KEGG   Rhinopithecus roxellana (golden snub-nosed monkey): 104673127
Entry
104673127         CDS       T03989                                 
Symbol
PLCB3
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3
  KO
K05858  phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
rro  Rhinopithecus roxellana (golden snub-nosed monkey)
Pathway
rro00562  Inositol phosphate metabolism
rro01100  Metabolic pathways
rro04015  Rap1 signaling pathway
rro04020  Calcium signaling pathway
rro04022  cGMP-PKG signaling pathway
rro04062  Chemokine signaling pathway
rro04070  Phosphatidylinositol signaling system
rro04071  Sphingolipid signaling pathway
rro04072  Phospholipase D signaling pathway
rro04081  Hormone signaling
rro04082  Neuroactive ligand signaling
rro04261  Adrenergic signaling in cardiomyocytes
rro04270  Vascular smooth muscle contraction
rro04310  Wnt signaling pathway
rro04371  Apelin signaling pathway
rro04540  Gap junction
rro04611  Platelet activation
rro04613  Neutrophil extracellular trap formation
rro04621  NOD-like receptor signaling pathway
rro04713  Circadian entrainment
rro04720  Long-term potentiation
rro04723  Retrograde endocannabinoid signaling
rro04724  Glutamatergic synapse
rro04725  Cholinergic synapse
rro04726  Serotonergic synapse
rro04728  Dopaminergic synapse
rro04730  Long-term depression
rro04742  Taste transduction
rro04750  Inflammatory mediator regulation of TRP channels
rro04911  Insulin secretion
rro04912  GnRH signaling pathway
rro04915  Estrogen signaling pathway
rro04916  Melanogenesis
rro04918  Thyroid hormone synthesis
rro04919  Thyroid hormone signaling pathway
rro04921  Oxytocin signaling pathway
rro04922  Glucagon signaling pathway
rro04924  Renin secretion
rro04925  Aldosterone synthesis and secretion
rro04926  Relaxin signaling pathway
rro04927  Cortisol synthesis and secretion
rro04928  Parathyroid hormone synthesis, secretion and action
rro04929  GnRH secretion
rro04933  AGE-RAGE signaling pathway in diabetic complications
rro04934  Cushing syndrome
rro04935  Growth hormone synthesis, secretion and action
rro04961  Endocrine and other factor-regulated calcium reabsorption
rro04970  Salivary secretion
rro04971  Gastric acid secretion
rro04972  Pancreatic secretion
rro04973  Carbohydrate digestion and absorption
rro05010  Alzheimer disease
rro05016  Huntington disease
rro05017  Spinocerebellar ataxia
rro05022  Pathways of neurodegeneration - multiple diseases
rro05142  Chagas disease
rro05143  African trypanosomiasis
rro05146  Amoebiasis
rro05163  Human cytomegalovirus infection
rro05200  Pathways in cancer
rro05415  Diabetic cardiomyopathy
rro05417  Lipid and atherosclerosis
Module
rro_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:rro00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    104673127 (PLCB3)
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    104673127 (PLCB3)
   04310 Wnt signaling pathway
    104673127 (PLCB3)
   04371 Apelin signaling pathway
    104673127 (PLCB3)
   04020 Calcium signaling pathway
    104673127 (PLCB3)
   04070 Phosphatidylinositol signaling system
