Rhinopithecus roxellana (golden snub-nosed monkey): 104664577
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Entry
104664577 CDS
T03989
Symbol
LRRK2
Name
(RefSeq) leucine-rich repeat serine/threonine-protein kinase 2 isoform X1
KO
K08844
leucine-rich repeat kinase 2 [EC:
2.7.11.1
]
Organism
rro
Rhinopithecus roxellana (golden snub-nosed monkey)
Pathway
rro05012
Parkinson disease
rro05022
Pathways of neurodegeneration - multiple diseases
Brite
KEGG Orthology (KO) [BR:
rro00001
]
09160 Human Diseases
09164 Neurodegenerative disease
05012 Parkinson disease
104664577 (LRRK2)
05022 Pathways of neurodegeneration - multiple diseases
104664577 (LRRK2)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
rro01001
]
104664577 (LRRK2)
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:
rro04131
]
104664577 (LRRK2)
09183 Protein families: signaling and cellular processes
04147 Exosome [BR:
rro04147
]
104664577 (LRRK2)
Enzymes [BR:
rro01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.1 non-specific serine/threonine protein kinase
104664577 (LRRK2)
Protein kinases [BR:
rro01001
]
Serine/threonine kinases: TKL group
LRRK family
104664577 (LRRK2)
Membrane trafficking [BR:
rro04131
]
Exocytosis
Calcium ion-dependent exocytosis
Kinases and associated proteins
104664577 (LRRK2)
Exosome [BR:
rro04147
]
Exosomal proteins
Exosomal proteins of other body fluids (saliva and urine)
104664577 (LRRK2)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
ARM_LRRK2
Beta-prop_LRRK2
ANK_LRRK2
Pkinase
PK_Tyr_Ser-Thr
LRR_8
Roc
LRR_4
COR-B
Ras
COR-A
LRR_14
LRR_9
LRR_13
Beta-prop_RSE1_2nd
WDR55
Beta-prop_WDR36-Utp21_1st
Arf
LRR_NXF1-5
Ank_2
Beta-prop_EML_2
WD40_CDC20-Fz
nSTAND3
T2SSE
AAA_22
Beta-prop_BBS7
LRR_6
ABC_tran
GTP_EFTU
AAA_7
Kdo
G-alpha
PduV-EutP
MobB
NACHT
WD40_Prp19
TrwB_AAD_bind
AAA_16
Beta-prop_THOC3
MMR_HSR1
Septin
TsaE
AAA_29
FtsK_SpoIIIE
NB-ARC
cobW
TniB
ResIII
SRPRB
WD40_WDHD1_1st
nSTAND_NTPase5
Beta-prop_WDR3_1st
AAA_23
ARM_LIN_2nd
Motif
Other DBs
NCBI-GeneID:
104664577
NCBI-ProteinID:
XP_010364413
UniProt:
A0A2K6R5W9
LinkDB
All DBs
Position
10:complement(74005790..74157662)
Genome browser
AA seq
2527 aa
AA seq
DB search
MASGSCQGCEEDEETLKKLIVRLNNVQEGKQIETLVQILEDLLVFTYSEHASKLFQGKNI
HVPLLIVLDSYMRVASVQQVGWSLLCKLIEICPGTMQSLMGPQDVGNDWEVLGVHQLILK
MLTVHNASVNLSMIGLKTLDLLLTSGKITLLILDEESDIFMLIFDAMHSFPANDEVQKLG
CKALHVLFERVSEEQLTEFVENKDYMILLSALTNFKDEEEIVLHVLHCLHSLAIPCNNVE
VLMSGNVRCYNIVVEAMKAFPISEKIQEVSCCLLHRLTLGNFFNILVLNEVHEFVVKAVQ
RYPENAALQISALSCLALLTETIFLNQDLEEKNENQENDDEGEEVKLFWLEACYKALTWH
