Sinocyclocheilus anshuiensis: 107668588 Help Entry 107668588         CDS       T04917                                  Name (RefSeq) ryanodine receptor 2-like   KO K04962   ryanodine receptor 2 Organism sanh  Sinocyclocheilus anshuiensis Pathway sanh04020   Calcium signaling pathway sanh04260   Cardiac muscle contraction sanh04261   Adrenergic signaling in cardiomyocytes sanh04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:sanh00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     107668588    04020 Calcium signaling pathway     107668588  09150 Organismal Systems   09153 Circulatory system    04260 Cardiac muscle contraction     107668588    04261 Adrenergic signaling in cardiomyocytes     107668588  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:sanh04040]     107668588    04990 Domain-containing proteins not elsewhere classified [BR:sanh04990]     107668588 Ion channels [BR:sanh04040]  Voltage-gated cation channels   Ryanodine receptor    107668588 Domain-containing proteins not elsewhere classified [BR:sanh04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    107668588 BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY Ins145_P3_rec MIR RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 EF-hand_8 Motif Other DBs NCBI-GeneID:  107668588 NCBI-ProteinID:  XP_016316010 LinkDB All DBs Position Unknown AA seq 4923 aa AA seqDB search MDIGEAEDEIQFLRTRDELVLRCCSSGPHQQKLCLAAEGFGDRLCYLESTSNSKNVPADL SVCVFVLDQCLSVRALQEMLANHEDQYAGVGNVVKGVRIHVSREAAGRRTLLYGQAVLFR HVYSDMYLCCLSTSGLSSDKLAFDVGLQEDTKGEVCWWTVHPASKQRSEGEKVRVGDDLI LVSVSSERYLHVSWSNREGNDNGIGRVDAAFQQTLWSVALVSTQTAETQGHVRGGDTVRL LHGHTDECLTIPAAEHRREERRSVHFEGGSVSLHARSLWRLETLHVAWSGSHTHWGQPFR LRHLSTGLYLGLTQDRGLQLVERERADVKCTAFCLRASKEESQESSHFKRRDCMGAPEIK YGDSLCFIQHFDTGLWLTYQTTDSKRQKESVPQRQAVLQAEGHMDDGITLSRSQREESEA ACLIRSSALLFSKFIRGLDDVSQKENITNLDLPIEMVHLTLQDLLGYFQYPEMGQDHEVR QGDIRALKKRQNLFQDEGIITLVLDCIDHLHVYNSATHFAEAAWKEAGESWEIILNSFYE LLAALIRGNRNNCAHFSGSLDWLVSRLERLEASSGILEVLHCVLVESPEALNVIKESHIK SIISLLDKHGRNHKTLDVLCSLCVCHGMAVRSNQHLICDTLLPERDLLLQTRLVNQVFSV RPNIFLCAKDDCAQYKKWYYEVVVEKAEPFVTAEPTHLRVGWASTEGYRPSTTGGHSWGS NGVGDDLCSYGFDGLQLWTGGVGQRVTSPNQHLLREDDVISCCLDLSAICISFRVNGQPV QGMLEDFSVDGLLFPVVSFSAGVQVRVLFGGRQGEFRFLPPAGFSPCAEALLPKTRCKLG LFHKLTRNHTESQRDLLGPVVPISPVTFIPIPVDSSEVEYPPQLEQIREILAENLHELWL IDKIEQGWTYGPVKDESRKIHLCLVEFSKLPDQERIHNLQSSEDILRTLLAFGVHIGLSD EHAEENVKYVRLSNKYELWNGYKPAPVDQSRVVLTAAQEELVDKLAENEHNIWARERIRQ GWSCGPQQDVMYKRSTQLVPFSLLDEKTKQAGRDAMKDALGTLLGFGYTVEPLEQEHASS SNIKSVTAERFRIFRLEQLFAVHDGKWYFEFEAITDGEMRVGWARPGCKPDVDLGSDNQA FVFDGSKGQWWHGGAERLGGSWKRGDVIGCLLDLTTCTMMVTLNGELLLNSRGSEVAVKD FNKSDGFLPVCSIGINQVGCLNLGRQVDSLKYFSVCGLQEGYQPFGLNMSKEIPLWMSWR