Sorex araneus (European shrew): 101547011
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Entry
101547011 CDS
T07854
Symbol
NOS3
Name
(RefSeq) nitric oxide synthase, endothelial
KO
K13242
nitric-oxide synthase, endothelial [EC:
1.14.13.39
]
Organism
sara
Sorex araneus (European shrew)
Pathway
sara00220
Arginine biosynthesis
sara00330
Arginine and proline metabolism
sara01100
Metabolic pathways
sara04020
Calcium signaling pathway
sara04022
cGMP-PKG signaling pathway
sara04066
HIF-1 signaling pathway
sara04071
Sphingolipid signaling pathway
sara04151
PI3K-Akt signaling pathway
sara04370
VEGF signaling pathway
sara04371
Apelin signaling pathway
sara04611
Platelet activation
sara04915
Estrogen signaling pathway
sara04921
Oxytocin signaling pathway
sara04926
Relaxin signaling pathway
sara04931
Insulin resistance
sara04933
AGE-RAGE signaling pathway in diabetic complications
sara05415
Diabetic cardiomyopathy
sara05417
Lipid and atherosclerosis
sara05418
Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:
sara00001
]
09100 Metabolism
09105 Amino acid metabolism
00220 Arginine biosynthesis
101547011 (NOS3)
00330 Arginine and proline metabolism
101547011 (NOS3)
09130 Environmental Information Processing
09132 Signal transduction
04370 VEGF signaling pathway
101547011 (NOS3)
04371 Apelin signaling pathway
101547011 (NOS3)
04066 HIF-1 signaling pathway
101547011 (NOS3)
04020 Calcium signaling pathway
101547011 (NOS3)
04071 Sphingolipid signaling pathway
101547011 (NOS3)
04022 cGMP-PKG signaling pathway
101547011 (NOS3)
04151 PI3K-Akt signaling pathway
101547011 (NOS3)
09150 Organismal Systems
09151 Immune system
04611 Platelet activation
101547011 (NOS3)
09152 Endocrine system
04915 Estrogen signaling pathway
101547011 (NOS3)
04921 Oxytocin signaling pathway
101547011 (NOS3)
04926 Relaxin signaling pathway
101547011 (NOS3)
09160 Human Diseases
09166 Cardiovascular disease
05417 Lipid and atherosclerosis
101547011 (NOS3)
05418 Fluid shear stress and atherosclerosis
101547011 (NOS3)
05415 Diabetic cardiomyopathy
101547011 (NOS3)
09167 Endocrine and metabolic disease
04931 Insulin resistance
101547011 (NOS3)
04933 AGE-RAGE signaling pathway in diabetic complications
101547011 (NOS3)
Enzymes [BR:
sara01000
]
1. Oxidoreductases
1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
1.14.13.39 nitric-oxide synthase (NADPH)
101547011 (NOS3)
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Motif
Pfam:
NO_synthase
FAD_binding_1
Flavodoxin_1
NAD_binding_1
Motif
Other DBs
NCBI-GeneID:
101547011
NCBI-ProteinID:
XP_004620205
LinkDB
All DBs
Position
Unknown
AA seq
1250 aa
