Rattus norvegicus (rat): 85384 Help Entry 85384             CDS       T01003                                  Symbol Sos2 Name (RefSeq) son of sevenless homolog 2   KO K03099   son of sevenless Organism rno  Rattus norvegicus (rat) Pathway rno01521   EGFR tyrosine kinase inhibitor resistance rno01522   Endocrine resistance rno04010   MAPK signaling pathway rno04012   ErbB signaling pathway rno04014   Ras signaling pathway rno04062   Chemokine signaling pathway rno04068   FoxO signaling pathway rno04072   Phospholipase D signaling pathway rno04150   mTOR signaling pathway rno04151   PI3K-Akt signaling pathway rno04510   Focal adhesion rno04540   Gap junction rno04630   JAK-STAT signaling pathway rno04650   Natural killer cell mediated cytotoxicity rno04660   T cell receptor signaling pathway rno04662   B cell receptor signaling pathway rno04664   Fc epsilon RI signaling pathway rno04714   Thermogenesis rno04722   Neurotrophin signaling pathway rno04810   Regulation of actin cytoskeleton rno04910   Insulin signaling pathway rno04912   GnRH signaling pathway rno04915   Estrogen signaling pathway rno04917   Prolactin signaling pathway rno04926   Relaxin signaling pathway rno04935   Growth hormone synthesis, secretion and action rno05034   Alcoholism rno05160   Hepatitis C rno05161   Hepatitis B rno05163   Human cytomegalovirus infection rno05165   Human papillomavirus infection rno05200   Pathways in cancer rno05205   Proteoglycans in cancer rno05206   MicroRNAs in cancer rno05207   Chemical carcinogenesis - receptor activation rno05208   Chemical carcinogenesis - reactive oxygen species rno05210   Colorectal cancer rno05211   Renal cell carcinoma rno05213   Endometrial cancer rno05214   Glioma rno05215   Prostate cancer rno05220   Chronic myeloid leukemia rno05221   Acute myeloid leukemia rno05223   Non-small cell lung cancer rno05224   Breast cancer rno05225   Hepatocellular carcinoma rno05226   Gastric cancer rno05231   Choline metabolism in cancer Brite KEGG Orthology (KO) [BR:rno00001]  09130 Environmental Information Processing   09132 Signal transduction    04014 Ras signaling pathway     85384 (Sos2)    04630 JAK-STAT signaling pathway     85384 (Sos2)    04068 FoxO signaling pathway     85384 (Sos2)    04072 Phospholipase D signaling pathway     85384 (Sos2)    04151 PI3K-Akt signaling pathway     85384 (Sos2)    04150 mTOR signaling pathway     85384 (Sos2)  09150 Organismal Systems   09151 Immune system    04650 Natural killer cell mediated cytotoxicity     85384 (Sos2)    04660 T cell receptor signaling pathway     85384 (Sos2)    04662 B cell receptor signaling pathway     85384 (Sos2)    04664 Fc epsilon RI signaling pathway     85384 (Sos2)    04062 Chemokine signaling pathway     85384 (Sos2)   09152 Endocrine system    04915 Estrogen signaling pathway     85384 (Sos2)    04917 Prolactin signaling pathway     85384 (Sos2)    04926 Relaxin signaling pathway     85384 (Sos2)    04935 Growth hormone synthesis, secretion and action     85384 (Sos2)   09156 Nervous system    04722 Neurotrophin signaling pathway     85384 (Sos2)   09159 Environmental adaptation    04714 Thermogenesis     85384 (Sos2)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     85384 (Sos2)    05206 MicroRNAs in cancer     85384 (Sos2)    05205 Proteoglycans in cancer     85384 (Sos2)    05207 Chemical carcinogenesis - receptor activation     85384 (Sos2)    05208 Chemical carcinogenesis - reactive oxygen species     85384 (Sos2)    05231 Choline metabolism in cancer     85384 (Sos2)   09162 Cancer: specific types    05210 Colorectal cancer     85384 (Sos2)    05225 Hepatocellular carcinoma     85384 (Sos2)    05226 Gastric cancer     85384 (Sos2)    05214 Glioma     85384 (Sos2)    05221 Acute myeloid leukemia     85384 (Sos2)    05220 Chronic myeloid leukemia     85384 (Sos2)    05211 Renal cell carcinoma     85384 (Sos2)    05215 Prostate cancer     85384 (Sos2)    05213 Endometrial cancer     85384 (Sos2)    05224 Breast cancer     85384 (Sos2)    05223 Non-small cell lung cancer     85384 (Sos2)   09172 Infectious disease: viral    05161 Hepatitis B     85384 (Sos2)    05160 Hepatitis C     85384 (Sos2)    05163 Human cytomegalovirus infection     85384 (Sos2)    05165 Human papillomavirus infection     85384 (Sos2)   09165 Substance dependence    05034 Alcoholism     85384 (Sos2)   09176 Drug resistance: antineoplastic    01521 EGFR tyrosine kinase inhibitor resistance     85384 (Sos2)    01522 Endocrine resistance     85384 (Sos2) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RasGEF RasGEF_N RhoGEF SOS1_NGEF_PH PH IQ_SEC7_PH RHG20_PH PH_19 Motif Other DBs NCBI-GeneID:  85384 NCBI-ProteinID:  NP_001129033 RGD:  620435 Ensembl:  ENSRNOG00000004826 UniProt:  F1MAI3 LinkDB All DBs Position 6:complement(93778971..93892161) Genome browser AA seq 1333 aa AA seqDB search MQQAPQPYEFFSEENSPKWRGLLVPALRKVQEQVHPTLSANEESLYYIEELIFQLLNKLC LAQPRTVQDVEERVQKTFPHPIDKWAIADAQSAIEKRKRRNPLLLPVDKIHPSLKEVLGY KVDYHVSLYIVAVLEYISADILKLAGNYVFNIRHYEISQQDIKVSMCADKVLMDMFDQDD DIGLVSLCEEEPCSSGELNYYDLVRTEIAEERQYLRELNMIIKVFREAFLSDKKLFKSSE IEKIFSNISDIHELTVKLLGLIEDTVEMTDESSPHPLAGSCFEDLAEEQAFDPYETLSQD ILAPEFNDHFSKLMARPAVALHFQSIADGFKEAVRYVLPRLMLVPVYHCWHYFELLKQLK ACSEEQEDRECLNQAITALMNLQGSMDRIYKQHSPRRRPGDPVCLFYNRQLRSKHLAIKK MNEIQKNIDGWEGKDIGQCCNEFIMEGPLTRIGAKHERHIFLFDGLMISCKPNHCQTRLP GYSSAEYRLKEKFVMRKIQICDKEDACEYKHAFELVSKDENSVIFAAKSAEEKNNWMAAL ISLHYRSTLDRMLDSVLLKEENEQPLRLPRPDVYRFVVTDSEENIVFEDNLQSRSGIPII KGGTVVKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLLIERFEIPDPEPTEADKL ALEKGEQPISADLKRFRKEYVQPVQLRVLNVFRHWVEHHFYDFERDLELLERLEAFISSV RGKAMKKWVESIAKIIKRKKQAQANGVSHNITFESPPPPVEWHISRAGQSETFDLMTLHP IEIARQLTLLESDLYRRVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVE AENFEERVAVLSRIVEILQVFQDLNNFNGVLEIVSAVNSVSVYRLDHTFEALQERKRRVL DDAVELSQDHFKKYLVKLKSINPPCVPFFGIYLTNILKTEEGNSDFLKRKGKDLINFSKR RKVAEITGEIQQYQNQPYCLRTEPEMRRFFENLNPMGLLSEKEFTDYLFNKSHEIEPRNC KQPPRFPRKSTFSLKSPGIRPNASRHGSTSGTFRGHPTPLEREPYKISFSRIAETELEST VSAPTSPNTPSTPPVSASSDHSVFLDVDLNSSCGSNTIFAPVLLPHSKSFFSSCGSLHKL SEEPLVPPPLPPRKKFDHDAPNSKGAMKSDDDPPAIPPRQPPPPKVKPRAPVLTGTFEGP VPSPPPPPPRDPLPDTPPPVPLRPPEHFINCPFNLQPPPLGHPHRDPDWLRDVSTCPNSP STPPPTPSPRIPRRCHLPSPSHNNLAHPPAPPVPPRQNSSPHLPKLPPKTYKRELSHPPL YRLPLFENAETPQ NT seq 4002 nt NT seq  +upstreamnt  +downstreamnt atgcagcaggcgccgcagccctacgagttcttcagcgaagagaacagcccgaaatggcgg ggactgttggtcccggccctgcggaaggttcaggagcaagtgcaccccaccctgtcggct aacgaagagtctctctattacatcgaagaactcatctttcaactgctcaataagctgtgc ctggctcaaccgaggactgttcaagatgttgaggaacgagttcaaaagacttttcctcat cctattgataaatgggcaattgctgatgcacagtctgccatagagaaacgaaaacgaaga aatcctctcttactacctgtggacaaaatccatccttccttgaaggaagttttggggtat aaagtggactaccatgtatccctctacattgtggctgtattggagtatatctcagcagat attttgaaattggctggtaattatgtttttaatatccggcattatgaaatatctcagcaa gacattaaagtgtcaatgtgtgcagataaggttttgatggacatgtttgaccaggatgac gatataggcttggtttctctctgtgaagaggaaccttgttcttctggtgagctaaactat tatgaccttgttagaactgaaatcgcagaagaaagacagtatctacgggaactgaatatg