Streptomyces ambofaciens: SAM23877_2578
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Entry
SAM23877_2578 CDS
T04055
Symbol
leuA
Name
(GenBank) 2-isopropylmalate synthase
KO
K01649
2-isopropylmalate synthase [EC:
2.3.3.13
]
Organism
samb
Streptomyces ambofaciens
Pathway
samb00290
Valine, leucine and isoleucine biosynthesis
samb00620
Pyruvate metabolism
samb01100
Metabolic pathways
samb01110
Biosynthesis of secondary metabolites
samb01210
2-Oxocarboxylic acid metabolism
samb01230
Biosynthesis of amino acids
Module
samb_M00432
Leucine biosynthesis, 2-oxoisovalerate => 2-oxoisocaproate
Brite
KEGG Orthology (KO) [BR:
samb00001
]
09100 Metabolism
09101 Carbohydrate metabolism
00620 Pyruvate metabolism
SAM23877_2578 (leuA)
09105 Amino acid metabolism
00290 Valine, leucine and isoleucine biosynthesis
SAM23877_2578 (leuA)
Enzymes [BR:
samb01000
]
2. Transferases
2.3 Acyltransferases
2.3.3 Acyl groups converted into alkyl groups on transfer
2.3.3.13 2-isopropylmalate synthase
SAM23877_2578 (leuA)
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Gene cluster
GFIT
Motif
Pfam:
HMGL-like
IPMS_D2
LeuA_dimer
Motif
Other DBs
NCBI-ProteinID:
AKZ55627
UniProt:
A0A0K2AS42
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All DBs
Position
complement(2697455..2699176)
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AA seq
573 aa
AA seq
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MANRQQPSSMPITKYRGYEQVDIPDRTWPHQRITTAPRWLSTDLRDGNQALIDPMSPARK
RAMFDLLVKMGYKEIEVGFPASGQTDFDFVRSIIEDPDAIPEDVTISVLTQAREDLIERT
VESLKGARRATVHLYNATAPVFRRVVFRGSRDDIKQIAVDGTRLVMEYAEKLLGPETEFG
YQYSPEIFTDTELDFALEVCEAVMDTYQPGPGREIILNLPATVERSTPSTHADRFEWMGR
NLSRREYVCLSVHPHNDRGTAVAAAELALMAGADRVEGCLFGQGERTGNVDLVTLGMNLF
SQGVDPQIDFSDIDEIRRTWEYCNQMEVHPRHPYVGDLVYTSFSGSHQDAIKKGFDAMEA
EAAAKGVTVDDIEWAVPYLPIDPKDVGRSYEAVIRVNSQSGKGGIAYVLKNDHKLDLPRR
MQIEFSKLIQAKTDAEGGEITPTAIWDVFQDEYLPNPDNPWGRIQVANGQTTTDRDGIDT
LTVEATVDGQETTLVGTGNGPISAFFHALQGVGIDVRLLDYQEHTMSEGASAQAASYIEC
AIGDKVLWGIGIDANTTRASLKAVVSAVNRAAR
NT seq
1722 nt
NT seq
+upstream
nt +downstream
nt
atggccaaccgccagcagcccagttccatgccgatcaccaagtaccgcggctacgagcag
gtcgacatccccgaccgcacctggccccaccagcgcatcaccaccgccccccgctggctc
tccaccgacctgcgcgacggcaaccaggcactgatcgaccccatgtcgcccgcccgcaag
cgcgcgatgttcgacctgctggtcaagatgggctacaaggagatcgaggtcggcttcccc
gcctccggccagaccgacttcgacttcgtacgctcgatcatcgaggacccggacgccatc
ccggaggacgtgacgatctccgtgctgacgcaggcccgtgaggacctgatcgagcgcacg
gtggagtccctgaagggcgccaggcgggccaccgtccacctgtacaacgcgaccgccccg
gtcttccgccgggtcgtcttccgcggctcccgggacgacatcaagcagatcgccgtcgac
ggcacccggctggtcatggagtacgccgagaagctgctgggccccgagacggagttcggc
taccagtacagccccgagatcttcaccgacaccgagctggacttcgccctggaggtctgc
gaggcggtgatggacacctaccagcccggccccggccgcgagatcattctcaacctgccg
gccaccgtggagcgttcgacgccgtccacgcacgccgaccgcttcgagtggatgggccgc
aacctctcccgccgcgagtacgtctgcctgtccgtccacccgcacaacgaccgcggtacg
gcggtggcggcggccgagctggcgctgatggccggcgccgaccgcgtcgagggctgcctg
ttcggacagggcgagcgcaccggcaacgtcgacctggtcaccctgggcatgaacctgttc
tcgcagggggtcgacccgcagatcgacttctccgacatcgacgagatccgtcgcacgtgg
gagtactgcaaccagatggaggtccacccgcgccacccgtacgtgggcgacctggtctac
acgtccttctccggctcccaccaggacgccatcaagaagggcttcgacgccatggaggcc
gaggcggccgccaagggcgtcaccgtcgacgacatcgagtgggccgtgccctacctgccg
atcgaccccaaggacgtcggccgctcctacgaggcggtcatccgcgtcaactcgcagtcc
ggcaagggcggcatcgcgtacgtcctgaagaacgaccacaagctggacctgccgcgccgg
atgcagatcgagttctccaagctgatccaggccaagacggacgccgagggcggcgagatc
acgcccacggccatctgggacgtcttccaggacgagtacctgcccaacccggacaacccc
tggggccgcatccaggtcgccaacggccagaccaccaccgaccgcgacggcatcgacacc
ctcaccgtcgaggccacggtcgacggccaggagaccacgctggtcggcaccggcaacgga
ccgatctcggcgttcttccacgccctgcagggcgtcggcatcgacgtacgcctgctggac
taccaggagcacacgatgagcgagggcgcctccgcgcaggccgcctcctacatcgagtgc
gccatcggcgacaaggtgctgtggggcatcggaatcgacgcgaacaccacgcgcgcctcg
ctgaaggcggtcgtctccgccgtcaaccgagcggcgcgctga
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