Rana temporaria (common frog): 120920819 Help Entry 120920819         CDS       T07929                                  Name (RefSeq) ryanodine receptor 3 isoform X1   KO K04963   ryanodine receptor 3 Organism rtem  Rana temporaria (common frog) Pathway rtem04020   Calcium signaling pathway rtem04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:rtem00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     120920819    04020 Calcium signaling pathway     120920819  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:rtem04040]     120920819 Ion channels [BR:rtem04040]  Voltage-gated cation channels   Ryanodine receptor    120920819 SSDB OrthologParalogGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 Ins145_P3_rec SPRY MIR RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 EF-hand_8 Motif Other DBs NCBI-GeneID:  120920819 NCBI-ProteinID:  XP_040189082 LinkDB All DBs Position 13:complement(55896164..56588735) Genome browser AA seq 4881 aa AA seqDB search MAEGGEVEDEIQFLRTDDEVVLQCIATIHKEQRKFCLAAEGLGNRLCFLEPTSEAKYVPP DLCICNFVLEQSLSVRALQEMLANTIANSNEGTSDLSRWASQGGGHRTLLYGHAILLRHS FSGMYLTCLTTSRSLTDKLAFDVGLQDTATGEACWWTIHPASKQRSEGEKVRIGDDLILV SVSSERYLHLSISNGMGNIQVDASFMQTLWNVHPTCSGSSVEEGYLLGGHVVRFFHGHDE CLTIPSTDPAEAQHRKVNYEAGGAGIRARSLWRVEPLRISWSGSHIRWGQTFRLRHITTG QYLALTEDQGLVLQDRAKSDTKSSAFCFRASKEKLDSGPKRDIDGMGVAEIKYGDSICFI QHVDSGLWLTYKAQDAKTARLGPLKRRAILHQEGHMDDGVTLQKCQHEESQAARIIRNTT GLFSQFISDLDSLTGNNRTVTAPVALPIEEVVQTLQDLIAYFQPPEEDLEHEDKQNKLRS LKNRQNLFKEEGMLALVLNCIDRLNVYSSAAHFAEIIGEKAGPAWKEILNLFYELLAALI RGNRSNCAQFSYNLDWLISKLERLESSSGILEVLHSILIESPEALNLIEKRHIRSVISLL DKHGRNYKVLDVLCSLCVCNGVAVRTNQNLICDNLLPRRDLLLQTRLVNDVTSMRPNIFL GVADGSAQYKKWYFEMIIDQVDPYLTPEPTHLRVGWASTSGYAPYPGGGEGWGGNGVGDD LFSYGFDGLHLWSGRVPRAVASSNQHLLASDDVVSCCLDLGVPSISFRINGQPVQGMFEN FNTEGLFFPAVSFSAGVKVRFLLGGRHGEFKFLPPAGYAPCYEALLPKEKMRVEPVKEYK RDCEGVRDLLGTTHFLSQASFIPCPIDTSQIVLPPHLEKIRDKLAENIHELWGMNKIELG WIYGKVRDDNKRQHPCLVEFSKLPETEKNYNLQMSTETLKTLLALGCLIVHSNQTAEENL KKVKLPKNYVMSNGYKPAPLDLSDVKLLPAQEVLVDKLAENAHNVWAKDRIKQGWTYGIQ QDLKNKRNPRLVPYALLDERTKKSNRDSLREAVRTFIGYGYNIEPPDQEITDQMTSRISI DKIRFFRVEQTYAVKSGKWYFEFEVVTGGDMRVGWARPTCRPDLQLGADDRAFVFEGSRG QCWNMGSSFFGRNWQPGDVVGSMINLDDKSMIFTLNGELLITNQGSELAFADFEIENGFV PVCSLGLSQIGRMNLGKDASTFKYYTMCGLQEGFQPYAVNMNREVAMWFSKRLPTFVNVP