Sorex araneus (European shrew): 101544164 Help Entry 101544164         CDS       T07854                                  Symbol RYR3 Name (RefSeq) ryanodine receptor 3 isoform X1   KO K04963   ryanodine receptor 3 Organism sara  Sorex araneus (European shrew) Pathway sara04020   Calcium signaling pathway sara04371   Apelin signaling pathway sara04713   Circadian entrainment sara04921   Oxytocin signaling pathway sara04970   Salivary secretion sara05010   Alzheimer disease sara05012   Parkinson disease sara05020   Prion disease sara05022   Pathways of neurodegeneration - multiple diseases Brite KEGG Orthology (KO) [BR:sara00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     101544164 (RYR3)    04020 Calcium signaling pathway     101544164 (RYR3)  09150 Organismal Systems   09152 Endocrine system    04921 Oxytocin signaling pathway     101544164 (RYR3)   09154 Digestive system    04970 Salivary secretion     101544164 (RYR3)   09159 Environmental adaptation    04713 Circadian entrainment     101544164 (RYR3)  09160 Human Diseases   09164 Neurodegenerative disease    05010 Alzheimer disease     101544164 (RYR3)    05012 Parkinson disease     101544164 (RYR3)    05020 Prion disease     101544164 (RYR3)    05022 Pathways of neurodegeneration - multiple diseases     101544164 (RYR3)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:sara04040]     101544164 (RYR3) Ion channels [BR:sara04040]  Voltage-gated cation channels   Ryanodine receptor    101544164 (RYR3) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 MIR SPRY Ins145_P3_rec RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 EF-hand_8 EF-hand_5 Motif Other DBs NCBI-GeneID:  101544164 NCBI-ProteinID:  XP_004609597 LinkDB All DBs Position Unknown AA seq 4873 aa AA seqDB search MAEGGEGGEDEIQFLRTEDEVVLQCIANIHKEQRKFCLAAEGLGNRLCFLEPTSEAKYVP PDLCVCNFVLEQSLSVRALQEMLANTVENGGEGAAQGGGHRTLLYGHAILLRHSFSGMYL TCLTTSRSQTDKLAFDVGLREHATGEACWWTIHPASKQRSEGEKVRIGDDLILVSVSSER YLHLSVSNGNIQVDASFMQTLWNVHPTCSGSSIEEGYLLGGHVVRLFHGHDECLTIPSTD QNDSQHRRIFYEAGGAGTRARSLWRVEPLRISWSGSNIRWGQAFRLRHLTTGHYLALTED LGLILQDRGKSDTKSTAFSFRASKEIKEKSDSTHKRDIEGMGVPEIKYGDSVCFVQHIAS GLWVTYKAQDAKTSRLGPLKRKVILHQEGHMDDGLTLQRCQREESQAARIIRNTTALFSQ FISGNNRTAAPVSLPIEEVLQTLQDLIAYFQPPEEEMQHEDKQNKLRSLKNRQNLFKEEG MLALVLNCIDRLNVYNSVTHFAGIAREESSMAWKEVLSLLYKLLAALIRGNRNNCAQFSN NLDWLISKLDRLESSSGILEVLHCILIESPEALNLIAEGHIKSIISLLDKHGRNHKVLDV LCSLCLCNGVAVRANQNLICDNLLPRRNLLLQTRLINDVTSIRPNIFLGVAEGSAQYRKW YFELIIDQVDSFLTAEPTHLRVGWASSSGYAPYPGGGEGWGGNGVGDDLYSYGFDGLHLW SGRIPRAVASINQHLLKSDDVVSCCLDLGVPSISFRINGQPVQGMFENFNTDGLFFPVVS FSAGVKVRFLMGGRHGEFKFLPPSGYAPCYEALLPKEKMRLEPVKEYKRDAEGVRDLLGT TQFLSQASFIPCPIDTSQVVLPPHLEKIRDRLAENIHELWGMNKIELGWTFGKIRDDNKR QHPCLVEFSKLPETEKNYNLQMSTETLKTLLALGCHIAHVNPAAEDDLKKVKLPKNYMMA