Rattus norvegicus (rat): 64363
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Entry
64363 CDS
T01003
Symbol
Araf
Name
(RefSeq) serine/threonine-protein kinase A-Raf isoform 1
KO
K08845
A-Raf proto-oncogene serine/threonine-protein kinase [EC:
2.7.11.1
]
Organism
rno
Rattus norvegicus (rat)
Pathway
rno01521
EGFR tyrosine kinase inhibitor resistance
rno01522
Endocrine resistance
rno04010
MAPK signaling pathway
rno04012
ErbB signaling pathway
rno04068
FoxO signaling pathway
rno04270
Vascular smooth muscle contraction
rno04650
Natural killer cell mediated cytotoxicity
rno04720
Long-term potentiation
rno04726
Serotonergic synapse
rno04730
Long-term depression
rno04810
Regulation of actin cytoskeleton
rno04910
Insulin signaling pathway
rno04914
Progesterone-mediated oocyte maturation
rno04928
Parathyroid hormone synthesis, secretion and action
rno05010
Alzheimer disease
rno05022
Pathways of neurodegeneration - multiple diseases
rno05034
Alcoholism
rno05160
Hepatitis C
rno05161
Hepatitis B
rno05200
Pathways in cancer
rno05205
Proteoglycans in cancer
rno05208
Chemical carcinogenesis - reactive oxygen species
rno05210
Colorectal cancer
rno05211
Renal cell carcinoma
rno05212
Pancreatic cancer
rno05213
Endometrial cancer
rno05214
Glioma
rno05215
Prostate cancer
rno05218
Melanoma
rno05219
Bladder cancer
rno05220
Chronic myeloid leukemia
rno05221
Acute myeloid leukemia
rno05223
Non-small cell lung cancer
rno05224
Breast cancer
rno05225
Hepatocellular carcinoma
rno05226
Gastric cancer
Brite
KEGG Orthology (KO) [BR:
rno00001
]
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
64363 (Araf)
04012 ErbB signaling pathway
64363 (Araf)
04068 FoxO signaling pathway
64363 (Araf)
09140 Cellular Processes
09142 Cell motility
04810 Regulation of actin cytoskeleton
64363 (Araf)
09150 Organismal Systems
09151 Immune system
04650 Natural killer cell mediated cytotoxicity
64363 (Araf)
09152 Endocrine system
04910 Insulin signaling pathway
64363 (Araf)
04914 Progesterone-mediated oocyte maturation
64363 (Araf)
04928 Parathyroid hormone synthesis, secretion and action
64363 (Araf)
09153 Circulatory system
04270 Vascular smooth muscle contraction
64363 (Araf)
09156 Nervous system
04726 Serotonergic synapse
64363 (Araf)
04720 Long-term potentiation
64363 (Araf)
04730 Long-term depression
64363 (Araf)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
64363 (Araf)
05205 Proteoglycans in cancer
64363 (Araf)
05208 Chemical carcinogenesis - reactive oxygen species
64363 (Araf)
09162 Cancer: specific types
05210 Colorectal cancer
64363 (Araf)
05212 Pancreatic cancer
64363 (Araf)
05225 Hepatocellular carcinoma
64363 (Araf)
05226 Gastric cancer
64363 (Araf)
05214 Glioma
64363 (Araf)
05221 Acute myeloid leukemia
64363 (Araf)
05220 Chronic myeloid leukemia
64363 (Araf)
05218 Melanoma
64363 (Araf)
05211 Renal cell carcinoma
64363 (Araf)
05219 Bladder cancer
64363 (Araf)
05215 Prostate cancer
64363 (Araf)
05213 Endometrial cancer
64363 (Araf)
05224 Breast cancer
64363 (Araf)
05223 Non-small cell lung cancer
64363 (Araf)
09172 Infectious disease: viral
05161 Hepatitis B
64363 (Araf)
05160 Hepatitis C
64363 (Araf)
09164 Neurodegenerative disease
05010 Alzheimer disease
64363 (Araf)
05022 Pathways of neurodegeneration - multiple diseases
64363 (Araf)
09165 Substance dependence
05034 Alcoholism
