KEGG   Sorex araneus (European shrew): 101540472
Entry
101540472         CDS       T07854                                 
Symbol
IKBKB
Name
(RefSeq) inhibitor of nuclear factor kappa-B kinase subunit beta
  KO
K07209  inhibitor of nuclear factor kappa-B kinase subunit beta [EC:2.7.11.10]
Organism
sara  Sorex araneus (European shrew)
Pathway
sara01523  Antifolate resistance
sara04010  MAPK signaling pathway
sara04014  Ras signaling pathway
sara04062  Chemokine signaling pathway
sara04064  NF-kappa B signaling pathway
sara04068  FoxO signaling pathway
sara04150  mTOR signaling pathway
sara04151  PI3K-Akt signaling pathway
sara04210  Apoptosis
sara04380  Osteoclast differentiation
sara04620  Toll-like receptor signaling pathway
sara04621  NOD-like receptor signaling pathway
sara04622  RIG-I-like receptor signaling pathway
sara04623  Cytosolic DNA-sensing pathway
sara04625  C-type lectin receptor signaling pathway
sara04657  IL-17 signaling pathway
sara04658  Th1 and Th2 cell differentiation
sara04659  Th17 cell differentiation
sara04660  T cell receptor signaling pathway
sara04662  B cell receptor signaling pathway
sara04668  TNF signaling pathway
sara04722  Neurotrophin signaling pathway
sara04910  Insulin signaling pathway
sara04920  Adipocytokine signaling pathway
sara04930  Type II diabetes mellitus
sara04931  Insulin resistance
sara04932  Non-alcoholic fatty liver disease
sara04936  Alcoholic liver disease
sara05010  Alzheimer disease
sara05132  Salmonella infection
sara05135  Yersinia infection
sara05142  Chagas disease
sara05145  Toxoplasmosis
sara05160  Hepatitis C
sara05161  Hepatitis B
sara05162  Measles
sara05163  Human cytomegalovirus infection
sara05164  Influenza A
sara05165  Human papillomavirus infection
sara05166  Human T-cell leukemia virus 1 infection
sara05167  Kaposi sarcoma-associated herpesvirus infection
sara05168  Herpes simplex virus 1 infection
sara05169  Epstein-Barr virus infection
sara05170  Human immunodeficiency virus 1 infection
sara05171  Coronavirus disease - COVID-19
sara05200  Pathways in cancer
sara05206  MicroRNAs in cancer
sara05208  Chemical carcinogenesis - reactive oxygen species
sara05212  Pancreatic cancer
sara05215  Prostate cancer
sara05220  Chronic myeloid leukemia
sara05221  Acute myeloid leukemia
sara05222  Small cell lung cancer
sara05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
sara05417  Lipid and atherosclerosis
sara05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:sara00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    101540472 (IKBKB)
   04014 Ras signaling pathway
    101540472 (IKBKB)
   04064 NF-kappa B signaling pathway
    101540472 (IKBKB)
   04668 TNF signaling pathway
    101540472 (IKBKB)
   04068 FoxO signaling pathway
    101540472 (IKBKB)
   04151 PI3K-Akt signaling pathway
    101540472 (IKBKB)
   04150 mTOR signaling pathway
    101540472 (IKBKB)
 09140 Cellular Processes
  09143 Cell growth and death
   04210 Apoptosis
    101540472 (IKBKB)
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    101540472 (IKBKB)
   04621 NOD-like receptor signaling pathway
    101540472 (IKBKB)
   04622 RIG-I-like receptor signaling pathway
    101540472 (IKBKB)
   04623 Cytosolic DNA-sensing pathway
    101540472 (IKBKB)