NGYKPAPLDLSDVKLLPPQEILVDKLAENAHNVWAKDRIKQGWTYGIQQDLKNKRNPRLV PYTLLDERTKKSNRDSLREAVRTFVGYGYNIEPSDQELADPAVEKVSIDKIRFFRVERSY AVRSGKWYFEFEVVTGGDMRVGWARPGCRSDIELGADDQAFVFEGSRGQRWHQGSGYFGR TWQPGDVVGCMINLEDASMIFTLNGELLITNKGSELAFADYEIENGFVPICSLGLSQIGR MNLGMDASTFKFYTMCGLQEGFEPFAVNMNRDVAMWFSKRLPTFVNVPKDHPHIEVVRID GTMDSPPCLKVTHKTFGTQKSSANMIYCRLSMPVECHSSFSHSPCLDSDAFQKRKQIQEM LSHTTTQCYYAIRIFAGQDPSCVWVGWVTPDYHLYSDKFDLSKNCTVTVTLGDERGRVHE SVKRSNCYMVWGGDVVATSQRSSRSNVDLEIGCLVDLAMGMLSFSANGRELGTCYQVEPN TKVFPAVFLQPTSTSLFQFELGKLKNTMPLSAAIFKSEEKNLVPQCPPRLDVQTIQPVLW SRMPNSFLKVETERVSERHGWVVQCLEPLQMMALYIPEENRCVDILELCEQEDLMRFHFH TLRLYSAVCALGNSRVAYALCSHVDLSQLFYAIDNKYLPGLLRSGFYDLLISIHLASAKE RKLMMKNEYIIPITSTTRKIHLYPDGSKRHGLPGVGLRTCLKPGFKFSTPCFVATSEEHQ KQSPEIPLEILKTKALTMLTEAVQCSGAHIRDPVGGSVEFQFVPVLKLIGTLLVMGVFDD DDIRHILLLIDPSVFGEHSGETEEGAEKEEVTQEEEKAVEAGEKASKEAPVKGLLQTRLP ESVKLQMCELLSYLCDCELQHRVEAIVAFGDIYVSKLQANQKFRYNELMQALNMSAALTA RKTREFRSPPQEQINMLLNFQLGENCPCPDEIREELYDFHEDLLVHCGVPLEEEEEEEED TSWTGKLRMLMSKVKGPPKLEKQQPREEEERCPTTLKELISQTMIRWAQEDQIQDAELIR MMFNLLRRQYDSIGELLQALRKTYTISQASVNDTINLLAALGQIRCLLSVRMGKEEELLM INGLGDIMNNKVFYQHPNLMRVLGMHETVMEVMVNVLGAEKSQIAFPKMVASCCRFLCYF CRISRQNQKAMFEHLSYLLENSSVGLASPSMRGSTPLDVAASSVMDNNELALGLEEPDLE KVVTYLAGCGLQSCPMLLAKGYPDVGWNPIEGERYLSFLRFAVFVNSESVEENASVVVKL LIRRPECFGPALRGEGGNGLLAAMQGAIKISENPALDLPSQGYKREISMEDDEDEEEIVH MGNAIMSFYSALIDLLGRCAPEMHLIQTGKGEAIRIRSILRSLVPTEDLVGIISIPLKLP SLNKDGSVSEPDMSANFCPDHKAPMVLFLDRVYGIKDQTFLLHLLEVGFLPDLRASASLD TVSLSTTEAALALNRYICSAVLPLLTRCAPLFAGTEHFSSLIDSTLQTIYRLSKGRSLTK AQRDTIEECLLAICNHLRPSMLQQLLRRLVFDVPQLNEYCKMPLKLLTNHYEQCWKYYCL PSGWGSYGLAVEEELHLTEKLFWGIFDSLSHKKYDPDLFRMALPCLSAIAGALPPDYLDT RISATLEKQVSVDAEGNFDPKPINTMNFSLPEKLEYIVTKYAEHSHDKWACDKSQNGWKY GISLDENVRTHPLIRPFKTLTEKEKEIYRWPARESLKTMLAVGWTVERTKEGEALVQQRE NEKLRSMSQASQGNSYSPVPLDLSNVVLSRELQGMVEVVAENYHNIWAKKKKLELESKGG GSHPLLVPYDTLTAKEKFRDREKAQDLFKFLQVNGITVSRGMKDLELDASSMEKRFAYKF LKKILKYVDSAQEFIAHLEAIVSSGKTEKSPHDQEIKFFAKVLLPLVDQYFTNHRLYFLS SPLKPLSSSGYASHKEKEMVASLFCKLAALVRHRISLFGSDSTTMVSCLHILAQTLDTRT VMKSGSELVKAGLRAFFENAAEDLEKTLENLKLGKFTHSRTQIKGVSQNINYTTVALLPI LTSIFEHVAQHQFGVDLLLGDVQISCYHILGSLYSLGTGKNIYVERQRPALGECLASLVA AIPVAFLEPTLNRYNPLSVFNTKTPRERSILGMPDTAEEMCPDIPHLEGLMKEINTLAES GARYTEMPHVIEVILPMLCNYLSYWWERGPEHQPPSTGPWCTKVTSEHLSVILGNILKII NNNLGIDEASWMKRIAVYAQPIISKARPDLLRSHFIPTLEKLKKKAVKTVQEEEQLKADS KGDTQEAELLILDEFAVLCRDLYAFYPMLIRYVDNNRSNWLKSPDADSDQLFRMVAEVFI LWCKSHNFKREEQNFVIQNEINNLAFLTGDSKSKMSKAMQVKSGGQDQERKKTKRRGDLY SIQTSLIVAALKKMLPIGLNMCTPGDQELISLAKSRYSYRDTDEEVKEHLRNNLHLQEKS DDPAVKWQLNLYKDVLKSEEPSNPEKTVERVQRISAAVFHLEQVEQPLRSKKAVWHKLLS KQRKRAVVACFRMAPLYNLPRHRSINLFLHGYQRFWIETEEYSFEEKLVQDLAKSPKVDE EKEEEEETERQPDPLHQIVLHFSRNALTERSKLEDDPLYTSYSSMMAKSCQSGEDEDEEE