    104673127 (PLCB3)
   04072 Phospholipase D signaling pathway
    104673127 (PLCB3)
   04071 Sphingolipid signaling pathway
    104673127 (PLCB3)
   04022 cGMP-PKG signaling pathway
    104673127 (PLCB3)
  09133 Signaling molecules and interaction
   04082 Neuroactive ligand signaling
    104673127 (PLCB3)
   04081 Hormone signaling
    104673127 (PLCB3)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04540 Gap junction
    104673127 (PLCB3)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    104673127 (PLCB3)
   04613 Neutrophil extracellular trap formation
    104673127 (PLCB3)
   04621 NOD-like receptor signaling pathway
    104673127 (PLCB3)
   04062 Chemokine signaling pathway
    104673127 (PLCB3)
  09152 Endocrine system
   04911 Insulin secretion
    104673127 (PLCB3)
   04922 Glucagon signaling pathway
    104673127 (PLCB3)
   04929 GnRH secretion
    104673127 (PLCB3)
   04912 GnRH signaling pathway
    104673127 (PLCB3)
   04915 Estrogen signaling pathway
    104673127 (PLCB3)
   04921 Oxytocin signaling pathway
    104673127 (PLCB3)
   04926 Relaxin signaling pathway
    104673127 (PLCB3)
   04935 Growth hormone synthesis, secretion and action
    104673127 (PLCB3)
   04918 Thyroid hormone synthesis
    104673127 (PLCB3)
   04919 Thyroid hormone signaling pathway
    104673127 (PLCB3)
   04928 Parathyroid hormone synthesis, secretion and action
    104673127 (PLCB3)
   04916 Melanogenesis
    104673127 (PLCB3)
   04924 Renin secretion
    104673127 (PLCB3)
   04925 Aldosterone synthesis and secretion
    104673127 (PLCB3)
   04927 Cortisol synthesis and secretion
    104673127 (PLCB3)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    104673127 (PLCB3)
   04270 Vascular smooth muscle contraction
    104673127 (PLCB3)
  09154 Digestive system
   04970 Salivary secretion
    104673127 (PLCB3)
   04971 Gastric acid secretion
    104673127 (PLCB3)
   04972 Pancreatic secretion
    104673127 (PLCB3)
   04973 Carbohydrate digestion and absorption
    104673127 (PLCB3)
  09155 Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    104673127 (PLCB3)
  09156 Nervous system
   04724 Glutamatergic synapse
    104673127 (PLCB3)
   04725 Cholinergic synapse
    104673127 (PLCB3)
   04728 Dopaminergic synapse
    104673127 (PLCB3)
   04726 Serotonergic synapse
    104673127 (PLCB3)
   04720 Long-term potentiation
    104673127 (PLCB3)
   04730 Long-term depression
    104673127 (PLCB3)
   04723 Retrograde endocannabinoid signaling
    104673127 (PLCB3)
  09157 Sensory system
   04742 Taste transduction
    104673127 (PLCB3)
   04750 Inflammatory mediator regulation of TRP channels
    104673127 (PLCB3)
  09159 Environmental adaptation
   04713 Circadian entrainment
    104673127 (PLCB3)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    104673127 (PLCB3)
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    104673127 (PLCB3)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    104673127 (PLCB3)
   05142 Chagas disease
    104673127 (PLCB3)
   05143 African trypanosomiasis
