Sorex araneus (European shrew): 101547379 Help Entry 101547379         CDS       T07854                                  Symbol PCLO Name (RefSeq) protein piccolo   KO K16882   protein piccolo Organism sara  Sorex araneus (European shrew) Pathway sara04911   Insulin secretion Brite KEGG Orthology (KO) [BR:sara00001]  09150 Organismal Systems   09152 Endocrine system    04911 Insulin secretion     101547379 (PCLO)  09180 Brite Hierarchies   09182 Protein families: genetic information processing    04131 Membrane trafficking [BR:sara04131]     101547379 (PCLO) Membrane trafficking [BR:sara04131]  Exocytosis   Calcium ion-dependent exocytosis    Others     101547379 (PCLO) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  zf-piccolo C2 PDZ FYVE_2 Motif Other DBs NCBI-GeneID:  101547379 NCBI-ProteinID:  XP_004602200 LinkDB All DBs Position Unknown AA seq 5179 aa AA seqDB search MGNEASLEGEGLPEGLAAAAAAGGGAGGAGSSVHTAVPAGMEADLSQLSEEERRQIAAVM SRAQGLPKGSAPPATAEPPSLHRKQELDSSHSPKQPGKPPDSGRAAQPGLSKSRTTDTFR SEQKLPGRSPSTISLKESKSRTDFKEEHKSSMMPSFLSEVNPLSAVSSVVNKFNPFDLIS DSDASQEETTKKQKAAPKEQGKPEGVTKPPSQQSPKPAPKQQGPVKAPLQQGVSPKSVPS QQPEKMKSQPSGKPIQGLTQAPQTDPVKLPLQRDAARPQTKQSDAVTGESVKPSLQSPSK PLVQQASPGKPPAKQPGPEKVALPQPGPAKSPAQQPGPAKPPAQPPGTVKPSPQPLSAKL PAQPPGTVKPAAQQPGPKSPAQPLGPAKPQVQPTATEKPPSQQPGPKPPAQPPVPAKSPV QQPGPAKLPAQQPGTPKSPAHQPAAASQPSGPAKTPTQQPGPGKTSQQPAQQPGPAKPAA QQPGPAKPAAQPPGPAKPAAQQPSPAKPSPSPQQPSPAKPAAQQPGPAKPSPQQPGAAKT SAQQPGPAKPSVQQPGLAKPSPQQPGPAKPLAQQPAKPASQAGVGKPVQPSISPSAGQTS VQGLPKTICPLCNTTELLLHAPEKANFNTCTECQITVCSLCGFNPNPHLTEIKEWLCLNC QMQRALGGELTPIPSSPQPKPKTASAVPTAAVSKPSTQPQQVSPKKDVAPKQDISKAPES KKPPPLVKQPTLHGSPPITAKQPPVADTSSKTTPSKEPPGPSEQAKGPPVDDKPKLPKMV KPPTDVVSSSSATTKPDIPSSKIQPQDQEKTTFPLKTDSAKPSQSFPPTGEKVTPVDSTV IPRPASDSKIVSQPGPSSESKGQKQVDPAQKREDPKKAQTKMSPKPDGKPVPKGSSAAPG TRPTPGQTAPVSQPPPKPQEQSRRFSLNLGSITDAPKSQPTTPSESMTGKLFGFGASIFS QASNLISTAGQPSSHAQGGPGALSKQVPSPSQPPVSQGPPKPTGQASPAPASTVPVKKET KAPGAEKLESKAERVPPVKRTETEKKPPLIKDTKPPTAEPQKSVPAPKLEKVPKPESVCP LCKTELNIGSKDPPNFNVCTECKKQVCNLCGFNPTPHLTEIQEWLCLNCQTKRAMSGQLG DMGKMLPAQPGPKAVPVPVSTEQPSQKIVPAQVKVKKKEQEVKLDAEKSIPDKGKETPLI EKISPKVATDKKQENKVEKDKTSAPPEKKPLPEDKKSLPEEKKSRPEEKREILEDQKPTS KDKTTVPEDEKLPSGVKISTLEEEQKPDLLKTQVQTAKETPEDKMSPRSMEEAEQPPIKK EDVPSGLPQIPSKEDDESIQKMKGLPQEICTAKPEQVESGKEKTEKEDDKSDTSSSQQPK SPQGLSDTGYSSDGISGSLGEIPSLIPSDEKDLLKGLKKDSFSQESSPSSPSDLAKLEST VLSILEAQASTLDEKAEKKTQPLEVSPEQPKDQQKPQSLSETPKFVTSEEDLKKGQEEKD SLKKDSQQDVPSKKDHKEKSELVEDTPVRRQPYDSVEDSSESENSPVPQRKRRLSIGSSS SDEYKQEDSQGSGEEEEEDFIRKQIIEMSADEDASGSDDDEFIRNQLKEISSSIEIQKKE EIKGKGKASTGKHRRLTRKSSASFDEDPGRRHSWHDEDDETFDESPELKYRETKSQESEE LALAGGGGLRRFKTIELNSTIADKYSTESSQKKSVLYFDEEPELEMESLTDSPEDRSRGE GSSSLHASSFTPGTSPTSVSSLDEDSDSSPSHKKGESKQQRKARHRSHGPLLPTIEDSSE EEELREEEELLKEQEKQRELEQQQRKSSSKKSKKDKDELRAQRRRERPKTPPSNLSPIED