DKEKTFEEKEMEKQKTLYQQARLHERGAAEMVLQMISASKGEMSPMVVETLKLGIAILNG GNAGVQQKMLDYLKEKKDAGFFQSLSGLMQSCSVLDLNAFERQNKAEGLGMVTEEGTLIV RERGDKVLQNDEFTRDLFRFLQLLCEGHNSDFQNFLRTQMGNTTTVNVIISTVDYLLRLQ ESISDFYWYYSGKDIIDESGQHNFSKALAVTKQIFNSLTEYIQGPCIGNQQSLAHSRLWD AVVGFLHVFANMQMKLSQDSSQIELLKELLDLLQDMVVMLLSLLEGNVVNGTIGKQMVDT LVESSTNVEMILKFFDMFLKLKDLTSSDTFKEYDPDGKGIISKKEFQKAMEGQKQYTQSE IDFLLSCAEADENDMFNYIDFVDQFHEPAKDIGFNVAVLLTNLSEHMPNDSRLKCLLDPA ESVLNYFEPYLGRIEIMGGAKKIERVYFEISESSRTQWEKPQVKESKRQFIFDVVNEGGE QEKMELFVNFCEDTIFEMQLASQISESDSAERPEEEEEEEEDPSYTLEMEGVEEEDTSFE SVSAFAMACAAVKKNVANFLKKATLRNLRKQYRKVKKMTVKELVKVFFSFFWMLFVGLFQ LFFTILGGIFQVLWSTVFGGGLVEGAKNIRVTKILGDMPDPTQFGIHDDAMEGERAEVTE PGITTELVHFVKGEKGDADLMSDLFGFHQKKEGGLKHGPEVGLGDLSEIIGKDEPPTLES TVRKKRKAQAAEIKAARDAEGKVDSEKTDVEDGEKEDRAKEEEQAETLWAETTKKKKRRR GQKVEKPEAFMANFFKGLEIYQTKLLHYLARNFYNLRFLALFVAFAINFILLFYKVTEEP LEEESEDVANLWNSFHEDEEEEAMVFFVLQESTGYMAPTLRALAIIHTVISLVCVVGYYC LKVPLVVFKREKEIARKLEFDGLYITEQPSEDDIKGQWDRLVINTPSFPNNYWDKFVKRK VINKYGDLYGAERIAELLGLDKNALDFSPVEETKAEAASLVSWLSSIDMKYHIWKLGVVF TDNSFLYLAWYTTMSILGHYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLL AVVVYLYTVVAFNFFRKFYNKSEDDDEPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIEDP AGDPYEMYRIVFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVREDMETKCFICGIG NDYFDTTPHGFETHTLQEHNLANYLFFLMYLINKDETEHTGQESYVWKMYQERCWDFFPA GDCFRKQYEDQLG NT seq 14622 nt NT seq  +upstreamnt  +downstreamnt atggccgaagggggagaaggaggcgaggacgagatccagttcctgcggactgaagatgaa gtggttctccagtgcatcgccaacattcacaaggagcaacggaagttctgcctggcagcc gagggtctggggaaccgcctgtgcttcttggaacccacttcagaagccaagtatgttcct ccagatctctgcgtctgcaattttgtcctggaacagtccttgtctgtcagagccctgcag gaaatgcttgccaacaccgttgaaaatggtggagaaggggcagcccaaggcggtggccac aggaccctgctgtatggccacgcgattctcctgcggcactccttcagcggaatgtattta acatgtttaacaacatcaagatcacaaacagataaacttgcctttgatgttggtctgcgg gagcatgccacaggggaagcctgctggtggaccatacaccctgcttccaaacagaggtcc gagggagagaaagttcgaattggtgatgacctcattcttgtaagcgtgtcctccgaaaga tacctccatctctcagtctcaaatggtaacatacaagtggatgcctcctttatgcaaaca ctctggaatgtacatcccacctgctcaggaagtagcatcgaagaaggatatcttcttggt gggcatgtagtacgtcttttccatggccatgatgagtgtttgacaataccatctacagac cagaacgattcccagcacaggaggatattctatgaagctgggggagctgggacgcgagcc aggtctctatggagagtggaaccccttcgaataagctggagtggcagtaacatcagatgg ggccaggctttccgtcttcggcacctaaccacaggccactacttggctttaacagaggat ttaggccttattctgcaagatcggggcaaatcagacacaaagtccacagccttctctttt cgggcatcaaaggaaatcaaggagaaatcagattccactcacaagcgagatatagaaggc atgggagttccagaaataaagtacggagattctgtctgctttgtccagcatatagccagt ggtctttgggtgacttacaaagcacaagatgccaaaacatctcgccttggaccactaaaa agaaaggtcatactccatcaggaaggccacatggatgatggattgacactgcagaggtgc cagcgtgaggaatcccaagctgctagaatcatccggaacacaactgccttattcagccag tttataagtggaaacaatcgtactgcagcccctgtcagcctacccatagaagaggtatta