atcattaaagtattccgggaagcctttctttcagacaaaaagttgttcaagtcttctgaa attgaaaagattttcagtaacatttcagatatacatgaactgactgtgaaacttttaggt ttgattgaagacacagtagaaatgacagatgaaagcagtcctcacccgctagctggtagc tgctttgaagatttagcagaggagcaggcttttgacccctatgaaacgttatcacaggac attcttgctccagagtttaatgaccacttcagcaagttgatggccagacctgcagttgct ctgcactttcagtccattgctgacggctttaaggaggctgttcgatatgtccttccgcgc ctcatgctggtgccggtgtatcattgttggcattactttgaattattaaagcagttgaaa gcatgtagcgaagaacaggaagaccgagagtgtttgaatcaggctatcactgccctcatg aacctccaaggcagcatggaccggatttacaagcagcactcgccaaggcgccggccaggg gatcctgtttgccttttttacaatcgtcaattaagaagcaagcacctggctatcaaaaaa atgaatgaaattcagaaaaacattgatgggtgggaaggcaaagatattggacagtgttgt aatgagttcataatggaaggaccattgaccagaattggtgctaagcatgaaaggcatatt ttcctcttcgatggcttaatgatcagctgtaaacccaatcattgccagactcgacttcca gggtatagtagtgcagaatacaggttaaaagagaagtttgtcatgaggaaaattcaaatc tgtgataaagaagacgcttgtgaatacaaacatgcttttgaattagtatccaaagatgaa aacagtgtaatatttgctgccaagtcagctgaagagaaaaacaactggatggcagccctt atctcccttcactatcggagcactctagatagaatgctggactctgtgttactgaaagag gagaacgagcagcccctgcggctaccgcggccagacgtgtaccgcttcgtggtgacagac tcagaggagaacatagtttttgaagacaacttgcaaagcagaagtggaatccccattatt aaaggaggcaccgtggtgaaactgatcgaaaggctaacatatcacatgtatgcagatccc aattttgttcgtactttccttactacgtatcgttcattttgtaagccacaggaattgcta agcttgctgatagaacggtttgaaattccagatccagagcctactgaggccgacaaactg gcgctagagaaaggcgagcagccaatcagcgcagatctgaaaagattccgcaaggaatat gtccaacccgtgcaacttagggtcttgaatgtctttcgccactgggttgagcatcatttt tatgactttgaaagagacttggaattgcttgaaagactggaagccttcatttcaagtgta agagggaaagccatgaagaagtgggtagaatccattgctaaaatcatcaagaggaagaag caagctcaggccaatggagtaagccataatatcacctttgaaagtccgcctccaccggtt gaatggcacataagtagggcgggacagtctgaaacctttgaccttatgacacttcatccc atagagattgcacggcagttaacactcttggaatctgatctctacaggagagtccagcct tctgaacttgtagggagtgtctggaccaaagaagataaagaaataaattctccaaatcta ttaaaaatgattcgccatacaacaaacctcactttgtggtttgaaaaatgcattgtggaa gcagaaaactttgaagaacgggtggcagtgctcagcagaatagtagaaattctgcaagtg tttcaagatctgaataatttcaatggcgtgttggagatagtcagtgcagtcaattcagtg tcagtgtacagactagaccacacatttgaggcattgcaggaaaggaagcggagagttttg gatgacgctgtggaattaagtcaggatcactttaaaaaatacctagtaaaacttaaatca atcaatccaccttgtgtgcctttttttggaatatatttaacaaatattctgaagactgaa gaagggaacagcgactttctaaagaggaaagggaaagatttgatcaatttcagtaagagg agaaaagtggctgaaataaccggagagattcagcagtatcagaaccaaccatactgctta cggacagaaccagagatgaggagattctttgaaaacctcaatcccatgggacttttatct gaaaaagagtttacagattatttgttcaacaaatctcatgaaattgaaccccgaaactgc aaacaaccacctcgatttcctaggaagtcaaccttttccttaaaatctcctggaataagg cccaatgccagccgccatggctctacctcaggcacgttccgaggtcacccaacccctctg gaaagggagccttataagataagctttagcaggatcgccgagacggagctagaatccacg gtgtcagcaccgacatctcccaacaccccatccaccccacctgtgtctgcttcttcagac cacagcgtgtttctagatgtggacctcaatagctcctgtggcagcaataccatctttgct ccagtcctcttgccacactcaaagtctttcttcagctcatgtggaagtctacacaaactg agtgaagagccactagttcctcctccgcttccccctcggaaaaagtttgatcacgatgct ccgaactccaagggagctatgaaatcggatgatgaccctcctgctattccaccaagacaa ccccctcctccaaaggtaaagccaagagctcctgtcctcacgggtacatttgaagggcct gtgcccagtccacctccacctcctcccagagaccctcttcctgatactcctccaccagtt cctcttcggcctccggaacactttataaactgtccgtttaatctccagccgcctccgctg ggacatcctcacagagacccagactggctcagagacgttagcacatgccctaattcacca agcactcctccccctacgccctcgccacggattccacgcagatgccatttgcccagcccc agtcacaacaatcttgctcaccctccagctcctcccgttccaccaaggcagaattcaagc cctcacctaccaaaactgccaccaaagacttacaagcgggagctttcacacccgccattg tacagactacctttgtttgaaaatgcagaaactcctcagtga

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