KDHPHIEVTRKDGTVESPPCLKVTHKTFGTQNSNEDMIYCRLSMPVEFHSAFINEENFQK RNQLQDASSHTTTLYYYSVRIFAGQDPSSVWVGWVTPDYHFYSENFDLSKNCTVTVTLGD ERGRVHESVKRSNCYMVWGGDLSTGSQRSGRSNVDIDIGCLVDLSTGLLSFTANGKDLGT CYQVEPNTKLFPAVFLQPTSTNLFQFELGKLKNTMPLSAAIFKSEEKNPVSQCPPRLDVQ TITPVLWSRMPNIFLKVETERVSERHGWVVQCLEPLQMLALHIPEENRCIDILELSEQED LMKFHYHTLKLYCAVCALGNNRVAHALCSHVDQSQLLYTIDNQYLPGLLRSGFFNLLISI YLESAKEGKLMMNNEFIIPITDETRQIRLFPDESKRHGLPGVGRSTCLKSDLHFTAPCFV LTGEERQQHGPEIPVDILKSKAISMLTEAVQSSGDHIRDPVGGKAEFQFVPVLKLIATLL IMGVFEDEDVRQILLLIDPNVFGDHKEEEAEENGEKEDVAQVEEKAVEAGEKPTRDAKAP AKGLLQTRLPESVKLQMCELLHYFCDCELKHRVESIVAFSDKYVSKLQYNQKFRYNELML ALNMSAALTAKKTREFRSPPQEQINMLLNFQMQEESPCPEEIRDELYEFHEDLLIHCGIP LEEEEKEEEDTSWTGRLRSLVYRIKGRPKAEEQAPAEEEEKSPTTLKELISQTMVRWAQE DHIQDPELVRIMFSLLRLQYDSIGELLRAMRKTYTISAASVEDTINLLASLGQIRSLLSV RMGKEEEMLMIDGLGDIMNNKVFYQHPNLMRVLGMHETVMEVMVNVLGGDKSQQIAFPKM VASCCRFLCYFCRISRQNQKAMFEHLAYLLENSSVGLASPSMRGSTPLDVAAASVMDNNE LALALQEPDLEKVVTYLAGCGLQSCLMLITKGYPDIGWNPIEGERYLSFLRFAVFVNCES VEENASVVVKLLIRRPECFGPSLRGEGGNGLLAAMQEAINISENPALDLPSQGYQREVVE EDEEEEEIVHMGNAIMSFYSALIDLLGRCAPEPHLIQAGKGEAIRIRAILRSLVPTEDLV GIISIPLKLPAFNKDGTVFEPDMAASFCPDHKAPMVLFLDRVYGIKDQSFLLHLLEVAFL PDLRASASLDTASLSVTEMALALNRYICSAVLPLLTRCAPLFSGTEHYAALIDSTLHTIY RLSKGRSLTKAQRDTIEECLLSICHHMRPSMLQQLLRRLVFDVPLLSEYCKMPLKLLTNH YEQCWKYYCLPSGWGSYGLASEEELHLTEKLFWGIFDSLSHKFLSLLQKYDAELFRMCMP CLSAIAGALPPDYVDTRIKATPEKQMSVDAEGNFDPKPINTANLTLPEKLEYIVNKFAEH SHDKWAYDKLHSGWKYGTTLDENTKSHPLLRPFKTLAEKEKEIYRWPIRESVKTMLAIGW SVERTKEGEALALHRENEKMRSISQTSQGNGYTPVAIDLSNVVLSRELQGMVEVMAENYH NIWAKKKKMDLETKGAGSHPLLVPYDTLTAKEKARDREKAQELFKFLQVNGYAISRGLKD MELDASSMEKRFAFKFLKKVLHYVDSAQEFIAHLEAVVGSGKSEKSPHEQEIKFFAKVLL PLVDQYFKNHCLYFLSSPIKTLSSSGYASNKEKEMVASLFCKLAALVRHRISLFGSDSTT MVSCLHILAQTLDTRTVMKSGSELVKAGVRAFFENAAEDLEKTLENLKLGKFTHSRTQMK GVSQNINYTTVALLPILTSIFEHVARHQFGVDLLLDDVQVACYRILCSLYSLGTGKNIYV ERQRPALGECLAALAGAIPVAFLEPSLNHNNPLSVFNTKSPRERAILGMPDTVEEMCCEM PHLDGLMKEINDLAESGARYTEMPHVIEVILPMLCNYLSYWWERGTENVPENARPCCTQV TSEHLSVILGNILKIINNNLGIDEASWMKRIAVYAQPIISKAQPDLLKSHFIPTLEKLKK KAIKIVQEEEQLKADSKSDTQEAELLILDEFAVLCRDLYAFYPMLIRYVDNNRSNWLKKP DVDSDDLFRMVAEVFILWCKSHNFKREEQNFVIQNEINNLAFLTGNNKSKMSKPIQVKSG GQDQERKRTKRRGDLYSIQTSLIVAALKKMLPIGLNMCTPGDQELISLAKSRYSLKDTDE EVKEHLSSNLHLQEKSEDPAVKWQLNLYKDILKSEETDPEKAIERVQKISAAVFHLEQVE