EPLFISISNDHPNIQVIRVDGTVDNTPCLKVTQKSFGQQERGTSDVGFYRLSMPIECAQV FSSPGEVTVPPSSSVVCHLRDPEEGDANSDFEVLMKAHRYAGSRDELNNHKDHSQEKPSR LKQRFLLKKKPELNTTHSSARLLEEVMAIEKDENNRLVHCTTYYYSVRIPYSQEPFYVWV GWVTSKFHHHDLPFDLDSICTVTVTLGDEWGKVQKSVKRSSCYMVCAAEGSSLSHSRNSS GLEIGCLVDTATGLLTFTANGKELATYYQVDPGTKLFPAVFAKATSSNVFQFELGRIKNV MPLSAGVFRSERRNAKPQCPPRLCVQHLTLMRWTRVPDHTQPVEVTRLEERYGWRARCTQ IRQIMTLHIPEENRCVDILELSELHDLLKFHDHTLHLYSALSAHGNTHVSHALCSHVDQS QLLFALQCSRMPGHLRTSYYNFLINTHLGAHASARQAMTHEYIVPMTDATQSTMLYKNNR KVQRFPGSDFSTSLWPRMRFTSPCFIRANRIDVMDRDEGGALWSNLRQNSPEIPLDVLKD VVITMLKKAVAAVGQGVRDPAGGSIELLMVPLLSLLHTLLLMGVYQGTDLEAVFSLILPA SYMRGTCKTEEMDELEESDGEREEKEGRDWEDNVPQQNLLQMKLPEAVKLQVCHLLKYLC DCQVRHRVEAVMSFSGDFVGRLQDNQRFRYNEVMDALNMSAALTACKTKEFRSPPQEQIN MMLSFREECQECPCPEDVQDLMWEFHQDLMSHCGIEIDSDSENEDEDNQSVRNHLQSLVD KIINLKRRMSGLPEEITSPFLVSLQQLILETMLHWAQEGTIEDPALVRAVFSLLHQQYAG LGGQMSAPLQKAYCISQTSVEDTLNLQWALARIRSLLTARMGKEEEELMIRGLGDIMNNK VFYQHPNLMRALGMHETVMEVMVNVLGARESKEIMFPKMVAHCCRFLCYFCRISRHNQRA MFDHLSYLLDNSNVGLASPSMRGSTPLDVVAASVMDNNELALALTEGDLEKVVQYLGGCG LRSCALLVSKGYPDIGWNPVEGERYLDFLRFAVFCNGESVEENAYVVVRLLIRRPECFGP ALRGEGGNGLLATIEEAIRISHLQDGTSAASTHSSNRTLDTLDDEDDDVIHMGHAIMTFY SALIDLLGRCAPETHLIEAGKGEAIRIRAILRSLVPREDLEGIINIPFSLPLVNTDDLVV EPDMSRIFCPDHKAAMVLFLDRVYGVQDQQFLLRLLENGFLLDLQAAVNMDAMGLGGTDM ALALNRYICVAVLPLLSKYSSLLCDSSSLRTGLVDELLQGVYSLSKASGLTKAQRDAIQD CLLAVCGKLNPSMLQSLLQNLVFDVPQLSENSKMPLKLLTNHYEQSRKYYCRNDGWCGFG SASEEELRLTRKLFWGIFSALAKKSYDPDLFKLALGCLSAVAGAIPPDHLDPSCTRGQER HSTMDSERRFCPRPLDTSNVTIPELLEFVVNKYAEHTHEKWSLEKFGNGWVYGEQFSESA KVHPLLKPYRALSEKDKEGYRAVIKETVKCMLVLGWTIERTNDGESQGFHNPARRISQSG KLSFEGASTFSPKPVDTSSVTLTWDQYAMAERLAENYHHIWAARKLQELESKGGGSHPLL VPYNALSVKDKSRVRDKAQDVLKFFHINGYSVRRNRKVADADSPAIVSRFAYGLLQQALC LTEQAQEQLLELGQINRAEKVPHEQQIHFFIKVVLPLLDQYFKNHYPYFLSTTCSLRDGC QSTNKEKEMATSLFCKLGALARRRISLFGNDALALVSCLQILAQSLDGRMLMKTTNESVR LSLWSFFEGAAEDLELTVDNVTWDEYGLNRAQGRGDSEVITYTTALIPVLNALFLHDAQR QHGGGLIVDEVHSCCYRILSCLYILGTCSGTFIERQRSVLGECLAALSVAFPVCFLELTD LHSLFDTMSNEESEACRLLPTLQEAFSEVEELAEAGPVARHALLTKVTEVTLPLLCSYVS RWGEADNQASQEGHFSCVTPQHANALLGHILSIIHAHLGTADSAWMKRLAVFGQPLISKA EPHLLKSHFLPLMEKLRKRAESVLLEEEHLKTAGRGDVSEQELDIQERFTVLVQDIYSFY PLLIPFIDLHRMSWLREVEADAEKLFSLVAEVFIFWAKSHNFKWEEQNFVVQNEINNMTF LVNSSKSRMYKGGVCNQERRKVKRKGDCYSTHTSLILAAPKKLLSVAMNGCCHGYQGLVT HAKSRFSQRDTEDEVRAYIRSNLPVKILFEPPHLAFLFSFCQDLCEYSIDPLSVERILSI ARVLFHLDQVRLGMNYYNQVERPQKTKRAVWHRMLSKQRKRAVVACLRMVPLYNLPRHRA VNLFLQGYERVWLKAERDSPEDRLIEDLAVSGAEQRNNIDPLRQLINLFSQSALTERSKL EDDDQYMCYADIMAKSCQSEEDQDEDGLKSFEEKEMEKQRLLYQQGRLHERGAAEMVLQN LSASTGDMGPMVAATLKLGIAILNGGNTSVQQKMLDYLRQKRDVGFFHSLVGLMQSCSVL DLNAFERQIKAESLGVGAEDSSGDRVMADEQLTCDLFRFLQLLCEGHNTDFQNYLRTQTG NNTTVNIIISTVDYLLRVQESISDFYWYYSGKDVIDERGQHNFSKAISVAKQVFNTLTEY IQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMQMKLSQDSSQIELLKALMDLQKDMVVMLL SMLEGNVVNGTIGKQMVDMLVESSSNVEMILKFFDMFLKLKDLTSSESFREYDPDGRGLI TKKDFHRAMEGFKHYSQSEIQFLLSCAETAESELLDYPDFVTRFHEPAKDIGFNVAVLLT NLSEHMPNDGRLQNFLELADSVLKYFHPHLGRIEILGSGKRIERVYFEISESSRTQWEKP QVKESKRQFIFDVVNKGGEKEKMELFVNFCEDTIFEMQLAAQISGSESGEELKAKDDKVE KNENLAEDNRMTKDLRWFSIRNIGKHLKGITMRSIISVMFSFFHNALLFITRAFLGLVWF FLYLLYHIFLSGWIIDMAKEMKLADLLGDLRDPTMVETIGFGEGVVRENNTCDTRAFSSR GDLRGMSLDLSAVSRDPQLLTDIFGLCLKKEGEKYTLSSRDQHGSLDGFLNTSKYQVDIC EENFHEAQEEDSETKKAFDEDKHKGEKKPKRRLRKLSSSKPDETEVQESAVWKTICSHST KLLNCFARNFYNIRLLALFFTFAINFILLFYKVSIDFPAKTSDLMLLVSSTIDEDEDVEI ALRDDSTKDSQEVYFELEENSGYMKMILHSLAVLHTLISLCCIIGYYCLKVPLVIFKREK ELARKLEFDGLYITEQPSEDDIKGQWDRMVINTPSYPSNYWDKFVKRKVMAKYGELYGSA RISELLGLDKAALDFSSEAQESKRPVQKVALFRLNPIDVKHQIWKLGVVFTDSSFLYLAW YMVVSVLGHYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVV AFNFFRKFYNKSEDGEPVDMKCDDMLSCYMFHMYVGVRAGGGIGDEIEDPAGDEFEFYRI IFDITFFFFVIVILLAIIQGLIIDSFGELRDQQEQVKEDMETKCFICGIGSEYFDTVPHG FESHTLQEHNLANYLFFLMYLINKDVTEHTGQESYVWKMFQERCWEFFPVGDCFRKQYEG QLS NT seq 14772 nt NT seq  +upstreamnt  +downstreamnt atggatataggagaagcggaagatgaaatacagtttctgcgaactagggatgagctggta ttgaggtgttgctcatcaggccctcatcagcagaaactgtgtttagctgcagaaggtttc ggtgaccggctgtgttatcttgagtccacctccaactcaaagaatgttcccgcagacctt tctgtgtgtgtgtttgtgcttgaccagtgtctgtctgtccgagcgctgcaggagatgctg gccaaccatgaagatcagtatgcaggggtgggtaatgtagtcaaaggtgtacgtattcat gtttcacgtgaggcagctgggcgtcgtactctgctctatggccaggcggttctctttcga catgtctacagcgacatgtatctctgctgtctgtccacatcaggcctctcctctgacaag ctggcttttgatgttggtttgcaggaggacacaaagggtgaggtgtgttggtggacggtt caccctgcctctaaacagaggtccgagggtgagaaagtcagagtgggtgatgatctaatc ttagttagtgtttcctctgagagatacctacatgtgtcgtggagtaatcgtgaaggtaat gacaatggcattggccgggtggatgctgctttccagcagacattgtggagtgtggctctt gtttctactcagactgcagagacgcagggtcatgtgagaggaggggatactgtgcgtctg ctacatggacacacagatgaatgtttgaccattcctgcagcagaacacagacgggaggaa cgcagatctgtacattttgaggggggctcggtatctcttcatgctcgatctttatggagg cttgaaacgttacatgttgcgtggagtggcagccacacacactggggtcagcctttccgt cttcgccacctttccaccggcttatacctgggactgactcaggatcggggactacagctg gtggagagagaaagagctgatgttaaatgcactgcgttctgtctccgtgcatcaaaggaa gagagccaggagagctcacactttaagaggagagattgcatgggtgcacctgagatcaaa tatggagactctctctgcttcattcagcactttgacacagggctttggctcacatatcag accactgactccaagagacagaaggaaagtgtgccacagagacaggctgttttgcaagca gaaggtcacatggatgatggaatcaccctctctcgctctcagagggaggagtcagaagct gcttgtttaattcgaagctccgcccttctcttctcaaaattcattaggggattagatgat gtcagccaaaaggaaaacatcacgaatttggatcttccaattgagatggtccatctgacc ctccaggatttgcttggttattttcaatatcctgaaatggggcaggatcatgaggtcaga cagggagatattagagcactgaaaaaaagacaaaatcttttccaagatgagggtataatc actctggtgctggactgcatcgatcacttgcatgtgtacaacagtgccactcattttgca