Rhincodon typus (whale shark): 109918354 Help Entry 109918354         CDS       T06055                                  Symbol ryr2a Name (RefSeq) ryanodine receptor 2   KO K04962   ryanodine receptor 2 Organism rtp  Rhincodon typus (whale shark) Pathway rtp04020   Calcium signaling pathway rtp04260   Cardiac muscle contraction rtp04261   Adrenergic signaling in cardiomyocytes rtp04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:rtp00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     109918354 (ryr2a)    04020 Calcium signaling pathway     109918354 (ryr2a)  09150 Organismal Systems   09153 Circulatory system    04260 Cardiac muscle contraction     109918354 (ryr2a)    04261 Adrenergic signaling in cardiomyocytes     109918354 (ryr2a)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:rtp04040]     109918354 (ryr2a)    04990 Domain-containing proteins not elsewhere classified [BR:rtp04990]     109918354 (ryr2a) Ion channels [BR:rtp04040]  Voltage-gated cation channels   Ryanodine receptor    109918354 (ryr2a) Domain-containing proteins not elsewhere classified [BR:rtp04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    109918354 (ryr2a) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY MIR Ins145_P3_rec RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 DUF3671 Motif Other DBs NCBI-GeneID:  109918354 NCBI-ProteinID:  XP_048457307 LinkDB All DBs Position 9:complement(73510216..73960409) Genome browser AA seq 4902 aa AA seqDB search MVFQNVPPDLSICTFVLEQSLSVRALQEMLANNEEKAEGATQGGGHRTLLYGHAVLLRHS YSGMYLCCLSTSRSSTDKLAFDVGLQEDTTGEACWWTIHPASKQRSEGEKVRVGDDLILV SISSERYLHLSYGCSSLHVDAAFQQTLWSVAPICSGSEVAQGYLKGGDVLRLLHGHMDEC LTVPSGELGEEQRRTVHYEGGAVSIHARSLWRLEMLRVAWSGSHIRWGQPFRLRHVTTGK YLSLIDEKGLLLMGKEKADVKSTAFCFRLSKEKLDTGIRKEVDGMGSPEVKYGDSVCFIQ HLDTGLWLTYQSVDAKSARMGTAQRKAIMHHEGHMDDGLTLSRSQHEESRTARVIRSTAF LFNRFIRGLDTLNKKGKSTAIDLPIESVSLSLRDLIGYFQPPDEHLEHEERQNRLRALKN RQNLFQEEGMINLVLECIDHLNVYSSAAHFTDVAGKEAGESWRAILNSLYELLAALIRGN RKNCAQFSGSLDWLISRLERLEASSGILEVLHCVLVESPEALNIIKEGHIKSIISLLDKH GRNHKVLDVLCSLCVCHGVAVRSNQHLICDNLLPGRDLLLQTRLINHVSSMRPNIFLGIS EGAAQYKKWYYELIVDNIDPFVTTEATHLRVGWASTDGYSPCPGGGEGWGGNGVGDDLYS YGFDGLHLWAGCVARTVNSPNQHLLKADDVISCCLDLSAPSISFRINGQPVQGMFENFNT DGLFFPVVSFSTGVKVRFLLGGRHGEFKFLPPPGYAPCFEALLPKEKMRVEHTNEYKQDH NGVRDLLGPNISLTQAAFTPMPVGTSQIVLPPHLDRVREKLAENIHELWVMNKIELGWTY GPIRDDNKRQHPCLVEFSKLPEQERNYNLQMSLETLKTLMALGCHVGITDDQAEEKVKKL KLSRNYQLPSGYKPAPMDLSHIKLTSTQEAMVDKLAENAHNVWARDRIRQGWTYGIQQDI KNRRNPRLVPYTLLDERTKKSNKDSLREAVRTLLGYGYNLEAPDQDHAARSDLLSSVAER FRIFRAEKTYAVKSGKWYFEFEAVTAEDMRVGWTRPGCRPDQELGTDDQSFVFDGFKAQR WHQGNEHFGRSWQAGDVVGCLVDMNEYTMTFTLNGEVLLDDSGSELAFKDFEVADGFIPV CSLGLSQVGRMNFGNDVGTLKYFTICGLQEGYEPFAVNMNRDITMWFSKRLPQFVPVPAN