Sorex araneus (European shrew): 101549131 Help Entry 101549131         CDS       T07854                                  Symbol ADCY6 Name (RefSeq) adenylate cyclase type 6   KO K08046   adenylate cyclase 6 [EC:4.6.1.1] Organism sara  Sorex araneus (European shrew) Pathway sara00230   Purine metabolism sara01100   Metabolic pathways sara01522   Endocrine resistance sara04015   Rap1 signaling pathway sara04022   cGMP-PKG signaling pathway sara04024   cAMP signaling pathway sara04062   Chemokine signaling pathway sara04072   Phospholipase D signaling pathway sara04081   Hormone signaling sara04082   Neuroactive ligand signaling sara04114   Oocyte meiosis sara04211   Longevity regulating pathway sara04213   Longevity regulating pathway - multiple species sara04261   Adrenergic signaling in cardiomyocytes sara04270   Vascular smooth muscle contraction sara04371   Apelin signaling pathway sara04540   Gap junction sara04611   Platelet activation sara04713   Circadian entrainment sara04714   Thermogenesis sara04723   Retrograde endocannabinoid signaling sara04724   Glutamatergic synapse sara04725   Cholinergic synapse sara04727   GABAergic synapse sara04742   Taste transduction sara04750   Inflammatory mediator regulation of TRP channels sara04911   Insulin secretion sara04912   GnRH signaling pathway sara04913   Ovarian steroidogenesis sara04914   Progesterone-mediated oocyte maturation sara04915   Estrogen signaling pathway sara04916   Melanogenesis sara04918   Thyroid hormone synthesis sara04921   Oxytocin signaling pathway sara04923   Regulation of lipolysis in adipocytes sara04924   Renin secretion sara04925   Aldosterone synthesis and secretion sara04926   Relaxin signaling pathway sara04927   Cortisol synthesis and secretion sara04928   Parathyroid hormone synthesis, secretion and action sara04934   Cushing syndrome sara04935   Growth hormone synthesis, secretion and action sara04961   Endocrine and other factor-regulated calcium reabsorption sara04962   Vasopressin-regulated water reabsorption sara04970   Salivary secretion sara04971   Gastric acid secretion sara04972   Pancreatic secretion sara04976   Bile secretion sara05032   Morphine addiction sara05163   Human cytomegalovirus infection sara05166   Human T-cell leukemia virus 1 infection sara05200   Pathways in cancer sara05207   Chemical carcinogenesis - receptor activation sara05414   Dilated cardiomyopathy Brite KEGG Orthology (KO) [BR:sara00001]  09100 Metabolism   09104 Nucleotide metabolism    00230 Purine metabolism     101549131 (ADCY6)  09130 Environmental Information Processing   09132 Signal transduction    04015 Rap1 signaling pathway     101549131 (ADCY6)    04371 Apelin signaling pathway     101549131 (ADCY6)    04072 Phospholipase D signaling pathway     101549131 (ADCY6)    04024 cAMP signaling pathway     101549131 (ADCY6)    04022 cGMP-PKG signaling pathway     101549131 (ADCY6)   09133 Signaling molecules and interaction    04082 Neuroactive ligand signaling     101549131 (ADCY6)    04081 Hormone signaling     101549131 (ADCY6)  09140 Cellular Processes   09143 Cell growth and death    04114 Oocyte meiosis     101549131 (ADCY6)   09144 Cellular community - eukaryotes    04540 Gap junction     101549131 (ADCY6)  09150 Organismal Systems   09151 Immune system    04611 Platelet activation     101549131 (ADCY6)    04062 Chemokine signaling pathway     101549131 (ADCY6)   09152 Endocrine system    04911 Insulin secretion     101549131 (ADCY6)    04923 Regulation of lipolysis in adipocytes     101549131 (ADCY6)    04912 GnRH signaling pathway     101549131 (ADCY6)    04913 Ovarian steroidogenesis     