    104673127 (PLCB3)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    104673127 (PLCB3)
   05016 Huntington disease
    104673127 (PLCB3)
   05017 Spinocerebellar ataxia
    104673127 (PLCB3)
   05022 Pathways of neurodegeneration - multiple diseases
    104673127 (PLCB3)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    104673127 (PLCB3)
   05415 Diabetic cardiomyopathy
    104673127 (PLCB3)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    104673127 (PLCB3)
   04934 Cushing syndrome
    104673127 (PLCB3)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:rro04131]
    104673127 (PLCB3)
Enzymes [BR:rro01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     104673127 (PLCB3)
Membrane trafficking [BR:rro04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    104673127 (PLCB3)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    104673127 (PLCB3)
SSDB
Motif
Pfam: PLC-beta_C PI-PLC-X PH_14 PI-PLC-Y PLCB1-4-like_EFh EF-hand_like C2
Other DBs
NCBI-GeneID: 104673127
NCBI-ProteinID: XP_010375377
UniProt: A0A2K6PSK0
LinkDB
Position
15:11470246..11486723
AA seq 1234 aa
MAGAQPGVHALQLEPPTVVETLRRGSKFIKWDEETSSRNLVTLRVDPSGFFLYWTGPNME
VDTLDISSIRDTRTGRYARLPKDPKIREVLGFGGPDARLEEKLMTVVSGPDPVNTVFLNF
MAVQDDTAKVWSEELFKLAMNILAQNASRNTFLRKAYTKLKLQVNQDGRIPVKNILKMFS
ADKKRVETALESCGLNFNRSESIRPDEFSLEIFERFLNKLCLRPDIDKILLEIGAKGKPY
LTLEQLMDFINQKQRDPRLNEVLYPPLRPSQARLLIEKYEPNQQFLERDQMSMEGFSRYL
GGEENGILPLEALDLSTDMTQPLSAYFINSSHNTYLTAGQLAGTSSVEMYRQVLLWGCRC
VELDVWKGRPPEEEPFITHGFTMTTEVPLRDVLEAIAETAFKTSPYPVILSFENHVDSAK
QQAKMAEYCRSIFGDALLIDPLDKYPLAPGVPLPSPQDLMGRILVKNKKRHRPSTGGPDS
AGRKRPLEQSNSALSESSAATEPSSPQLGSPSSDSCPGLSNGEEGGLEKPSLEPRKSLGE
EGLNRGPYALGPADREDEEEDEEEEEQTDPKKPTTDEGTASSEVNATEEMSTLVNYIEPV
KFKSFEAARKRNKCFEMSSFVETKAMEQLTKSPMEFVEYNKQQLSRIYPKGTRVDSSNYM
PQLFWNVGCQLVALNFQTLDVAMQLNAGVFEYNGRSGYLLKPEFMRRPDKSFDPFTEVIV
DGIVANALRVKVISGQFLSDRKVGIYVEVDMFGLPVDTRRKYRTRTSQGNSFNPVWDEEP
FDFPKVVLPTLASLRIAAFEEGGKFVGHRILPVSAIRSGYHYVCLRNEANQPLCLPALLI
YTEASDYIPDDHQDYAEALINPIKHVSLMDQRARQLAALIGESEAQAGQEMCQDTQSQQL
GSQLSPNPTPSPLDASPRRPPGPTTSPTSTSLSSPGQRDDLIASILSEVAPTPLDELRGH
KALVKLQSRQERDLRELRKKHQRKAVTLTRRLLDGLAQAQAEGRCRLRPGALGGAADVED
TKEGEDEAKRYQEFQNRQVQSLLELREAQVDAEAQRRLEHLRQALQRLREVVLDANTTQF
KRLKEMNEREKKELQKILDRKRHNSISEAKTRDKHKKEAELTEINRRHITESVNSIRRLE
EAQKQRHDRLVAGQQQVLQQLAEEEPKLLAQLAQECQEQRARLPQEIRRSLLGEMPEGLG
DGLLVACASNGHAPGSSGHLSGADSESQEENTQL
NT seq 3705 nt   +upstreamnt  +downstreamnt
atggcgggcgcccagcccggcgtccacgcgctgcagctggagccgcccaccgtggtggag
accctgcggcgcgggagtaagttcatcaaatgggacgaggagacctccagtcggaacctg
gtgaccctgcgtgtggaccccagtggcttcttcttgtactggacaggccccaacatggag
gtggacacactggacatcagttccatcagggacacacggacaggccggtacgcccgcctg
cccaaggaccccaagatccgggaagttctgggctttgggggtcccgatgcccggctggag
gagaagctgatgacggtggtgtctgggccagacccggtgaacacagtgttcttgaacttc
atggccgtgcaggatgacacagccaaggtctggtccgaggagctgttcaagctggctatg
aacatcctggctcagaatgcctcccggaacaccttcctgcgcaaagcatacacaaagctg
aagctgcaggtgaaccaggatggtcggatccccgtcaagaacatcctgaagatgttctca
gcagacaagaagcgggtggagactgcgctggaatcctgtggcctcaatttcaaccggagt
gagtccatccggcctgatgagttttccttggaaatctttgagcggttcctgaacaagctg
tgtctgcggccggacattgacaagatcctgctggagataggcgccaagggcaagccatac
