Salvelinus sp. IW2-2015 (Arctic char): 111951725 Help Entry 111951725         CDS       T05762                                  Name (RefSeq) ryanodine receptor 2-like   KO K04962   ryanodine receptor 2 Organism salp  Salvelinus sp. IW2-2015 (Arctic char) Pathway salp04020   Calcium signaling pathway salp04260   Cardiac muscle contraction salp04261   Adrenergic signaling in cardiomyocytes salp04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:salp00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     111951725    04020 Calcium signaling pathway     111951725  09150 Organismal Systems   09153 Circulatory system    04260 Cardiac muscle contraction     111951725    04261 Adrenergic signaling in cardiomyocytes     111951725  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:salp04040]     111951725    04990 Domain-containing proteins not elsewhere classified [BR:salp04990]     111951725 Ion channels [BR:salp04040]  Voltage-gated cation channels   Ryanodine receptor    111951725 Domain-containing proteins not elsewhere classified [BR:salp04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    111951725 BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 MIR SPRY Ins145_P3_rec RIH_assoc Ion_trans EF-hand_7 EF-hand_6 EF-hand_1 EF-hand_5 EF-hand_8 Motif Other DBs NCBI-GeneID:  111951725 NCBI-ProteinID:  XP_023825699 LinkDB All DBs Position LG25:19019894..19102582 Genome browser AA seq 4963 aa AA seqDB search MAESGESEDEIQFLRTNDEVVLQCIFTSQQEHLKLCLAAEGFGCRLCCLESTSNCKNVPP DLSVCSFVLAQCLSVRALQEMLANREDQAAGAGQGGGHRTLLYGHAVLLIHSYSRMYLCC LSTSQSSTDKLAFDVGLQDDKTGEACWWTIHPASKQRSEGEKVRVGDDLILVSVSSERYL HLSYGSVIDNTSESGSLIVDAAFQQTLWRVAPICSGSGVAQGYLKGGDTLRLLHGHTDEC LTVPSTDQGEELRKVVHYEGGAVSSHARSLWRLEILRVAWSSSHTRWGQPFRLRHVTTGR YLSLTEERGLHLVDRERADVKSTSFCFRPSKEKLECGPKKDIDGMGASEIKYGDSMCYVQ HVDSGLWLTYQAIDAKCARLGAVQRKAIMHSEGHMDDGLSLSRSQWEESHTARLIRSTVL LFTGFIRRLDGLSQRTNTPSLNLPLETVALSLQDLIGYLQPPGEGLGHEARQNSVRALKN RQNLFQEEGVIGLVLDCIDRLHLYSSASHFAAAAGKEAGDDWENILNSFYELLAALIRGN RRNCAQFSGSLDWLVSRLEGLEASTGVLEVLHCVLVESPETLNFIREGHIKSIISLLDKH GRNHKVLDVLCSLCVCHGMAVRSNQHLICDNLLPERDLLLQTRLVNQVTSMRPNIFLALG DDSAQYRRWYYEMTVDQVEPFLTAEPTHLRVGWANTEGYNPYLTGGEAWGGNGVGDDLSS YGFDGLYLWSGCVGRRVSSPYHHLLREDDVVSCCIDLVAPCISFRVNGQPVQGMLENFNT DGLLFPVVSFSAGVKVRFLLGGRHGEFRFLPPPGFAPCSEALLPRVKLRVEPCQDFTQEQ YLLGPTVPLTPATFTPSPVDISQVVLPVQLEHIRERLAENTHELWVMDKIDLGWTHGAVR DDSKKQDPCLVEFSRLPEQERNHSLQMSQDTLRTLVALGLHIGLADGRADEGVRYLRLSN KYEMPSGYRPAPVDLSHIILSPAQEAVVELLAENDHNVWARDRIRQGWTYSSHQDVKAKR SPHLVPYSLLDERSRQSGRDGVREAVCTLLGYGYSLEPLDQDRAVMPDPCHTAAEKFRVF RADKLYAVTRGKWYFEFEAVTEGDMRVGWARPHCTPNGELGSDMQAFVFDGSKAQWCHQG GEPLGRPWQSGDVVGCMVDMGECTMMVTLNGEVLLNDRGSELAAKDFDINQGFLPVCCLG VNQKARLNLGRDVASLCYFTECGLQEGYKPFAVNMARDPALWMSWRQPQFIPVQTDHDSI