gaggctgcttggaaagaggcaggagagtcttgggaaattatcttgaactctttttatgag ctactagctgcccttatcaggggtaatcggaataactgtgcccacttttctggttccttg gactggctggtcagcagactggagaggctggaggcttcctctggaatattggaagtgtta cactgtgttttagtagaaagtcctgaagctttgaacgttattaaggaaagtcacataaaa tctataatctcacttctggacaaacatggaaggaaccataagaccttggatgtgttgtgt tcactctgtgtgtgtcatggcatggccgtccgctctaatcagcatttgatttgtgacaca ctgctgccagaaagagacctgctgctacaaacaagactggttaaccaagttttcagtgtg cgtccaaacatctttctgtgtgcaaaagatgactgtgcccaatacaagaagtggtattat gaggttgtagttgagaaggcagagccttttgtgacagcagagcctactcatctgcgagtc ggttgggccagcactgaagggtaccgtccctccaccacagggggtcacagctgggggtca aacggtgtaggagatgacctctgctcttacggctttgatggactccagctctggacagga ggtgtaggtcagagggtcacctcacccaatcagcacttgctaagggaggatgatgtcatt agttgctgtcttgaccttagtgcaatctgcatctctttccgggtcaatggacagccagtt caaggcatgctggaggacttcagtgtggatgggctgctgtttccagtcgtcagcttctca gctggagtgcaggtgcgtgtgctgtttggaggtcgacagggggagtttaggtttcttcct ccagctggtttctctccatgtgctgaagctctcctcccaaaaacccgctgcaagctggga ctgtttcacaaactcacacgaaatcacaccgaaagccagcgtgacctcttaggccctgtg gtacctataagcccagtgacctttatccccattccagtggattccagtgaggttgaatat cctccacagctggagcagatcagagaaatattagcagaaaacctccatgaactctggctt attgacaaaatagagcaggggtggacctacggacctgttaaagatgagagcagaaaaata cacttgtgtctagttgagttttccaaacttccagatcaggagcgaattcataacctccag tcatctgaggatatcctcaggactcttctggcttttggtgtccatattggactctctgat gaacatgccgaggagaatgtgaaatatgtccgcctttcaaataagtatgagttatggaat ggatataaaccagccccggtggatcagtcccgtgtcgtgctaacagctgcacaggaagag ctggtggacaaactggctgagaatgaacacaacatctgggccagagagcgtatcaggcag ggctggagctgtggaccacagcaggatgtaatgtataagagaagtactcaactagtgcca ttttccctgttggacgagaagaccaaacaggctggtagagatgccatgaaggacgcactg ggtacccttcttggttttggatatactgtggaaccgctggagcaagaacatgcttcaagc agcaatattaagtctgtgactgcagagagatttcggattttccgtctggagcagctcttc gcagtgcatgatggaaaatggtactttgagtttgaggccataactgatggagagatgaga gtgggctgggcacgacctgggtgtaaacccgacgtggatcttgggtcagacaatcaggcc ttcgtgtttgatggttctaagggacagtggtggcatggtggggcagagcgattgggtggc agctggaagaggggggatgtaattggctgtttgttggacctgactacatgcactatgatg gttactcttaatggagagctactgctaaacagtcgtggttctgaagtggctgtaaaagac ttcaataaatctgacggttttctgcctgtctgtagcatagggatcaaccaggtgggttgt ttaaatttgggtcgtcaggttgactcactaaaatacttcagtgtttgtggcctacaagag ggataccagccctttggtttgaacatgagcaaagagataccactatggatgagctggaga gagcctttgttcatttctatatccaatgaccatcctaacatacaggtgattcgtgttgat ggaacagttgacaacactccatgtctgaaagtaacacagaagtcttttgggcagcaggaa aggggcacaagcgatgttggattttaccgtctgagcatgccaatagagtgtgcacaggtt ttctccagccccggtgaggtcactgtgccccccagcagcagtgtggtgtgccacctcaga gatccagaggagggagatgcaaattctgactttgaggtactgatgaaagctcacagatac gcaggatccagagatgaactcaataatcacaaagaccacagtcaggaaaagccatctaga ctcaaacagcggtttctgctgaagaagaaaccagagttaaacaccacccactcatcagca