELRGGSWVVIDPTIN PRHMEMYADRESRGSVLEPEGTVEIKFRKKDLVKTMRRVDPVYIRLAERLGTPELSPTER KELESKLKEREEFLIPIYHQVAVQFADLHDTPGRMQEKGVINDILDWKTSRTFFYWRLRR LLLEDLVKKKIHSANPELTDGQIQAMLRRWFVEVEGTVKAYVWDNNKDLVEWLEKQLTEE DGVRSVIEENIKYISRDYVLKQIRSLVQANPEVAMDSIVHMTQHISPTQRAEVVRILSTM DSPST NT seq 7038 nt NT seq  +upstreamnt  +downstreamnt atggatgaaccatctccgttggccaaaaccctggagctgaaccagcactcccgattcata attgggtccgtgtctgaagacaactcagaagatgagatcagtaacctggtaaagctggac ctagaggagaaggagggctccctgtcaccagcctctgtcagctcagatacactttctgat ttgggaatctctgccttacaggatggtttggcctttcacatgaggtccagcatgtccggc ttgcacctagtaaaacaaggtcgagacagaaagaaaatagactctcaacgagatttcact gtggcttcgccagcagaatttgttactcgttttgggggaaataaagtgattgagaaggtt cttatcgccaacaatggtattgcagcagtgaaatgcatgcgatctatccggcggtggtct tatgaaatgttccgcaatgaacgtgccatccggtttgttgtcatggttacacccgaagac cttaaagccaatgcagaatacattaagatggcggatcactatgttccagtgcctggagga gcaaacaacaacaattatgcaaatgtggaattgattcttgatattgcgaaaaggatacct gtacaggcagtgtgggctggctggggtcatgcctccgagaaccccaagctcccggagcta ctcttaaaaaatggcattgctttcatgggccctccgagtcaggccatgtgggcgttgggg gataagattgcatcgtctattgtggctcaaactgcaggtatccccactcttccctggagt ggcagtggtcttcgagtggattggcaagaaaatgatttttcgaaacgcatcttaaatgtt ccacaggatctgtatgagaaaggctatgtgaaggatgtggatgatggactgaaggcagcc gaggaggttggctatccagtgatgatcaaggcctcagagggaggaggagggaagggaatc agaaaagttaacaatgcagatgacttccctaacctcttcagacaggttcaagctgaagtc cctggatcacctatatttgtaatgagattagcaaaacagtctcgtcatctggaggtccag attctggcggatcagtatggcaatgcaatttctttgtttggtcgtgactgctctgtacaa cgcaggcatcagaagatcattgaagaagctcctgctgctattgctaccccagcagtattt gaacacatggaacagtgtgctgtaaaacttgccaaaatggttggttatgtgagcgctggg actgtggaatacttgtacagccaggacggaagcttctacttcttggaactgaaccctcgg ctacaggttgaacatccttgtacagagatggtggctgatgtcaatcttcctgcagcacag ctccagattgccatggggatccctctatttaggatcaaggatattcgtatgatgtatggg gtatctccttggggtgatgctcccattgattttgaaaattctgctcatgttccttgccca aggggccatgtgattgctgctcggatcaccagtgaaaacccagatgaggggtttaagccc agctctggaacagttcaggaacttaattttcgcagcaataagaatgtttggggttatttc agtgttgctgctgctgggggacttcatgaatttgctgattctcagttcggtcactgcttt tcctggggagaaaacagagaagaagcaatttcaaatatggtggtggcattgaaggagctg tctattcggggtgactttcgaactacagtagaatacctcatcaagctgctggagacagaa agctttcagttgaacagaatcgacactggctggctggacagactgattgcagagaaagtg caggcagagcgtcctgacaccatgttgggagttgtgtgtggggctcttcatgtggcagat gtgaacctgagaaatagcatctctaacttccttcactccttagagaggggtcaagtcctt cctgctcacacacttctgaacacagtagatgttgaacttatctatgaaggaatcaaatat gtacttaaggtgactcggcagtctcccaactcctacgtggtgataatgaacggctcgtgt gtggaagtggacgtgcaccggctgagtgatggtggactgctcttgtcctacgatggcagc