HEHVEVTRIDGTVDSSPCLKVIQRSFGSQNSNTDIAFYRLSMPIECAEVFCKVSIGGLAN TNILPQKNEIEDFDADSDFEVLMKTAHGHLASATAEKEKESAKTEFNNHKDYNQEKPSRL KQRFMLKRTKPDYNLAHSSPRLTEEVLAEDRDDYDFLMQTTTYYYSVRIFPGQEPTNVWV GWVTSDFHQYDAAYDLEKVRTVTVTLGDEKGKVHESVKRSNCYMVWAGESTSPGQSRNNN GLEIGCLVDTASGLLTFTANGKELNTYYQVEPSTKLFAAVFAQATSPNVFQFELGRVKNV MPLSAGLFKSERRNPTPQCPPRLHVQHLTPVLWSRVPNEFLKVDISRVSDRHGWQVQCTE PLRFMSLHIPEENRALDILELTEHEDLLKFHYHTLRLYSAVCALGNNRVAHALCSHVDES QLLYAIENKYVPGLLRTGYYDLLIDTYLSTYATARLMMNNEFIVPMTDETKSITLFPDDN QSHAVPGVGLSTSLRPRMQFSSASFVTVTGESFQYSPEFPLDILKAKTIEMLTEAVQEGS LHVRDPVGGTTEFLFVPLIKLFYTLLIMGIFGSEDLKHVLQLIEASVFAEDTQTTEENEM NEKDISKNDQKTEGGDEEFKSDKVPQEGLLQMKLPEPVKLQMCHLLQYLCDCQLRHRIEA IVAFSDDFVLKLQDNQRFRYNEVMQALNMSAALTAKKTKEFRSPPQEQINMLLSFKNDRR ECPCPVEIREELLDFHEDLMAHCGIELEEEEANNDDSDSTIRGRLMNLVEKVTYLKKKRE ENPVEQETKKPTTLQQLISETMVRWAQESVIEDPELVRAMFVLLHRQYDGIGELVRALPK TYTINGVSVEDTINLLASLGQIRSLLSVRMGKEEEKLMIRGLGDIMNNKVFYQHPNLMRA LGMHETVMEVMVNVLGGGESKEIIFPKMVANCCRFLCYFCRISRQNQKAMFDHLSYLLEN SSVGLASPSMRGSTPLDVAAASVMDNNELALALREPDLEKVVQYLAGCGLQSCAMLVAKG YPDIGWNPVEGERYLDFLRFAVFCNGESVEENANEVVRLLIRRPECFGPALRGEGGDGLL AAMEEAIKISEDPARDGLSSTDESSRRLDLEEEEDDTIHMGNAIMTFYSALIDLLGRCAP EIHLINAGKGEAIRIKSILRSLIPLEDLEGVVSIPFQMPTVAKDGTVVEPDMSAGFCPDH KAAMVLFLERVYGIEEQDFLLHLLEVGFLPDLRAAASLDTAALSATDMALALNRYLCTAV LPLLTKCAPLFAGTEHHASLIDSLLHTVYRLSKGCSLTKAQRDAIEECLLAICGQLRPSM MQHLLRRLVFDVPLLNEHAKMPLKLLTNHYERCWKYYCLPGGWGSFGATSEEELHLSRKL FWGIFDALSQKKYEPELFKLALPCLSAVAGALPPDYMESNYVAMMEKQSSVDTEGNFNPQ PVDTLSTTLPEKLDYFVNKYAEHSHDKWAMDKFANGWVYGETCNEAAKVHPLLKPFKLLS EKDKEVYRWPIKESLKTMVAWSWTIARTREGESMVLYNRTRRISQSSQVSVDSAHGYSPR PIDMSNVTLSRDLHAMAELLAENYHNIWAKKKKNELEVKGGGNHPLLVPYDTLTAKEKAR DREKAQEILKFLQINGYAVSRGFKEMELDTPSIEKRFAYSFLQQLIKYVDQAHDYILQFD LCSTSKGEKFVHEQEVKFFAKVVLPLIDQYFKNHRLYFLSTASNPLSSGGHASNKEKEMV TSLFCKLGVLVRHRISLFGNDATSIVNCLHILGQTLDARTVMKTGLESVKLALRAFFENA AEDLEKTIENLKLGQFTHTRTQPKGVTQIINYTTVALLPVLSSLFEHIGQHQFGEDLILD DVQVSGYRILSSLYALGTGKSIYVERQRPALGECLAALAGAFPVAFLETDSNKHNPFSSY NTKTPKDRAALKLPAKVEDMCPNIPSLERLLDEIMELTESGIRYTQMPHVMEVILPMLCS YMSHWWEHGPENNPEKAEQCCTALTSEHMNTLLGNILKIISNNLGIDEGAWMKRLAVFSQ PIISKVKPQLLKTHFLPLMEKLKKKVATVVMEEEHLKSEGRGDMSEAELLILDEFTVLTR DLYAFYPLLIRFVDYNRAKWLKEPNPEAEELFRMVAEVFIYWAKSHNFKREEQNFVIQNE INNMSFLITDTKSKMSKGGVSDQERKKSKRKGDRYSLQTSLIVAALKRLLPIGLNICAPG DQELISLAKNRFSMKDTEDEVREIIRNNLHLQGKLEDPAIRWQMALYKDLPNRNEASSDP EKTVIRVLDIANVIFHLEQVEHPQRSKKAVWHKLLSKQRKRAVVACFRMAPLYNLPRHRA VNLFLQGYEKSWIETEEHYFEDKLIEDIAKPGDEKPVDEEEGTKRLDPLHQLILLFSRTA LTEKCNLKEDFLYMAYADIMAKSCHVEEDEDGEEEVKSFEEKEMEKQKLLYQQARLHDRG AAEMVLQMISASKGEMGPMVASTLKLGIAILNGGNSTVQQKMLDCLKEKKDVGFFQSLAG LMQSCSVLDLNAFERQNKAEGLGMVTEEGSVITHERGEKVMQDDEFTCDLFRFLQLLCEG HNSDFQNYLRTQTGNNTTVNIIISTVDYLLRVQESISDFYWFYSGKDIIDEQGQRNFSKA INVAKQVFNTLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMQMKLSQDSSQIELLK ELMDLQKDMVVMLLSMLEGNVVNGTIGKQMVDMLVESSNNVEMILKFFDMFLKLKNLTSS DAFKEYDPDSKGLITKRDFQKAMESHKHYTQSETEFLLSCAETDENEMLDYEEFVERFHE PAKDIGFNVAVLLTNLSEHMPHDTRLQTFLELAESVLNYFQPFLGRIEIMGSAKRIERVY FEISESSRTQWEKPQVKESKRQFIFDVVNEGGEKEKMELFVNFCEDTIFEMQLAAQISES DSTERSVSKEETQKDKMEEEDPKMNFFSMTTIRSALMALRYNVMILMKLLTTKSLKKQMK KIKKMTMKDMVMTLFAFYWSLLIGFSHFVFSVFRGFFRIMYSTFLGGSLVEGAKKIKVTE LLANMPDPTHDEVRGELGEGEGKVTQSTLPSEDLTDLTAITEESDFLSDIFGLDLRREGG QYKLIPHNPNAGVRDLISPPYLTVPLPELRSSQQEKTKEDETNEKEDHKVESEKAEGENG EKEEKNTEKKSRRRRRRQQHAQKVEEPEVQESAFWKKITAYQQKLLNYFARNFYNMRMLA LFVAFAINFILLFYKVSTSPTLEEKECKHPGYYQEGGGSRWSSMGNGHRVTVHYVLQESS GYMEPTLRILAILHTVISFFCIIGYYCLKVPLVIFKREKEVARKLEFDGLYITEQPSEDD IKGQWDRLVINTQSFPYNYWDKFVKRKVMDKYGEFYGRDRISELLGMDKAALDFSDAQEK KKPKRDNSFSAVLNSIDVKYQIWKLGVVFTDNSFLYLAWYMTMSVLGHYNNFFFAAHLLD IAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFYNKSEDGDTPDMK CDDMLTCYMFHMYVGVRAGGGIGDEIEDPAGDEYEIYRIIFDITFFFFVIVILLAIIQGL IIDAFGELRDQQEQVKEDMETKCFICGIGNDYFDTVPHGFETHTLQEHNLANYLFFLMYL INKDETEHTGQESYVWKMYQERCWEFFPAGDCFRKQYEDQLN NT seq 14709 nt NT seq  +upstreamnt  +downstreamnt atggtattccagaatgtccctccagatctctctatctgtacctttgtgttggagcaatcc ctgtctgttcgggctcttcaagagatgctggcaaacaatgaggagaaagcagaaggggca actcaaggaggaggccatcggaccctcctgtatggacatgcagtgttgctcagacattcc tacagtggaatgtatctctgttgtttgtccacctctcgatcctcaacagacaaactagcc tttgacgttggattacaggaagatacaacaggggaagcgtgctggtggactatacaccct gcatctaaacaacgttcggaaggtgaaaaggtacgggtgggagatgaccttatcttagtc agcatttcgtcagagcggtacctgcatttgtcatatggctgtagcagtttacatgttgat gccgcattccagcaaactctctggagtgttgctccaatttgctctggaagtgaagtagca caaggatacctaaaaggaggagatgtgctgcggttactgcatggacacatggatgaatgt ttgactgtgccttcaggagaactcggagaagaacagcggaggacagttcattatgaaggc ggagcagtgtccattcatgctcgatcactgtggaggctggagatgctgagggtcgcgtgg agtggaagccatatcaggtggggtcagccattccgactgagacatgttacaacagggaag tacttgagcctcattgatgagaaaggccttcttctaatgggcaaagaaaaagctgatgta aaaagcacagctttctgcttcagattgtccaaggaaaaactggatacaggaataagaaaa gaggtggatggaatgggatccccagaggttaaatatggagattcagtgtgctttattcag cacctagacactggactttggctcacctatcagtctgtagatgcaaaatcagctcggatg ggaactgctcaacgtaaagccataatgcatcacgaaggccacatggatgatggcttaact ctctcacgctctcagcatgaagaatcaaggacagcacgggttatccgcagcacagctttt ctcttcaacaggtttattaggggccttgatactctcaataaaaaagggaagtccacagcc atcgatttgcccattgagtcagttagcctgagcttgcgggatctgattggttactttcag ccacctgatgaacatctggaacatgaagaacgacagaacagattgcgagcattgaagaac agacaaaatctcttccaggaagagggaatgattaacttagttcttgagtgcattgatcat ctcaacgtgtacagcagtgcagctcattttacagatgtagccgggaaggaagcaggagag tcatggagagcaattctaaattctctgtatgagctacttgctgccctgatcagaggcaat cgcaaaaactgtgcccaattttctggttccttggactggttaataagcagactagagaga