QVTRITGSTESPPCLKVTQRSLGPQSCGSDMGFYRLSMPIECAEAFSRPVGATLPISSSV STARKDLQEFEVDSDFEMLLKSAHVYTGSRDELNHKDYSHDKTSKLKQRFMLKKPKPELN KSHSSARLLQEVHADKDDYDHLAQSTTYYYSVRVLPGQDPSTVWVGWVTSDFHQHQLTFD LEKIRTVTVTLGNDMGKVHESVKRSNCYMVCAGESTGLGQSRRSAGLAIGCLIDTTTGLL TFSSNGMELGTFFQVEPSTRLFPAVFAKANSSNVFQFELGRVKNMLPLSAGLFRSQRRNA MPQCPPRLQVQVLSPILWTRVPDHTLRVQAAHPEDRLGWRVQCLEPLQVMTLLIPEENRC VDILELSELGDLLSFHHHTLLLYSALCALGNTRVGHALCSHLDQSQLLYAIQSPRLPGPL RSAFYHLLGQVHLSTHATARLAMNHEYIVPMTEQTRAITLYPSPRASRSPQWVPRMGLST SLRPRMHFTSPCFVRGDGMGVNGDTCGDGVVPTGEGIHIDSPEIPLELLKDLTGNMLTEA VWAVGQGVRDPEGGSIELLLVPLIRLFHTLLVMGLFGDEDLGKVLTLIEPGVFSRPADCS QEEEQEEEEEEQEDENVPDSDRESVMEREGDKRRKIPKLPTKGLLQMKLPEAVKLEICHL FQYLCDCQVRHRVEAVVAFSDTFVGYLQENQRFRYNEVIQALHMSAALTARKTKEFRSPP QEQINMLLGFREEQGDCPCPEDIREQLLDFHQDLMTHCGIEVDHDTEVVEDSNRSIKDRL FSLVGRVISLKRRSADPEEEDRAQNTMTLQQLISDTVVRWAQECVIENPALVRAMFSLLH RQYEGLGGQMGTPLHKAYTISQVSVEDTMALLASLVQIRSLLSVRMGKEEERLMIRGLGD IMNNKVFYQHPNLMRALGMHETVMEVMVNVLGEGESKEITFPKMVAHCCRFLCYFCRISR HNQGSMFEHLSYLLDNSSVGLASPSMRGATPLDVAAASVMDNNELALALREPDLEKVVQY LAGCGLQSCPMLVSKGYPDIGWNPVEGERYLDFLRFAVFCNGESVEENAYSVVRLLIRRP ECFGPALRGEGGDGLLAAMEEAIRISEDLTMDGPSTTYESNRTLNVLQDEEDDIIHMGHS IMTFYSALIDLLGRCAPEMHLIHAGKGEAIRIRAILRSLIPIQDLEGVIGIPFQIPSLAK DGTIVEPDPSTVFCPDHKAAMVLFLDRVYGIEDQNFLLHLLEVGFLPDLQAVASLDTTDL SATDMALALNRYLCTAVLPLLTKCSSLLSGTEGQGPLVDALLQAVYRLSRALSLTKAQRD AIEDCMLAICSKLRPSMMQPLLRRLVFDVPLLTNHTKIPLKLLTNHYEQSWKYYCLIGGL GHLGSASEEELHLCRKLFWGVFNALSRKHYDTELSKLALQCLAAAAGALPPDHMDPGCVA WIKRHPSMDAQGHFDPQPVDTSNVSVPEKLEFVVNKYAEHTHEKWSMDKFANGWVHGELC EKTKVHPLLKPYRALAERDKEAYRWSVKETVRSMLAFGWTIERTKEGDGLGLLTCSRRFS QAGQLSFEGASTFTPKPMDMSSVTLSWDQCSVTELLAENYHNTWSRKKKQEVDAKGGGGH STLVPYDTLPTKEKAKLREKAQDVLKFFQLNGYTVWRDRKAAEMDSPAIANRFAYTFLQQ LLSYTEETQEYMQELELMQARGQMPIEAPHQQQVDFFSKVALPLLEQYLKNHRLYFLSTA ARSRGNGGHASNKEKEMVTSLFCKLGALVRQRISLFGSDAPSIVSCLLILAQSLDVRTLM KTAPESARVSLRSFFEAAAVDLEMTVENLSMTQSWTQSRGVAQILDYTNTTLLPTLTSIF EHLSHNQYGEDLLVDSVQVSCYKILNSLHSLGISKSFYVEGQRPSAGACLAALSGAFPVC FLEPALNEDNPYSIYNTMSPREREDVGVPDEVEEVCPLLPSLQQLLGEVEELAGAGSGAR QAQYSHVTEITLPLLCSYVSRWWQHGPEGQLESPVCTSLTSQHASTLLGNILRIIHNHLG TGQGDWMKRLAVFSQPIICQAHPQLLRSHFLPLMEKLKKRAESVLQEEEQIKAEGRADAS EAELQIQEKFIVLVRDLYAFYPVLIPFVDYNRASWLREPNHEAEKMFGMVAEIFIFWAKS HNFKWEEQNYVVQNEINNMAFLVNNNNHKMSKVSDQERRKMKRKGDRYSTQTSLIVASLK RLLPVGLSACSPADRGLITLAKSRFTQKDTEDEIRESIHNGLLRLQSKREAPGARWQDVL FRDFPGPTRDTSDPLRTVERVLDIACVLYHLDQVEHPQRKKAVCHKVLSKQRKRAVVACL RMAPLYNLPRHRAVNLFLQGYDKCWISAEDHSFEEKLVDDLARAGKQERSEREEEGEDDD EQIDPLLQLITLFSRSALTESKLGDDSLYMSYAAIMAKSCCGEEDEEVKSFEEKEMEKQK LLYQQARLHDRGAAQMVLQTISASKGDMGSMVASTLKLGISILNGGNTTVQQKMLDYLKE KRDVGFFQSVAGLMQSCRQDRRISDVIQESSGEKVMPDEKLTCDLFRFLQLLCEGHNSDF QNYLRTQTGNNTTVNIIISTVDYLLRVQESISDFYWYYSGKDVIDEHGQRNFSKAINVAK QVFNSLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMQMKLSQDSSQIEILKELMDL QKDMVVMLLSMLEGNVVNGTIGKQMVDMLVESSSNVEMILKFFDMFLKLKDLTSSDAFKE YDHDGKGRISKKDFQKAMEAYKRYSQSETQFLLSCTETDESELLDYEAFVDRFHEPAKDI GFNIAVLLTNLSEHMPHDSRLGTFLQLAECVLSYFQPYLGRIEILGSGKRIERVYFEISE SSRTQWEKPQVKESKRQFIFDVVNEGDGKEKMEMFVNFCEDTIFEMQLAAQISGTDTGER TAGKEAEEEEEKDRGKNDGEELERSKMGFFSMSTIWLIVFALPYGLMMLMSMLSVKNLKK HIKKTTLRNLVMVFASFFQAMIMGLVHFVCSVVRFFLYVLYIVFVSGGLIEGAKKIRVFD LFGGILDPTLDEVTGGSGGYRERRYSTRSSRDELRGLGQSTVSSSDTNVLSDIFGLRVRR EGGQYRLMTHDLTASLTDLFNTATGQQSPAEPNGKQQVEGAREEDGKEGEEKESELEKAE REDSEKEAAKAKLRVRICSSKPEEPEPQESAFWEMITTHQKRLLNYFARNFYNMRMLALF VAFSINFILLFYKVSSSSSVTEEDEKVPVLYDSSGDLDEEGTLVNDNTSGIMQFVLEEST GYMEPSLRFLSIAHTLISFCSIIGYYCLKVPLVIFKREKDVARKMEFDGLYVTEQPPDED IKGQWDRLVITTQSFPSNYWDKFVKRKVMDKYGKFYGCDRISELLGLDKAALDFSSEGQE RRRPRREGAWTALLNSIDVKYQVWKLGVVFTDNSFLYLAWYMTMSVLGHYNNFFFAAHLL DIAMGFKTLRTILTSVTHNGKQLVLTLGLLAVVVYLYTVVAFNFFRKFYNKSEDGVALDM KCDDMLTCYMFHMYVGVRAGGGIGDEIEDPAGDEFEVVRIIFDITFFFFVIVILLAIIQG LIIDAFGELRDQQEQVKEDMETKCFICGIGNDYLDNVPHGFETHTLQEHNLANYLFFVMY LINKDETEHTGQESYVWKMYQERCWEFFPVGDCFRKQYEDQLC NT seq 14892 nt NT seq  +upstreamnt  +downstreamnt atggctgaatcaggagaaagcgaagatgagatccaatttctacgtacgaatgatgaggtg gtgctgcagtgcatcttcacatcccaacaggagcatctgaaactgtgcctggctgcagag ggctttggctgcagactctgctgtctggagtccacctccaactgcaagaatgttcctcca gacctgtcggtgtgttcctttgtgctggcccagtgtctgtctgtcagagctctgcaggag atgctggctaacagggaggaccaagcagcaggggctggtcagggaggtggtcatcgcacc ctcctctacggtcatgctgtactgctcatacactcctacagcaggatgtatctttgctgt ttgtccacatcccagtcttcgacagataagctagcgtttgatgttggtctgcaggatgat aaaacaggtgaggcatgctggtggaccattcaccctgcatccaagcagaggtcagagggg gagaaggtccgtgtcggggacgacctcatcctggtcagtgtgtcatctgagagatacctg catttgtcctatgggagtgtgatagacaatacgagtgagagtggcagcctcattgtggac gcagccttccagcagaccctctggagggtcgcccccatctgttctgggagtggagttgct caagggtatctgaagggaggggacacgttgaggctgctgcatggacacacagacgaatgt ctgactgtcccatctacagaccagggggaggagctacgcaaggtggtgcactacgagggt ggagcagtgtccagtcatgcccgctctctctggaggctcgagatcctgcgtgttgcctgg agtagtagccacacacgctggggtcagccattccggctccgccatgtcaccacagggagg tacctgagtctgaccgaggagagaggccttcacctggtggacagggagagggctgacgtg aagtccacatccttctgcttccgaccctccaaggagaagctagaatgtggcccaaagaag gacattgatggtatgggtgcctcagagatcaagtatggagactccatgtgctacgtccag catgtggactctggtctgtggctcacctatcaagcaattgatgccaagtgtgcccgcttg ggagcagtgcagcgcaaggccattatgcacagtgagggtcacatggatgacggtctgagc ctgtcccgttctcagtgggaggagtcccacacggccagactcatccgcagcaccgtcctc ctcttcacaggcttcatcaggagacttgatggtctcagtcagcgaacgaacaccccctcc ttaaacctgccactagagacagtggccctaagtttgcaggatctgattggctacctccag ccacctggggaggggctaggacacgaggctaggcagaacagtgtgcgagctctgaagaac agacagaatctatttcaagaggagggggtcatcggtttagttcttgactgtattgaccgt ttacacctatacagcagtgcctctcattttgctgcagctgctgggaaggaggcaggagat