cgtttgttggaggaagtgatggccatcgagaaagatgaaaacaaccgccttgttcattgc actacgtattattactctgtgagaatcccctacagtcaggagccgttttatgtttgggtt gggtgggtaacctctaagttccaccatcatgatttgccctttgacctggacagcatttgt actgtcacagtcactcttggggatgaatggggcaaagttcaaaagagtgtcaagcgtagc agctgttacatggtgtgtgcagcagagggcagtagtttgtcccatagccgcaacagcagt ggcctggagattggatgtctggttgacactgcaacagggctcctgacattcactgctaat ggcaaagaacttgcaacatactaccaggtggatccaggaaccaagctcttccctgctgta tttgctaaagccacaagttctaatgtcttccagtttgaattgggacgtatcaagaatgtg atgccactatcagcgggagtttttcggagtgaaagaagaaatgcaaaacctcagtgccct cctagattgtgtgttcaacacctaacgcttatgcggtggacccgagtacctgaccacact cagcctgtggaagtgacccgtctggaggagagatatggctggagagctcgctgcactcag atccgtcagatcatgaccctgcatatacctgaggagaacaggtgtgttgacattctggaa ctgtccgaactgcatgatctcctgaagttccatgatcacacccttcacctctactcagcc ctttcagctcatggaaacacacatgtaagccacgccctctgcagccatgtggaccaatca caactcttgtttgccttgcagtgctctagaatgccaggtcacctgcggacaagttactac aacttcctcatcaacacccacctcggtgcccacgccagtgccaggcaggccatgacccac gaatacattgtgcctatgacggatgccacgcagtctactatgctctacaaaaacaatagg aaggtgcagagattcccaggaagtgacttcagcacttccttatggcccagaatgcgtttt acgtcaccttgcttcatcagagctaatagaatagacgtgatggatagagatgagggcggg gctttgtggagtaacttgcgacaaaacagcccagagatcccattggatgtattaaaggat gttgtcataacaatgctgaagaaggcagtggcagcagtagggcagggtgtgagggatcct gcagggggaagcatagagctccttatggttcctttgctcagtttacttcacactctcctg ctgatgggtgtgtaccaggggacagatctggaggccgtgtttagtctcatcctgccagcc agttacatgagaggaacatgtaaaacagaagagatggatgaactggaagaaagtgatgga gaaagagaggaaaaggagggtagagattgggaggataatgtccctcagcaaaatcttctt cagatgaagcttccagaagctgtcaaattacaggtgtgccaccttttgaagtacctgtgt gactgccaggtacgtcatagagtagaagccgtgatgtcgttctcaggtgacttcgtaggt cgtcttcaagacaaccaacgctttcgatacaatgaagttatggatgcgctcaacatgtct gctgctctcacggcatgcaaaactaaagagttccgttccccgcctcaggaacagataaac atgatgttgagcttccgggaagagtgtcaagaatgtccttgtccagaggacgtccaagat ttgatgtgggaattccatcaggatctaatgagccactgtggaattgagatagacagtgat tcagagaatgaggatgaggacaaccagtcagtcaggaatcacctccaaagcctagtggat aaaataattaatttaaagaggagaatgtctggtctgcctgaagagattacctctcccttt ctagtctcactacagcagctgatattagagaccatgcttcactgggcccaggaggggacg atagaagacccagctctggtgcgtgctgttttcagcctgctgcatcaacagtatgctggg ctgggaggccagatgtctgcaccactacagaaggcttactgtatcagccagacatctgtg gaagacactcttaatctacagtgggctctagcacgcattcgttcattgctcacagccagg atgggcaaagaggaggaggaactcatgatcagaggactaggtgacattatgaacaataaa gttttctatcagcatcctaatctgatgagagctctggggatgcatgagaccgtcatggaa gttatggtgaatgtccttggtgctagagaatctaaggaaatcatgtttcctaagatggtt gcgcactgctgtcgtttcctttgttatttctgtcgaatcagtcggcataatcagagggcc atgtttgatcatctcagctacctgctggacaacagtaatgttggacttgcttctccctca atgagaggatcaactcctctggatgtggtggctgcttctgtcatggacaacaatgaactg gctcttgctcttacagagggagatctagagaaagtggtgcagtatttgggaggctgtggt ttgcgtagttgtgctctgctggtctccaaaggatacccagatattggttggaatcctgta