ttagaagcttcttctggaattcttgaagttttgcactgtgttcttgtggaaagtcctgaa gctttgaatattatcaaagaagggcacattaagtctataatttccttgctagataaacat ggaaggaatcataaggttttagatgtgttgtgctctctgtgtgtgtgtcacggagttgct gtgcgatctaaccagcatctaatttgtgacaacctgctaccaggaagagacctactgtta caaacacgactcatcaaccatgtcagcagtatgcgaccaaatatctttctgggaataagt gaaggtgctgcccaatacaagaagtggtactatgaattaatcgtggacaatattgacccc tttgtgacaacagaagctacacatcttcgagttggctgggcttcaacagatggttactca ccgtgccctggagggggtgagggatggggagggaatggcgttggagatgacctttactcc tatggatttgatggactccacttatgggcaggctgtgttgcccgaacggtaaattcacca aatcagcacctcctaaaagctgatgatgttatcagctgttgtctggatttaagcgctcca agcatttccttccgaattaatgggcaaccagtacaggggatgtttgaaaacttcaacact gatgggctcttctttcctgtggtcagcttctctacaggagtaaaagtccgttttttgctt ggcggtcgtcatggggagtttaagttcctgccacctccaggttatgctccttgttttgaa gccttgcttccgaaagagaagatgagggtggaacacactaacgaatacaaacaagatcat aatggtgtcagggacctccttggccctaacatctcactcactcaagctgcctttacacca atgcctgtgggtacatctcagattgtactcccacctcacctggaccgagttcgagaaaag ctagcagaaaacatccatgagctctgggtgatgaacaaaattgagcttggctggacatat gggccgatccgggatgacaacaaacggcaacatccttgtctggtggaattctccaaatta ccagaacaggaacgaaattacaatttgcagatgtcacttgaaaccctgaagacccttatg gctttgggttgccatgtaggcattactgatgaccaggcagaagaaaaggtgaagaaacta aagctttccaggaactaccagctgccaagtggctacaagccagctccgatggacctgagc cacatcaaattaacctcaacccaggaggcaatggtggacaaactggcggagaatgctcac aatgtctgggccagagatcgcatcagacaaggctggacgtacggcattcagcaggacatc aaaaacagaagaaaccctcgtctggttccatatacccttttggatgaacgcaccaaaaag tccaacaaagacagtctgcgtgaagcagttcggacacttcttggctatggatataatttg gaggcaccagaccaggaccatgctgcaagatctgatctgctgagcagcgtggctgagagg ttccgcattttccgagctgagaaaacctatgcagtgaaaagtgggaagtggtactttgaa tttgaagcagttactgctgaagatatgcgcgttggctggaccagaccaggctgtcgccca gatcaggagctggggacagatgaccagtccttcgtttttgatggtttcaaggcacaacgg tggcaccagggcaacgagcactttggccgttcatggcaggccggggatgttgtaggctgc ctggtcgatatgaacgagtacaccatgacattcactctgaacggggaggttctgctggat gactcgggatctgaactcgcgttcaaggactttgaagttgcagatggttttattccagta tgtagtctggggctctctcaagttggcagaatgaactttggcaatgatgttggcaccctg aagtacttcaccatttgtgggctgcaagaaggatatgagccctttgctgtgaacatgaac agagacatcacaatgtggtttagtaaacggttacctcagtttgtacctgtacctgcaaac cacgaacatgttgaggtgacacgaatagatggcactgttgacagctcgccctgcttgaaa gtcatacagaggtcatttggatctcaaaacagtaacacagacattgctttctatcgtctg agcatgcccattgaatgtgcagaagtgttctgcaaggtgtccattggtggtttggcaaat accaatatcctacctcagaaaaatgaaattgaagattttgatgcagactctgattttgaa gttttgatgaaaacagcacatggacatctagcctcagccacagcagaaaaagagaaagaa agtgccaaaacagagttcaacaaccataaggattacaatcaggaaaaaccttctcgtttg aaacagaggtttatgttaaaaaggacgaaacctgattataacttggctcactcttcacct cgacttacggaggaggtactggcagaggacagggatgattatgactttctgatgcagaca acaacatactattattctgtgagaatatttcctggtcaggagccaactaatgtgtgggtc