ASPTEELRQAAEMEELHRSSCSEYSPSIESDPDGFEISPEKIIEVQKVYKLPTAVSLYSP TDEQSIMQKEGGQKTLKSAEEMYEEMMHKTHKYKAFPAANERDEIFEKEPLYGGMLIEDY IYESLVEDTYNGSVDGSLLARQEDENGFLQQRGREQKVRLPEQIYEDPMQKITDLQKEFY ELESLHSVVPQEDIVSSSYIIPESHEIVDLGSMLTSTGEEKQLLDADAAYEELMKRQQLQ LSSGSIPTQPPIRDEVTDSIMDFDRMPDSSMTSSILSGASLTDSTSSATLSIPDVKITQH FSTEEIEDEYITDYTREIQEIISHESLILTYSEPSESATSVPPSDTPSLTSSISSVCTTD SSSPITTLDSITTVYTEPMDIATKFEDSEETYFQGSIIDYPEEVSVPLDKVSRADSRISA DHIMVSISDMTPSITDSVGTKHEGLFVDTVSTGIDIADKEPVKKSKKESGSGIILEVLEA YRDKREESAAELTKLSLSETVFDQLASSVTDLPLQEQVQSTHFVSGEIFGQAKPASQLPS GTHSVASLPTKTRPFFRSSSLDISAQPPPPPPPPPXXXXXPPPPPPPPLPPPTSPKPTVL PRKKLPVTAPVTLPTATTPRVDVFPTVVTTAIPKSNGLPVAPVTKICTTAPPPVPPKPSS IPSGLVFTHRPEPSKPPIAPKPVVPPLPVMTQKPTETHPKPIETHPKPTETHPKPTALPL ASNMTLNLVTTADYKLPSPTSPLSPHSNKSSPRYSKSLMETYVVITLPSEPGTPTDSSAS QAITSWPLGSPPKDLISIESVFSVIPPVPTTEMLSSSEQSLQNRALETFSAVPVTTLSSF QSTPTSFPQLITTEASKAEVPAARGVVPSIGLGSVSISIPPEPFVPECQHLEKQQPKENG TLPLVSDAIDLRTVPKLEVKVTEKGLDLSASAVDVKRPTTTSEIYGRHISAVQPAIINLS ATSSVTTPLSVATETVTFVTYTPSASYTTSTESLVGIEHATVTPLQLTTSGQAEPLYRAP STQAFPSVREEAPINLSLGVSAATKPVTVPPVGITNGWTDSSTTSQGITDGEVVDLSTTK SHRTVVTMDESTSGVVTKIIEDDEKPVDLTAGRRAVCCDVVYKLPFGRSCTSQQPATTLP EDRFGYRDDHYQYGRSGPYGYRGIGGMKPSMSDTNLAEAGHFLYKSKNAFDYSGGTDAAV DLTSGKITTGEVMDYSSKTTGPYPETRQVISGVGISTPQYSTARMTPPPGSQYGVGSVFR STNGVVYSSVATPVPSTFAITTQPGSIFSTTVRDLSGAHTTDAVTSLSTLHQSQPMPRSY FLTTGASETDITVTGIDINASLQTITMETLTAETIDSVPTLTTASEVFSEVAGDESALLV VSEEDKQQQQLDLERELLELEKIKQQRFAEELEWERQEIQRFREQEKIMVQKKLEELQSM KQHLLYQQEEERQAQFMMRQETLAQQQLQLEQIQQLQQQLHQQLEEQKIRQIYQYNYDPS GNASPQTTTEQAIMEGQYTAPEGGQFWATEDATTTASAVVAIEIPQSQGWYTVQSDGITQ YIAPPGILSTVSEIPLTDVVVKDEKQAKKRSSGAKVRGQYEEMGESTADDPRCFKKIVDS GVQTDDEDAGDRNYASRRRKSKKSVDTSVQTDDEDQDEWDMPTRARRKARAGKYGDGTTE ADKTKPLSRVSSIAVQTVAEISVQTEPVGTIRTPSIRARVDAKVEIIKHISAPEKTYKGG SLGCQTEADSDTQSPQYLSATSPPKDKKRPTPLEIGYSSHLRADSTLQLAPSPPKSPKVL YSPISPLSPGKALESAFVPYEKPLPDDISPQKVLHPDMAKVPPASPKTAKMMQRSLSDPK PLSPTADESSRAPFQYTEGYTTKGSQTMTPSGTQKKVKRTLPNPPPEETSTGTQSTYSTM GTASRRRICRTNTMARAKILQDIDRELDLVERESAKLRKKQAELDEEEKEIDAKLRYLEM GINRRKEALLKEREKRERAYLQGVAEDRDYMSDSEVSSTRPTRIESQHGIERPRTAPQTE FSQFMPPQTQTEAQLVPPTSPYTQYQYSSPALPTQAPTPYTQQSHFQQQTLYHQQVSPYQ TQPTFQAVATMSFTPQAQPTPTPQPSYQLPSQMMVIQQKPRQTTLYLEPKITSNYEVIRN QPLMIAPVSTDTTYAVSHLGSKYNSLDLRIGLEERSSMASSPISSISADSFYADIDHHTP RNYVLIDDIGEITKGTTSLSTTFSLHEKDLTKTDRLLRTTEARRSQDVTDFLAPLQTSSR LHSYVKAEEDPMEDPYELKLLKQQIKQEFRRGAESLDHLAGLSHYYHADTSYRHFPKSEK YSISRLTLEKQAAKQLPAAILYQKQSKHKKSLIDPKMSKFSPIQESRDLEPDYTSYMTSS TSSIGGISSRARLLQDDITFGLRKNITDQQKFMGSSLGSGLGTLGNTIRSALQDEADKPY SSGSRSRPSSRPSSVYGLDLSIKRDSSSSSLRLKAQEAEALDVSFSHASSSSRTKPTSLP ISQSRGRIPIVAQNSEEESPLSPVGQPMGMARAAAGPLPPISADTRDQFGSSHSLPEVQQ HMREESRTRGYDRDIAFIMDDFQHAMSDSEAYHLRREETDWFDKPRESRLDSGHGLDRKL PERLVHSRPLSQHQEQIIQMNGKTMHYIFPHARIKITRDSKDHTVSGNGLGIRIVGGKEI