QPLRSKKAVWHKLLSKQRKRAVVACFRMAPLYNLPRHKINNFFLSSYQRIWLEKVHENSD YDSLILVLTKPKKKDEEEEEETEKKPDPLHQIILHFSRNALTERSKLEDDPLYTAYAAMM AKSCQNEEEDEEKEKTFEEKEMEKQKTLYQQARLHERGAAEMVLQMISASKGEMSPMVVE TLKLGIAILNGGNTVVQQKMLDYLKEKKDAGFFQSLSGLMMSCSVLDLNAFERQNKAEGL GMVTEEGTLIVRERGEKVLQNDEFTRDLFRFLQLLCEGHNNDFQNFLRTQMGNTTTVNII ISTVDYLLRLQESISDFYWYYSGKDVIEESGQHNFSKSLAVTKQIFNSLTEYIQGPCIGN QQSLAHSRLWDAVVGFLHVFANMQMKLSQDSSQIELLKQLLDLLQDMVVMLLSLLEGNVV NGTIGKQMVDTLVESSSNVEMILKFFDMFLKLKDLTSSDAFKEYDPEGKGIISKKEFQKA MEGQKQYAQSEIEFLLSCAEADENDMFNYVEFVDRFHEPAKDIGFNVAVLLTNLSEHMPN DSRLQCLLDPANSVLNYFSPYLGRIEIMGGAKRIERVYFEISESSRTQWEKPQVKESKRQ FIFDVVNEGGEQEKMELFVNFCEDTIFEMQLASQISESDTADRPEEEEEEEPHHLLEVGE EDEEEKSLESSSAFIVACTALRKNTSDFFKMLTLKNVSKQFRKVKKMTIKELVKVFFSFF WTLFVGLFQFVFTIVWGIFQILWSTVFGGGLVEGAKNIKVTKILGDMPDPTQFGIHDDVL ENEKADAPEHTSSAELAHLVKGDKGEIDMPDIFGLQAKKEGSKHGPEIGLGDYTENVGTE NTTSLESAVHKQRKALEAELAKEHEDNSKAESEKADMEDGEKKDKAKTEEQSEFLESKGE PRKKRRRGQKKEKPEAFMANFLAGLEIYQTKMLNYLARNFYNLRFLALFVAFAINFILLF YKVTEEPASDDTDNEPNLWNTYQEDEEEAEGAVYFVLQESTGYMAPTLRILAVIHTIISF VCVIGYYCLKVPLVVFKREKEIARNVEFDGLYITEQPSDDDIKGQWDRLVINTPSFPNNY WDKFVKRKVINKYGDLYGADRIAELLGLDKNALDFSPVEKTKIEAGSLVSWLSSIDMKYH IWKLGVVFTDNSFLYLAWYTTMSILGHYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQ LVLTVGLLAVVVYLYTVVAFNFFRKFYNKSEDEDDPDMKCDDMMTCYLFHMYVGVRAGGG IGDEIEDPAGDPYEMYRIVFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVREDMET KCFICGIGNDYFDTTPHGFETHTLQEHNLANYLFFLMYIINKDETEHTGQESYVWKMYQE RCWDFFPAGDCFRKQYEDQLG NT seq 14646 nt NT seq  +upstreamnt  +downstreamnt atggctgaagggggcgaagtggaggatgagatacaattcctccgcactgatgatgaagtt gtccttcagtgcattgcaaccatccataaggaacagaggaaattttgtttggcagctgag ggacttgggaatcgactttgcttcttggagccaacatcagaagccaaatatgtccctcct gacctgtgcatatgtaattttgtgctggagcagtccctctctgtcagagcccttcaggaa atgttggcaaacacaatagcaaatagcaatgaagggactagtgacctctcaagatgggca tcacaaggaggcggacacagaactttactctatggccatgcaatcttacttagacattca tttagtggaatgtacttgacatgtttgactacatccagatctctcacagacaaacttgca tttgatgttggactgcaggacacagcaacaggagaagcttgttggtggacaatacatcct gcatccaaacagagatctgaaggagaaaaagttcgaattggagatgatctgattttagtc agtgtttcttctgaaagatacctacatctctccatatccaatggaatgggaaatattcag gtggatgcttcttttatgcaaacactgtggaatgtccatcctacgtgctccgggagcagt gtggaggaagggtatcttcttggtggacatgttgtcaggtttttccatggtcatgatgaa tgtttgacgattccatctaccgacccagcagaggcccagcataggaaagtaaattatgaa