gagggagaacgttacctggacttcctgcgttttgcagtattttgcaatggtgagagtgtt gaggagaacgcctatgtggtagtgaggcttctgattcgccgacctgaatgctttggcccc gcccttcgcggggaggggggaaatggtcttttagcaactattgaggaagccatcagaatt tcccacctgcaggatggaaccagtgcagccagtacacacagttccaaccggacacttgac acgcttgatgatgaagatgatgatgtcattcacatgggacacgccataatgaccttctac tctgctctcattgatctgttgggtcgttgcgcccctgagacgcatctcatagaagcgggg aaaggtgaggccattcggatcagggcaatcttgaggtctctcgttcccagagaggatctg gagggaatcatcaatattccttttagtttaccacttgtaaacacagatgatctagtggtg gagcctgacatgtctcggatattttgtccggatcacaaagcagccatggtgctgtttttg gaccgggtttatggagttcaggaccagcagtttttgctgcgtctactggagaatggtttc ctgctggacctgcaagcggctgttaacatggatgctatggggttaggtggaacagatatg gcactggcccttaatcgatacatatgtgtggctgtgctgccattgctgagtaagtattcc tctctgctgtgtgactcctcttcactgcggactgggctggtggatgagctcctgcagggt gtctacagcctctctaaagccagcggactgaccaaggcccagagagatgctatccaggac tgtctgctggcagtgtgcggaaaactgaatccctccatgttgcagtctctgctgcagaat cttgtgtttgacgtccctcaactatcagaaaactccaagatgccactcaagctgttgacc aatcattatgagcagagcaggaagtactactgtcggaatgatggatggtgtggctttggc tctgcctcagaggaagaacttcgtctgaccagaaagctgttttgggggatattcagtgct cttgccaaaaaatcttatgatccagacctattcaaactggccctgggttgtctcagtgca gttgccggggcgattcctcctgaccaccttgacccgagctgcacaagaggacaagagaga cactcaacgatggattcagagagacggttttgtcctcgacccctggacacctcaaatgtg acaatcccagagttgcttgagtttgtggtgaacaaatacgctgaacatacacatgagaaa tggtccctggaaaagtttggtaacggttgggtttatggagaacagttttctgagagtgct aaagttcatccactcctaaaaccttacagagctctgtctgagaaggataaagaaggttat cgagcggtcattaaagagacagtgaagtgcatgctggtcttgggatggactattgagagg accaatgatggggagtcacaaggctttcacaacccagctcggaggatttcacagtctggc aagctgtcttttgaaggagcttccacattcagtccaaagcctgtggataccagcagtgtc actctgacctgggatcagtatgccatggcagagcggttggctgagaattatcatcacatc tgggcagccaggaaactgcaggaactggagagtaaaggagggggcagtcaccctctgctt gtaccgtacaatgctctgagcgttaaagacaagagtcgagtcagagacaaagctcaagat gttctcaagttcttccacatcaatgggtactcagtgaggaggaacagaaaggtggcagat gctgattccccagcgattgtgagccgcttcgcttacggcctgttacagcaagccctctgt ctcactgagcaagcccaggagcagttactagagctggggcagattaacagggctgagaaa gttccccatgaacaacaaattcatttctttattaaggttgtattgccactattagatcaa tacttcaaaaatcactatccctacttcctctccactacgtgttcacttagagatggctgc cagtccaccaataaagaaaaagagatggccacaagtttattctgtaagctcggagctcta gccagacgcagaatctctctgtttggaaatgatgcccttgctttggtgagctgcctacaa atcctggcacagtccctggatggaaggatgttaatgaaaaccactaacgaatccgtcagg ctgtcgctgtggtcgttctttgaaggcgcggcagaagacctcgagctaacagtagataat gtgacctgggatgagtatggcctgaaccgagcccaaggcaggggagacagtgaggtcata acgtacaccaccgccctgatcccagtgctcaacgctctattcctgcacgacgcccagagg cagcatggagggggactgatcgtggatgaagtgcactcctgttgctacaggatcctcagc tgtctatacattcttggcacctgcagtggtacattcattgagaggcagaggtcggtcttg ggggagtgtctggctgctttatctgtagcctttcctgtgtgtttcttggagctgactgac