PGHSGEIGAYIAKILPGGSAEQTGKLMEGMQVLEWNGIPLTSKTYEEVQSIINQQSGEAE ICVRLDLSMLSDSENPQHLELHEPPKAVDKAKSPGVDPKQLAAELQKVSLQQSPLVRSSV VEKGSHGHSGPTSAGSSSVPSPGQPGSPSVSKKKHSSSKPTDAAKVVSHPITGEIQLQIN YDLGNLIIHILQARNLVPRDNNGYSDPFVKVYLLPGRGQVMVVQNASAEYKRRTKYVQKS LNPEWNQTVIYKSISMEQLKKKTLEVTVWDYDRFSSNDFLGEVLIDLSSTSHLDNTPRWY PLKEQSESIDHGKSHSSQSSQQSPKPSVIKSRSHGIFPDPSKDMQVPTIEKSHSSPGSSK SSSEGHLRSHGPSRSQSKTSVTQTHLEDAGAAIAAAEAAVQQLRLQPTKPSNHRPAESSA STGSSGCSFGSGYSVDAEGSNSTAGETNLFPIPRIGKMGQNGLEPVKQPGVGLGLTDTEV KTQVMGEIKIALKKEMKTDGEQLIVEILQCRNITYKFKSPDHLPDLYVKIYVMNISTQKK VIKKKTRVCRHDREPSFNETFRFSLSPAGHSLQILLFSNGGKFMKKTLIGEACIWLDKVD LRKRIVNWHKLLVSPTQTH NT seq 15540 nt NT seq  +upstreamnt  +downstreamnt atgggcaatgaggcgagcttggaaggcgaggggctccccgaaggactggcggcggccgcg gcggccggaggaggggccggcggggcggggagctccgtgcacaccgcggtcccggccggc atggaggcggatctgagccagctgagcgaagaggagcggagacagatcgcggctgtcatg tcaagggcgcaggggctgcccaagggaagcgctcccccggccactgcggagccgccctcc ttgcacaggaaacaagagttggacagcagtcattctccgaagcagcctggaaaaccacct gattcagggcgcgcagctcagcctggtctcagtaagagccgaactacagacacttttcgg tccgagcagaagttgcccggaaggagtccctccactattagcttaaaggaatccaagtcc aggactgattttaaggaagagcacaagtctagtatgatgcctagcttcctttctgaggtt aaccctttaagtgctgtctcctctgttgtaaataaattcaatccttttgatttgatatca gactctgatgcctcccaggaagaaaccaccaagaaacaaaaagcagccccgaaagaacaa ggaaaacctgaaggagtcaccaagcccccatcgcagcaatcacccaagccagctcctaag cagcaaggacctgtgaaagcccctcttcagcagggtgtctccccgaaatcagtaccttct cagcaaccagaaaaaatgaaatcacagccttcaggaaagccaattcaggggcttacccaa gctcctcagactgacccggttaagttgcctcttcaaagagatgcagccaggcctcagact aaacagtcagatgcagtgacaggggaatcagttaagccctcactgcagagcccatctaaa ccacttgttcagcaggcaagtcctggcaaacctccagctaaacaacctggacctgaaaaa gttgcattgccacagcctgggcctgcaaaatccccagctcagcaaccagggccagcaaaa cccccagcccaaccaccaggaactgtaaaaccctcacctcagcccctctcagcaaagctc ccagctcagcctccaggaacagtgaaacctgcagctcagcagcccggaccaaagtctcca gctcagcctcttggacctgcaaagcctcaagttcagccgactgcgacagagaagcctcca tcacagcagcctgggcccaagcctccagcacagcctccagtacctgcaaagtctccagtt cagcagccagggccagcaaagctcccagcccagcaaccaggaactccaaagtctccagct catcaacctgctgcagcatctcagccatctgggcctgcaaagacacctactcagcagcct ggtccagggaagacttctcagcaacctgctcaacagcctggcccagcaaagcccgcagct caacagcctggcccagcaaagcccgcagctcaaccgcctggcccagcaaagcccgcagct caacagccaagcccagcaaagccctcaccttcacctcagcaacccagcccagcaaagcca gcagctcagcagcctggcccagcaaagccctcacctcaacagcctggcgcagccaagact tcagctcaacaacctggtccagcaaaaccttcagttcaacagcctggtttagcaaagccc tcaccccaacagcctggcccagcaaaacctttagctcagcaacctgcaaaaccagccagc caagctggagttgggaaacctgtgcagccatcaatttctccatctgctggacagacttca gtacaaggcctcccgaaaaccatctgtcctctttgcaataccactgagcttctcttgcat gctccggaaaaggccaattttaacacatgcaccgagtgtcaaatcactgtctgtagtctc tgtggttttaatcccaatcctcatctaactgagataaaagagtggctctgtttaaactgt cagatgcaaagagctttaggaggtgagctgactccaattccatcatcaccgcagcctaaa