101549131 (ADCY6)    04915 Estrogen signaling pathway     101549131 (ADCY6)    04914 Progesterone-mediated oocyte maturation     101549131 (ADCY6)    04921 Oxytocin signaling pathway     101549131 (ADCY6)    04926 Relaxin signaling pathway     101549131 (ADCY6)    04935 Growth hormone synthesis, secretion and action     101549131 (ADCY6)    04918 Thyroid hormone synthesis     101549131 (ADCY6)    04928 Parathyroid hormone synthesis, secretion and action     101549131 (ADCY6)    04916 Melanogenesis     101549131 (ADCY6)    04924 Renin secretion     101549131 (ADCY6)    04925 Aldosterone synthesis and secretion     101549131 (ADCY6)    04927 Cortisol synthesis and secretion     101549131 (ADCY6)   09153 Circulatory system    04261 Adrenergic signaling in cardiomyocytes     101549131 (ADCY6)    04270 Vascular smooth muscle contraction     101549131 (ADCY6)   09154 Digestive system    04970 Salivary secretion     101549131 (ADCY6)    04971 Gastric acid secretion     101549131 (ADCY6)    04972 Pancreatic secretion     101549131 (ADCY6)    04976 Bile secretion     101549131 (ADCY6)   09155 Excretory system    04962 Vasopressin-regulated water reabsorption     101549131 (ADCY6)    04961 Endocrine and other factor-regulated calcium reabsorption     101549131 (ADCY6)   09156 Nervous system    04724 Glutamatergic synapse     101549131 (ADCY6)    04727 GABAergic synapse     101549131 (ADCY6)    04725 Cholinergic synapse     101549131 (ADCY6)    04723 Retrograde endocannabinoid signaling     101549131 (ADCY6)   09157 Sensory system    04742 Taste transduction     101549131 (ADCY6)    04750 Inflammatory mediator regulation of TRP channels     101549131 (ADCY6)   09149 Aging    04211 Longevity regulating pathway     101549131 (ADCY6)    04213 Longevity regulating pathway - multiple species     101549131 (ADCY6)   09159 Environmental adaptation    04713 Circadian entrainment     101549131 (ADCY6)    04714 Thermogenesis     101549131 (ADCY6)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     101549131 (ADCY6)    05207 Chemical carcinogenesis - receptor activation     101549131 (ADCY6)   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     101549131 (ADCY6)    05163 Human cytomegalovirus infection     101549131 (ADCY6)   09165 Substance dependence    05032 Morphine addiction     101549131 (ADCY6)   09166 Cardiovascular disease    05414 Dilated cardiomyopathy     101549131 (ADCY6)   09167 Endocrine and metabolic disease    04934 Cushing syndrome     101549131 (ADCY6)   09176 Drug resistance: antineoplastic    01522 Endocrine resistance     101549131 (ADCY6) Enzymes [BR:sara01000]  4. Lyases   4.6  Phosphorus-oxygen lyases    4.6.1  Phosphorus-oxygen lyases (only sub-subclass identified to date)     4.6.1.1  adenylate cyclase      101549131 (ADCY6) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  Guanylate_cyc AC_N Adcy_cons_dom HNOBA TBK1_ULD GBR2_CC Motif Other DBs NCBI-GeneID:  101549131 NCBI-ProteinID:  XP_004616974 LinkDB All DBs Position Unknown AA seq 1166 aa AA seqDB search MSWFGGLLVPKVDERKTAWGERNGQKRGHRGTRTGGFCTPRMSCLQDAQPPSPTPAVPPR CPWQGEAFTRRGGPGKGTELGLRAVALGFEDTETTSVAGATEVVPEVATRSGHSCWRRLV RVFQSKQFRSAKLERLYQRYFFQMNQSSLTLLMAVLVLLMAVLLAFHAAPARPQPAYVAL LACAAALFVALMVVCNRHSFRQDSMWVVSYVVLGILATVQVGGALAADPHSPSVGLWGPV FFVYITYTLLPIRMRAAVLSGLGLSTLHLILAWQLNRGDAFLWKQLGANVLLFLCTNVIG ICTHYPAEVSQRQAFQETRGYIQARLHLQHENRQQERLLLSVLPQHVAMEMKEDINTKKE DMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRI KILGDCYYCVSGLPEARTDHAHCCVEMGVDMIEAISLVREVTGVNVNMRVGIHSGRVHCG VLGLRKWQFDVWSNDVTLANHMEAGGRAGRIHITRATLQYLNGDYEVEPGRGGERNAYLK EQHIETFLILGASQKRKEEKAMLAKLQRTRANSMEGLGPRWVPDRAFARTKDSKAFRQMG