KEGG   Rattus norvegicus (rat): 81736
Entry
81736             CDS       T01003                                 
Symbol
Nfkb1
Name
(RefSeq) nuclear factor NF-kappa-B p105 subunit isoform 2
  KO
K02580  nuclear factor NF-kappa-B p105 subunit
Organism
rno  Rattus norvegicus (rat)
Pathway
rno01523  Antifolate resistance
rno04010  MAPK signaling pathway
rno04014  Ras signaling pathway
rno04024  cAMP signaling pathway
rno04062  Chemokine signaling pathway
rno04064  NF-kappa B signaling pathway
rno04066  HIF-1 signaling pathway
rno04071  Sphingolipid signaling pathway
rno04151  PI3K-Akt signaling pathway
rno04210  Apoptosis
rno04211  Longevity regulating pathway
rno04218  Cellular senescence
rno04380  Osteoclast differentiation
rno04613  Neutrophil extracellular trap formation
rno04620  Toll-like receptor signaling pathway
rno04621  NOD-like receptor signaling pathway
rno04622  RIG-I-like receptor signaling pathway
rno04623  Cytosolic DNA-sensing pathway
rno04625  C-type lectin receptor signaling pathway
rno04657  IL-17 signaling pathway
rno04658  Th1 and Th2 cell differentiation
rno04659  Th17 cell differentiation
rno04660  T cell receptor signaling pathway
rno04662  B cell receptor signaling pathway
rno04668  TNF signaling pathway
rno04722  Neurotrophin signaling pathway
rno04917  Prolactin signaling pathway
rno04920  Adipocytokine signaling pathway
rno04926  Relaxin signaling pathway
rno04931  Insulin resistance
rno04932  Non-alcoholic fatty liver disease
rno04933  AGE-RAGE signaling pathway in diabetic complications
rno04936  Alcoholic liver disease
rno05010  Alzheimer disease
rno05022  Pathways of neurodegeneration - multiple diseases
rno05030  Cocaine addiction
rno05132  Salmonella infection
rno05133  Pertussis
rno05134  Legionellosis
rno05135  Yersinia infection
rno05140  Leishmaniasis
rno05142  Chagas disease
rno05145  Toxoplasmosis
rno05146  Amoebiasis
rno05152  Tuberculosis
rno05160  Hepatitis C
rno05161  Hepatitis B
rno05162  Measles
rno05163  Human cytomegalovirus infection
rno05164  Influenza A
rno05165  Human papillomavirus infection
rno05166  Human T-cell leukemia virus 1 infection
rno05167  Kaposi sarcoma-associated herpesvirus infection
rno05168  Herpes simplex virus 1 infection
rno05169  Epstein-Barr virus infection
rno05170  Human immunodeficiency virus 1 infection
rno05171  Coronavirus disease - COVID-19
rno05200  Pathways in cancer
rno05202  Transcriptional misregulation in cancer
rno05203  Viral carcinogenesis
rno05206  MicroRNAs in cancer
rno05207  Chemical carcinogenesis - receptor activation
rno05208  Chemical carcinogenesis - reactive oxygen species
rno05212  Pancreatic cancer
rno05215  Prostate cancer
rno05220  Chronic myeloid leukemia
rno05221  Acute myeloid leukemia
rno05222  Small cell lung cancer
rno05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