ggttgggttacctcagattttcatcagtatgacgctgcgtatgatctggagaaggttcgc actgtgacggtaacactaggagatgagaaaggaaaagttcatgaaagtgtcaagcgaagc aattgctacatggtgtgggcaggagaaagcacaagccctggacagagccgtaataacaat gggctggaaataggctgcctagtggacactgccagtggcttattgacattcacagccaat ggcaaggaattaaatacttattatcaggtggaaccaagcacaaaactgtttgcagcagta tttgcacaagccacaagccccaatgtgttccaatttgaactcggaagagttaagaatgta atgcccctgtcagctggattgtttaaaagtgagcgcaggaatccaacaccacagtgtcct cctcggcttcatgtgcaacaccttacccctgtgctgtggagcagggtgccaaatgaattc ttaaaggtggacatcagtcgtgttagtgaccgccatggatggcaggtgcaatgtacagaa ccattaagattcatgtctttacatattcctgaagagaacagggctttggatatcttggaa ctcacagagcatgaggacctgctgaaatttcactaccataccttgcgtttgtattccgca gtttgtgctctgggtaataaccgagtggcccatgccctgtgcagccatgtggatgagtct caattgctgtacgcgatagaaaataaatatgtacctggtttgctgcggacaggttattat gatctactcattgacacttaccttagcacctacgccactgctaggctgatgatgaacaat gagttcattgttccgatgacagacgagaccaagagcattactttattcccggatgataac caaagccatgcagtccctggagtaggcctcagcacctcactcaggcccagaatgcagttt tcctcagccagttttgtcaccgtgactggggagtctttccaatacagcccagaatttccg ctggacatcctgaaggccaaaacaattgagatgttgacagaagccgtgcaggaaggcagt ctccatgtccgagacccagttggcggcaccaccgagttccttttcgtccccctgatcaag ctcttttacacactccttatcatgggtatttttggcagtgaagatttgaagcatgtttta cagctcattgaggccagtgtgtttgctgaagatactcagacgacagaggaaaatgaaatg aatgaaaaggatataagtaaaaatgaccaaaaaacggaaggaggtgatgaagaattcaaa agcgacaaagttccccaagaaggtctactgcagatgaaactccctgagccagttaaactt cagatgtgccaccttttgcagtatttgtgtgactgtcaactacgacacaggattgaagcc attgtcgccttttcagatgattttgtactaaagcttcaggacaaccaaagattccgatat aacgaagtgatgcaggcattaaacatgtctgctgcattgactgccaagaaaacgaaagaa ttccgatcacctccacaggagcagattaacatgttgctgagtttcaagaatgacaggcga gaatgcccctgccctgtagaaatccgtgaagagctgttggatttccatgaagacctcatg gcacattgtggcattgaactcgaagaagaagaagcgaataatgatgacagtgattctaca atcagagggcgacttatgaacttggtagaaaaagtgacctacttgaagaaaaagcgggaa gagaacccggtggaacaggagacaaagaagcccactactctacagcagttgatctctgag accatggtacgatgggcccaggagtcagtgattgaagacccagagttagttcgggccatg tttgtgctgttgcatcggcagtatgatggcattggtgagctggttcgtgctttacccaag acatatacaataaatggagtgtccgtggaggatacaatcaacttgcttgcttcactgggc caaatcagatctcttctaagtgtcagaatgggtaaagaagaggagaagttgatgatccgt gggcttggggacatcatgaataacaaagtattttaccaacacccaaatctaatgagagct ctggggatgcatgagacggtgatggaggtgatggtgaatgtgcttggaggtggagagtcc aaggaaattatcttcccaaagatggtcgccaattgttgccgtttcctgtgctatttctgt cgaattagcaggcaaaatcaaaaagccatgtttgaccacttaagctatttattggaaaac agcagtgttggattagcttctccttcaatgcgagggtctactcctttggatgttgcagca gcatctgtaatggacaacaatgaacttgccttagcattgcgagagcccgacttagagaaa gttgttcaatatttagctggctgtggcctccagagctgcgctatgctagttgccaagggt tacccagatattgggtggaatcctgtggaaggggagcggtatctggattttctccggttt gcagtattttgcaacggcgagagtgtggaagagaatgccaatgaggttgtaaggttgttg atacgtcgccccgagtgctttggcccagctctgagaggagaaggtggggacgggcttctc