ccgaagactgcctctgctgttcctacagcagcagtgagtaaaccatccacgcaaccacag caggtttctccaaagaaggatgttgcacccaaacaggatatctcaaaggcgcctgaatct aaaaagcccccaccgctggtgaaacaacccactcttcacggttctccccccatcacagcc aagcagcctccagtagctgacacatcatctaagaccactccatccaaagagcctcctgga ccatctgagcaggccaaaggccccccagttgatgataaaccaaagctgcctaagatggta aaaccaccgacggatgttgtgtcatcatcctcagcaaccacaaaacctgacattccaagt tcaaaaatacagccccaggatcaagagaaaactactttccctctcaaaacagattctgca aagccttctcaaagttttccaccaacaggagagaaagttaccccagtggactctacagtc ataccacgacctgcatcagattcaaaaattgtttcacagcccgggcctagctcagagagc aaaggtcaaaagcaagttgatccagctcaaaagagagaagaccccaaaaaagcacaaacc aaaatgagtcccaagccagatggcaagccagtgccaaaagggtcatcagcagccccaggc acacgacccactcctggccaaactgcccctgtttctcaaccacctccgaagccccaggaa cagtcaagacgctttagtctgaatctgggaagtattactgatgcccctaaatcccagccc acgactccttcagaaagtatgactgggaagctctttgggtttggagcttcaatctttagt caagcatcaaatcttatctccactgcaggccagcctagttctcatgcgcaaggcggacca ggagccctgagcaaacaggttccatctccttcacagccaccggtgtctcaggggccaccc aaacctacaggtcaggcttcacccgcgcctgcaagcactgtacctgtgaaaaaagaaaca aaagctccaggagctgaaaaattagagtctaaagctgaaagagttccacctgtaaaaaga acagaaacagaaaagaaacctccacttattaaggatactaaacctcccacagccgagcct caaaaatctgtccctgcacccaaactcgagaaagtccccaaaccagaatctgtctgtcct ctctgcaaaactgaactcaacataggttctaaggatcctcccaacttcaatgtttgcact gaatgcaagaaacaagtgtgtaatctctgtggatttaaccctacgccacatctgactgag atacaagaatggctttgtttaaattgccaaaccaagagagcaatgtcaggacagcttgga gacatgggcaaaatgctacctgcacagccaggaccaaaagcagttcctgtgcctgtctca acagaacagccttctcagaaaatagttcctgctcaagtaaaagtgaaaaagaaggaacaa gaagtaaaattagatgctgagaaaagcattccagataaaggaaaagaaacccctttgatt gaaaaaatttcccctaaagtagccacagataaaaaacaagagaataaagtagagaaagac aagacttcagcacctccagaaaaaaagccacttccagaagacaaaaagtcactcccagaa gaaaaaaagtcacggccagaagaaaagagggaaatccttgaagatcaaaagccaacctct aaagacaaaacaactgtacctgaggatgagaagctaccatcaggagtcaaaatctcaact ttagaggaggagcagaaacctgacttacttaaaactcaagtacagactgctaaagaaaca cctgaagacaaaatgtctccaaggtcaatggaagaagcagaacaacccccaatcaagaag gaagatgttccctctggcttgcctcagattccctctaaggaagatgatgagtctattcaa aaaatgaaaggactgcctcaggaaatatgcacagcaaagcctgaacaggtggaatctggg aaagaaaaaacagaaaaggaagatgacaaatcagacacctcaagttctcagcaaccgaaa agcccacaaggtctgagtgatactggatattcttctgatgggatatcaggttcccttggt gaaattccaagtcttatccccagtgatgaaaaggatttgctcaaaggactcaaaaaagac tcattctcacaagaaagcagcccttccagcccctcagatttggctaaattagaaagtact gtcttgtccattttggaagctcaagcgagtacacttgatgaaaaagctgaaaagaaaaca caaccccttgaagtttctcctgagcagcccaaggaccagcagaaaccccagagtttatct gaaacaccaaaatttgtgacatcggaagaggatctcaagaagggtcaagaggaaaaagac tctttaaaaaaagatagccagcaagacgttccttccaaaaaggatcataaagagaaatct gagcttgttgaggacacacctgtgagaagacagccttatgattcagttgaagacagtagt gaaagtgaaaactcacctgttcctcagagaaaacggagattgagcattggttcctcaagc agtgatgagtataaacaggaagatagtcagggctccggtgaggaggaggaggaggacttt