RKNKHVQEAACWALNNLLMYQNSLHEKIGDEDGHFPAHREVMLSMLMHSSSKEVFQASAN
ALSTLLEQNVNFRKILLSKGIYLNVLELMQKHIHSPEVAESGCKMLNHLFEGSNTSLDTM
AAVVPKIITVMKSHETSLPVQLEALRAILHFIVPGMPEESREDTESHRKLNMVKKQCFKN
DIHKLVLAALNRFIGNPGIQKCGLKVISSIAHFTDALEVLSLEGAMDSVLHTLQMYPDDQ
EIQCLGLSLIGCLITKKNLCIGTGHLLAKILASSLYRFKDVAEVQTEGFQTILAILKLSA
SFSKLLVHHSFDLVIFHQMSSNIVEQKDQQFLNLCCKCFAKVAMDDDLKNVMLERACDQN
NSIMVECLLLLGADANQAKDGTSLICQVCEKESSPKLVELLLNSGSREQDVRKALTISIG
KGDSQIISLLLRRLALDVANNSICLGGFCIGKVEPSWLGPLFPDKTSNLRKQTNIASTLA
RMVIRYQMKSAIEEGATSSSDGNFFEDVLSKFDEWTFIPDSSMDSVFAQSDDLDSEGSEG
SFLVKKKSNSISVGEFHRDAVLQRCSPNLQRHSSSLGPIFDHEDLLRRKRKILSSDDSLR
SSKLQSHMRHSDSISSLASEREYITSLDLSANELRDIDALSQKCCISGHLEHLEKLELHQ
NALMSFPQQLCETLKSLTHLDLHSNKFTSFPSYLLKMSCVANLDVSRNDIGPSVVLDPAV
KCPTLKQFNLSYNQLSSVPENLADVVEKLEQLILEGNKISGICTPLRLKELKILNLSKNH
ISSLSENFLEACPKVESFSARMNFLAAMPFLPPSMTSLKLSQNKFTCIPEAILNLPHLRS
LDMSSNDIQRLPGPAHWKSLNLRELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKEI
PPEIGCLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPLDELRLNFDFKHIGCKAKDIIR
FLQQRLKKAVPYNRMKLMIVGNTGSGKTTLLQQLMKTKKSDLGMQSATVGIDVKDWPIQI
RGKRKRDLVLNVWDFAGREEFYSTHPHFMTQRALYLAVYDLSKGQAEVDAMKPWLFNIKA
RASSSPVILVGTHLDVSDEKQRKACISKITKELLNKRGFPAIRDYHFVNATEESDALAKL
RKTIINESLNFKIRDQPVVGQLIPDCYVELEKIILSERKNVPVEFPVIDQKRLLQLVREN
QLQLDENELPHAVHFLNESGVLLHFQDPALQLSDLYFVEPKWLCKIMAQILTVKVEGCPK
HPKGIISRRDVEKFLSKKRRFPKNYMSQYFKLLEKFQIALPIGEEYLLVPSSLSDHRPVI
ELPHCENSEIIIRLYEMPYFPMGFWSRLINRLLEISPYMLSGRERALRPNRMYWRQGIYL
NWSPEAYCLVGSEVLDNHPESFLKITVPSCRKGCILLGQVVDHIDSLMEEWFPGLLEIDI
CGEGETLLKKWALYSFNDGEEHQKILLDDLMKKAEEGDLLVNPDQPRLTIPISQIAPDLI
LADLPRNIMLNNDELEFEQTPEFLLGDGSFGSVYRAAYEGEEVAVKIFNKHTSLRLLRQE
LVVLCHLHHPSLISLLAAGIRPRMLVMELASKGSLDRLLQQDKASLTRTLQHRIALHVAD
GLRYLHSAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRA
PEVARGNVIYNQQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELAIQGKLPDPVKEYG
CAPWPMVEKLITKCLKENPQERPTSAQVFDILNSAELVCLTRHILLPKNVIVECMVATHH
NSRNTSIWLGCGHTDRGQLSFLDLNTEGYTSEEVAESRILCLALVHLPVQKESWIVSGTQ
SGTLLVINTEDGKKRHTLEKMTDSVTCLYCNSFSKQSKQKNFLLVGTADGNLAIFEDKTV
KLEGAAPLKILNIGNVSTPLMCLSESTNSTERNVMWGGCGTKIFSFSDDFTIQKLIETRT
SQLFSYAAFSDSNIVTVVVDTALYIAKKNSPVVEVWDKKTEKLCELIDCVHFLREVMVKV
NKESKHKMSYSGRVKALCLQKNTALWIGTGGGHILLLDLSTRRVIRIIYNFCDSVRVMMT
AQLGSLKNVMLVLGYNRKSTEGTQQQKEIQSCLTVWDINLPHEVQNLEKHIEVRKELAEK
MRGTSIE
NT seq
7584 nt
NT seq
+upstream
nt +downstream
nt
atggctagtggcagctgtcaggggtgcgaggaggacgaggaaactctgaagaagttgata
gtcaggctgaataatgtccaggaaggtaaacagatagaaacgctggtccaaatcctggag
gatctgctggtgttcacgtactccgagcacgcctccaagttatttcaaggcaaaaatatc