cagactctacaggatctaatcgcctatttccagcccccagaagaggaaatgcagcatgaa gacaagcagaacaaacttcgttcactcaaaaatagacagaatcttttcaaggaagaggga atgttggctctcgtattaaattgcattgatcgcttaaacgtctacaacagcgtcacacat tttgcagggattgcaagggaagaaagcagcatggcctggaaagaagttctgagcctcctg tacaaattactggctgctctcattcgaggaaatagaaacaattgtgctcagttctccaat aaccttgattggttaatcagcaaattggacagactcgaatcttcctcaggtatcttggaa gttttgcactgtattctgattgaaagcccagaagccttaaatctaattgcagagggtcac atcaagtccatcatctccctgttggacaagcatgggcggaatcacaaggttctggatgtg ctgtgttccctgtgcttgtgcaatggggttgctgtgagagccaaccagaatctcatctgt gacaacttgttgccccggcgaaacctgctcctgcagacacggctgattaatgatgtgacc agtatccggccaaacatctttttgggagtggctgagggctcggcacagtacaggaagtgg tacttcgagctgattatcgaccaagtggactccttcctgacagcagaacccacacatctg cgagtgggctgggcctcctcttcaggctacgctccctaccctggtggtggagaaggatgg ggaggcaatggtgttggtgatgacctgtactcctacggttttgacggacttcacctttgg tcaggccggatacccagagctgtggcctctatcaaccagcacctcctgaaatcagatgat gtggtgagctgttgcctggatcttggagttcctagtatatccttccgcatcaatggtcag cctgtgcaaggaatgtttgagaacttcaacacagatgggctcttcttccctgtggtgagc ttttcagcaggtgtcaaagtacgttttctgatgggtggacgtcatggagaatttaagttc ctgcctccctctggctatgccccttgctatgaagccttacttcccaaagagaagatgaga ttggagcctgtgaaagaatataagcgcgacgcggaaggtgttagagatctactgggtacc acccagttcctctcccaggcctctttcatcccatgccccatagacaccagtcaggtagtg ttaccacctcatcttgagaagatcagagacagactagctgaaaacattcatgagctttgg gggatgaataaaattgagcttggctggacttttggcaagatacgggatgacaataaaaga caacacccctgccttgtggagttttcaaagctccctgaaacagagaagaattataacctg caaatgtcaactgaaaccttaaaaaccctcctggcccttggatgccacattgcccatgta aatccagctgctgaagatgatctcaagaaagtaaaacttcccaaaaattatatgatggct aatggctataagccagctcctttggatttgtctgatgtgaaattgttgcctcctcaagaa attttagtggataagcttgcagagaatgcccataatgtttgggcaaaggacagaataaaa caaggatggacctatggcattcaacaggatttgaagaacaaaaggaatccccgcctagtg ccatacacattacttgatgagagaaccaagaagtcaaacagagatagccttcgggaagct gttaggacattcgttggttatgggtataacattgaaccatcagatcaggagcttgctgac ccagctgtggaaaaagtcagcatagacaagattcgatttttccgggtagagcggtcctat gccgtgaggtctggaaagtggtatttcgagtttgaagtcgtgactggaggagatatgcgt gttggttgggccaggcccggctgtcgatctgacattgagctgggggctgatgaccaggcc tttgtatttgaaggcagcaggggtcaacgctggcaccagggaagtgggtattttggacga acctggcagccaggagatgtggttggatgcatgattaacctagaggatgcttcgatgatc ttcacactgaatggggagctgctgatcaccaacaaaggctcagaacttgcctttgctgac tacgagattgaaaatggctttgtgcccatctgctccctgggcctgtctcagatcggtcgc atgaatcttgggatggatgccagtaccttcaagttttataccatgtgcggcctccaagag ggctttgagcctttcgctgtcaacatgaaccgagatgttgccatgtggttcagcaagcgc ctcccaacatttgtcaacgtgcctaaggatcatccgcatatagaggtcgtgaggatcgat ggcaccatggacagccccccgtgcctcaaggtgacccacaaaacgtttggcacacagaaa agcagtgccaacatgatctactgccgcctgagcatgcctgttgagtgtcactcctccttc agccacagcccctgcctggacagcgacgctttccagaagaggaaacagattcaggaaatg