gctgctatggaggaagctataaagatctctgaagatccagcaagagatggcctgtcatca actgatgaatctagtagaaggctagaccttgaagaagaggaagatgacaccattcacatg gggaatgctatcatgaccttctattctgctttaattgatttattgggtcgttgtgcgcca gagatccatctcattaatgcaggcaaaggggaggcaatccgaattaaatccattctccgt tcattgattccgctggaagacttggaaggagttgtcagcattcccttccagatgccaaca gttgcgaaggatggcacggttgtggagccggacatgtcagcaggattctgtccagatcac aaagccgccatggttttattcctggaaagggtatacggaatcgaagagcaagatttcctt ttacatctgctggaagttggctttttgccagacctccgtgctgctgcctcgctggacacg gctgccttgagtgctacagatatggcattggcactgaatcgatacctgtgcactgctgtt ctgccactgttaaccaagtgtgccccactttttgctggtacagaacatcatgcgtctctt attgattccttattgcacactgtctacaggctgtctaaagggtgctccctcactaaggcc cagagggatgccattgaggagtgcttactagcaatctgtggccaattacgaccatccatg atgcagcacttgttgaggagattggtgtttgatgtccccttgctgaacgaacatgcaaag atgcctctgaaattattaactaatcactatgaaaggtgttggaagtattactgtcttcct ggaggttggggtagctttggagcaacttcagaagaggaacttcatctctccaggaagttg ttctgggggatttttgatgccctgtcccagaagaaatatgaaccagagttatttaagtta gctttgccctgtttgagcgctgttgcaggggccctgcctccagattacatggaatccaac tatgtggcaatgatggagaaacaatcgtcagtggatactgaaggaaatttcaacccgcaa cccgtagatactttaagtacaaccctgccggaaaagttggattattttgttaacaaatat gcagaacacagtcatgacaagtgggcaatggacaagtttgcaaatggatgggtgtatggt gaaacatgcaatgaagctgccaaggttcatcctttgctaaaaccattcaaacttctatct gaaaaggacaaagaagtgtatcgttggccaataaaggagtctctaaaaacaatggttgcc tggagttggacaattgcgcgaacgagagaaggtgaatccatggtcctatataacagaaca cgccgaatatctcagtcaagtcaggtttctgtagattctgcacatgggtacagcccaagg cctattgacatgagcaatgttacgctttctagggacctgcatgcaatggcagagctacta gcagagaactatcataatatctgggctaaaaaaaagaaaaatgaattggaagttaaagga ggaggaaaccaccctttgttggtgccctatgatacactgacggcgaaggagaaagccaga gaccgagagaaagcccaggaaatcctcaagtttcttcagatcaatggttatgcagtctca aggggttttaaagagatggagttggataccccttccattgaaaaaagatttgcttacagc ttcctgcaacagctcatcaaatatgttgatcaggctcatgattacatattgcagtttgat ctttgttccacaagtaaaggagaaaaatttgtgcatgagcaggaagtcaagttctttgct aaggtcgttctacctctgattgatcaatattttaagaaccaccgcctgtatttcctgtct actgcgagtaaccctctcagtagtggaggccatgcatctaacaaggaaaaggagatggta acaagcctcttctgcaaacttggagtgcttgtcagacataggatatcactgtttgggaat gacgccacatcaattgtaaactgtcttcacatattgggccagactttggatgccagaacg gtgatgaagactggcctggagtctgttaagttggctctacgagccttttttgaaaatgcg gcagaagatttggaaaagaccatagagaaccttaaacttggtcaattcactcacaccagg acacagccaaagggagtgacccagatcatcaattacactacagtggcactgctaccagtc ttgtcatcattgtttgaacacattggacagcaccagtttggagaagatctgatcttggat gacgtacaagtttctggttacagaatattaagcagcttatatgcattgggtacagggaaa agcatatatgtagaaaggcagcgaccagcattaggggaatgtctggcagcattggctgga gcctttccagttgcattcctagaaactgactcgaataaacacaatccattctcgagctac aacacgaagacaccgaaagatcgagcagctttgaagttaccggccaaagtggaagatatg tgccccaatattccttctctggaaagactactggatgagatcatggagctgacagaatct