catgtgcctctgttgatcgtcttggactcgtatatgagagtcgcgagtgtgcagcaggtg
ggttggtcacttctgtgcaaattaatagagatctgtccaggtacaatgcaaagcttaatg
ggaccccaggatgttggaaatgattgggaagtccttggtgttcaccaattgattcttaaa
atgctaacagttcataatgccagtgtaaacttgtcaatgattggactgaagaccttagat
ctcctcctaacttcaggtaaaatcaccttactgatattggatgaagaaagtgatattttc
atgttaatttttgatgccatgcactcatttccagccaatgatgaagtccagaaacttgga
tgcaaagctttacatgtgctgtttgagagagtctcagaggagcaactgactgaatttgtt
gagaacaaagattatatgatattgttaagtgcgttaacaaattttaaagatgaagaggaa
attgtacttcatgtgctgcattgtttacattccctagcgattccttgcaataatgtggaa
gtccttatgagtggcaatgtcaggtgttataatattgtggtggaagctatgaaagcattc
cctatcagtgaaaaaattcaagaagtgagttgctgtttgctccataggcttacattaggt
aatttttttaatatcctggtattaaacgaagtccatgaatttgtggtgaaagctgttcag
cggtacccagagaacgcagcattacagatctcagcgctcagctgtttggccctcctcact
gagaccattttcttaaatcaagatttagaggaaaagaatgagaatcaagagaatgatgat
gagggggaagaagttaaattgttttggctggaagcctgttacaaagcattaacgtggcat
agaaagaacaagcatgtgcaggaggctgcatgctgggcactaaataatctccttatgtac
caaaacagtttacatgagaagattggagatgaagatggccatttcccagctcatagggaa
gtgatgctctccatgctgatgcattcttcatcaaaggaagttttccaggcatctgctaat
gcattgtcaactctcttagaacaaaatgttaatttcagaaaaatcctgttatcaaaagga
atatacctgaatgttttggagttaatgcagaagcatatacattctcctgaagtggctgaa
agtggctgtaaaatgctaaatcatctttttgaaggaagcaacacttccctggatacaatg
gcagcagtggtccccaaaataataacagttatgaaaagtcatgagacatcattaccagta
cagctggaggcacttcgagctattttacattttatagtgccaggcatgccagaagaatcc
agggaggatacagaatctcatcgtaagctaaatatggttaaaaaacagtgtttcaagaat
gatattcacaaactggtcctagcagctttgaacaggttcattggaaatcctgggattcag
aaatgtggattaaaagtaatttcttctattgcacattttactgatgcattagaggtgtta
tccctggaaggtgctatggattcagtgcttcacacactgcagatgtatccagatgaccaa
gaaattcagtgtctgggtttaagtcttataggatgcttgattacaaagaagaatttatgc
ataggaactggacatctgctggcaaaaattctggcttccagcttataccgatttaaggat
gttgctgaagtacagactgaaggatttcagacaatcttagcaatcctcaaattgtcagca
tctttttctaagctgctggtgcatcattcgtttgacttagtaatattccatcaaatgtct
tccaatatcgtggaacaaaaggatcaacagtttctaaacctctgttgcaagtgttttgca
aaagtagctatggatgatgacttaaaaaatgtgatgctagagagagcgtgtgatcagaat
aacagcatcatggttgaatgcttgcttctattgggagcagatgccaatcaagcaaaggac
ggaacttctttaatttgtcaggtatgtgagaaagagagcagtcccaaattggtggaactc
ttattgaatagtggatctcgtgaacaagatgtacgaaaagcgctgacgataagcattggg
aaaggcgacagccagatcatcagcttgctcttaaggaggctggccctggacgtggccaac
aatagcatttgccttggagggttttgtataggaaaagtcgaaccttcttggcttggtcct
ttatttccagataagacttctaatttaaggaaacaaacaaatatagcatctacactagca
agaatggtgatcagatatcagatgaaaagtgccatagaagaaggagcaacctcaagcagt
gatggaaatttttttgaagatgtgctgtctaaatttgatgaatggacctttattcctgac