64363 (Araf)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
64363 (Araf)
01522 Endocrine resistance
64363 (Araf)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
rno01001
]
64363 (Araf)
Enzymes [BR:
rno01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.1 non-specific serine/threonine protein kinase
64363 (Araf)
Protein kinases [BR:
rno01001
]
Serine/threonine kinases: TKL group
RAF family [OT]
64363 (Araf)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
PK_Tyr_Ser-Thr
Pkinase
RBD
C1_1
Kinase-like
zf-RING-like
ABC1
Pkinase_fungal
TUG-UBL1
Kdo
Motif
Other DBs
NCBI-GeneID:
64363
NCBI-ProteinID:
NP_071977
RGD:
2148
Ensembl:
ENSRNOG00000010838
UniProt:
P14056
A6JZR6
LinkDB
All DBs
Position
X:complement(3780932..3845919)
Genome browser
AA seq
604 aa
AA seq
DB search
MEPPRGPPASGAEPSRAVGTVKVYLPNKQRTVVTVRDGMSVYDSLDKALKVRGLNQDCCV
VYRLIKGRKTVTAWDTAIAPLDGEELIVEVLEDVPLTMHNFVRKTFFSLAFCDFCLKFLF
HGFRCQTCGYKFHQHCSSKVPTVCVDMSTNRRQFYHSIQDLSGGSRQQEVPSNLSVNELL
TPQGPSPFTQQRDQEHFSFPAPANPPLQRIRSTSTPNVHMVSTTAPMDSSLMQFTAQSFS
TDAAGRGGDGAPRGSPSPASVSSGRKSPHSKLPAEQRERKSLADEKKKVKNLGYRDSGYY
WEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVAQPTAEQAQAFKNEMQVLRKTR
HVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHA
KNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQD
PNPYSFQSDVYAYGVVLYELMTGSLPYSHIGSRDQIIFMVGRGYLSPDLSKIFSNCPKAM
RRLLTDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAA
RLVP
NT seq
1815 nt
NT seq
+upstream
nt +downstream
nt
atggaaccaccacgaggccctcctgctagtggggctgagccatctcgggcagttggcact
gtcaaagtgtacctgcctaacaagcaacgcacagtggtgactgtccgggatggcatgagt
gtctatgactctttggacaaggccctcaaggtgcggggtctcaatcaggactgctgtgtg
gtctacagactcatcaaaggaagaaagacagtcactgcctgggacacagccattgcacct
ctggatggcgaggagctcattgtggaggtcctggaagatgtgccactgaccatgcacaat
tttgtacggaagacattcttcagtttggccttctgtgacttctgccttaagtttctgttc
cacggctttcgctgccaaacctgtggctacaagttccaccagcattgttcctccaaggtc
cccacggtctgcgttgacatgagtaccaaccgccgacagttctaccacagcatccaggat
ttgtctggaggctccaggcagcaggaggttccctcaaatctctctgtgaatgagctgcta
accccccagggtcccagtccctttacccagcaacgtgaccaggagcacttctccttccct
gcccctgccaatcccccactgcagcgcatccgctccacatctactcctaacgtccacatg
gtcagcaccacagctcccatggactccagcctcatgcagtttactgctcagagcttcagc
accgatgctgctggtagaggtggtgatggagctcctcggggtagccctagcccagctagt
gtgtcttcagggaggaagtccccacattccaagttacctgcagaacagcgggaacggaag
tccttggcagatgaaaagaaaaaagtgaagaacctggggtaccgggactcaggctattac
tgggaggtgccacccagtgaggtacagctgttgaagaggatcgggacaggctcttttggc
actgtgtttcgggggcgttggcatggcgatgtagctgtgaaagtgctcaaggtggcccaa
cctaccgctgagcaggcccaggccttcaagaatgagatgcaggtgctcaggaagacacga
catgtcaacattttgctgtttatgggtttcatgactcggccagggtttgccatcatcaca
cagtggtgtgagggttccagcctctaccaccacctacatgtggctgacacgcgctttgac
atggtccagctcattgatgtggcccggcagactgcccagggcatggactacctccacgcc
aagaacatcattcaccgagacctaaagtccaacaatatcttcctacatgaggggctcaca
gtcaagattggtgacttcggcctggccacagtgaagacacgatggagtggggcccagccc
ttagagcagccctcagggtctgtgctgtggatggcagctgaggtgatccgaatgcaggac
ccgaacccctacagcttccagtcggatgtctatgcctatggtgttgtgctctatgagctt
atgaccggctcactgccctacagccacattggcagccgtgaccagatcatctttatggtg
ggtcgtggctatctgtctccggacctcagcaaaatcttcagtaattgccccaaagccatg
aggcgcttgctgactgactgcctcaagttccagcgggaggagcggcctctatttccccag
attctggccacgatcgagctgctgcagcggtcactccccaagattgagcggagtgcctcc
gaaccctccttgcaccgtacccaggctgatgagttgcctgcctgccttctcagcgcagcc
cgccttgtgccttag
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