gactgggagaacatcctcaactccttctatgaactactggctgctcttatcaggggaaat cgcaggaactgtgcccagttctcaggctccctggactggctggtgagcaggctggaggga ctggaggcctccactggtgtcctggaggttttacactgtgtccttgtggagagtcctgag actctcaactttataagggaaggacacattaaatccatcatctctctactggataagcat gggcggaaccataaggtcctggatgtgctgtgttctctctgtgtgtgtcatggtatggca gtgcgttccaaccagcatctgatctgtgataacctgctaccagagcgagacctgcttctc cagactcgcctcgtcaaccaggtcaccagcatgaggcccaacatcttcctggccctgggt gatgactcggcccagtacaggaggtggtactatgagatgactgtagaccaggtggagccc ttcctcacggctgagcccactcacctgcgtgtgggctgggccaacactgagggttacaac ccctatctcacgggtggagaggcctgggggggcaacggggtaggagatgacctaagctcc tatggctttgacgggctgtacctctggtcaggctgtgttggccggagagtgagctctccc tatcaccaccttctgagggaggacgatgtggtcagctgctgcattgacctcgttgccccc tgcatctccttccgggtcaacgggcagccggtccagggcatgctggaaaacttcaacact gacggactgctcttcccagtggtcagcttctctgctggtgtcaaggtgcgttttctgctg ggtgggagacatggagagttccgtttcctgccccctccaggcttcgccccgtgttccgag gctctgctccccagggtgaagctgagggtggagccgtgtcaggacttcacccaggagcaa taccttctgggccccactgtacccctcaccccagcaacctttacccctagtccagtagac atcagccaggtggtgttgcctgttcaactggagcatattcgtgagagactagcagaaaac acccatgagctgtgggtcatggacaagattgaccttggatggacccatggagctgtgaga gatgacagtaagaagcaggacccctgtctggtggagttctccaggctcccagaacaggag cggaaccacagccttcagatgtcccaggatactctccggactctcgttgcccttggtttg catattggactggcagatggccgtgctgatgagggagtgagatacctgaggctctccaac aagtatgagatgcctagtgggtacagaccagccccggtagacctgagccacatcatcctg agtcctgcccaggaggcggtggtggagctgctggctgagaacgatcacaacgtgtgggcc agggaccggatcaggcagggctggacctacagctcacaccaggatgtgaaggccaagcgg agcccccacctggtgccctacagcctgctggatgagaggagcagacaatctggcagagac ggtgtgagggaggctgtgtgcaccctgctgggctacggctacagtctggagcccctggac caggacagagctgtgatgccagacccatgtcacacagcggctgagaagttcagggtcttc agggcagacaagttgtatgctgtgaccagggggaagtggtactttgagtttgaggcggtg acggaaggggacatgagggtaggctgggctcgtccccactgcacaccgaatggggaacta ggatcagacatgcaggcttttgtgtttgacggctccaaggcccagtggtgtcaccaggga ggtgagcccctgggtcggccctggcagagtggtgatgtggtgggctgtatggttgacatg ggtgaatgcaccatgatggtcactctcaatggagaggtgcttttgaacgaccgcggatca gagctggctgccaaggactttgacatcaaccagggcttcctccctgtgtgttgtctcggg gtgaaccagaaggccaggctgaatctgggtcgtgacgtggcctcactgtgttacttcaca gagtgtggcctacaggaaggttataagccatttgctgtaaacatggccagagacccagcc ctgtggatgagctggagacaaccacagttcatccctgtacagacagaccatgatagcata caggtgacaagaatcactgggtccactgagagcccaccgtgcctaaaggtaacacagagg tcattggggccccagagttgtggcagtgacatggggttctacagactcagtatgcctata gagtgtgctgaggccttctccagaccagtaggggctactctacctatcagcagcagtgtc tccacagccaggaaagacctgcaggagtttgaggtggactctgactttgagatgctgctg aaatcagctcatgtttacactggctccagggatgagcttaaccacaaggactacagccat gataaaacatccaaactcaaacaacggttcatgttgaagaaacccaaaccagagttgaac aaaagccactcatctgcccgtctactgcaggaggttcatgctgacaaagatgactatgac catctggcccagtccactacgtactattactcagtgagggtgttacctggtcaggacccc