rno05321  Inflammatory bowel disease
rno05415  Diabetic cardiomyopathy
rno05417  Lipid and atherosclerosis
rno05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:rno00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    81736 (Nfkb1)
   04064 NF-kappa B signaling pathway
    81736 (Nfkb1)
   04668 TNF signaling pathway
    81736 (Nfkb1)
   04066 HIF-1 signaling pathway
    81736 (Nfkb1)
   04071 Sphingolipid signaling pathway
    81736 (Nfkb1)
   04024 cAMP signaling pathway
    81736 (Nfkb1)
   04151 PI3K-Akt signaling pathway
    81736 (Nfkb1)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    81736 (Nfkb1)
   04620 Toll-like receptor signaling pathway
    81736 (Nfkb1)
   04660 T cell receptor signaling pathway
    81736 (Nfkb1)
   04658 Th1 and Th2 cell differentiation
    81736 (Nfkb1)
   04659 Th17 cell differentiation
    81736 (Nfkb1)
   04657 IL-17 signaling pathway
    81736 (Nfkb1)
   04662 B cell receptor signaling pathway
    81736 (Nfkb1)
   04062 Chemokine signaling pathway
    81736 (Nfkb1)
  09152 Endocrine system
   04917 Prolactin signaling pathway
    81736 (Nfkb1)
   04926 Relaxin signaling pathway
    81736 (Nfkb1)
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    81736 (Nfkb1)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    81736 (Nfkb1)
  09149 Aging
   04211 Longevity regulating pathway
    81736 (Nfkb1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    81736 (Nfkb1)
   05202 Transcriptional misregulation in cancer
    81736 (Nfkb1)
   05206 MicroRNAs in cancer
    81736 (Nfkb1)
   05207 Chemical carcinogenesis - receptor activation
    81736 (Nfkb1)
   05208 Chemical carcinogenesis - reactive oxygen species
    81736 (Nfkb1)
   05203 Viral carcinogenesis
    81736 (Nfkb1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    81736 (Nfkb1)
  09162 Cancer: specific types
   05212 Pancreatic cancer
    81736 (Nfkb1)
   05221 Acute myeloid leukemia
    81736 (Nfkb1)
   05220 Chronic myeloid leukemia
    81736 (Nfkb1)
   05215 Prostate cancer
    81736 (Nfkb1)
   05222 Small cell lung cancer
    81736 (Nfkb1)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    81736 (Nfkb1)
   05170 Human immunodeficiency virus 1 infection
    81736 (Nfkb1)
   05161 Hepatitis B
    81736 (Nfkb1)
   05160 Hepatitis C
    81736 (Nfkb1)
   05171 Coronavirus disease - COVID-19
    81736 (Nfkb1)
   05164 Influenza A
    81736 (Nfkb1)
   05162 Measles
    81736 (Nfkb1)
   05163 Human cytomegalovirus infection
    81736 (Nfkb1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    81736 (Nfkb1)
   05169 Epstein-Barr virus infection
    81736 (Nfkb1)
   05165 Human papillomavirus infection
    81736 (Nfkb1)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    81736 (Nfkb1)
   05133 Pertussis
    81736 (Nfkb1)
