Rattus norvegicus (rat): 687266
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Entry
687266 CDS
T01003
Symbol
Fpgs
Name
(RefSeq) folylpolyglutamate synthase, mitochondrial precursor
KO
K01930
folylpolyglutamate synthase [EC:
6.3.2.17
]
Organism
rno
Rattus norvegicus (rat)
Pathway
rno00790
Folate biosynthesis
rno01100
Metabolic pathways
rno01240
Biosynthesis of cofactors
rno01523
Antifolate resistance
rno04981
Folate transport and metabolism
Brite
KEGG Orthology (KO) [BR:
rno00001
]
09100 Metabolism
09108 Metabolism of cofactors and vitamins
00790 Folate biosynthesis
687266 (Fpgs)
09150 Organismal Systems
09154 Digestive system
04981 Folate transport and metabolism
687266 (Fpgs)
09160 Human Diseases
09176 Drug resistance: antineoplastic
01523 Antifolate resistance
687266 (Fpgs)
Enzymes [BR:
rno01000
]
6. Ligases
6.3 Forming carbon-nitrogen bonds
6.3.2 Acid-D-amino-acid ligases (peptide synthases)
6.3.2.17 tetrahydrofolate synthase
687266 (Fpgs)
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Gene cluster
GFIT
Motif
Pfam:
Mur_ligase_M
Mur_ligase_C
Motif
Other DBs
NCBI-GeneID:
687266
NCBI-ProteinID:
NP_001139597
RGD:
1587713
Ensembl:
ENSRNOG00000050780
UniProt:
A6JU77
M0R401
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Position
3:complement(36370505..36391314)
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AA seq
587 aa
AA seq
DB search
MSWARSHLCSALSLAAVSARGATMEGAAYRWLSAWPAPQEPSMEYQDAVRTLNTLQTNAS
CLEEVKRQRSDPQAQLEAMEVYLARSGLQVEDLNQLKIIHVTGTKGKGSTCAFTERILRN
YGLKTGFFSSPHLVQVRERIRINGKPISPELFTKYFWHLYQQLEEFKDDSHISMPSYFRF
LTLMAFHVFLQEKVDLAVVEVGIGGAFDCTNIIRKPVVCGVSSLGIDHTSLLGDTVEKIA
WQKGGIFKPGVPAFTVLQPEGPLAVLRDRAQQISCPLYLCPPLEALEQVGLPLSLGLEGE
HQRHNAALALQLARCWLEQQNYHDIQELKASKPSIRWQLPLAPVFRPTPHMRRGLRDTEW
PGRTQVLQRGPVTWYLDGAHTTSSVQACVHWYCQSLERSRRTDGGHEVHILLFNSTGDRD
SAALLKLLQPCHFDYAVFCPNVTEISSIGNADQQNFTVTLDQVLLRCLQHQKHWNCLAEK
QASSNLWGSCGPESARPGSLLLAPHPPQPTSTSSLVFSCISHALQWISQGRDPIFQPESP
PRNLLNHPTANSGASILREAAAIHVLVTGSLHLVGGALRLLDPSMSQ
NT seq
1764 nt
NT seq
+upstream
nt +downstream
nt
atgtcgtgggcgcggagccacctgtgctcggctctatccttggcagctgtttctgcgcgt
ggtgcaacgatggagggcgcggcgtatcggtggttgagcgcgtggccagcgccgcaggag
ccgagcatggagtatcaggatgctgtgcgcacgctcaacaccctgcaaaccaatgccagc
tgcctggaggaggtaaagcgtcaacggagtgaccctcaggcgcagctagaagctatggag
gtgtacctcgcacggagtggactgcaggtggaggatttgaaccaactaaaaattatccat
gtcactgggaccaaaggaaagggctccacctgtgccttcactgaacggatcctgcggaat
tacggcctgaaaactggcttctttagctctccccacctggtgcaggtgcgtgagcggatt
cgaatcaacgggaagcccatcagccccgaactctttaccaagtacttctggcacctctat
cagcagctggaggaattcaaggatgacagccacatttccatgccctcttacttccgcttc
ctcacactcatggctttccatgtcttcctccaagagaaggtggacctggccgtggtggaa
gtgggcattggtggggcttttgactgcaccaacatcatcagaaagccagtggtgtgtgga
gtctcctctcttggcattgaccacaccagtctgctaggagatacagtggagaaaatagca
tggcagaaagggggcatctttaagcctggtgtccctgccttcactgtgctacagccagaa
ggtcccctggccgtgctgagggatagagcccagcagatctcatgccccctgtacctgtgt
ccaccattggaagccctggagcaggttggattgccattgagcctgggcctggagggagag
caccagcggcataatgcagccttggccttgcagctggcccgttgttggctggagcagcag
aactaccatgacatccaggagctgaaggcatccaagccaagcattcggtggcagctgccg
ctggcacctgtgttccgccccacgccccacatgagacgtgggcttcgggacacagagtgg
cctggtcggacacaggtactccagcggggacctgttacctggtacctggatggcgctcat
accaccagcagtgtgcaggcctgtgtgcactggtactgccagtcactggagcgcagcaga
cgcaccgacggtgggcatgaagtacacatcttgctcttcaactccactggtgacagggac
tctgctgccctactgaagttgctgcagccctgccattttgattacgctgtcttctgcccc
aatgtgacagagatttcatccataggaaacgcagaccagcagaacttcacggtgactctg
gaccaagtgctcctccgctgcctgcagcaccagaagcattggaactgcctggcagagaaa
caggccagctccaacctctggggcagctgtggcccagagtctgcccggccaggctccctg
ctgctggcaccgcacccacctcagcccactagcacgagctcccttgttttcagctgcatc
tcccacgccttgcagtggatcagccaaggccgggatcccatctttcagcccgagagccct
ccaaggaaccttctgaaccaccccacggccaacagcggggcgagcattctccgagaggcc
gctgccatccacgtactggtcacggggagcctgcacctggtgggtggggcgctgaggctg
cttgatccctccatgtctcagtag
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