tccactgtctgggtgggctgggtcacctctgacttccaccagcaccagctgacctttgac ctggaaaagatccgcacagtgaccgtcaccctcggaaatgacatgggcaaggtccatgag agtgtgaaacgtagtaactgctacatggtgtgcgccggagagagcacgggcctggggcag agcaggaggagtgcaggcctggccataggctgtctgatagacaccaccactggactgcta acattcagctccaacggcatggagctggggaccttctttcaggtggagcccagcactagg ctgtttcctgcagtctttgccaaggccaacagctccaatgtgttccagtttgagctaggg cgcgtaaagaacatgctgcccctgtcagcgggtctgttcaggagccagaggaggaatgct atgccccagtgtccccccaggctgcaggttcaggtgctgtcacccatcctttggacccgt gtaccagaccacaccctgagggtgcaggctgcccaccctgaagaccgcctcggctggagg gtccagtgcttagagcccctgcaggtcatgaccctgctcatcccagaggagaacaggtgt gtggacatcctggaactctctgagttaggtgaccttctgtctttccatcaccacaccctg ctcctctactctgccctctgtgctctgggcaatactcgtgtgggccacgccctctgcagc cacctggaccaatcacagctcctctatgccatccagagcccccgcctccccgggccgctc cgctccgccttctaccacctcctgggccaggtgcacctcagcacccacgccacggcccgc ctcgctatgaaccacgagtacatcgtccccatgacggagcagaccagggccatcaccctc taccccagccccagggctagtcgaagcccccagtgggttcccagaatgggcctcagcacc tccctcagaccccggatgcacttcacctccccctgcttcgtcagaggagatggcatggga gtcaatggggatacttgtggtgatggcgtggttccgactggggaaggcatccatatagac agcccagagatcccactggaacttctgaaggacctgacagggaatatgctgactgaggct gtgtgggctgtggggcagggtgtgagggatcctgaagggggcagcattgagctgctgctg gtgcccctaattcggctgttccacaccctgctggtgatggggttgtttggggacgaggat ctagggaaagtgctgacactgatcgagcctggggtcttctcccgacctgcagattgttcc caagaagaggagcaggaggaggaagaggaagagcaggaggatgaaaatgtgccagatagt gatagggaaagtgtgatggagagggagggggataaaaggaggaaaattccaaagcttcca acaaaaggactgcttcagatgaagctaccagaagctgtcaaacttgagatctgccacctg ttccaatacctgtgtgactgtcaggtgcgtcacagggtggaggcggtggtggccttctca gacactttcgtggggtacctgcaggagaaccagcgcttccgctacaatgaggtgatacag gctctccacatgtctgctgccctcaccgcccgcaagaccaaggagttccgctccccgcca caagaacagatcaacatgttactgggcttcagagaggagcagggggactgtccatgtcca gaggacatcagagagcagctgctggacttccaccaggacctcatgactcactgtggaatt gaagttgaccatgacacagaggttgtggaggattccaatcgctccatcaaagatcgtctc ttcagcttggttgggagagtaatcagcttgaagaggagatctgcagatcctgaagaggaa gacagagcacagaataccatgactcttcagcagctcatctctgacacggtggtgcgctgg gcccaggagtgtgtgatagagaacccagctctggtcagggccatgttctctctgttgcac cggcagtacgagggcttggggggccagatgggcactcccctccacaaggcctacaccatc agccaggtgtcagtggaggacaccatggccttgctggcctctctggtgcagattcgctct ctgctcagcgtccgcatgggcaaggaggaggagagactcatgatccggggactgggagac ataatgaacaataaggtgttctaccagcaccccaacctgatgagggctctggggatgcac gagacggtcatggaggtgatggtgaacgtcctgggggagggagagtccaaggagatcacc tttcctaagatggtggcccattgctgtcgcttcctttgttacttctgtcgcatcagtagg cacaatcagggatccatgttcgagcacctcagctacctgttggataatagcagtgttggc ctagcatctccgtccatgcgtggagcaacccctctggatgtggcagctgcctctgtcatg gacaacaatgagctggccctggccctgagggaaccagacctggaaaaagtggtgcagtac ttggcaggctgtggtctacagagttgtcccatgctggtgtctaaaggctaccctgacatt