gcaggtggagcaggtattcgcgccagatcattatggagagtggaacccctcagaatcagt tggagtggaagtcacatccgatgggggcagacattccgccttcgccatattacaactggc cagtatttggcactgacagaggaccaaggactagtgctacaagaccgagcaaagtcggat actaaatcatcagctttctgcttcagagcatccaaagaaaaattggattctgggcctaag cgagacatcgatggaatgggagtagcagaaataaaatatggggattctatttgctttatc cagcatgttgacagtggcctgtggctgacctacaaagcccaagatgccaaaacagcaaga ctaggaccacttaaaagaagagcaatcctgcaccaggaaggtcatatggacgatggcgtt accttacagaagtgccagcatgaagagtcccaggctgctagaatcattcgtaacaccaca ggcctgtttagtcagttcattagcgatttggattctctaacggggaacaatcggacagta acagcccccgtcgccctgcctattgaggaggtagttcaaaccctgcaagacttgattgct tattttcagcctccagaggaagatctagaacatgaagataaacaaaataaactccgttca ctaaagaataggcagaaccttttcaaagaggagggaatgctggctttagtactaaattgc attgatcgcctaaatgtgtacagcagtgcggcacactttgctgaaattattggagaaaaa gcagggccagcatggaaagaaatactgaacctcttctatgaattgctagctgccctgatt cgtggaaataggagcaactgcgcacaattttcctataatctcgattggcttattagtaaa ctagaacgtcttgagtcttcttcaggaatattggaggttctgcacagtatcttgattgaa agcccagaggctttaaacttaatagagaaaagacacattcgctctgtcatttccctgttg gacaagcatggaagaaactacaaggtcctggatgtcctttgctctctgtgtgtttgcaat ggagttgcagtacgtaccaatcagaacctaatatgtgacaacttgctgcccaggagagat ttattgttacaaacccgcttggttaatgatgtcaccagtatgagaccaaacatcttcctg ggtgtggcagatggctcagctcaatacaaaaagtggtactttgagatgattattgatcaa gtagatccctatttgacaccagagccaactcatttgcgcgtcggctgggcttcaacctca ggttacgctccatatcctggaggaggtgaaggatggggaggcaatggtgtaggtgatgac cttttctcctatggctttgatggtcttcacttatggtctggtcgagtaccaagagcagtg gcttcaagtaaccagcatttactagcttctgatgacgtggtcagctgctgcttagaccta ggcgtgcccagcatttcatttcgcattaacggccaacctgtccaaggcatgtttgaaaac ttcaatactgaaggcttattttttccagcagtgagcttctctgctggagtcaaggttcgc tttcttcttggtggccggcatggtgaattcaagtttttacctcctgctggctatgctcca tgctatgaagccttattaccaaaagagaagatgagagtggagcctgtgaaagagtacaag agggattgtgaaggagttcgagatttgttgggcacaacgcactttctttcacaagcctca ttcatcccatgtcctattgacaccagccagattgttttaccacctcaccttgagaagatt cgagacaagctagcagaaaatattcatgaactttggggcatgaacaaaattgagcttgga tggatttatggaaaggtgcgagatgataataaacgccagcatccttgcttggtagaattc tcaaagctaccagaaacagagaagaactacaatctacaaatgtcaacagagactttaaaa actttacttgctctgggatgtctcattgttcactcaaatcaaacagctgaagaaaatctt aagaaagtaaaactcccaaaaaactatgtgatgtccaatggctacaaacctgccccgttg gacctatctgatgtaaaactgttaccagcccaggaagttcttgttgataaacttgcagag