cttcattccctcttcgacactatgagtaatgaagagagtgaagcctgtaggctcctcccc actttgcaggaggctttctcagaggttgaagagctcgcagaggcaggaccagtggcccgt catgcccttttgacaaaggttactgaggtgacgcttcctctgctgtgtagttatgtctct cgctggggggaagctgataaccaagcatcccaggagggccacttttcttgtgtcacaccc cagcatgctaatgccctactgggtcacatcctctccatcatccacgcccatctggggacc gcagacagtgcttggatgaaacgcctcgcagtatttggccagcctctcatcagcaaggca gagccacacctcctgaagagccacttcctgcctttgatggaaaagttgaggaagagggca gagtcagttctcctggaggaggagcatttgaagacagcggggcgtggcgatgtctcagag caggagttagacatccaggaaaggtttactgtgttggtccaagatatctactcgttttac cctttactcattccatttatagaccttcacagaatgagttggctgagagaggtggaggca gatgctgagaagcttttctccctcgtagctgaagtcttcattttttgggctaaatctcat aatttcaaatgggaagaacagaactttgttgttcaaaatgaaatcaacaacatgacattc ctggtgaacagcagcaaaagcaggatgtataagggaggggtgtgcaaccaggagaggaga aaggtgaagaggaagggtgattgttactccacacacacctctctcattttggcagcacca aaaaaactcctctcggttgccatgaatggatgttgccatggctatcagggcctggtcact catgccaaaagccgtttctctcagagggacacagaggatgaggtcagagcgtacattcgc agcaaccttcctgtgaaaattctatttgagcctcctcacctggcttttcttttttctttt tgccaggatctgtgtgaatactcaatagatcccctcagtgttgagaggatcttaagcatc gctcgtgttcttttccatctggatcaggttagactgggaatgaattactacaatcaggtg gagcgccctcagaagacgaagagggcagtgtggcataggatgttgtctaagcagaggaaa cgggctgtagttgcttgtttgagaatggttcctttgtacaatctccccaggcacagagcg gtgaaccttttcctgcagggttatgagagagtctggctgaaggcagagcgtgactcacct gaggacagactaattgaggatttggctgtgagtggagcggagcagagaaacaacatcgat ccactccgtcagcttatcaatctcttcagtcaaagtgccttgactgagaggagtaagctt gaggatgatgaccagtacatgtgctatgctgacatcatggccaagagttgccaaagtgag gaagaccaggatgaagatggcctgaagtcatttgaggaaaaagagatggaaaagcagagg ctgctgtatcagcagggccgacttcatgaacgcggagctgctgagatggtcctacagaac ctcagcgccagcacaggtgatatggggcctatggtagcagccacattaaagctgggcatt gcaatcctgaatggaggaaacacgtctgtccagcagaaaatgctggattacctgcgacag aagagagacgtgggcttctttcacagtctggtcggcttaatgcagtcttgcagcgtgctg gatttgaacgcatttgagaggcagatcaaagcagagagtttaggagtgggtgctgaggac agttcaggcgacagagtaatggcagatgaacagctgacctgtgatcttttccgattcctc cagcttctttgtgaaggccataatactgacttccagaactacctgcggactcaaactgga aacaacacaacggtcaacatcatcatctccactgtggactatctgctcagggttcaggag tccatcagtgatttctactggtattattcagggaaggatgtgattgatgagcgtggtcag cacaacttctccaaagccatcagcgtggccaagcaggtgttcaacacactcactgaatac attcagggtccgtgtacaggaaaccagcagagtttggcccacagtcgtctgtgggacgct gtagttggcttcctccatgtgtttgcccatatgcaaatgaagctttctcaggattctagt caaatagagctgctgaaggctttgatggacttacaaaaagacatggtggtaatgctgctt tccatgcttgaaggaaatgtagtgaatgggaccattgggaaacagatggtagatatgcta gtagaatcatccagcaatgtggagatgatcctcaagttctttgatatgttcctcaaactc aaagacctcacgtcgtctgaatcctttcgtgaatacgacccagacggcagagggctcatt accaaaaaggacttccaccgagccatggaaggtttcaagcactactctcaatcagagatc cagttcctgttatcctgtgcagagacggcggaaagcgagcttctggattacccagacttt