ctctctcatacaacaacacagtgctactatgcaatccgcatctttgctggacaggacccc tcctgtgtctgggttggatgggtgactccggactatcatttgtacagtgataaatttgac ctgagtaaaaactgtacagtgacagttaccctgggagatgaaagaggccgggtccatgaa agtgtgaagcgcagcaactgctacatggtctggggtggggatgttgtggccacatcccaa agatcaagtcggagcaatgtggacctagaaattggctgcctcgtggatctggcaatggga atgttgtccttttcagccaatgggagagaactcggcacctgctaccaggtggagcccaac accaaagtgttcccagcagttttcctgcaacctacgagcacttctttgtttcagtttgaa ctggggaagctgaagaatacaatgcccctgtcggcagccatatttaagagtgaagagaag aacctagtgcctcagtgtccccctcggctcgacgtccaaaccatccagcctgtgctctgg agccgcatgcccaacagcttcctgaaggtggagactgagcgggtgagcgagcgccatggc tgggtggtacagtgcctggaaccactgcagatgatggcgctctacatccctgaggagaac aggtgtgtggatatcctggagctttgtgagcaggaggacctgatgcggttccatttccac acactgagactctacagtgctgtgtgtgccctgggaaacagccgagtggcttacgccctg tgtagccacgtcgacctctcccagctcttctacgccattgacaacaagtacctccctggc ctccttcggtctggtttctatgacctgctcatcagcatccacctcgccagtgccaaggaa aggaagcttatgatgaagaatgaatacattatccccattaccagcaccactaggaaaatc cacctgtacccagatggatccaagaggcacggactgcccggggtgggcctaaggacgtgc ctcaagccagggttcaagttctccaccccttgctttgttgcgaccagcgaagagcaccaa aagcagagtcctgagattcccttggagattctcaagacaaaagcactgaccatgctgaca gaagcagtgcaatgcagtggggctcacatccgggacccagttgggggatctgtggagttc cagtttgtgcctgtgctgaaactcatcggaaccttgctggtcatgggcgtatttgatgat gatgacattcggcatatcctcctcctcatcgatccctctgtatttggggagcacagtgga gagacagaggagggagctgagaaagaggaagtgacccaggaggaggagaaagctgtggag gccggggaaaaggccagcaaggaggccccagtcaaaggcttgctgcagacacgattacca gaatccgtcaaactgcagatgtgtgagctcctcagctatctctgtgattgtgagctacag caccgagtggaggccattgtggcatttggcgacatttatgtctccaagctccaggcaaat cagaagttccgctacaatgagctcatgcaagccctgaacatgtctgcagccctgactgcc cggaagaccagagagtttcgctcacccccgcaggagcagatcaacatgctgcttaacttt caactgggggagaactgcccctgtccagacgagattcgggaagaactctacgacttccat gaggacctgctcgttcactgcggggttcccttggaggaagaggaggaggaggaagaggac acctcctggactgggaagctccgtatgctgatgtctaaggtcaaaggaccccccaagttg gagaagcagcagccaagggaggaggaggagcgatgccctaccaccctcaaggagctcatc tcacagacaatgatccgctgggcccaggaggaccagatccaggatgcagagctcatccgc atgatgttcaacctgctccggaggcagtacgacagcatcggggagctgctgcaggcactg cggaagacctacaccatcagccaggcctctgtgaatgacaccatcaacctgctggcagcc ctgggccagatccgctgcctcctcagcgtcagaatgggcaaggaagaggagctgctgatg atcaacgggctgggagacatcatgaacaacaaggtgttttaccagcaccccaacctcatg cgcgtccttggcatgcacgagacagtgatggaggtgatggtgaacgtgctgggagcagag aagtcccagattgcttttccaaagatggttgctagctgttgccgcttcctttgttatttc tgtcgaattagccggcaaaatcagaaggccatgtttgagcatctaagctacctactggag aatagcagtgtcggtctagcctccccttctatgaggggatccaccccactggatgtggca gcttcctctgtgatggacaacaacgagttagcgctgggcttagaggagccagacctcgag aaggtggtgacctacttggcaggctgtggcttgcagagctgccctatgcttctggccaaa ggataccctgatgttggctggaatcccatcgaaggagagcgatacctatctttcctgagg tttgccgtcttcgtgaacagtgaaagtgtggaggaaaacgcaagtgttgtggtcaaacta