   05134 Legionellosis
    81736 (Nfkb1)
   05152 Tuberculosis
    81736 (Nfkb1)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    81736 (Nfkb1)
   05145 Toxoplasmosis
    81736 (Nfkb1)
   05140 Leishmaniasis
    81736 (Nfkb1)
   05142 Chagas disease
    81736 (Nfkb1)
  09163 Immune disease
   05321 Inflammatory bowel disease
    81736 (Nfkb1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    81736 (Nfkb1)
   05022 Pathways of neurodegeneration - multiple diseases
    81736 (Nfkb1)
  09165 Substance dependence
   05030 Cocaine addiction
    81736 (Nfkb1)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    81736 (Nfkb1)
   05418 Fluid shear stress and atherosclerosis
    81736 (Nfkb1)
   05415 Diabetic cardiomyopathy
    81736 (Nfkb1)
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    81736 (Nfkb1)
   04932 Non-alcoholic fatty liver disease
    81736 (Nfkb1)
   04931 Insulin resistance
    81736 (Nfkb1)
   04933 AGE-RAGE signaling pathway in diabetic complications
    81736 (Nfkb1)
  09176 Drug resistance: antineoplastic
   01523 Antifolate resistance
    81736 (Nfkb1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors [BR:rno03000]
    81736 (Nfkb1)
Transcription factors [BR:rno03000]
 Eukaryotic type
  beta-Scaffold factors with minor groove contacts
   RHR (Rel homology region) Rel/Ankyrin
    81736 (Nfkb1)
SSDB
Motif
Pfam: RHD_DNA_bind RHD_dimer Ank_2 Ank Ank_4 Ank_3 Ank_5 Death
Other DBs
NCBI-GeneID: 81736
NCBI-ProteinID: NP_001263640
RGD: 70498
Ensembl: ENSRNOG00000023258
LinkDB
Position
2:complement(226689745..226805897)
AA seq 972 aa
MADDDPFGTGQMFHLNTALTHSIFNAELYSTDIPLSTDGPYLQILEQPKQRGFRFRYVCE
GPSHGGLPGASSEKNKKSYPQVKICNYVGPAKVIVQLVTNGKNIHLHAHSLVGKHCEDGI
CTVTAGPKDMVVGFANLGILHVTKKKVFETLEARMTEACIRGYNPGLLVHSDLAYLQAEG
GGDRQLTDREKEIIRQAALQQTKEMDLSVVRLMFTAFLPDSTGSFTRRLEPVVSDAIYDS
KAPNASNLKIVRMDRTAGCVTGGEEIYLLCDKVQKDDIQIRFYEEEENGGVWEGFGDFSP
TDVHRQFAIVFKTPKYKDVNITKPASVFVQLRRKSDLETSEPKPFLYYPEIKDKEEVQRK
RQKLMPNFSDSFGGGSGAGAGGGGMFGSGGGGGGSTGSPGPGYGFPHYGFPAYGGIAFHP
GATKSNTGITHGTINTKFKNEPRDCAKSDDREILNPPEKETQGEGPSLFMASTKTEAIAP
ASTMEDKEEDVGFQDNLFLEKALQLAKRHANALFDYAVTGDVKMLLAVQRHLTAVQDENG
DSVLHLAIIHLHAQLVRDLLEVTSGSISDDIINMRNDLYQTPLHLAVITKQEDVVEDLLR
VGADLSLLDRWGNSVLHLAAKEGHDKILGVLLKNSKAALLINHPNGEGLNAIHIAVMSNS
LSCLQLLVAAGAEVNAQEQKSGRTALHLAVEYDNISLAGCLLLEGDALVDSTTYDGTTPL
HIAAGRGSTRLAALLKAAGADPLVENFEPLYDLDDSWEKAGEDEGVVPGTTPLDMAANWQ
VFDILNGKPYEPVFTSDDILPQGDIKQLTEDTRLQLCKLLEIPDPDKNWATLAQKLGLGI
LNNAFRLSPAPSKTLMDNYEVSGGTIKELVEALRQMGYTEAIEVIQAAFRTPETTASSPV
TTAQAHLLPLSSSSTRQHIDELRDNDSVCDSGVETSFRKLSFSESLTGDGPLLSLNKMPH
NYGQDGPIEGKI
NT seq 2919 nt   +upstreamnt  +downstreamnt
atggcagacgacgatcctttcggaactgggcaaatgtttcatttgaatactgctttgact
cactccatatttaatgcagaattatattcaacagatataccactgtcaacagatggccca
taccttcaaatactagagcaaccgaaacagagaggatttcgattccgctacgtgtgcgaa