tcttctatggacagtgtctttgctcagagtgatgatctagatagtgaaggaagtgaaggc
tcatttcttgtgaaaaagaaatcaaattcaattagtgtaggagaatttcaccgagatgcc
gtattacagcgttgctcaccaaatttgcaaaggcattccagttccttggggcccattttt
gatcatgaagatttactgaggagaaaaagaaaaatattatcttcagatgattcactcagg
tcatcaaaacttcaatcccatatgaggcattcagacagcatttcttctctggcttctgag
agagaatatattacatcactagacctttcagcaaatgaactaagagatattgatgcccta
agccagaaatgctgtataagtggtcatttggagcatcttgaaaagctggagcttcaccag
aatgcactcatgagctttccacaacagctatgtgaaactctgaagagtttgacacatttg
gacttgcacagtaataaatttacatcatttccttcttacttgttgaaaatgagttgtgtt
gctaaccttgatgtctctcgaaatgacattggaccctcagtggttttagatcctgcagtg
aaatgtccaactctgaaacagtttaacctgtcatataaccagctgtcttctgttcctgag
aaccttgctgatgtggtagagaaactggagcagctcattttagaaggaaataaaatatca
gggatatgcacccccttgagactgaaggaactgaagattttaaaccttagtaaaaaccac
atttcatccctatcagagaactttcttgaggcttgtcctaaagtggagagtttcagtgcc
agaatgaattttcttgctgctatgcctttcttgcctccttccatgacaagcctaaaatta
tctcaaaacaaatttacatgtattccagaagcaattttaaatcttccacacttgcggtct
ttagatatgagcagcaatgatattcaacgtctaccaggtcctgcacactggaaatctttg
aatttaagggaactcttatttagccataatcagatcagcatcttggacttgagtgaaaaa
gcatatttatggtccagagtagagaaactgcatctttctcacaataaactgaaagagatt
cctcctgagattggctgtcttgaaaatctgacatctctggatgtcagttacaacttggaa
ctaagatcctttcccaatgaaatggggaaattaagcaaaatatgggatcttcctttggat
gaactgcgtcttaactttgattttaaacatataggatgtaaagccaaagacatcataagg
tttcttcaacagcggttaaaaaaggctgtgccctataaccgaatgaaacttatgattgtt
ggaaatactgggagtggtaaaaccaccttattgcagcaattaatgaaaaccaagaaatca
gatcttggaatgcaaagtgccacagttggcatagatgtgaaagactggcctatccaaata
agaggcaaaagaaagagagatctcgttctgaatgtgtgggattttgcaggtcgtgaggaa
ttctatagtactcatcctcattttatgacgcagcgagcattgtaccttgctgtctatgac
ctcagcaaaggacaggctgaagttgatgccatgaagccttggctcttcaatataaaggct
cgcgcttcttcttcccctgtgattctcgttggcacacatttggatgtttctgatgagaag
cagcgcaaagcctgcataagtaaaatcaccaaggaactcctgaataagcgagggttccct
gctatacgagattatcactttgtgaatgccaccgaggaatctgatgctttggcaaaactt
cggaaaaccatcataaatgagagccttaatttcaagatccgagatcagcctgttgttgga
cagctgattccagactgctatgtagaacttgagaaaatcattttatcggagcgtaaaaat
gtgccagttgaatttcctgtaattgaccagaaacgattattacaactagtgagagaaaat
cagttgcagttagatgaaaatgagcttcctcacgcagttcactttctaaatgaatcagga
gtccttcttcattttcaagacccagcactgcagttaagtgacttgtattttgtggaaccc
aagtggctttgtaaaatcatggcacagattttgacagtgaaagtggaaggttgtccaaaa
caccctaagggaattatttcacgtagagatgtggaaaaatttctttcgaagaaaaggaga
tttccaaagaactacatgtcacagtattttaagctcctagaaaaattccagattgctttg
ccaataggagaagaatatttgctggttccaagcagtttgtctgaccacaggcctgtgata
gagcttccccattgtgagaactctgaaattatcatccgactatatgaaatgccttatttc
ccaatgggattttggtcgaggttaatcaatcgattacttgagatttcaccttacatgctt
