| Entry |
|
| Symbol |
PLCB4
|
| Name |
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1
|
| KO |
|
| Organism |
sara Sorex araneus (European shrew)
|
| Pathway |
| sara04070 | Phosphatidylinositol signaling system |
| sara04261 | Adrenergic signaling in cardiomyocytes |
| sara04613 | Neutrophil extracellular trap formation |
| sara04621 | NOD-like receptor signaling pathway |
| sara04723 | Retrograde endocannabinoid signaling |
| sara04750 | Inflammatory mediator regulation of TRP channels |
| sara04925 | Aldosterone synthesis and secretion |
| sara04928 | Parathyroid hormone synthesis, secretion and action |
| sara04933 | AGE-RAGE signaling pathway in diabetic complications |
| sara04935 | Growth hormone synthesis, secretion and action |
| sara04961 | Endocrine and other factor-regulated calcium reabsorption |
| sara04973 | Carbohydrate digestion and absorption |
| sara05022 | Pathways of neurodegeneration - multiple diseases |
|
| Module |
| sara_M00130 | Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4 |
|
| Brite |
KEGG Orthology (KO) [BR:sara00001]
09100 Metabolism
09101 Carbohydrate metabolism
00562 Inositol phosphate metabolism
101546811 (PLCB4)
09130 Environmental Information Processing
09132 Signal transduction
04015 Rap1 signaling pathway
101546811 (PLCB4)
04310 Wnt signaling pathway
101546811 (PLCB4)
04371 Apelin signaling pathway
101546811 (PLCB4)
04020 Calcium signaling pathway
101546811 (PLCB4)
04070 Phosphatidylinositol signaling system
101546811 (PLCB4)
04072 Phospholipase D signaling pathway
101546811 (PLCB4)
04071 Sphingolipid signaling pathway
101546811 (PLCB4)
04022 cGMP-PKG signaling pathway
101546811 (PLCB4)
09133 Signaling molecules and interaction
04082 Neuroactive ligand signaling
101546811 (PLCB4)
04081 Hormone signaling
101546811 (PLCB4)
09140 Cellular Processes
09144 Cellular community - eukaryotes
04540 Gap junction
101546811 (PLCB4)
09150 Organismal Systems
09151 Immune system
04611 Platelet activation
101546811 (PLCB4)
04613 Neutrophil extracellular trap formation
101546811 (PLCB4)
04621 NOD-like receptor signaling pathway
101546811 (PLCB4)
04062 Chemokine signaling pathway
101546811 (PLCB4)
09152 Endocrine system
04911 Insulin secretion
101546811 (PLCB4)
04922 Glucagon signaling pathway
101546811 (PLCB4)
04929 GnRH secretion
101546811 (PLCB4)
04912 GnRH signaling pathway
101546811 (PLCB4)
04915 Estrogen signaling pathway
101546811 (PLCB4)
04921 Oxytocin signaling pathway
101546811 (PLCB4)
04926 Relaxin signaling pathway
101546811 (PLCB4)
04935 Growth hormone synthesis, secretion and action