ggttggaaccctgtggagggggaacgctacctggacttcctacgctttgctgtcttttgc aacggggagagtgtggaggagaatgcctactcggtagtgaggctgctgattcgccgtccg gagtgttttggccccgccctgcgaggtgagggtggcgatggtctcctggcagccatggag gaagccatcaggatctcagaggacctgactatggacggaccctccacgacctacgagtcc aacagaacactgaacgtgctgcaggatgaggaggatgacataatccacatgggccactcc atcatgaccttctactccgccctcatcgacctgctgggccgctgtgccccggagatgcac ctgatccatgctgggaagggcgaggccatccgtatccgggccatcctgaggtccctcatc cccatccaggacctggagggagtcatcggcatccccttccaaatcccctctctagcaaaa gatggcaccatagtcgaaccagacccatccactgtgttctgcccggaccacaaggcagcc atggtgctgttcctggaccgtgtgtacggcatcgaggaccagaacttcctgctccacctg ttggaagtgggcttcctgccagacctgcaggctgtggcctctttggacacaactgatctg agtgccacagacatggccctggcactgaacaggtacctgtgtacggctgtgctgcccctg ctcactaagtgctccagcctgttgtctgggacagagggccaggggccgctggtggatgct ctcctccaggccgtctaccgcctgtccagggccctcagcctcaccaaggcccagagagac gccatcgaggactgcatgctggccatatgcagtaagctcaggccgtccatgatgcaacct ctactccgacggcttgtttttgatgtgccccttctgacaaatcacactaaaataccactc aagctgttgaccaatcactatgagcagagctggaagtactactgtctgattggaggtttg gggcacctgggctctgcctcagaggaggagcttcacctctgcaggaagctgttctgggga gtgttcaatgctctgtccaggaagcactatgacactgagctctccaagctggctctgcag tgtctggcagctgcagctggagccctccctcctgaccacatggaccctggctgtgtagcc tggattaagagacacccctccatggacgcacagggacactttgacccccagcctgtagac acctccaatgtgtcagtaccagagaaactggaatttgtggtgaataaatatgcagaacac acccatgagaagtggtcaatggacaagtttgccaatggctgggtccatggggagctctgt gaaaagaccaaagtacaccctctcctgaagccttacagagctctggctgagagggacaaa gaggcatatcgctggtctgtaaaggagaccgtgcgaagtatgttggcctttggctggacc atagagagaactaaagagggagatggccttggcctactcacctgctcacgccgcttctcc caggctggacagctgtcgtttgaaggagcatcaactttcacccccaagccaatggacatg agcagtgtgacactctcatgggaccagtgttctgtgactgaattgctggctgagaactac cataacacctggtccaggaagaagaagcaggaagtggatgctaaagggggagggggtcat tctacgctggtgccctatgataccctccctaccaaggagaaagccaaactgagagagaaa gcccaggatgtcttgaagttcttccagctgaacggctacacagtgtggagggacagaaag gcagcagagatggactcaccagccatagcaaaccgttttgcctacactttcctacagcag ctcctctcatacacagaggagacccaagaatacatgcaggagctggagcttatgcaggca agaggtcagatgccaatagaggctccccaccaacagcaggttgactttttcagcaaggtg gcgttaccccttctggagcagtacctgaagaaccatcgcctctacttcctttccaccgca gccagatcacgaggcaacggaggtcatgcctccaataaggagaaggagatggtcaccagc ctgttctgcaaattgggagctcttgtcagacaaaggatctctctgtttgggagcgatgca ccttccatcgtcagctgtcttctcatactggcccagtctcttgatgtcaggactttgatg aagactgctccagaatcagccagggtctcactacggtccttcttcgaggctgcagcggtg gacctggagatgaccgtggagaacctctctatgacccagagctggacccagtccagaggg gtggcccagatcctggactacaccaataccaccctgctgccgactctcacctccattttt gaacacctcagccacaatcagtatggagaggacctcttggtggacagtgtccaggtgtcc tgttataagatcctcaacagcctccactcacttggcatcagcaaaagtttctacgtggag gggcagaggccgtcagcaggagcgtgtctggcagcgctgtcaggggctttccctgtgtgt ttcctggagccagctctgaatgaggacaacccgtactccatctacaacaccatgagcccc