tcagggagagaacgagcacttcgcccaaacagaatgtattggcgacaaggcatctactta
aattggtctcctgaagcttattgtctggtaggatctgaagtcttagacaatcacccagag
agtttcttaaaaattacagttccttcttgtagaaaaggctgtattcttttgggccaagtt
gtggaccacattgattctctcatggaggaatggtttcctgggttgctggagattgatatt
tgtggtgaaggagaaactctgttgaagaaatgggcattatatagttttaatgatggtgag
gagcatcaaaaaatcttacttgatgacttgatgaagaaagcagaggaaggagatctctta
gtaaatccagatcaaccaaggctcaccattccaatatctcagattgcccctgacttgatt
ttggctgacctgcctagaaatattatgttgaataatgatgagctggaatttgaacaaact
ccagagtttctcctaggtgatggcagttttggatcagtttatcgagcagcctatgaagga
gaagaagtggctgtgaagatttttaataaacacacatcacttaggctgttaagacaagag
ctggtggtgctttgccacctccaccaccccagtttgatatctttgctggcagctggtatt
cgtccccggatgttggtgatggagttagcctccaagggttccttggatcgcctgcttcag
caggacaaagccagcctcactagaaccctacaacacaggattgcactccatgtggctgat
ggtttgagatacctccactcagccatgattatataccgagacttgaagccccacaatgtg
ctgcttttcacactgtatcccaatgctgccatcattgcaaagattgctgactatggcatt
gctcagtactgctgtagaatggggataaaaacgtcagagggtacaccagggtttcgtgca
cctgaagttgccagaggaaatgtcatttataatcaacaagctgatgtttattcatttggt
ttgctactctatgacattttgacaactggaggtagaatagtagagggtttgaagtttcca
aatgagtttgatgaattagcaatacaaggaaaattacctgatccagttaaagaatatggt
tgtgccccatggcctatggttgaaaaattaattacaaagtgtttgaaagaaaatcctcaa
gaaaggcctacttctgcccaggtctttgacattttgaattcagctgaattagtctgtctg
acgagacacattttattacctaaaaacgtaattgttgaatgcatggttgctacacatcac
aacagcaggaatacaagcatttggctgggctgtgggcacaccgacagaggacagctctca
tttcttgacttaaatactgaaggatacacttctgaggaagttgctgagagtagaatattg
tgcttagccttggtgcatcttcctgttcaaaaagaaagctggattgtgtctgggacacag
tctggtactctcctggtcatcaataccgaagatgggaaaaagagacataccctagaaaag
atgactgattccgtcacttgtttgtattgcaattccttttccaagcaaagcaaacaaaaa
aattttcttttggttggaaccgctgatggcaatttagcaatttttgaagataagactgtt
aagcttgaaggagctgctcctttgaagatactaaatataggaaatgtcagtactccattg
atgtgtttgagtgaatccacaaattcaacagaaagaaatgtaatgtggggaggatgtggc
acaaagattttctccttttctgatgatttcaccattcagaaactcattgagacaagaaca
agccaactgttttcttatgcagctttcagtgattccaacatcgtaacagtggtggtagac
actgctctctatattgctaagaaaaatagccctgttgtggaagtgtgggataagaaaact
gaaaaactctgcgaactaatagactgtgtgcactttttaagggaggtaatggtaaaagta
aacaaggaatcaaaacacaaaatgtcttattctgggagagtgaaagctctctgccttcag
aagaacactgctctttggataggaactggaggaggccatattttactcctggatctttca
actcgtcgagttatacgtataatttacaacttttgtgattcggtcagagtcatgatgaca
gcacagctagggagccttaaaaatgtcatgctggtattgggctataaccggaaaagtact
gaaggtacacaacagcagaaagagatacaatcttgcttgactgtttgggacatcaatctt
ccacatgaagtgcaaaatttagaaaaacacattgaagtgagaaaagaattagctgaaaaa
atgagaggaacatctattgaataa
DBGET
integrated database retrieval system