gggatacgctacactcagatgccccatgtgatggaagtcattttacccatgttgtgcagc tacatgtcccattggtgggaacatgggccagagaataaccctgagaaggcagagcagtgt tgcactgctctcacctccgaacacatgaacacccttctgggcaacattctgaagataata tctaacaacttgggcatcgatgaaggagcctggatgaaaagattagcagtgttctcacag ccaattatcagcaaagtgaaaccacagctccttaaaacacacttcctgcctctgatggag aagctgaaaaagaaagtggccaccgtggtgatggaagaggaacaccttaaatcagagggc agaggagacatgtctgaggctgagctgctaattctggatgaatttactgtgctcacccga gatctttatgctttctacccactactgatcagatttgtggattataaccgcgcaaaatgg ctcaaagaaccaaatcctgaagcagaggagcttttccgcatggtagccgaagtatttatc tactgggcaaaatctcacaattttaaaagagaagaacagaacttcgtgattcagaatgaa atcaacaacatgtctttcctcattactgatacaaagtccaagatgtcaaagggaggtgtg tctgatcaagagaggaagaaatcaaagaggaaaggagatcgctattctcttcaaacttca ctcattgttgcagcgttgaagagactgctgcctattgggttaaatatttgtgcacctggt gaccaggaattaatctcgttagctaaaaatagatttagtatgaaagatacggaagatgaa gttagagaaataattcgcaataatcttcaccttcaggggaaattggaagatcctgccatt aggtggcagatggccctttacaaagatctacctaacaggaatgaagcttcatctgatcca gagaaaacagtgatacgtgtgctggatattgccaatgtgatcttccacttggagcaggtg gagcatccccagagatctaaaaaggctgtctggcacaagctgctgtcaaagcaacgtaaa cgagcagttgtggcctgcttccggatggctccactctataatttaccacggcaccgagct gtcaatctcttccttcaaggctatgaaaagtcctggattgagactgaggaacattatttt gaagacaagctaatagaggatatagctaaaccaggggatgaaaaaccagtggatgaagag gagggaaccaaacgccttgaccctcttcaccaacttattctacttttcagtcggacagct ttaactgaaaaatgcaatctcaaagaagatttcctctacatggcttatgctgacattatg gcaaagagctgtcatgtggaagaagatgaggatggtgaggaagaagtcaaaagctttgaa gagaaggaaatggagaagcaaaagcttctttatcagcaagcgagactccacgaccgagga gctgctgagatggttctgcagatgatcagcgccagcaaaggggagatgggaccaatggtt gcatccactctaaagcttgggattgctattctaaatggtggaaactcaacagttcaacag aaaatgctggactgtctaaaagagaagaaggatgtaggtttctttcagagtctcgctggc ctcatgcagtcttgcagtgtacttgatctaaatgcatttgaacgccaaaacaaagcagaa gggcttggcatggtgacagaagagggatcagtcatcactcatgagcgcggtgagaaggtg atgcaggatgatgagtttacgtgtgatctctttcgatttctccagctgctctgtgaaggt cacaactcagatttccagaattatctacgaacccagacgggcaacaacacaacagtcaat atcatcatttcaactgtggactacctcttgagagttcaggaatcaatcagtgacttctac tggttttattctgggaaggacatcattgatgaacagggacagcgcaatttctcgaaggca atcaatgtggcaaagcaagtgttcaacacacttactgagtacattcagggcccctgcact gggaatcaacaaagtctggcacatagcagactatgggatgcagtggttggctttcttcac gtgtttgcccatatgcaaatgaaactgtcccaggattctagccaaattgagctgctgaag gagttgatggaccttcagaaggatatggtcgttatgctgctttcaatgctggaaggtaat gtcgtcaatggaactattggcaagcagatggtggacatgttggtagagtcttcaaacaat gtagaaatgatcctcaaattctttgacatgttccttaagctaaagaacctcacatcatct gatgcattcaaagaatatgatcctgatagcaaaggtctaatcaccaaaagggacttccag aaggccatggagagtcataaacactacacacagtcagaaactgaattcctactctcctgt gcagagactgacgagaacgagatgctagattatgaagagtttgttgaaagatttcatgaa cctgcaaaagacattggtttcaatgttgcagtgctactgaccaacttgtcggagcacatg