   04625 C-type lectin receptor signaling pathway
    101540472 (IKBKB)
   04660 T cell receptor signaling pathway
    101540472 (IKBKB)
   04658 Th1 and Th2 cell differentiation
    101540472 (IKBKB)
   04659 Th17 cell differentiation
    101540472 (IKBKB)
   04657 IL-17 signaling pathway
    101540472 (IKBKB)
   04662 B cell receptor signaling pathway
    101540472 (IKBKB)
   04062 Chemokine signaling pathway
    101540472 (IKBKB)
  09152 Endocrine system
   04910 Insulin signaling pathway
    101540472 (IKBKB)
   04920 Adipocytokine signaling pathway
    101540472 (IKBKB)
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    101540472 (IKBKB)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    101540472 (IKBKB)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    101540472 (IKBKB)
   05206 MicroRNAs in cancer
    101540472 (IKBKB)
   05208 Chemical carcinogenesis - reactive oxygen species
    101540472 (IKBKB)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    101540472 (IKBKB)
  09162 Cancer: specific types
   05212 Pancreatic cancer
    101540472 (IKBKB)
   05221 Acute myeloid leukemia
    101540472 (IKBKB)
   05220 Chronic myeloid leukemia
    101540472 (IKBKB)
   05215 Prostate cancer
    101540472 (IKBKB)
   05222 Small cell lung cancer
    101540472 (IKBKB)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    101540472 (IKBKB)
   05170 Human immunodeficiency virus 1 infection
    101540472 (IKBKB)
   05161 Hepatitis B
    101540472 (IKBKB)
   05160 Hepatitis C
    101540472 (IKBKB)
   05171 Coronavirus disease - COVID-19
    101540472 (IKBKB)
   05164 Influenza A
    101540472 (IKBKB)
   05162 Measles
    101540472 (IKBKB)
   05168 Herpes simplex virus 1 infection
    101540472 (IKBKB)
   05163 Human cytomegalovirus infection
    101540472 (IKBKB)
   05167 Kaposi sarcoma-associated herpesvirus infection
    101540472 (IKBKB)
   05169 Epstein-Barr virus infection
    101540472 (IKBKB)
   05165 Human papillomavirus infection
    101540472 (IKBKB)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    101540472 (IKBKB)
   05135 Yersinia infection
    101540472 (IKBKB)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    101540472 (IKBKB)
   05142 Chagas disease
    101540472 (IKBKB)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    101540472 (IKBKB)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    101540472 (IKBKB)
   05418 Fluid shear stress and atherosclerosis
    101540472 (IKBKB)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    101540472 (IKBKB)
   04936 Alcoholic liver disease
    101540472 (IKBKB)
   04932 Non-alcoholic fatty liver disease
    101540472 (IKBKB)
   04931 Insulin resistance
    101540472 (IKBKB)
  09176 Drug resistance: antineoplastic
   01523 Antifolate resistance
    101540472 (IKBKB)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:sara01001]
    101540472 (IKBKB)
Enzymes [BR:sara01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.10  IkappaB kinase
     101540472 (IKBKB)
Protein kinases [BR:sara01001]
 Serine/threonine kinases: Other
  IKK family [OT]
   101540472 (IKBKB)
SSDB
Motif
Pfam: IKBKB_SDD Pkinase PK_Tyr_Ser-Thr IKKbetaNEMObind Pkinase_fungal Kdo ubiquitin YrbL-PhoP_reg APH MYO15 Spectrin_SYNE1_2 Glyco_hydro_65m
Other DBs
NCBI-GeneID: 101540472