attcgaaaacagatcatagaaatgagtgctgatgaagatgcttcaggttctgatgatgat gagttcattaggaaccagctaaaagagatcagtagtagcattgagatccagaagaaggaa gaaataaaaggaaaaggaaaagcatcaacagggaaacacagaagattgacccgaaaaagt agtgccagctttgatgaggatcccgggagacgccattcttggcatgatgaagatgatgag acttttgatgaaagtcctgaacttaaatacagagaaaccaagagtcaggagagtgaagag cttgcactggctggaggaggagggctccgtcgattcaaaacgattgaacttaacagcaca atagcagataaatattcgactgagtcgtcacagaaaaaatcagttttgtattttgatgaa gagcccgagttagaaatggaaagcctgacagactctccagaagataggtcaaggggggaa ggatcttctagccttcatgcttccagcttcactcctggcacctcccctacatcagtatca tcactggatgaagacagcgacagtagccctagtcacaaaaaaggagagagcaaacaacag cgcaaagcgagacacagatcacatggcccacttttaccgactattgaagattcttctgag gaggaagaattgagagaggaggaagaattattgaaggagcaagaaaagcaacgcgaatta gaacagcaacaaagaaagagttcaagtaaaaaatcgaagaaggacaaagatgaactcaga gctcagagaagaagggaaagaccaaaaacaccacccagtaacctctctcctattgaagat gcttcaccaacggaagaattacgtcaggctgcagaaatggaggagctgcatagatcttct tgttctgaatattcacctagcatagaatcagacccagacggttttgaaataagcccagaa aaaataatagaagtgcaaaaagtgtataaattgcccacagctgtgtctttatactcaccg acagatgagcagtctattatgcagaaagaaggtggtcaaaagacattaaaaagtgctgag gagatgtatgaagaaatgatgcataaaacccataaatataaagcatttccagctgcaaat gaacgagatgaaatatttgaaaaagagcctttgtatggtggcatgttgatagaggattat atttatgaatctttagtagaggacacatacaatggttcagtagatggcagtctgctagca aggcaagaagatgagaatgggtttttgcagcagagagggagagaacaaaaagtaagactt ccagagcagatttatgaagatcctatgcagaaaattacagacctccagaaagaattttat gaattagaaagcttgcattctgttgtgcctcaagaagacattgtttcaagctcttatatc attccagaaagtcatgagatagtggatcttggtagtatgctaacatctactggtgaagaa aagcaattattagatgctgatgctgcgtatgaagaactcatgaagaggcaacagttgcag ttatcatcgggatcaattcccactcagccccccatcagggatgaggtgacagattcgatt atggactttgacagaatgcctgactcatctatgacatcaagtattctctcaggagcatct cttacagattcaactagcagtgcaacactctcaatcccagatgtgaaaataacccaacat ttttcaacagaagaaattgaggatgaatacataactgattacacaagggaaattcaagag ataatttctcatgaatcactgattttgacctactctgagccttcagaaagtgctacatct gtcccaccctctgatacgccttctctcacatcatcaatttcttcagtctgcaccacagat agctcctcacccataactacgctggatagcataaccacggtttatacagagccaatggac attgcaactaaatttgaagattctgaagaaacatatttccaaggcagcattatagattat ccagaagaagtaagtgtgcctttagataaagtttccagagcagatagtagaattagtgct gatcacattatggtttccatatctgatatgacaccttctatcacagactcagttggaact aagcatgaaggactttttgtggacactgtatctactggcatagacatagctgacaaagaa ccagtaaagaaatccaagaaagaatctgggagtggaattattctggaagttttggaagcc tacagagataaaagggaggagtctgcagctgaactaacaaaactcagcttatctgaaact gtgtttgaccaacttgcttcttctgtaacagatcttcccctgcaggaacaggttcaaagt acccactttgtatctggagagatctttggtcaagcaaaacctgcatctcagttaccatct ggtactcattctgttgcctctcttccaactaaaactcgtccattctttcgaagttcttct ttggacatttcagcccaacctcctcctccccctcctcctcctccnnnnnnnnnnnnnnnn cctcctcctcctcctcccccaccacttcctccaccaacctctcctaaaccaaccgttctt cctagaaaaaagttaccagttactgctccagtgactcttcctactgcaactacacctcga