101546811 (PLCB4)
04918 Thyroid hormone synthesis
101546811 (PLCB4)
04919 Thyroid hormone signaling pathway
101546811 (PLCB4)
04928 Parathyroid hormone synthesis, secretion and action
101546811 (PLCB4)
04916 Melanogenesis
101546811 (PLCB4)
04924 Renin secretion
101546811 (PLCB4)
04925 Aldosterone synthesis and secretion
101546811 (PLCB4)
04927 Cortisol synthesis and secretion
101546811 (PLCB4)
09153 Circulatory system
04261 Adrenergic signaling in cardiomyocytes
101546811 (PLCB4)
04270 Vascular smooth muscle contraction
101546811 (PLCB4)
09154 Digestive system
04970 Salivary secretion
101546811 (PLCB4)
04971 Gastric acid secretion
101546811 (PLCB4)
04972 Pancreatic secretion
101546811 (PLCB4)
04973 Carbohydrate digestion and absorption
101546811 (PLCB4)
09155 Excretory system
04961 Endocrine and other factor-regulated calcium reabsorption
101546811 (PLCB4)
09156 Nervous system
04724 Glutamatergic synapse
101546811 (PLCB4)
04725 Cholinergic synapse
101546811 (PLCB4)
04728 Dopaminergic synapse
101546811 (PLCB4)
04726 Serotonergic synapse
101546811 (PLCB4)
04720 Long-term potentiation
101546811 (PLCB4)
04730 Long-term depression
101546811 (PLCB4)
04723 Retrograde endocannabinoid signaling
101546811 (PLCB4)
09157 Sensory system
04742 Taste transduction
101546811 (PLCB4)
04750 Inflammatory mediator regulation of TRP channels
101546811 (PLCB4)
09159 Environmental adaptation
04713 Circadian entrainment
101546811 (PLCB4)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
101546811 (PLCB4)
09172 Infectious disease: viral
05163 Human cytomegalovirus infection
101546811 (PLCB4)
09174 Infectious disease: parasitic
05146 Amoebiasis
101546811 (PLCB4)
05142 Chagas disease
101546811 (PLCB4)
05143 African trypanosomiasis
101546811 (PLCB4)
09164 Neurodegenerative disease
05010 Alzheimer disease
101546811 (PLCB4)
05016 Huntington disease
101546811 (PLCB4)
05017 Spinocerebellar ataxia
101546811 (PLCB4)
05022 Pathways of neurodegeneration - multiple diseases
101546811 (PLCB4)
09166 Cardiovascular disease
05417 Lipid and atherosclerosis
101546811 (PLCB4)
05415 Diabetic cardiomyopathy
101546811 (PLCB4)
09167 Endocrine and metabolic disease
04933 AGE-RAGE signaling pathway in diabetic complications
101546811 (PLCB4)
04934 Cushing syndrome
101546811 (PLCB4)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:sara04131]
101546811 (PLCB4)
Enzymes [BR:sara01000]
3. Hydrolases
3.1 Acting on ester bonds
3.1.4 Phosphoric-diester hydrolases
3.1.4.11 phosphoinositide phospholipase C
101546811 (PLCB4)
Membrane trafficking [BR:sara04131]
Exocytosis