agttacaccacatacatgaaggaggaggtagacagataccgaatcacaattggcaataaa acctgtgtgtttgagaaggaaaatgacccgtctgtaatgcgctccccgtctgctgggaag ttaatccagtatattgtggaagatggaggccatgtgtttgctggccagtgctatgcagag attgaggtaatgaagatggtaatgactttgacagctgtagaatctggctgcatccattat gtcaagcgacctggagcagcacttgacccaggctgtgtgatagccaaaatgcagctggac aatcccagtaaagttcaacaggctgagcttcacacgggcagtctgccccagatccagagc acagctctccgaggcgaaaagctccatcgagttttccactatgtcctggataacctggtc aatgtgatgaatggatactgccttccagaccctttcttcagcagcaaggtaaaggactgg gtagaacggttaatgaagactctgagagacccctccctgcctcttctagaattgcaggat atcatgaccagtgtctctggccggatccccctcaacgtggagaagtctattaagaaggaa atggctcagtatgctagcaacatcacatcggtcctgtgtcagtttcccagccagcagatt gccaacatcctagatagtcatgcagctacactgaaccggaaatcggagcgggaagtcttc ttcatgaacacccagagcattgtccagctggtgcagaggtaccgaagtggcatccgtggc cacatgaaggctgtggtgatggatctgctccggcagtacctgcgggtggagacacagttt cagaatggccactacgacaaatgtgtattcgcccttcgggaagagaacaaaagtgacatg aacaccgtactgaactacatcttctcccacgcccaggtcaccaagaagaatctcctggtg acaatgcttattgatcagttgtgtggccgggaccctacacttactgatgagctgctaaac atcctcacagagctaactcagctcagcaaaaccaccaacgccaaagtggcactgcgggct cgccaggttcttattgcctcccatttgccatcgtacgagcttcgccataaccaagtagag tccatcttcttatcagccatcgacatgtatggacaccagttttgcattgagaacctgcag aaactcatcctatcagaaacatctattttcgatgtcctcccaaactttttttaccacagc aaccaggtggtgaggatggcggctctggaggtatatgttcgaagagcttatatcgcctat gagctcaacagtgtacagcatcgccagcttaaggacaacacctgtgtggtagaatttcag ttcatgctgcccacatctcatccaaacagagggaacatccccacgctaaacagaatgtcc tttgcctccaacctcaaccactacggcatgactcatgtagctagtgtcagcgatgttctg ttggacaacgccttcacaccaccttgtcaacgcatgggcgggatggtctctttccggacc tttgaagatttcgtcaggatctttgatgaagtaatgggctgcttctgcgactccccaccc caaagccccacattcccagagtccggtcacacttcactctatgatgaggacaaggtcccc agggacgaaccaatacatattctgaatgtggctatcaagactgatggcgatattgaggat gacaggcttgcagctatgttcagagagttcacccaacagaataaagctactctggttgag catgggatccggcgacttacgttcctagttgcacaaaaggatttcagaaaacaagtcaac tgtgaggtggatcagagatttcatagagaattccccaaatttttcacattccgagcaagg gataagtttgaggaggaccgcatttatcgacatctggagcctgctctggctttccagtta gagctgaaccggatgagaaattttgaccttactgccattccatgcgctaatcacaagatg cacctgtaccttggggctgctaaggtggaagtaggcacagaagtgactgactacaggttc tttgttcgtgcgatcatcaggcactctgatctggtcacgaaggaagcttcttttgaatat ctacaaaatgaaggagagcgactgctcctggaagccatggatgaattggaagttgctttc aataacacaaatgttcgcacagactgtaaccatatattcctcaactttgtgcccacagtc atcatggacccatcaaagattgaagaatctgtgcggagcatggtaatgcgctatggaagc cggctgtggaaattgcgggtcctccaggcagaactgaaaatcaacattcgcctgacaaca actggaaaagcgattcccatccgcctcttcctgacaaacgagtctggctactacttggac