Ruminococcus bicirculans (ex Wegman et al. 2014): RBI_II00152
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Entry
RBI_II00152 CDS
T03158
Symbol
leuA
Name
(GenBank) 2-isopropylmalate synthase
KO
K01649
2-isopropylmalate synthase [EC:
2.3.3.13
]
Organism
rus
Ruminococcus bicirculans (ex Wegman et al. 2014)
Pathway
rus00290
Valine, leucine and isoleucine biosynthesis
rus00620
Pyruvate metabolism
rus01100
Metabolic pathways
rus01110
Biosynthesis of secondary metabolites
rus01210
2-Oxocarboxylic acid metabolism
rus01230
Biosynthesis of amino acids
Module
rus_M00432
Leucine biosynthesis, 2-oxoisovalerate => 2-oxoisocaproate
Brite
KEGG Orthology (KO) [BR:
rus00001
]
09100 Metabolism
09101 Carbohydrate metabolism
00620 Pyruvate metabolism
RBI_II00152 (leuA)
09105 Amino acid metabolism
00290 Valine, leucine and isoleucine biosynthesis
RBI_II00152 (leuA)
Enzymes [BR:
rus01000
]
2. Transferases
2.3 Acyltransferases
2.3.3 Acyl groups converted into alkyl groups on transfer
2.3.3.13 2-isopropylmalate synthase
RBI_II00152 (leuA)
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GFIT
Motif
Pfam:
HMGL-like
IPMS_D2
LeuA_dimer
Motif
Other DBs
NCBI-ProteinID:
CCO05926
UniProt:
A0AAW5KH72
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All DBs
Position
II:165481..167151
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AA seq
556 aa
AA seq
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MKNVEKYERGYYMPPVKCMKWAEKEYVDHAPAWCSVDLRDGNQALIIPMSLEEKLEFFTK
LVEIGFKEIEIGFPAASETEYEFCRTLIEKNMIPDDVTIQVLTQSREHIIKKTFEAIDGA
KNAVVHLYNSTSVAQREQVFRKSKEEIIKIATDGAKLCNEYKKHAKGNIVFEYSPESFTG
TEPEFARDICNAVIDIWQPTPDNKVIINLPVTVEMSMPHVYAQQVEYMCDTLHNRENVIV
SLHPHNDRGCAVADCEMGLLAGADRIEGTCFGNGERTGNADIVTIALNMYTHGVDPKLDF
SDMPALVELYERVTRMKVYDRSPYSGALVFAAFSGSHQDAIAKGMNWRKEKSCDKWTVPY
LPIDPHDVGREYDGDVIRINSQSGKGGIGFILQNQFGYDLPKKMREDFGYKVKAVSDHKH
KELMPDEVYKIFKDEYLNKCAPVDIPEAHYVQKQNGTICAAITASVNGVTDDHTAEGNGR
LDAVANAIKQALNFDFTVETYTEHALERKSTSEAVSYVGISCGDKMYWGVGRHSDIIVSS
IKGLVSAINNAFADKK
NT seq
1671 nt
NT seq
+upstream
nt +downstream
nt
atgaaaaacgtagaaaagtatgagagaggctattatatgcctcctgtaaagtgcatgaag
tgggctgaaaaagagtatgttgaccacgctcctgcatggtgttctgttgacctgagagat
ggaaatcaggctcttatcattcctatgagccttgaagaaaagctggagtttttcacaaag
ctcgttgagataggcttcaaggagatagagataggtttccctgccgcctctgaaacagag
tatgagttctgccgcacacttattgagaagaacatgatacctgatgatgttactattcag
gtgctcacacagtcaagagagcatatcataaagaaaacatttgaagctatcgacggtgca
aagaacgctgttgtccacctttataactcaacatctgttgcacagagagagcaggttttc
cgaaagtctaaggaagagataataaagatagctacagacggtgcaaagctctgtaacgag
tataagaagcacgcaaagggcaatatcgtattcgagtattctcctgagagcttcacaggc
acagagcctgagtttgcaagagatatctgcaacgctgttatcgacatctggcagcctaca
cctgataacaaggtcatcatcaacctgcctgtaacagttgaaatgtcaatgcctcatgtt
tatgctcagcaggtagagtatatgtgcgacactcttcacaacagagagaacgttatagtt
tcacttcacccacataatgacagaggctgtgcagtggcagactgcgaaatgggtctgctt
gcaggtgctgacagaatagagggtacttgtttcggcaatggtgagagaacaggcaatgcc
gatatcgttactatcgcacttaatatgtacactcacggagttgaccctaagctggacttc
tcagatatgcctgcactggtagagctttatgagagagttacaagaatgaaggtttatgac
agaagcccatattcaggcgcacttgtattcgctgcattctcaggctcacatcaggacgct
atcgcaaagggcatgaactggagaaaagaaaagagctgtgacaagtggactgttccttat
ctgcctatcgacccacatgatgttggaagagagtatgacggtgacgttatcagaataaac
tcgcaatcaggcaagggaggaattggctttatcctccaaaatcagttcggctatgatctt
ccaaagaagatgagagaggactttggctacaaggtaaaggctgtttcagaccacaagcac
aaggagcttatgcctgatgaggtctacaagatattcaaggacgagtacctcaacaagtgc
gcacctgttgacattcctgaagcacactatgttcagaagcagaacggcactatctgcgcc
gctatcacagcttcagtaaacggtgtaacagacgatcatacagcagagggcaacggacgt
cttgacgctgtggcaaatgctatcaagcaggctttgaactttgattttaccgtggaaaca
tacacagaacacgctcttgaaagaaagtcaacatctgaggctgtttcgtatgttggaatt
tcctgcggtgataagatgtattggggcgtcggcagacactcagatatcatcgtatcttct
atcaagggtcttgtttcagctatcaacaacgcttttgcagataagaagtaa
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