ccccatgatactcgcctgcagaccttcctggagttggcagagagtgttctcaactatttt cagccttttcttggccgtatagagattatgggaagtgccaaacggattgagagagtctac tttgagatcagtgaatccagcaggacacagtgggagaagccacaagtaaaggaatctaag agacaattcatcttcgacgttgtgaatgaaggaggagagaaagaaaagatggaactgttt gtgaatttctgtgaagacactatctttgaaatgcagttagctgcacagatctcggagtca gattccactgagaggtctgtgagtaaagaggagacacaaaaggataaaatggaggaagaa gatcccaaaatgaactttttctccatgacaacaattagatctgccttaatggctctcagg tataatgtgatgattctcatgaagttgctcacaactaaaagcctcaaaaaacagatgaag aaaattaaaaaaatgacaatgaaggacatggttatgaccttgtttgctttctattggagt ttattgattgggttctcccattttgtatttagtgttttccgtggattcttccgcatcatg tatagcactttcttggggggcagccttgttgagggagccaagaagatcaaagttacagaa cttttagccaacatgccagatccaacacatgatgaggtacgaggtgaacttggagaagga gaggggaaagttacacaatcaaccctgccttcagaagacttgactgacctaacggctatc accgaggagagtgacttcctgtctgatatctttggtttagacttacgacgtgagggaggc caatacaaactaataccacacaatcccaacgctggtgtgagggatctaattagtccacct tacctcactgttccacttccagaacttcgaagcagccaacaggagaaaacaaaggaagat gagacaaatgaaaaagaagaccataaagttgagtcagagaaagccgaaggggagaatgga gaaaaagaggaaaaaaatacagaaaagaagtcccgtcgacgaagaagaagacagcaacat gcacagaaagttgaagaaccagaagtgcaagaatctgccttctggaagaaaattacagca tatcagcagaagctacttaattactttgcacgcaatttctacaacatgaggatgctggca ttgtttgtcgcctttgcaattaacttcattctcctgttctataaggtctccacttctcca accctagaagagaaagaatgtaaacacccaggatactatcaggaaggtggaggttctcga tggagcagtatgggaaatgggcacagggtcacagtgcattatgttctccaagaaagcagt ggctatatggaacccaccctgcgaattctagccatcctgcatactgtcatctcatttttc tgcatcattggctactactgtttaaaagtccctctggttattttcaagagagagaaagag gttgccaggaagttggagtttgatgggttatacatcacagagcaaccttcagaggatgac atcaagggacaatgggataggctggtcataaacacacaatcatttccttataactactgg gacaagtttgtgaaaagaaaggttatggataagtatggtgaattctatgggagagatagg atcagcgaactgctgggaatggataaagctgctttagatttcagtgatgctcaggagaag aagaaacccaagagggataactccttctctgcagtgctgaactccattgatgtcaagtat caaatctggaagttgggagtagtattcacagacaattccttcttgtaccttgcctggtac atgaccatgtcagtgctgggacattataacaactttttctttgctgcccatttgctggat attgcaatgggatttaaaacattacgtaccatcctatcatctgtgacacacaatggcaaa cagctggtattaactgtgggcttattggccgttgtggtgtatctgtacacagtggttgct tttaatttctttcgcaaattctacaacaaaagtgaggatggagacacgccagacatgaag tgtgatgatatgctgacgtgttacatgtttcacatgtacgtcggtgtccgtgctggtgga ggtatcggtgatgagatcgaagacccagctggggatgaatacgaaatctatcgaattatc tttgatatcaccttcttcttctttgtgatcgtcatcctgttggccatcattcaaggtcta attattgatgcttttggtgaactaagagatcagcaagagcaagttaaagaagatatggag accaagtgcttcatttgtgggattggcaatgactacttcgacacagtccctcatggcttt gagactcacacgctgcaggagcataatttggcaaattacctgtttttcttgatgtatcta attaacaaagatgaaacagaacacaccggccaggaatcctacgtatggaaaatgtatcag gaacgttgctgggaattcttccctgccggagattgcttccgtaagcagtacgaggaccag ctcaactga

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