ctgacactggagcagctcatggacttcatcaaccagaagcaacgcgacccgagactcaac
gaagtgctgtacccgccgctgcggccctcccaggcccgactgctcatcgaaaagtatgag
cccaaccagcagtttctggagcgagaccagatgtccatggagggctttagccgctacctg
ggaggcgaggagaatggcatcctgcccctggaagccctggatctgagcaccgacatgacc
cagccgctgagtgcctacttcatcaactcctcgcataacacctatctcactgctgggcag
ctggccgggacctcgtcggtggagatgtaccgccaggtgctgctgtggggctgccgctgt
gtggagctggatgtgtggaaaggacggccgcccgaggaggaacccttcatcacccatggc
ttcaccatgaccacggaggtgcctctgcgcgacgtgctggaggccattgccgagactgcc
ttcaagacctcgccctaccccgtcatcctctccttcgagaaccacgtggactcggcaaag
cagcaggcaaagatggctgagtactgccgctccatttttggagatgcgctactcatcgat
cctctggacaagtacccgctggccccaggtgttcccctgcccagcccccaggacctgatg
ggccgtatcctggtgaagaacaagaagcggcacagacccagcacaggtggcccagacagc
gctgggcgcaagcggccgctggagcagagcaattcagccctgagcgagagctccgctgcc
actgagccctcctccccgcagcttgggtcgcccagctctgacagctgcccaggcctgagc
aacggggaggagggggggcttgagaagcccagcctagagcctcggaagtctctgggcgag
gagggcctgaaccggggcccctatgctcttggacctgctgaccgtgaggatgaggaggaa
gatgaggaagaggaggagcagacagaccccaaaaagccgaccacagatgagggcacggcc
agcagcgaggtgaatgccactgaggagatgtccacgcttgtcaactacatcgagcctgtc
aagttcaagtcctttgaggctgctcgaaagaggaacaaatgcttcgagatgtcgtccttc
gtggagaccaaggccatggagcaactgaccaagagtcccatggagtttgtggaatacaac
aagcagcagctcagccgcatctaccccaagggcacccgtgtggactcttccaactacatg
ccccagctcttctggaacgtagggtgccagcttgttgcgctcaacttccagacccttgat
gtggcgatgcagctcaacgcgggcgtttttgagtacaacgggcgcagcgggtacctgctg
aagccggagttcatgcggcggcctgacaaatccttcgaccccttcactgaggtcatcgtg
gatggcatcgtggccaatgccttgcgggtcaaggtgatctcggggcagttcctatccgac
aggaaggtgggcatctacgtggaggtggacatgtttggcctccctgttgacacgcggcgc
aagtaccgcacccggacctctcaggggaactcgttcaaccccgtgtgggatgaggagccc
tttgacttccccaaggtggtgctgcctacgctggcttcacttcgcatcgcagcctttgag
gaggggggtaaatttgtagggcaccggatcctgcctgtctctgccatccgctctggttac
cactacgtctgcctgcggaacgaggccaaccagccgctgtgccttccggccctgctcatc
tacactgaagcctcggactacattcctgatgaccaccaggactacgcggaggccctgatc
aaccccattaagcacgtcagcctgatggaccagagggcccggcagctggccgccctcatt
ggggagagtgaggctcaggctggccaagagatgtgccaggacacccagtctcagcagctg
gggtctcagctgtccccaaaccccacccctagcccactggatgcctccccccgccggccc
cctggccccaccacctcccctaccagcacctccctcagcagcccagggcagcgtgacgat
ctcatcgccagcatcctctcagaggtggcccccaccccgctggatgagctccgaggtcac
aaggctctggtcaagctccagagccggcaagagcgagacctgcgggagctgcgcaagaag
catcagcggaaggcagtcaccctcacccgccgcctgctggatggcctggctcaggcacag
gctgagggcaggtgccggctgcggccaggtgccctaggcggggccgctgatgtggaggac
acgaaggagggggaggacgaggcaaagcggtatcaggagttccagaacagacaggtgcag
agcctgctggagctgcgggaggcccaggtggacgcagaggcccagcggaggctggagcat
ctgagacaggctctgcagcggctcagggaggtcgtccttgatgcaaacacaactcagttc
aagaggctgaaagagatgaacgagagggagaagaaggaactgcagaagattctggacaga
aagcgccataacagcatctcggaggccaagacgagggataagcataagaaggaggcggaa
ctgacggagattaaccgtcggcacatcactgagtcagtcaactccatccgtcggctggag
gaggcccagaagcagcggcatgaccgtcttgtggctgggcagcagcaggtcctgcaacag
ctggcagaagaggagcccaagctgctggcccagctggcccaggagtgtcaggagcagcgg
gcgaggctcccccaggagatccgcaggagcctgctgggcgagatgccggaggggctgggg
gatgggcttctggtggcctgtgccagcaacggtcacgcacctgggagcagcgggcacctg
tcgggcgctgactcggagagccaggaggagaacacacagctctga

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