aatgcacacaatgtctgggctaaagacaggataaaacaaggatggacctatggcattcag caggacctgaagaacaaacgaaaccctcgcttggtgccatatgctttactagatgaacgg actaaaaagtctaatagagacagcttgcgtgaagctgtgagaacatttattggctatggc tataatatcgaaccgccagaccaagaaatcactgaccaaatgacgtcgcgaatcagcatt gataagattcgcttctttagggtggagcagacatatgctgtcaaatctgggaagtggtat tttgaatttgaagtggtgactggaggtgatatgcgagtaggctgggctcgacccacttgc aggccagatcttcaacttggagcagatgatcgggcatttgtatttgaaggaagcagaggc cagtgctggaacatgggaagctctttttttggtcgcaactggcaaccaggagatgtggtg ggatccatgattaatttggatgataaatctatgattttcacattaaatggggaacttcta ataactaatcaagggtctgaactggcatttgcagattttgaaattgaaaatggttttgtt ccggtctgctctttgggactgtctcagattggtcgcatgaatctaggaaaagatgccagt accttcaaatactacacaatgtgtggtcttcaggagggctttcaaccatatgctgtaaat atgaacagagaggttgccatgtggttcagcaaacgcttacctacctttgtcaatgtgcca aaagatcatcctcacattgaggtgacaagaaaagatggtactgtggaaagccctccatgc ttaaaggttacacacaaaacctttggaacccagaacagtaatgaagacatgatatactgc aggctgagtatgcctgttgagttccattctgccttcatcaatgaagaaaatttccaaaag agaaaccagttgcaggatgcatcttcacatactaccacgttgtattattattctgtacga atatttgctggtcaagatccctcttctgtatgggtaggatgggtgactcctgactaccac ttctatagtgagaattttgacttaagcaagaactgcactgtgactgtcactttaggagat gaacggggcagagtgcatgaaagtgtaaaacgtagcaattgttacatggtgtggggaggg gacctctccacgggctctcagaggtcaggccgcagcaatgtagatatagacattgggtgc cttgttgatctgtctacagggctgctttcatttacagctaatggaaaagacctcggaacc tgctaccaggttgaaccaaacaccaagctgtttccagcagtctttctgcagccaactagc actaatctctttcagtttgaacttggaaaattaaagaacaccatgccactatcagctgca atttttaagagtgaagagaagaatcctgtttcacagtgtccacctcgtttggatgtgcag actataaccccagtgctatggagtcgcatgccgaacattttcttgaaagtggagacagaa cgtgtcagcgaacgtcacggctgggtggtgcaatgcctagaacccctgcagatgttggcc ttgcatatacctgaagagaatcggtgtattgacatcctggaactgtctgagcaagaagat ctcatgaaatttcattaccacactcttaaactatactgtgctgtatgtgcactgggtaac aaccgtgttgcacatgccttgtgcagtcatgtggatcagtcccagctactctatactatt gataaccagtacctgcctggcctcttgcgttctggtttcttcaaccttcttatcagcatc tacctggagtctgccaaggagggcaagcttatgatgaacaatgaatttatcatacccatc actgatgagacaaggcaaattcgactgttccctgatgagtcaaagaggcatggcttacct ggtgttggtcgtagtacttgtctgaagtcagaccttcattttacagcaccttgctttgtg ctgaccggagaggagaggcaacagcatggaccggaaattccagtggatattcttaagtcc aaagctattagcatgcttacagaggctgtgcagagcagtggggatcacatcagagaccct gttgggggaaaagcagagttccagtttgtgccagtactcaagcttattgccactcttctt