AA seq
DB search
MALPSSRRAGALEEVIRLGLLDAAASQQGREPGGKSGLPQPAAPDRSPACETPAPPGGLR
AAPPGWGESRHGRADPRAGVRGGGAQRETKPSDPPVPHSPLLSRALEGPKFPRVKNWEVG
SIAYDTLSAQAQQDGPCTPKRCLGSLVLPRKPHSRGAPGPSAPELLRQARAFIDQYYSSI
KRGGSQAHELRLQEVEAEVAATGTYQLRESELVFGTKQAWRNAPRCVGRIQWGKLQVFDA
RDCSSAQEMFTYICNHIKYATNRGNLRSAITVFPQRVPGRGDFRIWNGQLIRYAGYRQQD
GSVRGDPANVEITELCVQHGWSPGNGRFDVLPLLLQVPDEPPELFTLPPELVLEVPLEHP
TLEWFSELGLRWYALPAVSNMLLEIGGLEFPAAPFSGWYMSTEIGTRNLCDPHRYNILED
VAVCMDLDTRTTSSLWKDKAAVEINVAVLHSFQLAKVTIVDHHAATASFMKHLENEQKAR
GGCPADWAWIVPPISGSLTPVFHQEMVNYVLSPAFRXQPDPWKGSSAKGAGITRKKTFKE
VANAVKISASLMGTVMAKRVKATILYGSETGRAQGYAQQLGRLFRKAFDPRVLCMDEYDV
VSLEHETLVLVVTSTFGNGDPPENGESFAAALMEMSGPYNSSPRPEQHKSYKTRFNSISC
SDQLVSTWRRKRKESSNTDSAGALGTLRFCVFGLGSRAYPHFCAFARAVDTRLEELGGER
LLQLGQGDELCGQEEAFRGWAQAAFQASCETFCVGEDAKAAAHDIFSPKRSWKRQRYRLS
AQAQGLQLLPGAAXXXXXXXXXSPPLPASPLRSSATRAPLPRSRATILVRLDTAGQEGLQ
YQPGDHVGICPPNRPGLVEALLSRVEDPPPPREPVAVEQLEKGSPGGPPPGWVRDPRLPP
CTLRQALTFFLDITTPPSPRLLQLLSTLAEEPGEQQELETLSQDPRRYEEWKWFRCPSLL
EVLEQFPSVALPAPLLLTQLPLLQPRYYSVSSAPSAHPGEIHLTVAVLAYRTQDGLGPLH
YGVCSTWLSQLKAGDSVPCFIRGAPSFRLPPDPNLPCILVGPGTGIAPFRGFWQERLHDI
DRKGLQPFPMTLVFGCRCSQLDHLYRDEVQDAQRRGVFGRVLTAFSREPNSPKTYVQDIL
RTELAEEVHRVLCLEQGHMFVCGDVTMATSVLQTVQRILATEGNMELDEAGDLIGVLRDQ
QRYHEDIFGLTLRTQEVTSRIRTQSFSLQERRRGAVPWAFDPPGPDTAGP
NT seq
3753 nt
NT seq
+upstream
nt +downstream
nt
atggccctcccttcctcccgccgggccggggctctggaggaagtgataaggctcgggctc
ctcgacgccgcggccagtcagcagggccgggagccaggagggaaatcgggccttcctcag
ccggccgccccggaccggagccctgcatgcgagacccccgccccgccaggcggcctgcgt
gcggcccctccgggatggggagagagcaggcacgggcgggcggatccacgagcgggggtg
cggggagggggcgcccagagggagacaaagcccagtgacccccccgttccccacagcccc
ctgctctcccgggccctggagggacccaagttcccccgagtgaagaactgggaggtgggc
agcatcgcctacgacacgctgagcgcccaggcccagcaggatgggccctgcacccccaag
cgctgcctgggctccctggtgctcccgcggaagccgcacagtaggggcgcccccgggccc
agcgcccccgagctgctgcgccaggcccgggccttcatcgaccagtactacagctccatc
aagaggggcggctcccaggcccacgagctgcggctgcaggaggtggaggccgaggtggcg
gccacaggcacgtaccagctgcgggagagcgagctggtgttcgggaccaagcaggcctgg
cgcaacgccccccgctgcgtgggccgcatccagtggggcaagctgcaggtgttcgacgcg
cgggactgcagctcggcccaggagatgttcacctacatctgcaaccacatcaagtacgcc
accaacaggggcaacctccgctcggccatcacggtcttcccccagcgcgtccccggccgc
ggggacttccggatctggaacgggcagctcatccgctacgcagggtaccggcagcaggac
gggtcggtgcggggggaccctgccaacgtggagatcaccgagctctgcgtccagcatggc
tggagccccgggaacggccgcttcgacgtgctgccgctgctgctgcaggtgcctgacgag
ccccccgagctcttcaccctgccccccgagctggtcctcgaggtgcctctggagcacccc
acgctggagtggttctcggagctgggcctgcgctggtacgccctcccggccgtgtccaac
atgctgctggagatcgggggcctggagttccccgcggcccccttcagcggctggtacatg
agcacggagatcggcacgcggaacctgtgcgacccgcaccgctacaacatcctggaggac
