Rana temporaria (common frog): 120936980
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Entry
120936980 CDS
T07929
Symbol
GCLC
Name
(RefSeq) glutamate--cysteine ligase catalytic subunit
KO
K11204
glutamate--cysteine ligase catalytic subunit [EC:
6.3.2.2
]
Organism
rtem
Rana temporaria (common frog)
Pathway
rtem00270
Cysteine and methionine metabolism
rtem00480
Glutathione metabolism
rtem01100
Metabolic pathways
rtem01240
Biosynthesis of cofactors
rtem04216
Ferroptosis
Module
rtem_M00118
Glutathione biosynthesis, glutamate => glutathione
Brite
KEGG Orthology (KO) [BR:
rtem00001
]
09100 Metabolism
09105 Amino acid metabolism
00270 Cysteine and methionine metabolism
120936980 (GCLC)
09106 Metabolism of other amino acids
00480 Glutathione metabolism
120936980 (GCLC)
09140 Cellular Processes
09143 Cell growth and death
04216 Ferroptosis
120936980 (GCLC)
Enzymes [BR:
rtem01000
]
6. Ligases
6.3 Forming carbon-nitrogen bonds
6.3.2 Acid-D-amino-acid ligases (peptide synthases)
6.3.2.2 glutamate---cysteine ligase
120936980 (GCLC)
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Motif
Pfam:
GCS
Motif
Other DBs
NCBI-GeneID:
120936980
NCBI-ProteinID:
XP_040205762
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Position
4:complement(214822092..214874265)
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AA seq
636 aa
AA seq
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MGLLSAGSPLSWEETKKYADHVRQHGIIQFLNIYHKLKDRQKDVLKWGDEVEYMLLAFDH
ENQKVRLVLEGEDMLETLQDRGEKTNPNHPTLWRPEYGSYMIEGTPGQPYGGIMAEFNTV
EDNMRKRRQEASSLLPNNQSICTVTSFPRLGCPGFTLPEFLPTPVEKGASKSLFFPDEAI
NKHPRFSTLTRNIRHRRGEKVAINVPIFKDQNTPSPFIEKFPNATGDDAKAAMPDHIYMD
AMGFGMGNCCLQVTFQACSIAEARSLYDQLATICPLVMALSAAAPFYRGYVSDIDCRWGV
ISASVDDRTKEERGLEPLKNNKYRISKSRYDSIDSYLSSCGEKYNDIDLTIDKDICSQLT
KEGIDPLMAQHIAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSD
IGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAV
RQGMFYFKKDICKAGIAAVDGCYTTLNGAEAEPEDYTLMSIDTIINGKEGVFPGLLPILN
SYLENMEVDVDTRCTILNYLKLIKKRASGDLMTVARWMREFVSNHPDYKHDSVITDKINY
DLMVRCNKIANGQTSCPELVGFTTSKTKPSGNETIV
NT seq
1911 nt
NT seq
+upstream
nt +downstream
nt
atggggctgctgtctgccggctctccgcttagctgggaagagaccaagaagtacgccgac
cacgtccggcaacacggcatcatccagttcctgaacatctatcacaagctgaaggaccgg
cagaaggacgtgctgaaatggggcgatgaggtggagtacatgttgcttgcctttgatcac
gaaaatcaaaaggttcgtttagtactcgaaggcgaggacatgcttgaaactcttcaagac
agaggtgaaaaaacaaacccaaatcacccaacactctggagaccagagtatggcagttac
atgattgaggggacaccaggacagccttatggaggtataatggcagaatttaacacagtg
gaagacaatatgcggaaacgtcggcaggaagcctcatcacttttaccaaacaaccaatca
atatgcactgttacctcttttccaagattgggatgtcctggatttacattgccagaattt
ctacccaccccagtggagaagggagcatccaagtcgcttttttttccagatgaagcaatc
aacaaacatccacgatttagtactttgacaagaaatattcggcacagacgtggagaaaaa
gtcgccattaatgttccaatttttaaagaccaaaataccccctctccatttattgagaaa
ttcccaaatgctactggtgatgatgcaaaagcagcaatgcctgatcatatttatatggat
gccatgggtttcggaatgggcaactgttgcctccaggtcacttttcaggcatgtagcatt
gcagaagcacgatccctgtatgaccagctggctactatatgtccacttgtgatggctctg
agtgcagctgctcctttctacagaggatatgtatcggacattgactgtcgatggggagtt
atttctgcctctgtagacgatcgaactaaagaggaaagaggcctggagcctctgaagaat
aacaaatacagaatcagtaaatctcgatacgattctatagacagttacctgtctagctgt
ggggaaaagtacaacgacattgatttgactatagataaagacatctgtagccaactaaca
aaagagggaattgaccccctcatggcccaacacattgcacatctctttattagagatcct
ttgacattgtttgaagagaagatacatttggatgatgcaaatgaatctgaccactttgag
aatatccagtcaactaactggcagacaatgagatttaagcctcctccacctaactctgat
ataggttggcgagtggagtttcggcctatggaggtccaattaacagactttgaaaactct
gcctatgtagtgtttgtggtgttgctgaccagagtcattctttcttacaagttggatttt
cttattccattgtcaaaggttgatgaaaacatgaaagtggcccagaaacgtgatgctgtg
cgtcaaggaatgttttactttaaaaaggatatttgcaaagctggcattgctgcagttgat
ggctgttatacgacacttaatggagcagaagctgaaccggaagattataccctcatgagc
attgatactataatcaatggaaaggaaggggtttttccaggtttgcttcccatccttaat
tcttacctggaaaacatggaggtagatgtcgacacacgctgcaccatactaaactacctt
aaacttattaagaaaagagcttcaggtgacctgatgacagttgctcgatggatgagagaa
tttgtatcaaaccatccagactataagcatgacagcgtgataacggacaaaattaattat
gacttgatggttagatgtaacaagattgcaaatggacaaacaagttgtccagaattggtt
ggttttacaacttctaaaacaaagcccagtggaaacgagacgattgtatga
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