Streptomyces actuosus: DMT42_13535
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Entry
DMT42_13535 CDS
T08084
Name
(GenBank) dihydrofolate synthase
KO
K11754
dihydrofolate synthase / folylpolyglutamate synthase [EC:
6.3.2.12
6.3.2.17
]
Organism
sact
Streptomyces actuosus
Pathway
sact00790
Folate biosynthesis
sact01100
Metabolic pathways
sact01240
Biosynthesis of cofactors
Brite
KEGG Orthology (KO) [BR:
sact00001
]
09100 Metabolism
09108 Metabolism of cofactors and vitamins
00790 Folate biosynthesis
DMT42_13535
Enzymes [BR:
sact01000
]
6. Ligases
6.3 Forming carbon-nitrogen bonds
6.3.2 Acid-D-amino-acid ligases (peptide synthases)
6.3.2.12 dihydrofolate synthase
DMT42_13535
6.3.2.17 tetrahydrofolate synthase
DMT42_13535
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Gene cluster
GFIT
Motif
Pfam:
Mur_ligase_C
Mur_ligase_M
Motif
Other DBs
NCBI-ProteinID:
AWT43241
UniProt:
A0A2U9P222
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Position
complement(2859727..2861238)
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AA seq
503 aa
AA seq
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MSDIPGNDQPDPLDSFDEIIEAETTRDPDLAVIEAGSRTLRTQGGPPEADVPGRPEDPEV
DKALREVEAELATRWGETKLEPSVARIAALMDVLGEPQRSYPSIHITGTNGKTSTARMIE
ALLGAFELRTGRYTSPHVQSITERISLDGAPVSAERFIETYRDIQPYVEMVDSSQEYRLS
FFEVLTGMAYAAFADAPVDVAVVEVGMGGSWDATNVIDGDVAVVTPIDLDHTDRLGDTTA
AIAGEKSGIIKQDATVILAQQPVDAAQVLLKKAVEVDATVAREGLEFGVVARQVAVGGQM
LTLRGLGGEYTEVYLPLHGAHQAHNAAVALAAVEAFFGVGAQRAEPLDIDTVRKAFAAVS
SPGRLEVVRRSPTVVLDAAHNPAGARVTAEAIGEAFQFSRLVGVVGASGDKNVRGLLEAF
EPVFAEVVVTQNSSHRAMDADELAAIAVEVFGEDRVQVEPRLPDALEAAITLAEEEGEFA
GGGVLVTGSVITVGEARLLLGKG
NT seq
1512 nt
NT seq
+upstream
nt +downstream
nt
gtgagcgacatccccggcaacgaccagcccgaccccctcgactccttcgacgagatcatc
gaagcggagaccacccgcgaccccgacctcgccgtcatcgaggccggcagccgcaccctg
cgcacccagggcggcccgcccgaggccgacgtgcccggccgccccgaggaccccgaggtc
gacaaggcgctgcgcgaggtcgaggccgagctggccacccgctggggcgagaccaagctg
gagccctccgtcgcccggatcgccgcgctcatggacgtcctgggcgagccgcagcggtcg
tacccgtcgatccacatcacgggcacgaacggcaagacctccaccgcccgcatgatcgag
gcactcctcggcgccttcgagctgcgcacggggcggtacacgagcccgcacgtgcagtcg
atcaccgagcggatcagcctggacggcgcgccggtctcggcggagcggttcatcgagacg
taccgcgacatccagccgtacgtggagatggtcgactcctcgcaggagtaccgcctgtcc
ttcttcgaggtgctcaccggcatggcgtacgcggcgttcgccgacgcgcccgtcgacgtg
gccgtcgtcgaggtcggcatgggcggctcctgggacgccaccaacgtcatcgacggggat
gtcgccgtggtgacccccatcgacctggaccacaccgaccggctcggggacacgaccgcc
gcgatcgccggcgagaagtccgggatcatcaagcaggacgcgaccgtcatcctggcgcag
cagccggtggacgccgcccaggtgctgctgaagaaggccgtcgaggtcgacgccacggtg
gcccgcgagggcctggagttcggtgtcgtcgcccggcaggtcgccgtcggcgggcagatg
ctcacgctgcgcggcctcggcggcgagtacaccgaggtgtacctgccgctgcacggcgcc
caccaggcgcacaacgcggccgtggcactcgccgccgtcgaggcgttcttcggcgtgggc
gcccagcgcgccgagcccctggacatcgacacggtccgcaaggcgttcgcggccgtctcc
tctccgggccgtctggaggtcgtacgccgctcgccgaccgtcgtgctggacgccgcgcac
aacccggcgggcgcgcgggtgacggccgaggcgatcggggaggcgttccagttcagccgg
ctcgtcggcgtggtgggcgcgagcggcgacaagaacgtgcggggtctgctggaggccttc
gagccggtcttcgccgaggtcgtcgtcacacagaactccagccaccgcgcgatggacgcc
gacgagctggccgcgatcgccgtcgaggtgttcggcgaggaccgcgtccaggtcgagccg
cggctgccggacgcgctggaggccgcgatcaccctcgcggaggaggagggcgagttcgcg
ggcggcggcgtgctcgtcaccggctccgtcatcacggtgggcgaggcccgcctgctcctc
gggaagggctga
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