NCBI-ProteinID: XP_004606897
LinkDB
Position
Unknown
AA seq 756 aa
MSWSPSLPTQTCGSWEMKERLGTGGFGNVIRWHNQETGEQLAIKQCRQELSPRNRERWCL
EIQIMRRLNHPNVVAARDVPEGMQSLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREG
AILTLLSDIASALRYLHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELDQGSLCT
SFVGTLQYLAPELLEQVKYTVTVDYWSFGTLAFECITGFRPFLPNWQPVQWHSKVRQKSE
MDIVVSEDLTGTVKFSSSLPHPNNLNSVLAQRLEKWLQLMLMWHPRQRGTDPCYGPNGCF
KALDDILNLKLVHILNMVTGTIHTYPVTEDESLQSLKARIQQDTGIPEQDQELLQEAGLA
LIPDKPATQCISDGKLNEGRTLDMDLVFLFDNSKVTYETQISPRPQPESVSYILQEPKRS
LPFFQLRRVWGQVWHSIQALKEDCSRLQQGQRAAMMNLLRNNSCLSKMKNSMASMSQQLK
AKLDFFKTSIQIDLEKYSEQTEFGITSDKLLLAWREMEQAVALCGRENEVKHLVELMMAL
QTDIVDLQRSPMGRKQGGTLDDLEEQARDLYRKLREKPRDQRNEGDSQDMVRLLLQAIQS
FEKKVRVIYTQLSKTVVCKQKALELLPKVEEVVSLMNEDEKTVVRLQEKRQKELWNLLKI
ACSKVRGPVSGSPDSMNASRLSHPGQLLSQPCTAPGSLPESATESEELVAEAQTLCAQLE
NVIQDAVNQQGQSLKSLDWSWLQTEEEDQNSLQQAS
NT seq 2271 nt   +upstreamnt  +downstreamnt
atgagctggtcaccttccctgccaactcagacctgtgggagctgggagatgaaggagcgg
ctgggcaccgggggctttggcaacgtcatccgttggcacaatcaggagacgggggagcag
ctcgccatcaagcagtgccggcaggagctgagtccccggaaccgcgagcgctggtgtctg
gagatccagatcatgcgaaggctcaaccaccccaatgtggtggctgcccgggatgtcccc
gaggggatgcagagtctggcccccaatgacctgcccctgctggccatggagtactgccaa
ggaggagatctccggaagtacctgaaccagtttgagaactgctgtggcctccgggaaggc
gccatcctcaccctgctgagcgacatcgcctctgcacttagataccttcatgaaaatagg
atcatccatcgggatctgaaaccagagaatatcgtcctgcagcaaggagagcaaagatta
atccacaaaattattgacctaggatatgccaaagaactggatcagggcagtctctgcacc
tcgtttgtgggaaccctgcagtacctggccccggagctgctggagcaggtgaagtacacc
gtgaccgtggactactggagcttcggcaccttggccttcgagtgcatcacgggcttccgg
cccttcctgcccaactggcagcctgtgcagtggcactccaaagtccggcagaagagtgag
atggacatcgttgtcagtgaagacctgacgggaacagtgaagttctccagctccctgcca
caccccaataaccttaacagtgttttggcacaacgcctggagaagtggctgcagctgatg
ctgatgtggcacccccggcagaggggcaccgacccctgctatgggcccaacggctgcttc
aaggcccttgatgacatcttaaacttgaagctggtgcacatcttgaacatggtcacaggc
accattcacacctacccggtgactgaagatgagagtctccagagcttaaaggccagaatt
cagcaggacaccggcattcctgagcaggaccaggagctgctgcaggaggcaggcctggcc
ctgatccccgacaagccagccacacagtgcatctcagatggcaagttgaatgaaggccgc
acactggacatggatcttgtttttctttttgacaacagcaaagtcacctatgagactcag
atatccccacggccgcaacctgaaagtgtcagctatatccttcaagagcccaagaggagc
ctgcctttcttccaactgcggagagtgtggggccaggtctggcacagcatccaggccctg
aaggaggactgcagccggctgcagcagggacagcgagctgccatgatgaatctcctccgg
aataacagctgtctttctaaaatgaagaattccatggcttccatgtctcagcagctcaag
gccaaattggatttttttaaaaccagcatccagattgacctggagaagtatagtgagcaa
accgagtttggaattacatcagataaattgttgcttgcatggagggaaatggaacaggct
gtggcgctctgtgggcgggagaatgaagtgaagcacctggtggagctgatgatggccctg
cagacggacatcgtggacctgcagaggagccccatggggaggaagcagggaggcacgctc
gacgacctagaggagcaagccagggacctttatcggaagctgagggagaaaccgcgagac
cagcgaaatgaaggggacagtcaggacatggtgcggctgctgctgcaggcaatccagagc
tttgagaagaaagtgcgggtgatttacactcagctcagtaagactgtagtctgcaagcag
aaggccctggagctgctgcccaaggtggaagaggtggtgagtttaatgaatgaggatgag
aagactgtcgtccggcttcaggagaagcggcagaaggagctctggaatcttctgaagata
gcttgtagcaaggtccgtgggcctgtcagtggaagccctgatagcatgaacgcctctcgc
cttagtcatccaggtcagctcctgtctcagccttgcacagcccccggcagcttacctgag
tcggccacagaaagtgaggagttggtggccgaagcacagactctctgcgcacagctggaa
aatgtgattcaggatgctgtgaaccagcaaggccagagtctaaagtctctagactggagc
tggttacagactgaggaggaggaccagaacagtctgcagcaggcctcttga

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