ggcccgtcccacggagggcttcccggtgcctccagtgagaagaacaagaaatcttacccg
caggtcaaaatttgcaactatgtggggcctgcaaaggttatcgttcagttggtcacaaat
ggaaaaaatattcacctgcacgcccacagcctggtgggcaagcactgtgaggacggcata
tgcaccgtgacagcaggacccaaggacatggtggttggctttgcaaacctgggaatactt
cacgtgactaagaaaaaggtattcgaaacactggaagcacggatgacagaggcgtgtata
aggggctataaccctggacttctggtgcattctgaccttgcctatctacaggcagaaggc
ggaggagaccggcaactcacagacagagagaaggagatcatccgccaggcagctctgcag
cagaccaaggagatggacctgagtgtggtgcgcctcatgttcacagccttcctccccgac
agcacgggcagcttcactcggagactggaacctgtggtgtcagacgccatctatgacagc
aaagcccccaacgcgtccaacctgaagatcgtaagaatggacagaacagcaggctgcgtg
acgggaggggaagaaatctatcttctctgtgacaaggtccagaaagatgacatccagatt
cggttttatgaagaggaagaaaatggtggagtttgggaaggatttggggacttttccccc
acggatgttcacagacagtttgccattgtcttcaaaacaccgaagtataaggatgtcaac
attacaaagccagcttccgtgtttgttcagcttcggagaaaatcggatttggaaactagt
gaaccgaaaccctttctctactaccccgaaatcaaagacaaggaggaagtacagaggaaa
cgccagaagctcatgcccaacttctccgacagtttcggcggcggcagtggagcgggagcg
ggtggcggaggcatgttcggtagtggcggtggcggtggagggagtaccggaagtcctggc
ccagggtatggcttcccgcactatggatttcctgcttacggtgggattgcattccatccc
ggagccactaaatccaacacaggcatcacccatggcaccataaacaccaaatttaaaaac
gagcctagagattgtgccaagagtgacgacagggagattctgaatccccctgagaaagaa
acacaaggtgaggggcccagcctgttcatggccagcaccaagaccgaagcaattgccccg
gcatccaccatggaagacaaggaagaggatgtggggtttcaggataacctctttcttgag
aaggcgctgcagctcgccaagcggcatgccaacgccctcttcgactacgcggttacggga
gatgtgaagatgctgctggcggtacagcgccatctcaccgcggtgcaggatgagaacggg
gacagtgtcctacacttagccatcatccaccttcatgctcagctcgtgagggatctgcta
gaagtgacatctggttcgatctctgatgacatcatcaacatgagaaacgatctgtatcag
acacctttgcacttggccgtgatcaccaagcaggaagatgtggtggaggacttgctgagg
gttggggctgacctgagtcttctggaccgctggggcaactctgtcctgcacctagctgcc
aaagaaggacatgataaaatcctcggggtcctactcaagaacagcaaggcagcactcctt
atcaaccaccccaacggggaaggtctgaatgccattcacatagctgtgatgagcaacagc
ctgtcatgtctgcagctgcttgtggctgctggggcagaagtcaacgctcaggagcagaag
tctgggcgcacggcactgcacctggccgtggagtacgacaacatctcgttggccggctgc
ctgctcctggagggtgacgccctcgtggacagcaccacctacgatgggacgacacctcta
cacatagcagctggaagagggtccaccaggctggcagctcttctcaaagcagcaggagca
gaccccctggtggagaactttgagcctctctatgacctggacgactcttgggagaaggct
ggagaagatgagggagtagtgccaggcaccacacccctggacatggctgccaactggcag
gtatttgacatactaaatgggaaaccatatgagccagtgttcacatctgatgacatactc
ccacaaggggacattaagcagctgacagaagacacgaggctgcaactctgcaagctcttg
gaaattcctgatcccgacaagaactgggccactctggcgcagaagttaggtctggggata
ttgaacaatgccttccggctgagtcccgccccttctaaaactcttatggacaactatgag
gtctctggggggaccatcaaagagctggtggaggccctgcgacagatgggctacacagag
gccattgaagtgatccaggcagccttccgcaccccggaaaccacagcctccagccccgtg
accactgctcaggcccacttgctgcctctctcgtcctcctccacaagacagcacatagat
gagctccgagataatgacagcgtgtgtgacagtggtgtggagacatccttccgcaaactc
agcttctcggagtccctcactggagatggcccactgctatctctgaacaaaatgcctcac
aattatgggcaggatggacctatagaaggcaaaatttag

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