Calcium ion-dependent exocytosis
Phospholipases
101546811 (PLCB4)
Endocytosis
Macropinocytosis
Phospholipase C
101546811 (PLCB4)
|
| SSDB |
|
| Motif |
|
| Other DBs |
|
| LinkDB |
|
| Position |
Unknown
|
| AA seq |
1194 aa
MAKPYEFNWQKEVPSFLQEGAVFDRYEEESFVFEPNCLFKVDEFGFFLTWRSEGKEGQVL
ECSLINSIRLGTIPKDPKILAALEAVGKSENDLEGRIVCVCSGTDLVNISFTYMVAENPE
VTKQWVEGLRSIIHNFRANNVSPMTCLKKHWMKLAFMTNTNGKIPVRSITRTFASGKTEK
VIFQALKELGFPSGKNDEIEPAAFTYEKFYELTQKICPRTDIEDLFKKINGDKTDYLTVD
QLVSFLNEHQRDPRLNEILFPFYDVKRAMQIIEMYEPDEDLKKKGLISSDGFCRYLMSDE
NAPVFLDRLELYQEMDHPLAHYFISSSHNTYLTGRQFGGKSSVEMYRQVLLAGCRCVELD
CWDGKGEDQEPIITHGKAMCTDILFKDVIQAIKETAFVTSEYPVILSFENHCSKYQQYKM
SKYCEDLFGDLLLKQALESHPLEPGRTLPSPNDLKRKILIKNKRLKPEVEKKQLEALKSM
MEAGESAAPANILEDDNEEEIESADQEEEAHPEYKFGNELSADDLGHKEAVANSVKKGLV
TVEDEQAWMASYKYVGATTNIHPYLSTMINYAQPVKFQGFHVAEERNIHYNMSSFNESVG
LGYLKTHAIEFVNYNKRQMSRIYPKGGRVDSSNYMPQIFWNAGCQMVSLNYQTPDLAMQL
NQGKFEYNGSCGYLLKPDFMRRPDRTFDPFSETPVDGVIAATCSVQVISGQFLSDKKIGT
YVEVDMYGLPTDTIRKEFRTRMVMNNGLNPVYNEESFVFRKVILPDLAVLRIAVYDDNNK
LIGQRILPLDGLQAGYRHISLRNEGNKPLSLPTIFCNIVLKTYVPDGFGDIVDALSDPKK
FLSITEKRADQMRAMGIETSDIADVPSDTSKNDKKGKANTAKANVTPQSSSELRPTTTAA
MGSGVEAKKGIELIPQVRIEDLKQMKAYLKHLKKQQKELNSLKKKHAKEHSTMQKLHCTQ
VDKIVAQYDKEKSTHEKILEKAMKKKGGSNCLEMKKETEIKIQTLTTDHKSKVKEIVAQH
TKEWSEMINTHSAEEQEIRDLHLSQQCELLKKLLITAHEQQTQQLKLSHDRESKEMRAHQ
AKISMENSKAISQDKSIKNKAERERRVRELNSSNTKKFLEERKRLAMKQSKEMDQLKKVQ
LEHLEFLEKQNEQLLKSCHAVSQTQGEGDAADGEIGSRDGPQTSNSSVKLQNAN |
| NT seq |
3585 nt +upstreamnt +downstreamnt
atggccaaaccctatgagtttaactggcagaaagaagttccttcctttttgcaagaagga
gccgtttttgatagatatgaagaggagtcctttgtgtttgaaccgaactgtctcttcaaa
gtggacgaatttggcttttttctgacttggagaagtgaaggcaaggaaggacaagtgcta
gaatgttcactcatcaacagtattcggttgggaaccattccaaaggatcccaaaatccta
gctgcccttgaagctgttggaaaatcagaaaatgacctggaagggcgaatagtttgtgtc
tgcagtggcacagatctggtgaacataagttttacatacatggtggctgaaaatccagaa
gttactaagcaatgggtcgaaggtctgagatcaatcatacacaacttcagggccaacaac
gtcagcccaatgacctgcctcaaaaaacactggatgaaattggcatttatgaccaatact
aatggtaaaattccagtgcggagtattactagaacctttgcttcggggaaaacggaaaag
gtgatctttcaagcactcaaggagctaggctttcccagtggaaagaatgatgaaattgaa
cctgcagcatttacttacgaaaagttctatgaactgacacaaaagatttgtcctcggaca
gacatagaagacctttttaaaaaaatcaatggagacaaaactgattatttaacggtagac
caattagtgagctttctaaatgaacatcaacgagatcctcgactgaatgaaattttattc
ccattttatgatgttaaaagggcaatgcagattattgaaatgtatgagcctgatgaagat
ttgaagaaaaaaggacttatatcaagtgatgggttttgccgatacctgatgtcagatgaa
aatgccccggtctttctagatcgtttagagctgtaccaggagatggaccatcctctggct
cattacttcatcagttcttcgcataatacctatctcaccggccggcagttcggagggaag
tcttcagtagaaatgtacagacaggttctcttggctggctgcagatgtgttgaacttgac
