Sorex araneus (European shrew): 101548691 Help Entry 101548691         CDS       T07854                                  Symbol TLR4 Name (RefSeq) toll-like receptor 4   KO K10160   toll-like receptor 4 Organism sara  Sorex araneus (European shrew) Pathway sara04064   NF-kappa B signaling pathway sara04066   HIF-1 signaling pathway sara04145   Phagosome sara04151   PI3K-Akt signaling pathway sara04217   Necroptosis sara04613   Neutrophil extracellular trap formation sara04620   Toll-like receptor signaling pathway sara04621   NOD-like receptor signaling pathway sara04936   Alcoholic liver disease sara05132   Salmonella infection sara05133   Pertussis sara05134   Legionellosis sara05135   Yersinia infection sara05140   Leishmaniasis sara05142   Chagas disease sara05144   Malaria sara05145   Toxoplasmosis sara05146   Amoebiasis sara05152   Tuberculosis sara05161   Hepatitis B sara05162   Measles sara05164   Influenza A sara05170   Human immunodeficiency virus 1 infection sara05171   Coronavirus disease - COVID-19 sara05205   Proteoglycans in cancer sara05235   PD-L1 expression and PD-1 checkpoint pathway in cancer sara05321   Inflammatory bowel disease sara05323   Rheumatoid arthritis sara05417   Lipid and atherosclerosis Brite KEGG Orthology (KO) [BR:sara00001]  09130 Environmental Information Processing   09132 Signal transduction    04064 NF-kappa B signaling pathway     101548691 (TLR4)    04066 HIF-1 signaling pathway     101548691 (TLR4)    04151 PI3K-Akt signaling pathway     101548691 (TLR4)  09140 Cellular Processes   09141 Transport and catabolism    04145 Phagosome     101548691 (TLR4)   09143 Cell growth and death    04217 Necroptosis     101548691 (TLR4)  09150 Organismal Systems   09151 Immune system    04613 Neutrophil extracellular trap formation     101548691 (TLR4)    04620 Toll-like receptor signaling pathway     101548691 (TLR4)    04621 NOD-like receptor signaling pathway     101548691 (TLR4)  09160 Human Diseases   09161 Cancer: overview    05205 Proteoglycans in cancer     101548691 (TLR4)    05235 PD-L1 expression and PD-1 checkpoint pathway in cancer     101548691 (TLR4)   09172 Infectious disease: viral    05170 Human immunodeficiency virus 1 infection     101548691 (TLR4)    05161 Hepatitis B     101548691 (TLR4)    05171 Coronavirus disease - COVID-19     101548691 (TLR4)    05164 Influenza A     101548691 (TLR4)    05162 Measles     101548691 (TLR4)   09171 Infectious disease: bacterial    05132 Salmonella infection     101548691 (TLR4)    05135 Yersinia infection     101548691 (TLR4)    05133 Pertussis     101548691 (TLR4)    05134 Legionellosis     101548691 (TLR4)    05152 Tuberculosis     101548691 (TLR4)   09174 Infectious disease: parasitic    05146 Amoebiasis     101548691 (TLR4)    05144 Malaria     101548691 (TLR4)    05145 Toxoplasmosis     101548691 (TLR4)    05140 Leishmaniasis     101548691 (TLR4)    05142 Chagas disease     101548691 (TLR4)   09163 Immune disease    05323 Rheumatoid arthritis     101548691 (TLR4)    05321 Inflammatory bowel disease     101548691 (TLR4)   09166 Cardiovascular disease    05417 Lipid and atherosclerosis     101548691 (TLR4)   09167 Endocrine and metabolic disease    04936 Alcoholic liver disease     101548691 (TLR4)  09180 Brite Hierarchies   09182 Protein families: genetic information processing    04131 Membrane trafficking [BR:sara04131]     101548691 (TLR4)   09183 Protein families: signaling and cellular processes    04054 Pattern recognition receptors [BR:sara04054]     101548691 (TLR4)    04090 CD molecules [BR:sara04090]     101548691 (TLR4)    00536 Glycosaminoglycan binding proteins [BR:sara00536]     101548691 (TLR4) Membrane trafficking [BR:sara04131]  Endocytosis   Phagocytosis    Toll-like receptors     101548691 (TLR4) Pattern recognition receptors [BR:sara04054]  Membrane-bound pattern recognition receptors   Toll-like receptors    101548691 (TLR4) CD molecules [BR:sara04090]  Proteins   