gtgacacgatttcatgaaccggccaaagatattggctttaatgtggctgttcttctgacc aatctgtccgaacacatgccaaatgatggccgcttgcagaatttcctagagctggcggac agcgtgcttaagtatttccatcctcacctgggaaggatcgaaatcctgggcagcgggaaa cggatcgaaagggtctactttgagatcagcgaatccagccggacacagtgggagaaacca caggtgaaggagagcaaacggcagttcatctttgatgttgtgaataagggcggagagaag gaaaaaatggagctatttgtcaacttctgtgaagacaccatctttgaaatgcagcttgcg gcacaaatatctggttcagagagtggagaggaactgaaagcaaaggatgacaaggtggag aagaatgaaaaccttgctgaagacaacaggatgaccaaagacttgagatggttttccata aggaacatcggaaaacacttaaaagggataaccatgaggagtatcatctcagtgatgttc tctttcttccacaatgctctgttgtttatcactcgtgcctttttaggtctggtttggttc ttcctttatctgctctaccacatcttcttgagtggatggattattgacatggctaaagaa atgaaactggctgaccttttaggtgaccttcgggatcctaccatggttgagaccataggg tttggagaaggggtggttagagagaataatacgtgtgatacacgtgccttttcttctcgt ggtgatcttagagggatgagtctggatctgtctgcagtgtccagggacccacagcttctc acagatattttcggcttgtgtttgaagaaggaaggagaaaagtacacactgtcgagcaga gaccaacatggcagtctggatggatttctaaacacgtccaaatatcaggtggacatctgt gaggagaattttcatgaggcgcaagaggaggattcagagactaagaaagcttttgatgag gacaaacataaaggggaaaagaagcctaaacggagacttagaaagctcagctcttcaaaa ccagatgagacagaggtccaggaatcagctgtttggaaaacgatctgctctcatagcacc aaactgctgaactgttttgcaagaaatttctacaacattagattgttggctctgttcttt acttttgccatcaattttattcttctgttctacaaggtgagtattgatttccctgctaaa acatcagatttaatgttgttggtttcatcaaccattgatgaggatgaagatgtggagatc gctcttcgtgacgacagcaccaaggattcacaggaagtttattttgaactagaagagaac agtggctacatgaaaatgattcttcacagtctggctgtcctgcatacactcatctcactc tgttgtatcatcggctactactgtctgaaggttcctttagtcatttttaagcgagaaaag gagctggctcgtaaattggagttcgacggactctatatcacagagcaaccttctgaagat gacattaaaggccagtgggacagaatggtcatcaatacaccatcatacccaagtaattat tgggataaatttgtgaaaaggaaggtgatggcgaaatatggagagctgtatggatcggca cgcatcagtgagctgctgggtttggataaagctgctctggacttcagctcagaggctcag gagagcaagagacccgtgcaaaaggttgccctcttcagattaaaccccattgatgtgaag catcagatatggaagctaggagtggttttcactgacagttccttcctttatctggcctgg tatatggttgtgtcagttctgggtcattataacaatttcttcttcgctgcccacctgcta gacatcgccatgggcttcaaaacactgcgcaccatactatcatctgttacacataatggc aaacagctggttttgacagtgggactgttggctgtggttgtgtatctctacaccgttgtt gcctttaacttcttccgcaaattttacaacaaaagcgaagacggtgaaccagtggatatg aaatgtgatgatatgctctcatgttacatgtttcacatgtacgttggcgtgcgagccgga ggagggattggagatgaaatcgaagacccggccggtgacgagtttgagttctaccgtatc atcttcgacatcactttcttcttcttcgtcatcgtcatcctccttgccatcattcagggt ctgatcattgattcatttggcgagttgagagaccagcaggagcaggttaaagaggacatg gagactaagtgttttatctgtggcattgggagcgagtattttgacacggtgccccatggc ttcgagtcgcacacgttgcaagagcacaacctggccaactatctgttctttctgatgtat ctcatcaataaggatgtcacagaacataccggacaggaatcatacgtgtggaagatgttc caggaacgctgctgggagttctttcctgttggagactgtttccggaaacagtatgagggt caactcagctga

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