tgttgggatggaaaaggtgaagaccaagaaccaataataactcatgggaaagcaatgtgt
acagatattctttttaaagatgtcattcaagccatcaaggaaactgcatttgtcacatct
gagtatcctgtcattctctcctttgaaaatcactgcagcaaatatcaacagtacaagatg
tccaaatattgcgaagatctatttggggatctcctgttgaaacaagcacttgaatcgcat
ccacttgaaccaggccgaaccttgccatccccgaatgacctcaaaagaaaaatactcatc
aaaaacaaaagactgaaacctgaagttgagaagaagcagcttgaggctttgaaaagcatg
atggaggctggagaatctgcagccccagctaatatcttggaggatgataatgaggaggaa
atagagagtgctgaccaagaagaggaagctcaccctgaatacaaatttggaaatgaactt
tctgctgatgacttgggtcacaaggaagctgttgcaaacagtgtcaagaagggcctggtg
accgtcgaagacgagcaggcatggatggcatcttacaagtatgtaggcgccaccaccaac
atccacccttacttgtcaacaatgatcaactatgcacagcctgtaaagttccaaggtttc
catgtggccgaagaacgcaatattcattataacatgtcttcttttaatgaatctgttggt
ctcggctacttgaagacacatgccattgaatttgtgaattataacaaacggcaaatgagt
cgcatttaccccaagggaggccgagtcgattccagtaattacatgcctcagattttctgg
aacgcaggctgccagatggtttcactgaactatcagaccccagatttagcgatgcaattg
aatcagggaaagtttgagtataatggatcgtgcgggtaccttctcaaaccagattttatg
agacgacctgatcgaacatttgatcccttctctgaaactcctgttgatggggttattgca
gctacttgctcagtacaggtcatatctggtcagttcttatcagataagaaaatcggcacc
tacgtagaagtggatatgtacgggctgcccactgacaccatccggaaggagttccgtact
cgcatggtgatgaacaacgggctcaaccccgtgtacaacgaagaatcgtttgtctttcgg
aaggtgattctccctgacctggcagtcttgagaatagcagtgtatgatgacaacaacaag
ctgatcggccagaggattctcccactggacggcctccaagcaggctatcgacatatttcc
cttcgaaatgaggggaataagcctttatcgctgccaacaattttctgcaatattgttctt
aaaacttatgtgcctgatggatttggagatattgtggatgctttgtctgatccaaagaaa
tttctttccattacggaaaagagagcagaccaaatgagggctatgggcattgaaactagt
gacatagctgatgtgcccagtgatacttcaaagaatgacaagaaagggaaggccaacact
gccaaagcaaatgtcacccctcaaagtagctccgagctcagaccaaccactacggctgcc
atggggtctggcgtggaagccaagaagggtatagaactcatccctcaagtgagaatagaa
gatttgaaacagatgaaggcttacttgaaacacttaaagaaacaacagaaggaactaaat
tctttaaagaagaagcatgcaaaggagcacagtactatgcagaagctacactgcacacaa
gttgacaaaattgtggcccagtatgacaaagagaagtcaactcatgagaaaatcctagag
aaggcaatgaagaagaaagggggaagtaattgtcttgagatgaaaaaagaaacagaaatc
aagattcagacgctcacaacagatcacaaatctaaggtcaaagaaattgtagcacagcac
acaaaggaatggtcagaaatgatcaacacccacagtgcagaggagcaagaaatccgggac
ctgcacctcagccaacagtgcgagctgctgaaaaagctcttgatcactgctcatgagcag
caaacccagcagctgaaactctctcacgacagggaaagcaaggaaatgagagcacaccaa
gctaagatttctatggaaaatagcaaagccatcagccaagataaatctatcaaaaataaa
gccgaacgggaaaggagagtcagggagttaaacagcagcaacactaaaaagtttctagaa
gaaagaaagagacttgcaatgaaacaatccaaagaaatggatcagttgaaaaaagttcag
cttgaacacctagaattcctggagaaacagaatgagcagctgttgaaatcctgtcatgca
gtgtcccaaacgcaaggcgaaggagatgcagcagatggtgaaattggaagccgagatgga
ccgcagaccagcaacagtagtgtaaaactccaaaatgcaaactga |