gtggccgtgtgcatggacctggacacccgcaccacctcctccctgtggaaggacaaggcg
gccgtggagatcaacgtggccgtgctgcacagcttccagctggccaaggtcaccatcgtg
gaccaccacgcggccacggcgtccttcatgaagcacctggagaacgagcagaaggcgcgc
gggggctgccccgccgactgggcctggatcgtgccgcccatctcgggcagcctcacgccc
gtcttccaccaggagatggtcaactacgtgctgtcccccgccttccgctngcagccagac
ccctggaagggcagctcggccaagggcgccggcatcaccaggaagaagaccttcaaggaa
gtggccaacgcagtcaagatctccgcatccctcatgggcaccgtgatggccaagcgcgtg
aaggcgaccatcctgtacggctcggagacgggccgcgcgcagggctacgcgcagcagctg
ggcaggctcttccggaaggccttcgacccccgggtgctgtgcatggatgagtacgacgtg
gtgtccctggagcacgagacgctggtgttggtggtgaccagcacattcgggaacggggac
cccccagagaacggagagagtttcgccgcagccctcatggagatgtcggggccctacaac
agctccccaaggccggagcagcacaagagctacaaaacccgcttcaacagcatctcctgc
tcagaccagctggtgtccacgtggcgccggaagagaaaggagtcgagtaacacggacagc
gccggggcgctgggcaccctcaggttctgtgtgttcgggctgggctcccgggcgtacccc
cacttctgcgcctttgcccgggcggtggacactcggctggaggagctgggcggggagcgg
ctcctgcagctgggccagggcgacgagctgtgcggccaggaggaggccttccgcggctgg
gcccaggccgccttccaggcctcctgcgagaccttctgtgtgggagaggacgccaaggcc
gccgcccacgacatcttcagccccaagcgcagctggaaacgccagaggtaccggctgagc
gcccaggcccagggcctccagctgctgccaggtgcggcnnnnnnnnnnnnnnnnnnnnnn
nnnnnntccccgcccctccccgcctctcccctccgctcctcggcaacacgcgctcctctc
ccccgcagccgggccaccatcctggtgcgcctggacacggccggccaggaggggctccag
taccagcccggggaccacgtgggcatctgcccgcccaaccggcccggcctggtggaggcg
ctgctgagccgcgtggaggacccgccgccgccccgagagcccgtggccgtggagcagctg
gagaagggcagcccgggtggccctcccccaggctgggtgcgggacccccggctgcccccc
tgcacgctgcgccaggccctcaccttcttcctggacatcaccacgccgcccagcccgcgg
ctgctgcagctgctcagcacgctggccgaggagccgggagagcagcaggagctggagacc
ctcagccaggacccccggcgctacgaggagtggaagtggttccgctgcccgtcgctgctg
gaggtgctggagcagttcccgtccgtggcgctgcccgcgcccctgctcctcacgcagctg
cccctgctgcagccgcgctactactcggtcagctccgcgcccagcgcccaccccggggag
atccacctcaccgtggccgtgctggcctaccgcacccaggacggcctgggtcccctgcac
tacggggtctgctccacgtggctgagccagctcaaggccggagacagcgtcccctgcttc
atcaggggggcgccctccttccgcctaccccctgaccccaatttgccctgcatcctggtg
ggcccaggcactggcatcgcccccttccgggggttttggcaagagcggctccatgacatc
gaccgcaaagggttgcagcccttcccgatgaccctggtgttcggctgccgatgctcccag
ctcgaccatctctaccgcgacgaggtgcaggatgcccagcggcgcggggtgttcggccgc
gtcctcacggccttctcccgggagcccaacagccctaagacgtatgtgcaggacatcctc
agaacggagctggccgaggaggtgcaccgcgtgctgtgcctcgagcaaggccacatgttc
gtctgtggcgacgtcaccatggcaaccagtgtcctgcagacggtgcagcgcatcctggcc
accgagggcaacatggagctggacgaagccggggaccttattggcgtgctgcgggatcag
caacgctatcacgaggacattttcgggctcaccctacgcacccaggaggtgacaagccgc
attcgcacccagagcttctccctgcaggagcgacgccggggtgcagtgccctgggctttt
gaccccccaggcccagacaccgcaggcccctga
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