gttgatgtttttcctactgtagtgaccacagccattccaaaaagtaacgggttacctgta gcacctgtaacaaaaatatgtaccactgcacctcctccagttcctcctaagccatcttca attccatctggacttgtatttacacatagacctgagccaagtaaacctccaattgcccct aaaccagtagttcctccgcttccagtaatgactcaaaaaccaacagaaacacaccccaaa ccaatagaaacacatcccaaaccaacagaaacacaccccaaaccaacagctttgcctttg gcttcaaatatgacattaaatttggtgacaacagcagattataaattgccttcccctact tcccctctctctccccattctaacaaatcctcaccaagatattccaagtctcttatggaa acttatgtggtcatcacattaccatctgaacctgggactccaacagattcttcagctagt caggccattaccagttggcccctcggatcacctcccaaagacctgatatctattgagtca gtgttttctgtaattcctcccgtaccaactacagaaatgttaagttcttctgaacagagc cttcagaacagagctttggagacattttctgctgttcctgtcacaacactctcttcattt caatctaccccaacttcatttccccagttgatcacaaccgaagcttccaaagctgaggtt ccagcagccagaggtgtagtgcccagtatcggtctcggcagtgtctctatatccattcca ccagagcctttcgttccagagtgtcaacatctagagaaacagcaacctaaagaaaatgga acgctgcctcttgttagtgatgccattgatttgcggacggtgcccaaactagaagttaaa gtaacagaaaaaggcctagatctttctgcttctgcagtggatgtgaagaggccgaccacc acaagtgaaatctatggacgacatattagtgctgttcaacccgctattatcaatctcagt gctacttcatcagttacaactccactctccgtggctactgagacagtgacctttgtcacg tacacacctagtgcaagttataccacaagcacagaaagccttgtgggtatagaacatgca acagtaacgcctctccagcttacaacttcaggtcaggctgaacctctgtacagggcaccg agcactcaggcttttccttctgttagagaggaagcaccaataaatttatctttaggcgtg tcagctgctacaaaacctgttactgtgcctcctgttggtatcacaaatggttggactgat agcagcaccacatcccaggggatcactgatggggaagtagtcgatcttagtacaacaaag tcccatagaactgttgtaacaatggatgaatctacttcaggtgtggtgaccaaaataata gaagatgatgaaaaacctgttgatctgaccgcaggaagaagagctgtgtgctgtgatgtg gtttataagttaccctttgggagaagttgtacatcccagcagcctgcaactactcttcct gaggatcgttttggttatagagatgaccactatcaatatggtcgctcggggccatatggt tatagaggtattgggggaatgaaaccttccatgtctgacactaatttagcagaagctgga cattttctctataagagtaagaatgcctttgattattctggaggaactgatgcagcagta gatctaacttcagggaaaattactacaggtgaggtaatggattattcaagcaagacaaca ggtccatatccagaaacacggcaagtcatttcaggagttgggattagtaccccacaatat tccacagcaagaatgactccacctccaggatcccagtatggtgtggggagcgttttcagg tcaactaatggtgttgtctattcttcagtggcaactccagtaccctccacatttgctatc accacacaacctggctccattttcagcactactgtgagggatctgtctggtgcacacacc actgatgcagtgacttcattatccaccctccatcaaagccagccaatgcctagatcatat ttcctaacaacaggtgcatctgaaacagacatcacagtaactggcattgatattaatgcc agtttgcagactattacaatggaaactctgaccgctgagacaatagactcagttcccact ttaaccacagcatctgaagtgttttctgaagtggctggagatgaaagtgctcttttagtg gtctccgaggaagataaacaacagcagcagctagacttggagcgagagctcttggaattg gagaaaattaagcaacagcgttttgctgaggaattggagtgggagcgtcaggaaatccaa aggttccgagaacaagaaaagatcatggttcaaaaaaaactggaggagctgcagtctatg aagcagcaccttctctatcagcaagaagaagaaaggcaagcccagttcatgatgaggcag gaaacattagctcagcagcagttgcagctggaacagatccaacagctgcagcagcagcta caccagcagctggaggaacaaaagatccgccagatctaccagtataactatgacccctct ggaaatgcttctccacaaaccacaacagaacaggcaattatggagggtcagtatactgct