Rattus norvegicus (rat): 64677
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Entry
64677 CDS
T01003
Symbol
Srd5a2
Name
(RefSeq) 3-oxo-5-alpha-steroid 4-dehydrogenase 2
KO
K12344
3-oxo-5-alpha-steroid 4-dehydrogenase 2 [EC:
1.3.1.22
]
Organism
rno
Rattus norvegicus (rat)
Pathway
rno00140
Steroid hormone biosynthesis
rno01100
Metabolic pathways
rno05215
Prostate cancer
Module
rno_M00976
C19-Steroid hormone biosynthesis, pregnenolone => testosterone => dihydrotestosterone
Brite
KEGG Orthology (KO) [BR:
rno00001
]
09100 Metabolism
09103 Lipid metabolism
00140 Steroid hormone biosynthesis
64677 (Srd5a2)
09160 Human Diseases
09162 Cancer: specific types
05215 Prostate cancer
64677 (Srd5a2)
Enzymes [BR:
rno01000
]
1. Oxidoreductases
1.3 Acting on the CH-CH group of donors
1.3.1 With NAD+ or NADP+ as acceptor
1.3.1.22 3-oxo-5alpha-steroid 4-dehydrogenase (NADP+)
64677 (Srd5a2)
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Gene cluster
GFIT
Motif
Pfam:
Steroid_dh
DUF1295
PEMT
Motif
Other DBs
NCBI-GeneID:
64677
NCBI-ProteinID:
NP_073202
RGD:
621480
Ensembl:
ENSRNOG00000027042
UniProt:
P31214
A6H9Z5
LinkDB
All DBs
Position
6:27178089..27217588
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AA seq
254 aa
AA seq
DB search
MQIVCHQVPVLAGSATLATMGTLILCLGKPASYGKHTESVSSGVPFLPARIAWFLQELPS
FVVSVGMLAWQPRSLFGPPGNVLLALFSAHYFHRTFIYSLLTRGRPFPAVLFLRATAFCI
GNGLLQAYYLVYCAEYPEEWYTDVRFSFGVFLFILGMGINIHSDYTLRQLRKPGEVIYRI
PRGGLFTYVSGANFLGEIIEWIGYALATWSVPAFAFAFFTLCFLGMQAFYHHRFYLKMFK
DYPKSRKALIPFIF
NT seq
765 nt
NT seq
+upstream
nt +downstream
nt
atgcagattgtctgccatcaggtcccggtgctggcaggtagcgccacattggccactatg
gggaccctgatcctgtgcttagggaaacctgccagttacgggaaacacacagagagtgtg
tcgtcgggagttcccttcctgccggcacgcattgcctggttcctgcaggagttgccttcc
tttgtggtgtcggtagggatgctcgcttggcagccgcgctccctcttcggaccgcccggg
aatgtcctgctggctctcttctctgcacattacttccacaggacatttatttactcgttg
ctcacaagagggaggcctttcccagcggtgctgtttttgagagccactgccttctgcata
gggaacggactccttcaagcctactacctggtttactgcgcagaataccctgaggagtgg
tacacagatgtgcggtttagctttggtgtcttcctgtttattctggggatgggaatcaac
atccacagtgactacaccctgcgccagctcaggaagcctggagaagtcatctataggatt
cctcgaggtggcttgtttacgtatgtctctggagccaatttcctgggcgagattattgaa
tggattggctacgccttggccacgtggtccgtcccagccttcgctttcgcctttttcaca
ctttgtttcctggggatgcaagccttttaccaccacaggttctaccttaagatgtttaag
gattaccccaaatctaggaaagctctcattccattcatcttttaa
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