agagagcgagaggatgtgggagttccggacgaggtggaggaggtgtgtcctctcttgcca tctctgcagcagcttctgggggaggtggaggagctggcaggggcaggctcaggggcacgc caagcccagtacagccatgtcaccgagatcaccctacccttgctctgcagctacgtgtcc cgttggtggcagcacggtcccgagggccagctggagagcccggtctgcacctcactcacc tcccagcatgcaagcacactgctgggcaacatcctccgcatcatccacaaccacttggga acaggccagggagactggatgaagcgcctggcagttttctctcagccaatcatctgccag gcccacccccagttgctgaggagccacttcctgcctctgatggagaaactgaagaagagg gcagaatcagtgcttcaggaggaggagcagataaaggctgaggggagggccgatgcgtct gaggcggagctacagattcaggagaaattcattgtgctggtgcgagacctctacgccttt taccctgtcctcatcccattcgtggactacaatagagcaagttggctacgggaaccgaac catgaggctgagaagatgttcggcatggtggcagagatcttcatattctgggccaagtct cacaacttcaaatgggaggaacagaactatgtggtccagaatgagatcaacaacatggct ttcttggtcaataataacaatcacaaaatgtccaaggtgtcagaccaggagaggaggaag atgaagcggaaaggggatcgctactccacacagacctctctcatcgtagcctccctgaag agattgcttcctgtgggactgagtgcgtgttccccagcagaccgcggccttatcacactg gccaagagccgcttcactcagaaggacacagaggacgagattcgagagagcattcataat ggcctgctacgtcttcagagcaaacgggaggccccaggggctcggtggcaggatgtcctg ttcagggacttcccaggccccacacgggacacctctgaccctctgaggacagtagaaagg gtcctggacattgcttgcgtgctttaccacctggaccaggtagagcatccccagaggaag aaggcagtgtgtcacaaggtgttatccaaacagaggaagagagctgtggtggcctgcctt agaatggctcctctctacaacctacccaggcaccgggctgtcaacctctttctacagggc tatgataagtgctggatatctgctgaggatcactcctttgaggaaaagttggttgacgat ttggctagagctggaaagcaggagcgttctgagagagaggaggaaggagaggacgatgac gaacagattgatccgctcctgcagctcatcacactgttcagtcggagtgctctgaccgag agtaagcttggcgatgacagtctttacatgtcctatgctgccataatggcaaagagttgc tgtggtgaagaggatgaggaggtgaaaagctttgaagagaaggagatggagaaacagaag ctgttgtatcagcaggccaggctgcatgaccgtggagctgctcagatggtcctccagact atcagtgctagtaaaggtgacatggggtccatggtggcctccactctgaagcttggtatt tctattctgaatggaggaaataccactgttcagcagaaaatgttggattacctgaaagag aagagggacgtgggtttcttccagagtgtggcaggactcatgcagtcttgcagacaagac cgaaggattagcgatgtcatccaggagagctcaggggagaaggttatgcctgatgagaag ttgacctgtgatctttttcgcttcctacagctcctctgtgaaggacacaactcagatttt cagaattatttgagaacacaaacaggaaacaacacgactgtgaacatcattatatccact gtggactaccttctcagagtacaggagtcgataagtgatttctactggtattactctggg aaggatgtgattgacgaacatggccagcgtaacttctccaaggccatcaatgtggccaaa caggtcttcaactctctcacagagtacatccaggggccgtgtactggtaaccagcagagt ctggcccacagtcgtctatgggatgcagtggtgggctttctccatgtctttgctcacatg cagatgaagctgtctcaggattccagccaaattgaaattctgaaagaattgatggatttg caaaaggacatggttgttatgttgttgtccatgttagaaggtaatgtggtaaatggaaca attggcaagcagatggtggacatgttggtggaatcatctagcaatgttgagatgatccta aagttcttcgacatgttcctcaaactcaaagacctgacatcctctgacgcattcaaagag tatgatcacgacggcaaaggtcgcatctccaaaaaggacttccagaaggccatggaggcc tacaagcgctactctcaatccgagacccagttcctcctctcctgcacggagacggatgaa agcgagctcctggattatgaggccttcgtggatcgcttccacgagccagccaaagacatt ggcttcaacattgctgttctcctaaccaacctgtccgagcacatgcctcacgattcacgt