ctcatccgacgcccagaatgctttggtcctgccctgaggggtgaaggaggaaatggtctg ttggccgccatgcagggcgccattaagatctcagagaatccagcccttgacctgccctca cagggatacaagagggaaatcagcatggaagatgatgaggatgaagaagagattgtgcac atgggaaatgcaattatgtcattttattctgctctcatagatctactgggccgttgtgct cccgaaatgcatcttatccagacaggaaaaggggaagccatccggatcaggtcaatcctg cgctccctagtccccacggaggacttggttgggatcatcagcatccccctgaaactgcca tccctgaacaaagatgggtcagtgagcgagccagacatgtcagccaacttctgccctgac cacaaggctcccatggtgctcttcctggatcgtgtgtatggcatcaaggatcagactttt ctgctccacttgctggaggttggatttttacccgatttaagagcctccgcctctctagat acagtttctctgagcaccacagaggcggcgctggcactcaatcggtatatatgttctgca gtgctcccactgctcaccagatgcgccccgctctttgcgggaactgagcacttctcctct ttgattgattccacactgcagaccatctaccggctttccaagggccgttccctcaccaag gcccagagggacaccattgaagaatgtttgctcgccatttgcaaccacttgagaccttcc atgttacaacagctccttcgacgtcttgtttttgatgtcccacagctcaatgaatactgc aaaatgcctctgaagcttctgacaaatcactatgagcagtgctggaagtattactgtctg ccttcaggatgggggagctacggtctcgctgtggaggaggagctgcacctgacggagaag ctcttctgggggatttttgactccctctcccataagaaatatgacccggatcttttccga atggccctgccttgtctcagtgccatagctggggccttgccaccagattatttagacacc agaatctcagccacattggaaaaacaggtctcagtggatgcagaaggcaactttgacccc aaacctatcaacaccatgaatttctccttgcctgaaaaactggagtacatcgtcaccaag tatgctgagcattcacatgataaatgggcctgcgacaagagccagaatggatggaaatat ggaatttccctggatgaaaatgtgaggacccaccccctgataagacctttcaagacatta acagagaaggaaaaggaaatctaccgctggcctgccagagagtccctgaaaaccatgttg gctgtggggtggactgttgagagaactaaagaaggagaagccttggttcaacagcgggaa aacgagaagcttcgaagcatgtcccaggccagccagggcaacagctatagccctgttccc ctggacctttccaacgttgtgctgtccagagagctccagggcatggtggaagtcgtggcc gagaactaccataatatctgggccaagaagaagaaactggagctggagagcaaaggtggt ggcagtcaccctcttttagtgccctacgacaccttgacagccaaagaaaagttcagagat cgagagaaggcacaggacctattcaaattcctccaggtgaatggcatcacagtttctaga ggaatgaaggatttggagctggatgcttcttccatggaaaagagatttgcctataaattt ttgaagaagatcctaaaatacgtcgactctgctcaggagtttattgctcatttagaagcc attgtcagcagtgggaaaactgaaaagtctccccatgaccaggagatcaagttctttgcc aaagttctcctccctctagttgaccagtacttcaccaatcaccgcctctacttcctgtct tcccctctgaagcccctgagcagcagtgggtatgcctcccacaaggagaaggaaatggtg gccagcctgttctgcaaactcgctgctcttgttagacacaggatttctctctttgggagt gattctactacaatggtgagctgtcttcatatcttagctcagacgcttgacacacggact gtcatgaagtccggctctgagctggtgaaagccggcttgcgagccttttttgaaaatgct gccgaagacttagagaagactttggaaaacctgaagctggggaagtttacccattccaga acacagattaaaggcgtttctcagaacatcaactataccacggtggctctgctccccatc ctcacttccatcttcgagcatgtggctcagcatcagttcggggtggatttgctcttgggc gacgtgcagatttcatgctaccatatattgggaagtctgtactccctcgggacaggaaag aacatctatgttgaaaggcaacgccctgcccttggagaatgtctggcctccctggtagca gctattccagtggcattcctggagcccacccttaaccgctataatcctctctctgtcttc aacaccaagacccccagggagagatctatcctggggatgccagacacagcagaggagatg