attatgggagtattcgaggatgaggatgtgcgtcagattctactgctcattgacccaaat gtatttggtgaccacaaggaagaggaagcagaggagaatggggagaaggaagatgttgct caggttgaagagaaagctgtagaggctggtgagaaaccaacaagagatgccaaggctcct gccaagggtttactgcagactcgacttccagagtctgtaaaactccagatgtgcgaactt cttcattacttctgtgactgtgagctgaaacaccgcgtggaatccattgttgccttttca gataaatatgtttcaaagttgcaatacaaccagaaattccgatacaatgagcttatgctg gcattgaacatgtcagcagctctaactgccaaaaagactagggaatttcgttctcctcca caggaacagattaacatgcttctgaatttccaaatgcaagaagagagcccttgcccagag gaaatacgggatgagctatatgagttccatgaagatcttctcatacactgtggtattcct cttgaggaagaagaaaaggaggaggaagatacatcgtggacaggtcgccttcgatctcta gtatataggatcaagggtcggccaaaggcagaagagcaagcacctgcagaggaggaggag aagtctcctaccacactaaaagagctcatctcacaaacaatggtgcgctgggcacaagaa gatcatatccaagaccccgagcttgtgcgtatcatgtttagcctgctccgcctacagtat gatagcattggagagttattacgggcgatgcggaaaacttatacgatcagtgctgcatct gtggaagataccatcaacctcttggcttccttgggtcaaatacggtccctcttaagtgtg cgtatgggcaaggaggaggagatgctcatgattgatggcttaggtgacattatgaacaac aaggtcttctatcagcatccaaacctgatgcgtgttttagggatgcatgagactgttatg gaggtaatggtgaatgtgctaggaggagacaagtctcagcaaattgcttttcccaagatg gtggcaagctgttgcagattcctctgctatttttgtaggattagtcggcaaaatcaaaag gcaatgtttgagcatctagcctacctactggagaacagtagtgtcggtttagcatctcct tctatgagagggtctacaccactagatgtcgctgctgcatctgtaatggacaacaatgag cttgctttggctttgcaagaaccagacctggagaaggttgtgacatatttggcaggttgt ggactgcagagctgtctaatgttaataaccaaaggatacccagatattggatggaatcct atagagggagagcgttacctatcattcctacgttttgctgtctttgtaaactgtgagagt gttgaagaaaacgccagtgtggtggtgaagctactaatccgtcgcccagagtgttttgga ccttcccttagaggagaagggggcaatggtttgttggcagctatgcaggaggctattaac atctctgagaacccagctttggaccttccttctcaggggtatcagagggaagtggtcgag gaagatgaagaagaagaagagattgtacacatgggaaatgctataatgtcattttattct gcactcatagatttgctgggacgttgtgcaccagaaccacatttgatccaagctggtaaa ggtgaagccattcgaatacgcgccattctgcgatcactcgtacctacggaagatcttgtt gggattattagtatccctctaaagctgcctgcttttaacaaagatggcacagtgtttgaa ccggacatggctgccagtttttgccctgatcacaaggcccccatggtgcttttcctggac cgtgtctatggcatcaaggaccaaagcttccttctccatctgctagaggtggcattttta cctgacctaagagcatcggcatcacttgatacagcttccctgagtgtcactgagatggct cttgctttgaaccgatatatctgctctgcggtactcccattgcttactcgctgtgctccc ctcttttccggcacagagcactatgcagcactaatagattccaccctgcatactatatac agactgtccaaggggcgctctctaaccaaagctcagagagacacaattgaagagtgtctg