101548691 (TLR4) Glycosaminoglycan binding proteins [BR:sara00536]  Hyaluronan   Cell surface receptors    101548691 (TLR4) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  LRR_8 LRR_4 TIR LRR_1 TIR_2 LRR_9 LRR_Zer-1 LRR_NXF1-5 LRR_EndoS LRR_At5g56370 ThsB_TIR ANG-1 LRR_LRWD1 Motif Other DBs NCBI-GeneID:  101548691 NCBI-ProteinID:  XP_004615739 LinkDB All DBs Position Unknown AA seq 842 aa AA seqDB search MMPLTRLAGTLIPAMAFFSCLRSERWDPCVQVVPNITYQCMEKNLYRIPDNIPKSTKNLD LSFNPLKRLSSHSFSSFPELQVLDLSRCEIHVIEDDAYQGLNHLSALILTGNPIQSLAPG AFSGLSNLKKLVAVEINLASLEDFPISHIRSLKDLNVAHNFIHSFKFPDYFSNLPNLEKL DLCNNKIQNIYHEDLKVLRDIPLPKLSIDLSMNPLDFIQPDTFKEIKLRELIFRSSFRNS NIMKSCIQGLAGVKLDRLVLGEFRNIKMLELLEISTLEGLCNLTIGEVRIVHLREFPKDT TDIFNCFANASAIALVSLDLTQLRTFPKDFRWQQLEFVRCEFEEFPILRLTSLSKLVFTL SRGKMIFTDVYLPNLEYLDISRNGISYMHCCSKKQFGTTKLKYLDISFNGIISMNSNFVG LEQLEYLDVRYSHLKQANEFSMFSSLKSLIYLDISYTQTQVVFHGIFDGLISLQKLKMSG NSFLNNFLPNIFMQLANLTFLDLSNCQLEQVSSVAFDSLPRLQLLNMSHNNLKELDTLPY ESLSNLHVLDYSFNRIVASTVQKLHQFPSNLTFLNLTQNNFACVCEHKSFLQWIKDQKKL LVATDQMLCKSPLNMQGMPVLNFKNSTCQMSNVVISLLVLTVLAVAVVLLLLYKFYFHLM LLAGCKTYGRGESVYDAFVIYSSQDEDWVRNELVKNLEEGVPRFQLCLHYRDFIPGVAIA ANIIQEGFHKSRKVIVVVSQHFIQSRWCIFEYEIAQTWQFLSSRRAGIIFIVLHKLEKSL LKQQVELYRLLSRNTYLEWEDSVLGRHIFWRRLRKALLDGKTWVPEETEDAEDSQHEAED PT NT seq 2529 nt NT seq  +upstreamnt  +downstreamnt atgatgcctctcacacgcctggctgggactctgatcccagccatggctttcttctcctgt ctgagatcggagaggtgggacccttgcgtgcaggtggttcctaatatcacataccaatgc atggagaagaatctttacagaatccctgacaacattcctaaatcaaccaagaatttggac ctgagctttaatccgctgaagcgtttaagtagtcatagcttctccagcttcccagaactg caggtgctggatttaagcaggtgtgaaattcacgttattgaagatgatgcctatcaaggg ttaaaccacctgtctgccttgatattgacaggaaaccccattcagagtttagcccctgga gccttttcaggactatcaaacttaaagaagctggtggctgtggagatcaacctagcatct ctagaggattttcccattagtcatatcagaagcttgaaggacttgaatgtggctcataat ttcatccattccttcaaattccctgattatttttctaacttgcccaacctggagaaattg gacctttgcaataacaagatccaaaatatttatcatgaagatttaaaagttctacgtgac atacctctgcccaaactttctatagacttgtctatgaaccctttagactttatacagcca gatacttttaaagagattaaactccgtgagttgattttcagaagtagttttaggaatagc aatataatgaaaagttgcattcaagggctggctggtgtaaaacttgataggttggttctg ggagaatttagaaatataaagatgttggaacttctagaaatatctacactagaggggttg tgcaacttaaccattggggaagttcgaattgtacatttgagagaattcccaaaggatact actgatatatttaattgttttgcaaatgcttctgccatagctttagtgagtttggattta actcaattaagaacatttcctaaagatttcaggtggcagcaattagaatttgttcgttgt gaatttgaagaatttcccatattaaggctgacatctctcagtaagttagtttttactctc agtagaggtaagatgatatttactgatgtttatctaccaaaccttgaatatctagatatt agtcgaaatggcatcagttatatgcattgctgttctaaaaaacaatttgggacaaccaaa ctgaagtatttagatataagcttcaatggcattatttccatgaattcaaacttcgtgggc ttagagcaactagaatatctagatgtccggtattcccatttgaaacaggccaatgaattt tcaatgttttcatccctaaagagtctcatttaccttgatatttcttatactcaaacccaa gttgttttccatggtatctttgatgggctaattagcctccaaaagttaaaaatgtctggt aattcttttctaaacaacttccttccgaatattttcatgcaactggctaacttgaccttt ctggacctttctaactgtcaactggaacaggtgtcctcagtggcatttgactcactgcct agacttcaattactaaatatgagtcacaacaacctcaaggaacttgacacacttccttat gaatctctcagcaacctgcatgttctagattacagttttaatcgcattgtggcttccaca gtacaaaaattgcatcagttcccaagtaatctcactttcttaaatctcactcaaaacaac tttgcttgtgtctgtgaacacaagagtttccttcagtggatcaaggaccagaagaaactc ttggtggctactgatcaaatgctgtgcaagtcacctttaaatatgcagggcatgcctgtg ctgaattttaaaaactcaacatgtcagatgagcaatgttgttatcagtctgttggttctc actgtacttgctgtagccgtggttttacttcttctctataagttctattttcacctgatg cttcttgctggctgcaaaacatatggccgaggtgaaagtgtttatgatgcctttgttatc tattcaagccaggatgaggactgggtgaggaatgaattggtgaagaatttggaggaaggg gtgccccgatttcaactctgccttcactatagagactttatacctggtgtggccattgct gccaacatcatccaggaaggtttccataaaagccggaaggttatcgttgtggtgtctcag cacttcatccagagccgatggtgtatctttgagtatgaaatagcccagacctggcaattt ctgagcagccgccgtgctggcatcatcttcattgtcctgcataaactagaaaagtctctg cttaagcagcaggtcgagctgtatcgtcttcttagcaggaatacatacctggaatgggag gacagtgtcttggggcgccacatcttttggagacgactcaggaaagctctcctggatggt aaaacttgggttccagaagaaacagaggatgcagaagacagccagcatgaagccgaagac cccacctaa

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