tgtcctgacatcccacatctggaaggcctgatgaaggaaatcaacacactggccgagtcg ggggcccggtacacagagatgccccacgtcattgaggtgatcttgcccatgctctgcaac tacctgtcctactggtgggagcgggggcctgagcaccagccccccagcacagggccctgg tgcaccaaggtcacctctgaacacctcagtgttatcctgggcaacattctgaaaatcatc aacaacaacctgggcatcgacgaggcctcctggatgaagcgaatcgcagtgtacgcccag ccgatcatcagcaaagccaggcctgacctgctcagaagccactttatcccaactctggag aagctgaagaaaaaggctgtcaagaccgtgcaggaagaagaacagctgaaagcagatagc aaaggggatactcaggaggcagagctgctcatcctggatgagtttgcagtgctctgccgg gacctctacgctttctaccccatgctgatccgctatgtggacaataacagatctaactgg ctcaaaagccctgatgctgattccgaccagctttttcgcatggtggcagaggtcttcatc ctgtggtgtaaatctcataacttcaagagggaagagcagaattttgtgattcagaatgaa attaataatttggcatttttgactggagacagcaaaagcaagatgtcaaaagccatgcaa gtaaagtctggaggccaggaccaggaacggaagaagaccaagaggcggggggacctgtat tccatccagacctccctcattgtggccgcactcaagaagatgctgcccattggtttgaat atgtgcacccccggtgatcaggagttgatctcccttgcaaaatcacggtacagctataga gacacagacgaagaggttaaggagcatcttcggaataacttgcatttgcaggaaaagtct gatgacccagctgtcaagtggcaactgaacctctacaaagatgttttgaagagtgaagaa ccgtccaatccagaaaagacagtggagcgtgtgcagagaatttctgcagctgtcttccat ctggagcaggtggaacagcctctgaggtccaagaaggctgtctggcataaactattgtca aagcaacgcaagcgggctgtggtggcctgcttcaggatggcacctctctacaatctgccc aggcaccgctctattaacctcttcctccatggctatcagagattttggatagaaacagag gagtattcctttgaagagaaactagtacaggatttggctaaatctcccaaggtggatgag gagaaggaggaggaggaagaaacggaaaggcagccggacccactccatcagatcgtccta catttcagccgcaatgccctcacggagaggagcaaactagaagatgatcctctgtatact tcctattccagcatgatggccaagagttgtcagagtggggaagatgaagatgaggaggaa gacaaggaaaaaacatttgaagagaaggaaatggaaaagcagaaaaccctttatcagcag gctcggctgcatgagcgtggagcagcagaaatggtcctgcagatgataagcgccagcaaa ggtgagatgagccccatggtggttgagacgctgaagctgggcatcgccatcctgaatggg ggcaatgcaggcgtgcaacagaaaatgctagattacctaaaagagaaaaaggatgctgga ttctttcaaagcctttctggtcttatgcagtcttgcagtgtccttgatttgaatgcattt gagcgacagaataaagctgaaggcctggggatggttactgaagaaggaacactcattgtt cgtgagcgtggtgacaaagtcctccaaaatgacgagtttacacgagatctctttagattc ctacagctactttgtgaaggacataacagtgactttcagaacttcctgcggacccaaatg ggcaacaccaccactgtgaatgttatcattagcactgtggactatctgctgcgtctgcag gaatccatcagtgatttttactggtattattctgggaaggacatcattgatgaatctgga cagcacaatttttccaaagctttggcagtcaccaagcagatttttaactctctaacagaa tatatccagggcccttgcattgggaaccagcagagcctggctcacagcaggctgtgggac gcagtggtcggcttcctccatgtctttgctaacatgcagatgaaactctctcaggattcc agtcagatcgagctgctgaaggaactcttggatctccttcaggacatggtggtgatgctt ctgtccctcctggaagggaatgtggtaaatggaactattggcaagcagatggttgacaca ctggtagaatcatctaccaatgtagaaatgatcttgaaattctttgacatgttcttgaaa cttaaagacttaaccagctcagataccttcaaagaatatgacccagatggtaaagggatt atctccaaaaaagagttccagaaggccatggaagggcaaaaacagtacacccagtcagaa attgactttctcctctcatgtgcagaagctgatgagaatgatatgtttaattacattgat tttgtagaccagttccatgagccggccaaggacatagggtttaatgtggcagtgttattg