ctgtcaatatgccatcatatgcggccctcaatgctccagcagctcctgcggcgtcttgtt tttgatgtccccttgctcagtgaatactgcaaaatgcctctgaagcttttgacaaaccat tatgaacagtgctggaaatattactgcctgccttcaggatggggcagctacggtttggcg tcagaggaggaactgcatctgactgagaagctgttctgggggatttttgattccctttca cataagttcctatctctcctgcagaagtatgatgctgaacttttcagaatgtgcatgccc tgtctcagtgcaatagctggagctctgccaccagattatgttgacaccagaattaaagca acacctgagaagcagatgtcagtggatgctgaaggaaactttgatccaaaacccattaat actgccaacctcacattacctgagaagctggaatatattgtcaataaattcgcagagcac tcccatgataaatgggcctatgacaagctacacagtggatggaagtatggaacgactctt gatgaaaatacaaaatcccaccctctgctgagacccttcaagacactagctgaaaaggag aaagaaatttatcgttggcctataagagaatctgtgaaaactatgctagcaatcggatgg agtgtagaaagaactaaagaaggagaagccctagcactgcatcgggaaaatgaaaagatg cgtagcatatcccaaacaagccagggcaatggctacacacctgtcgcaattgatctgagc aatgttgtcctctccagggagctccagggaatggttgaagtaatggcagaaaattaccac aatatatgggcaaaaaagaagaagatggatttggagactaaaggtgcaggaagccatcca ctgttggtaccctatgataccttaacggcaaaagaaaaggcaagggatcgtgaaaaagcc caggaacttttcaagttcctccaagtaaatggatatgctatatccagaggattgaaggat atggagttagatgcttcttccatggagaagagatttgcctttaaatttctcaagaaagtt ctgcattacgttgattcggctcaggaattcattgcacatttagaggcagttgttgggagt ggtaaaagtgaaaaatccccacatgaacaagaaatcaagttttttgccaaagttctttta ccactcgttgaccagtactttaagaaccactgcctatattttctctcttctccaattaaa actctcagcagtagtggctatgcatccaacaaggagaaagaaatggtggcaagtctgttc tgcaaactggcagctcttgtcagacataggatatcattgtttgggagtgattctactact atggtgagctgtttacacattctggcccagactcttgacacacgcactgtaatgaagtct ggatctgagctggtgaaagctggggttcgtgctttctttgaaaatgcagcagaagatttg gaaaagacattagaaaatctcaagctggggaaatttactcattctaggactcagatgaag ggagtttctcagaacatcaactacaccacagtggccctccttcctatactaacttccatt tttgaacatgtggctcgtcatcagtttggagtggatttgctgttggatgatgttcaagtt gcctgctaccggatcctctgcagcctttactcacttggaacaggaaaaaacatctatgtt gaaaggcaacgacctgccctaggagaatgtctggcagctctagctggagctattcctgtg gcttttcttgagccatcattaaaccacaacaatccactctccgttttcaataccaaatct cctcgggagagagccattctaggcatgccagacacagtggaagagatgtgttgtgagatg 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aatgactttcagaatttcctcagaacccagatgggcaataccactactgtaaatattatt attagcaccgtggattatcttctccgtctccaggaatctatcagtgacttctactggtac tactcagggaaagatgtgattgaggaatctggacagcacaacttttccaagtctctggct gttaccaaacaaatattcaactcgctcacagaatacattcagggcccatgcatagggaac cagcagagtttggcacacagtaggctatgggatgctgtggttggttttctccatgtcttt