Rattus norvegicus (rat): 63885
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Entry
63885 CDS
T01003
Symbol
Pde10a
Name
(RefSeq) cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform 1
KO
K18438
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10 [EC:
3.1.4.17
3.1.4.35
]
Organism
rno
Rattus norvegicus (rat)
Pathway
rno00230
Purine metabolism
rno01100
Metabolic pathways
rno04024
cAMP signaling pathway
rno05032
Morphine addiction
Brite
KEGG Orthology (KO) [BR:
rno00001
]
09100 Metabolism
09104 Nucleotide metabolism
00230 Purine metabolism
63885 (Pde10a)
09130 Environmental Information Processing
09132 Signal transduction
04024 cAMP signaling pathway
63885 (Pde10a)
09160 Human Diseases
09165 Substance dependence
05032 Morphine addiction
63885 (Pde10a)
Enzymes [BR:
rno01000
]
3. Hydrolases
3.1 Acting on ester bonds
3.1.4 Phosphoric-diester hydrolases
3.1.4.17 3',5'-cyclic-nucleotide phosphodiesterase
63885 (Pde10a)
3.1.4.35 3',5'-cyclic-GMP phosphodiesterase
63885 (Pde10a)
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GFIT
Motif
Pfam:
PDEase_I
GAF
GAF_2
GAF_3
SpoVT_C
HD
DUF7334
Motif
Other DBs
NCBI-GeneID:
63885
NCBI-ProteinID:
NP_071572
RGD:
68434
Ensembl:
ENSRNOG00000011310
UniProt:
Q9QYJ6
Structure
PDB
PDBj
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Position
1:complement(54313343..54765668)
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AA seq
794 aa
AA seq
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MEDGPSNNASCFRRLTECFLSPSLTDEKVKAYLSLHPQVLDEFVSESVSAETVEKWLKRK
NNKAEDEPSPKEVSRYQDTNMQGVVYELNSYIEQRLDTGGDNHLLLYELSSIIRIATKAD
GFALYFLGECNNSLCVFTPPGMKEGQPRLIPAGPITQGTTISAYVAKSRKTLLVEDILGD
ERFPRGTGLESGTRIQSVLCLPIVTAIGDLIGILELYRHWGKEAFCLSHQEVATANLAWA
SVAIHQVQVCRGLAKQTELNDFLLDVSKTYFDNIVAIDSLLEHIMIYAKNLVNADRCALF
QVDHKNKELYSDLFDIGEEKEGKPVFKKTKEIRFSIEKGIAGQVARTGEVLNIPDAYADP
RFNREVDLYTGYTTRNILCMPIVSRGSVIGVVQMVNKISGSAFSKTDENNFKMFAVFCAL
ALHCANMYHRIRHSECIYRVTMEKLSYHSICTSEEWQGLMHFNLPARICRDIELFHFDIG
PFENMWPGIFVYMIHRSCGTSCFELEKLCRFIMSVKKNYRRVPYHNWKHAVTVAHCMYAI
LQNNNGLFTDLERKGLLIACLCHDLDHRGFSNSYLQKFDHPLAALYSTSTMEQHHFSQTV
SILQLEGHNIFSTLSSSEYEQVLEIIRKAIIATDLALYFGNRKQLEEMYQTGSLNLHNQS
HRDRVIGLMMTACDLCSVTKLWPVTKLTANDIYAEFWAEGDEMKKLGIQPIPMMDRDKRD
EVPQGQLGFYNAVAIPCYTTLTQILPPTEPLLKACRDNLNQWEKVIRGEETAMWISGPAT
SKSTSEKPTRKVDD
NT seq
2385 nt
NT seq
+upstream
nt +downstream
nt
atggaagatggaccctctaacaatgcgagttgcttccgaaggctgaccgagtgtttcctc
agccccagtttgacggatgaaaaggtgaaggcctatctttccctccatccccaggtatta
gacgagtttgtttctgaaagtgttagtgcggagaccgtggagaagtggctgaagaggaaa
aacaacaaagcagaagatgaaccatctcctaaggaagtcagcaggtaccaggacacgaac
atgcagggagtcgtgtacgagctgaacagctacatagagcagcgcctggacaccggcggg
gacaaccacctgctcctgtacgagctaagcagtatcatcaggatagccacaaaagccgac
ggatttgcactgtacttccttggagagtgcaataatagtctgtgtgtcttcacaccaccc
ggaatgaaggaaggtcaaccccgtctcatccccgcagggcccatcacccagggcaccacc
atctctgcctatgtggccaagtctaggaagaccctgctggtagaggacatccttggggat
gagcgatttcccagaggcactggtctggagtcaggaacccgaatccagtctgtcctttgc
ttgcctattgtcactgccattggagacttgattggcatccttgaactgtacaggcactgg
ggcaaagaggccttctgcctcagccatcaggaggttgcaaccgccaatctcgcttgggct
tccgtagcaatacaccaggtgcaggtgtgcagaggtctcgccaagcagaccgaactgaat
gacttcctgctcgatgtatcaaagacatactttgataacatagtcgccatagactctcta
cttgaacacatcatgatatatgcaaaaaatctagtgaacgccgaccgctgcgcgctcttc
caggtggaccacaagaacaaggagctgtattcggacctgtttgacattggggaggagaag
gaggggaagcccgtcttcaagaagaccaaggagatcagattttccattgagaaagggatt
gctggtcaagtggcaagaacgggagaagtcctgaacattcctgatgcctacgcagacccg
cgctttaacagggaggtggacctgtacacaggctataccacgcggaacattctgtgtatg
cccatagtgagccgcggcagcgtgatcggtgtggtgcaaatggttaacaagatcagcggc
agcgccttctccaagacggatgagaacaacttcaagatgtttgctgtcttctgcgctctg
gccctgcactgcgctaacatgtaccacaggatccgccactcagagtgcatctacagggtt
accatggagaagctgtcttaccacagcatctgcacctctgaggaatggcaaggcctcatg
cacttcaacttgccagcacgcatctgccgggacatcgagctattccactttgacattggt
cctttcgagaacatgtggcctgggatctttgtctacatgatccatcggtcttgtgggaca
tcctgttttgaacttgaaaaattgtgccgttttatcatgtctgtgaagaagaactatagg
cgggttccttaccacaactggaagcatgcagtcacggtggcgcactgcatgtacgccata
cttcaaaacaacaatggcctcttcacagaccttgagcgcaaaggcctgctaattgcctgt
ctgtgccatgacctggaccacaggggcttcagtaacagctacctgcagaaattcgaccac
cccctggctgcgttgtactccacctccaccatggagcaacaccacttctcccagacggtg
tccatcctccagctggaaggacacaacatcttctccaccctgagctccagcgagtacgag
caggtgctggagatcatccgcaaagccatcatcgccactgacctcgcactgtactttggg
aacaggaagcagttggaggagatgtaccagacagggtcgctgaacctccacaaccagtcc
catcgagaccgtgtcatcggcttgatgatgactgcctgcgatctttgctctgtgacgaaa
ctatggccagttacaaaattgacagcaaatgatatatatgcagagttctgggctgagggg
gatgagatgaagaagttggggatacagcccatccctatgatggacagagacaagcgagat
gaagtccctcaaggacagcttggattctacaatgctgtggccatcccctgctataccacc
ctgacgcagatcctcccacccacagagcctctgctgaaggcctgcagggataacctcaat
cagtgggagaaggtaattcgaggggaagagacagcaatgtggatttcaggcccagcaact
agcaaaagcacatctgagaagccgaccaggaaggtcgatgactga
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