ccagagggcggtcagttttgggccacagaagatgcaaccaccacagcttcagctgttgtg gcaattgaaataccacaaagccaagggtggtacacggttcagtctgatggcattactcag tacattgccccgcctggcattctgagcactgtttcagaaatacctctaacagatgttgtg gtgaaagatgaaaaacaagccaaaaagagaagttccggggccaaggtccgtggacagtat gaagagatgggggaaagcacggctgacgatccccgctgttttaaaaagatcgtggacagt ggtgtgcagacggatgatgaagatgcaggtgatcgcaactatgcaagtaggagaagaaaa agcaaaaagagtgttgacacaagtgtccaaactgatgatgaagatcaggatgagtgggac atgcctactcgagcaaggaggaaagctcgggcagggaagtatggtgacggcactacggag gctgacaagaccaaacccctttccagagtctccagtatagcagttcaaacagtagcagag atatctgtacaaaccgagcctgtcggaaccataagaacaccttcgatacgggcgcgcgtg gatgccaaggtagaaataattaaacacatttcagcacccgaaaagacctacaaagggggc agtttaggatgtcaaacagaagcagattcagacacacaaagtcctcaatatctgagtgcc acatctccacccaaagacaagaaacgcccaacacctttagaaatcgggtactcatctcac ctccgggcagattccacacttcagctggctccttccccacccaaatctccaaaagtcctt tactcacccatctcaccactttcaccaggcaaagccttagaatcagcctttgtaccttat gagaaacccctccccgatgacataagtccacagaaagtgttgcatccagatatggctaaa gttcccccagcaagtcctaagacagccaagatgatgcagcggtctctgtcagaccccaag cctctgagtccaacagcagatgaaagttccagggctcctttccaatataccgagggctat acgacaaaaggttctcaaaccatgacaccatcaggcactcagaagaaagttaaaagaact ctgccaaacccacctcctgaagagacttccacaggaactcagtcaacctacagcacaatg ggcacagcctccagaagaaggatttgtagaaccaacaccatggcacgagcaaaaattctc caggatatagacagagaacttgatcttgtggagagagaatcagcaaagcttagaaagaaa caggcggaacttgatgaagaagaaaaggagatcgatgccaaattacggtacttggaaatg ggaattaatagaaggaaggaagcattactaaaggagagagaaaagagagagagagcttac cttcagggggtagctgaggatagggattatatgtctgacagtgaggtgagcagcacgaga cctacccgaatagaaagtcagcacggcatagagcgaccaagaacggctcctcaaactgaa ttcagccagttcatgccaccacaaacacaaacggaagctcagcttgttcctcctacaagt ccttatactcagtatcagtactcttcccctgctctccctacccaggcacccaccccgtac acccagcagtcccattttcagcaacaaactttatatcatcagcaagtttcaccttatcag actcagccaacattccaagccgtggcaacaatgtcctttacacctcaagctcaacctaca ccaactccacaaccatcttatcagttaccatcacagatgatggtaatacagcagaagccg aggcaaactacattatatttggagcccaagataacttcaaactatgaagttatccgcaac cagccactaatgatcgcacctgtttccactgatactacatacgctgtttcccatctgggc agcaagtataatagcttagacttgagaataggattggaggaaagaagtagcatggcaagc agcccaatatcaagcatatctgcagattccttttatgcagacattgaccaccatacccca cggaattatgtcttaatcgatgacattggagaaattaccaaagggacaacatcattaagc actacatttagtcttcatgagaaggatttgacaaagacagaccgtcttcttcgaaccacc gaggcacggaggtctcaagatgtgacagattttctagcacctttacagacttcctccaga ttgcatagttacgtgaaagctgaggaagatccaatggaggatccgtatgaattaaagctt ctgaaacagcagattaagcaagaattccggagaggggcagagagtttagatcacctggct ggactctcccattattaccatgctgatactagctatagacatttccccaaatctgaaaaa tatagcattagcaggctcacactagaaaaacaagcagcaaaacaattgccagcagccata ctttatcaaaagcaatcgaagcataagaaatcactaattgaccctaaaatgtcaaaattt tctcctattcaagaaagtagagaccttgaaccagactatacaagctatatgacttcgagc acttcttctattggtggcatttcttccagagcaaggctccttcaagatgatatcacattt ggcctcaggaaaaatattacggaccaacagaaatttatgggctcttctcttggctcaggg