gcaaacatgcaaatgaaattgtcacaggactctagccagattgaactgcttaaacagctc cttgatctccttcaagacatggtggtcatgctactctctcttctagaaggcaacgtagtt aatggaactattggaaaacaaatggttgacactcttgtagaatcttccagcaatgttgaa atgatacttaagttctttgacatgttcctaaagctgaaagacctaactagctctgatgca tttaaagagtatgacccagaggggaaaggtattatctccaaaaaagagttccaaaaagcc atggaggggcaaaaacaatatgcacagtctgaaattgaattccttctctcttgtgctgaa gcagatgaaaatgacatgtttaactatgttgaatttgtagacagatttcatgaaccagct aaagatattggatttaacgtggctgttctgttgactaatctctctgagcatatgccaaat gattcacgactccagtgtttgttggatcctgcaaacagtgtactgaactacttttctcca tacttgggtcgtattgaaataatgggcggagcaaaaagaatagagagagtatattttgag ataagtgagtcaagccggacacagtgggaaaagccacaagtcaaggaatccaagagacaa 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ttcctggcaggattggagatctaccaaaccaaaatgctaaattatctggcaagaaatttc tacaacctacgattccttgctctgtttgttgcatttgccattaacttcattttattgttc tacaaggtaacggaggaaccagctagtgatgacacagataatgaaccaaatctctggaac acatatcaggaagatgaggaggaagcagagggagccgtttactttgttctacaggaatct actggctacatggctccaacattgcgtatcctggctgttattcacaccatcatttctttt gtctgtgttattggatattactgtcttaaggtccctctggtggtatttaaacgtgaaaag gaaattgctcgcaatgtggagtttgatggcctatacatcacagagcagccctcagatgat gacattaaggggcaatgggatcgccttgtcatcaatactccgtctttccctaataactac tgggataagtttgttaagaggaaggtcatcaataaatatggagacttatatggagcagat agaattgccgaactccttggattggataaaaatgctctggattttagccctgtagaaaag accaaaatagaggcgggatcacttgtatcatggctgagttcaattgacatgaagtaccat atctggaagcttggagtggtttttactgacaattcattcctttaccttgcctggtacaca accatgtcaatacttggacactacaacaacttcttctttgcagctcatctcttagacatt gcaatggggttcaagaccctaagaaccattctctcctcagttacccacaatggaaaacag ctggtgctcacagtcggtcttctggcagtagttgtttatctctacactgttgtggccttc aacttcttccgaaaattttacaacaaaagtgaagatgaagatgaccccgatatgaagtgt gatgacatgatgacgtgttatctgttccacatgtatgtgggtgtgagagccggaggtggc attggagatgagattgaagaccctgccggtgacccttacgagatgtatcgtattgtgttt gacatcaccttcttcttctttgttatcgtcatacttctagccattattcaaggtttgatt attgatgcttttggagaactgagagatcaacaagaacaagtgagggaagacatggagaca aaatgtttcatttgtggaatcggaaatgattactttgacacaacaccgcacggctttgaa acacacaccttacaagagcacaatttggccaactatctgttcttccttatgtatataatt aataaagacgaaacggaacacactggccaggaatcttatgtctggaaaatgtatcaggag agatgttgggatttcttcccagcaggtgactgtttccgcaaacagtatgaagaccaactc ggataa

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