KEGG T00182: SAR2144

Staphylococcus aureus subsp. aureus MRSA252 (MRSA): SAR2144

Entry

SAR2144           CDS       T00182

Symbol

leuA

Name

(GenBank) 2-isopropylmalate synthase

K01649

2-isopropylmalate synthase [EC:2.3.3.13]

Organism

sar Staphylococcus aureus subsp. aureus MRSA252 (MRSA)

Pathway

sar00290

Valine, leucine and isoleucine biosynthesis

sar00620

Pyruvate metabolism

sar01100

Metabolic pathways

sar01110

Biosynthesis of secondary metabolites

sar01210

2-Oxocarboxylic acid metabolism

sar01230

Biosynthesis of amino acids

Module

sar_M00432

Leucine biosynthesis, 2-oxoisovalerate => 2-oxoisocaproate

Brite

KEGG Orthology (KO) [BR:sar00001]
09100 Metabolism
  09101 Carbohydrate metabolism
   00620 Pyruvate metabolism
    SAR2144 (leuA)
  09105 Amino acid metabolism
   00290 Valine, leucine and isoleucine biosynthesis
    SAR2144 (leuA)
Enzymes [BR:sar01000]
2. Transferases
  2.3  Acyltransferases
   2.3.3  Acyl groups converted into alkyl groups on transfer
    2.3.3.13  2-isopropylmalate synthase
     SAR2144 (leuA)

SSDB

Motif

Pfam:

HMGL-like LeuA_dimer HCS_D2 ABC2_membrane_3

Other DBs

NCBI-ProteinID:

CAG41125

UniProt:

Q6GF16

LinkDB

Position

2207139..2208668

AA seq 509 aa
MSSHIQIFDTTLRDGEQTPGVNFTFDERLRIALQLEKWGVDVIEAGFPASSTGSFKSVQA
IAQTLTTTAVCGLARCKKSDIDAVYEATKDAAKPVVHVFIATSPIHLEHKLKMSQEDVLA
SIKEHVTYAKQLFDVVQFSPEDATRTELPFLVKCVQTAVDAGATVINIPDTVGYSYHDEY
AHIFKTLTESVTSSNEIIYSAHCHDDLGMAVSNSLAAIEGGARRIEGTVNGIGERAGNAA
LEEVALALYIRNDHYGAQTALNLEETKKTSDLISRYAGIRVPRNKAIVGQNAFSHESGIH
QDGVLKHRETYEIMTPQLVGVSTTELPLGKLSGKHAFSKKLKALGYDIDKEAQIDLFKQF
KAIADKKKSVSDRDIHAIIQGSEHEHQALYKLETLQLQYVSSGLQSAVVVIKDKEGHIYQ
DSSIGTGSIVAIYNAVDRIFQKETELIDYRINSVTEGTDAQAEVHVNLLIEGKTVNGFGI
DHDILQASCKAYVEAHAKFAAENVEKVGN

NT seq 1530 nt +upstreamnt +downstreamnt
atgagtagtcatattcaaatttttgatacgacactaagagacggtgaacaaacaccagga
gtgaattttacttttgatgaacgcttgcgtattgcattgcaattagaaaaatggggtgta
gatgttattgaagctggatttcctgcttcaagtacaggtagctttaaatctgttcaagca
attgcacaaacattaacaacaacggctgtatgtggtttagctagatgtaaaaaatctgac
atcgatgctgtatatgaagcaacaaaagatgcagcgaagccggtcgtgcatgtttttata
gcaacatcacctattcatcttgaacataaacttaaaatgtctcaagaagacgttttagca
tctattaaagaacatgtcacatacgcgaaacaattatttgatgttgttcaattttcacct
gaagatgcaacgcgtactgaattaccattcttagtgaaatgtgtacaaactgcagttgac
gctggagctacagttattaatattcctgatacagtcggctacagttaccatgatgaatat
gcacatattttcaaaaccttaacagaatctgtaacatcttcaaatgaaattatttatagt
gctcattgccatgacgatttaggaatggctgtttcaaatagtttagctgcgattgaaggc
ggtgcgagacgaattgaaggcactgtaaatggtattggtgaacgagcaggtaatgcagca
cttgaagaagtcgcgcttgcactatacattcgaaatgatcattatggtgctcaaactgcc
cttaatctcgaagaaactaaaaaaacatcggatttaatttcaagatatgcaggtattcga
gtgcctagaaataaagcaattgttggccaaaatgcatttagtcatgaatcaggtattcac
caagatggcgtattaaaacatcgtgaaacatatgaaattatgacacctcaacttgttggt
gtaagcacgactgaacttccattaggaaaattatctggtaaacacgccttctcaaagaag
ttaaaagcattaggttatgacattgataaagaagcgcaaatagatttatttaaacaattc
aaggccattgcggacaaaaagaaatctgtttcagatagagatattcatgcgattattcaa
ggttctgagcatgagcatcaagcactttataaattggaaacactgcaactacaatatgtc
tctagcggccttcaaagtgctgttgttgttattaaagataaagagggtcatatttaccag
gattcaagtattggtactggttcaatcgtagcaatttacaatgcagttgatcgtattttc
caaaaagaaacagaattaattgattatcgtattaattctgtcactgaaggtactgatgcc
caagcagaagtacatgtaaatttattgattgaaggtaagactgtcaatggctttggtatt
gatcatgatattttacaagcctcatgtaaggcatacgtagaagcacatgctaaatttgca
gctgaaaatgttgaaaaggtaggtaattaa

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