acaaatctttctgaacatatgcctaatgattctcgccttaagtgtttgttggacccagca gaaagtgtgctcaattactttgaaccttacctaggacgcattgaaatcatgggtggggcc aagaaaatcgagcgtgtttattttgagatcagtgaatccagtcgaactcagtgggaaaaa ccccaagtgaaggaatctaagaggcagttcatctttgatgtggtcaatgaaggtggagag caagaaaagatggaactatttgtgaacttctgtgaggataccatctttgaaatgcagcta gcatcacagatctctgaatcggactcagccgagaggccagaagaggaagaagaagaggag gaagatccttcatacacattagaaatggaaggcgtagaggaggaggacacatcttttgag tctgtctctgcatttgctatggcctgtgctgctgtaaagaaaaatgttgccaactttctg aaaaaggcaaccctgagaaacctcaggaaacagtacaggaaggtgaaaaagatgactgta aaggagctagtgaaggtgttcttttcatttttttggatgttgtttgtgggtctgttccag ttgttcttcaccatactgggaggaatctttcaggtcctctggagcacagtgtttggaggg ggcctggtagaaggggcaaagaacatcagggtgaccaagatcctgggtgatatgcctgac ccaacccaatttggtatccatgatgatgctatggagggtgagagggcagaagtgactgag ccaggtatcacaactgaactagtgcacttcgtaaaaggtgagaagggagatgcggatctt atgtcagatctctttggattccaccaaaagaaagaaggtggcttaaagcatgggcctgaa gtgggtttgggtgatctctctgagattatcggcaaggatgagcctcctacactagaaagt actgtacggaaaaaaaggaaagcacaggcagcagaaataaaggcagcacgtgatgccgaa ggaaaagtcgactctgagaagacagatgtggaagatggggagaaggaggatagagccaaa gaagaggaacaagctgagaccctatgggcagaaacaacaaaaaagaagaagcgacggcgt ggccagaaagttgagaagcctgaagccttcatggccaatttctttaaaggactggaaatc tatcagaccaagttactgcattacctggccaggaatttctacaacctgaggttccttgct ctgtttgtagcttttgctatcaacttcatcctgctcttttacaaggtcactgaagaacct ttagaggaagagtcagaggatgttgcaaacctgtggaattcctttcatgaggatgaggag gaagaagccatggtgttctttgtcctgcaggagagcactggctacatggcaccaacgctg cgggccctggccattatccacactgtcatctccttggtctgtgtggtgggctattactgc ctgaaggttcctctagtggtgtttaaaagagaaaaagaaattgccaggaagctggagttt gatggcctgtatatcactgaacagccatctgaagatgacatcaagggacaatgggatcgc ttagtaatcaacacaccgtcttttcctaataactactgggacaagtttgtaaagagaaag gtgatcaacaagtatggagacctctatggagcagaacgtattgctgagctactgggtttg gacaaaaatgccctggactttagcccagtagaagagactaaagctgaagcagcctctctt gtgtcatggctgagttccattgacatgaagtaccatatctggaagctgggagtcgttttt accgataattcctttctctacctggcctggtacacaaccatgtcaatcctgggccactac aacaacttcttctttgctgctcatctactagatattgcaatgggcttcaagactctgagg actatcctgtcatctgtaactcataatggcaaacagttggtgctgacggtcggtctcctg gctgtcgtggtttatctctacactgtggtggccttcaacttcttccgcaagttctacaac aaaagtgaagatgacgacgagcctgatatgaagtgtgatgacatgatgacgtgttaccta ttccacatgtatgtgggtgtgagagcaggaggcggcattggggatgaaatcgaagaccct gctggcgatccttacgaaatgtaccgcattgtctttgacatcaccttcttcttcttcgtt attgtcatcttgttggccatcattcaaggtcttatcattgatgcttttggagagctaagg gaccagcaggaacaagtgcgagaagatatggagactaaatgtttcatctgcgggattggc aatgactattttgacaccacccctcatggttttgagacacatacgttacaagagcacaac ttagccaactacctgttctttctgatgtacttgattaataaagacgaaacagagcacaca ggtcaggaatcttatgtctggaagatgtaccaagaaaggtgttgggacttcttcccagct ggtgactgctttcgaaaacaatatgaagatcagctcggataa

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