cttggtacctttctgcagcttgcagagtgtgttctgagctacttccagccctacctgggc cgtattgagatccttggcagtggcaagcgcatcgagagggtctactttgagatcagcgag tccagccgcacgcagtgggagaagcctcaggtcaaagagtccaagagacagttcatattt gacgtggtcaatgagggcgacgggaaagagaagatggagatgtttgtcaacttctgcgaa gacaccatctttgagatgcagctggctgcccagatatcagggacagacactggggagagg accgcaggcaaagaggctgaagaagaggaagaaaaagacagggggaagaatgacggggag gagttggaaagatccaaaatgggatttttctccatgtccacaatatggctcatcgtcttc gctctaccttatggcttgatgatgctgatgtctatgctctctgtgaaaaacctgaagaag catattaagaagacaactctgaggaatttagtcatggtatttgcttccttcttccaggcc atgatcatgggtctggttcactttgtctgttctgtagttcgcttcttcttatatgtactg tacattgtttttgtaagtggaggactcatagagggggccaagaagataagggtgttcgac ctttttggaggcatccttgaccccacactcgatgaggtcacaggggggtcagggggttac agggagaggagatacagcacaaggtcctcccgggacgagctgagggggctgggccagtca acagtttcctccagtgacaccaatgtcctgtcagacattttcggtctgcgagtgaggaga gaaggaggtcaatacagactaatgactcatgacttaacagccagtctgactgacctgttc aacacagccactggccaacaatcccctgctgagcccaatgggaaacaacaggttgagggt gccagagaagaagatggtaaagaaggagaagagaaagagtctgagttggagaaagcagaa agggaagattctgagaaggaggcggcgaaggctaaactgagagttaggatatgctccagc aaacctgaggagccagagcctcaggaatcagccttctgggaaatgataaccactcaccag aagagactgttgaattactttgcgaggaatttctacaacatgcggatgctggctttgttt gttgccttctctatcaacttcattctccttttctacaaggtgtcatcatcctcttctgta actgaggaagacgagaaggtgccagtgctttacgacagctcaggggacctggatgaagaa ggcaccttggtcaatgacaacacctcaggcattatgcagtttgtcctggaggagagcact ggttacatggagccctctctccgcttcctgtccatcgctcacaccctcatctctttctgc tctatcattggctactactgcttgaaggtcccgctggttatttttaagcgggagaaagac gtggcgaggaagatggagtttgacggcctctatgtcactgagcagccacctgatgaggac atcaaaggccaatgggacaggcttgtcatcaccacacaatcatttcccagtaattactgg gataaatttgtgaaaaggaaggtgatggacaagtatgggaagttttatggttgtgaccgc atcagtgagctgctggggctggataaggctgctctcgacttcagctccgagggacaggag aggagaaggcccaggagagagggagcctggactgctctattaaactcaattgatgtcaag tatcaggtgtggaaactaggagtagtgttcactgacaactccttcctgtacctggcatgg tatatgaccatgtctgtcctgggccactataataacttcttcttcgctgctcacctgttg gatattgccatgggctttaagacccttagaaccatcctgacctctgttacccacaatggc aaacagttggtcctgactttagggctgctggcagtggtggtgtatctctacaccgtggtg gccttcaacttcttccgcaagttctacaacaagagtgaagatggagtagctctggacatg aaatgtgacgacatgctcacttgctatatgttccacatgtatgtgggcgtgagagcgggg ggtggcatcggtgatgagattgaggacccggccggggacgagtttgaggtggtcaggatc atctttgacatcaccttcttcttcttcgtcatcgtcatcctcctggccatcattcagggt ttgataattgatgcctttggggagctccgtgaccagcaggagcaggtgaaagaggacatg gagaccaagtgtttcatctgtggaatcgggaatgactacttggacaatgtgccccatgga ttcgaaacacacactctgcaggaacacaacctggccaactatctattctttgtgatgtac ctcattaacaaagatgaaacggaacacacgggccaggaatcctacgtatggaaaatgtac caggagcgatgctgggaattctttcctgtcggtgactgtttccgtaaacagtatgaagac cagctctgctga

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