ctgggcacgttaggaaatactataagatctgctcttcaggatgaagcagataagccatac agtagtgggagtaggtcaagaccctcttccagaccttcctctgtctatggccttgattta tcaattaaaagagattcatccagctcttccctgagactcaaagctcaggaggctgaagcg ctagatgtttcctttagtcatgcatcatcctccagcagaactaagccgacaagtttgcca attagccagagcagaggaagaataccaattgtggcccagaattctgaagaagaaagtcca cttagtcctgttggccagccaatggggatggcaagggctgcagcaggacccttgccacca atatctgcagatacaagagatcagtttggatcaagtcattcattaccagaagttcagcaa cacatgagagaagaatcacgaactcgaggttatgaccgtgatatagcgttcatcatggat gacttccaacatgccatgtcagacagtgaagcctatcacttacgccgtgaagaaacggat tggtttgacaagcccagagaatctcgtttggatagtggacatggtctggatcgaaaactg cctgagagattagtccactctagaccacttagtcaacatcaagaacaaattatacagatg aatggaaagactatgcactacatttttcctcatgcaaggataaaaataacaagagattct aaggatcacacagtttcaggtaatggattaggaattagaattgtgggtggtaaagaaatc cctggacatagtggagaaatcggagcctatattgccaagattcttcctgggggaagtgca gaacagacagggaaacttatggaaggaatgcaagtattggaatggaatgggattccttta acttctaagacatatgaagaagttcagagtatcattaatcaacaaagtggggaagcagaa atatgtgtaagactggaccttagtatgctatcagattctgaaaatccccagcatttggaa ctgcatgaaccacccaaagctgtggacaaagccaaatcccctggggttgatcctaagcag ttagctgcagagctccagaaggtctctctgcagcagtcaccgctagtcaggtcttcagtg gttgaaaagggatcacatggtcattcaggccctacctcggcaggatccagttctgttcca agccctggtcaaccagggtctccttcagtgagcaaaaagaaacacagcagcagcaagcct actgatgcagcaaaggttgtttctcatccaattactggagaaattcagcttcaaatcaac tatgatcttggaaatcttataatacacatactccaagcaagaaaccttgtccctagagac aacaatggttattctgatccttttgttaaagtgtatcttcttccaggaagaggtcaagtc atggttgtccagaatgcaagtgccgagtataagagacgaactaagtatgttcaaaaaagt cttaatcctgagtggaaccaaacagtaatttataaaagtatctccatggaacagctcaag aagaaaacactggaggttacagtctgggattatgatcgtttttcttccaatgacttcctt ggcgaggtcttgattgatttatctagcacatctcatcttgataacactcctaggtggtat cctctcaaggaacagagtgaaagcattgaccatggaaagtcccattccagtcaaagcagt cagcagtccccaaagccatctgtcatcaaaagtagaagccatggtatcttccctgaccca tccaaggacatgcaggttcccaccattgagaaatcccatagtagtcctggtagctcgaaa tcctcatccgaaggccacctccgctctcatggaccatctcgcagtcaaagcaaaaccagc gtcactcagacccacctggaagacgcaggggctgctatagccgctgcagaggccgccgtg caacaactccgccttcaaccaacaaagccttccaatcaccggcctgcagaaagctccgca tccacaggctcctctggctgcagttttggcagtggatatagtgtggacgctgaaggaagc aacagcactgcaggggagactaatctatttcctattccaaggatagggaagatgggtcag aatgggctagagcctgtgaagcagccaggagtaggcctaggactgactgacactgaagtt aaaactcaggtaatgggagaaatcaagattgcactgaagaaggaaatgaagacagatggg gaacagctaatagttgaaattctccaatgcagaaatattacctacaagtttaaatcccct gatcacttaccagatttatatgtgaaaatatatgtgatgaatatttctacccaaaagaag gtgatcaagaaaaaaacaagagtatgtagacatgatcgagagccttcgttcaatgaaact ttcagattcagtctaagtcccgcagggcattcacttcagattttacttttctccaatgga gggaagtttatgaaaaagaccttgatcggtgaagcctgtatctggcttgacaaagtggat ctcagaaaaagaattgtcaactggcacaaacttttggtcagtcctactcaaacccattga

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