atcagcctgtataaggaagtgactgactccaggacagcacagatcatgtttcaggcgtat ggagacaagcagggaccactgcatggaatgttaatcaatactccgtatgtgaccaaagac cttcttcaatcaaagaggtttcaggcacagtccttgggaacaacgtatatatatgatatc ccagagatgtttcggcagtcgctcatcaagctctgggagtccatgtccactcaagcattt cttccttcaccccctttgccttccgacatactgacgtatactgaactggtgttggatgat caaggccagcttgtccatatgaacagacttccaggaggaaacgagattggcatggtagcc tggaaaatgagccttaaaagccctgaatatccagatggccgagatgtcattgtcatcggc aatgacattacatatcggattggctcctttgggcctcaggaagatttgctgtttctcaga gcttctgaacttgccagagcagaaggcatcccacgcatctacgtagcagccaacagtgga gctagaattggactggcagaagaaatccgtcatatgttccacgtggcctgggtagactct gaggatccttacaagggatacaagtatttatatctgacaccccaggattataaaagagtg agtgctctcaattctgtccactgtgaacatgtggaagatgaaggagaatccaggtacaag ataacagacattatcgggaaagaagaaggacttggagcagagaaccttcggggttctgga atgattgctggggaatcctcattggcttatgatgagatcatcaccatcagcctggttaca tgccgggccattggtattggggcttaccttgtccggctgggacaaagaaccatccaggtt gagaactctcacttaattctaacaggagccggtgccctcaacaaagtccttggtcgggaa gtatacacctccaacaatcagcttgggggcatccagataatgcacaacaacggagttacc cattgcactgtttgtgatgactttgagggagtgttcacagtcttacactggctgtcatac atgcctaagaacgtgcacagttcagttcctctcctgaattccaaggatcctatagataga atcatcgagtttgttcccacaaaggccccgtatgatcctcggtggatgctggcaggccgt cctcacccaacccagaaaggccaatggttgagtggattttttgattatggctctttctca gaaatcatgcagccctgggcgcagaccgtggtagttggcagagccaggttggggggaata cctgtgggagtagttgctgtagaaacccgaaccgtggagctcagtgtaccagctgatcct gcaaacctggattctgaagccaagataatccagcaggccggccaagtttggtttccagac tctgcatttaagacctatcaagctatcaaggactttaaccgtgaagggctacctctaatg gtctttgccaactggagaggcttctctggtgggatgaaagatatgtatgaccaggtgctc aagtttggtgcttatattgtggatggcttgcgggaatgttcccagcctgtgatggtctac attcccccacaggctgagcttcggggtggttcttgggttgtgatcgacccaaccatcaat cctcggcacatggagatgtatgctgaccgggaaagcaggggatccgttctggaaccagaa gggacagtagaaatcaaattccgcaaaaaggatctggtgaaaaccatgcgtcgcgtagac ccagtctacatccgcttggctgagcgactgggcaccccagagctaagccccactgagcgg aaggagctggagagcaagttgaaggagcgggaggagttcctaattcccatttaccatcag gtagctgtgcagtttgctgacttgcacgacaccccaggccggatgcaggagaagggtgtc attaatgatatcttagattggaaaacatcccgcaccttcttctactggcgactgaggcgt ctcctgctggaagacctggtcaagaagaaaatccacagtgccaaccctgagctgaccgat ggccagatccaggccatgttgagacgctggtttgtggaagtggaaggcacagtgaaggct tacgtctgggacaataataaggatctggtggaatggctggagaagcagctgacagaggaa gatggtgtccgctctgtgatagaggagaacatcaaatacatcagcagggactatgtcctc aagcagatccgcagcttggtgcaggccaatccagaagttgccatggactccatcgtccac atgacccagcacatctcccccactcagcgagcagaggttgtaaggatcctttccactatg gactccccttctacgtag

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