IDDSSKDNRGAQDALNPEDEVDEFLGRAIDARSIDQLRKDHVRRFLLTFQRADLEKKYSR KVDPRFGAYVACALLVFCFIAFIQLLVFPHSALMLGVYAAIFVLLLLTVLACAVYSCGSL FPAALRRLSRSIVRSRAHSTAVGIFSVLLVFASTVASMFTCDHTPIRTCAAQLLNVTPEA VTACHLQQLNYSLGQEAPLCEGPGPTCSFPEYFVGNVLLSLLASSVFLHISSIGKLAMTF VLGLIYLVLLLLGPPATVFDNYDLLLGVHGLASSNETFSGPDCPVTGRVALKYMTPVILL VFALALYLHAQQVESTARLDFLWKLQATGEKEEMEELQAYNRRLLHNILPKDVAAHFLAR ERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIISEER FRQLEKIKTIGSTYMAASGLNASTYDQVGRSHVTALADYAMRLMEQMKYINEHSFNNFQM KIGLNMGPVVAGVIGARKPQYDIWGNTVNVSSRMDSTGVPDRIQVTTDLYQVLAAKGYQL ECRGVVKVKGKGEMTTYFLNGGPSSS NT seq 3501 nt NT seq  +upstreamnt  +downstreamnt atgtcatggtttggtggtctcctggtacccaaagtggacgagcggaaaacagcctggggc gaacgcaatgggcagaagcgtgggcaccgtggaactcggacgggtggcttttgcacgcct cgcatgagctgcctccaggatgcacagccgccgagccctacccctgccgtgccccctcgc tgcccctggcagggggaagccttcacccggaggggcggcccaggcaaaggcacagagctg ggcctgcgggccgtggccctgggctttgaagatacagagaccacatcggtggctggggcc accgaggtggtgcccgaggtggccaccaggagcgggcattcgtgctggcgccggttggtg cgggtgttccagtcgaagcagttccgctcggccaagctggagcgcctgtaccagcgctac ttcttccagatgaaccagagcagcctgacgctgctcatggcggtgctcgtgctgctcatg gctgtgctgctggccttccacgccgcgccggcgcgtccccagccggcctacgtggccctg ctggcctgtgccgcggccctcttcgtggcactcatggtggtgtgcaaccgacacagcttc cgccaggactccatgtgggtggtgagctacgtggtgctgggcatcctggcgacagtgcag gtggggggcgccttagcagctgacccccacagtccttctgtgggtctctgggggcccgtg ttctttgtctacatcacctacacgctcctgcccatccgcatgcgggcagctgtcctgagc ggcttgggcctctccacgctacacctgatcctggcctggcagctgaaccggggcgacgcc ttcctctggaagcagctcggggccaacgtgctactgttcctctgcaccaatgtcatcggc atctgcacacactaccctgccgaggtgtcccagcgccaggccttccaggagacccgcggc tacatccaggcccggctccacctgcagcatgagaatcggcagcaggagcggctgctgctg tccgtgttaccccagcatgttgccatggaaatgaaagaagacatcaacacaaagaaagag gacatgatgttccacaagatctacatccagaagcatgacaatgtcagcatcctgtttgca gacatcgagggcttcaccagcctggcatcccagtgcaccgcgcaggagctggtcatgacc ctcaatgagctctttgcccggtttgacaagctggccgcggagaatcactgcctgaggatc aagatcctgggggactgttactactgtgtgtcagggctgcccgaggctcgcacggaccat gcccactgctgcgtggagatgggggtggacatgatcgaggccatctcactggtgcgtgag gtgacgggcgtgaatgtcaacatgcgagtaggcatccacagcgggcgtgtgcactgcgga gtcctgggcctgcggaagtggcagtttgacgtgtggtccaacgatgtgacgctggccaac cacatggaggctgggggccgcgctggccgtatccacatcactcgggccacgctgcagtac ctgaacggggactatgaggtggagccaggccggggcggcgagcgcaatgcctacctcaag gagcagcacatcgagaccttcctcatcctgggggccagtcagaagcggaaggaggagaag gccatgctggccaagctgcagcggactcgggccaactccatggaggggctggggccgcgc tgggtgcccgaccgcgccttcgcccgtaccaaggactccaaggcgttccgccagatgggc atagatgattccagcaaagacaaccggggtgcccaagatgccttgaaccctgaggatgag gttgatgagttcctgggccgggccatcgacgcccgcagcatcgatcagctgcggaaggac cacgtgcgccggtttctgctcaccttccagagggcggacctggagaagaagtactctcgc aaggtggacccacgcttcggcgcctacgtggcctgcgccttgctggtgttctgtttcatc gccttcatccagctcctcgtcttcccacactccgccctgatgctcggggtctacgcagcc atcttcgtcctgctgctgctcacggtgctggcctgtgccgtctactcctgcggctctctc ttccccgcggccttgcggcgcctgtcccgaagcatcgtccgttcgcgcgcgcacagcacg gccgtcggcatcttctcggtgctgcttgtgttcgcctccacggttgccagcatgttcacc tgtgaccacacccccatccgcacgtgcgcggcccagctcctgaacgtgacacccgaagct gtcaccgcctgccacctgcagcagctcaattactctctgggccaggaggcgccgttatgc gagggcccggggcccacctgcagctttcccgagtactttgttgggaatgtgctgctgagt ctcttggccagttccgtgttcctgcacatcagcagcatcgggaagctggccatgaccttt gtcctggggctcatctatttggtgctgcttctgctggggcccccggctactgtcttcgac aactatgacctgctgctcggcgtccatggcttggcttcttccaacgagaccttcagcggc ccagactgccccgtgacagggagggtggcactcaaatatatgacccctgtgattctgctg gtgtttgccttggcgctgtatctgcatgcccagcaggtagaatctaccgcccgcctggac ttcctctggaaactgcaggctacaggtgagaaggaggagatggaggagctccaggcgtat aaccggaggctgctgcataacattttgcccaaggacgtggctgcacacttcctggcccgg gagcgcaggaacgacgagctctactatcagtcctgcgagtgcgtggcggtcatgttcgcc tccattgccaacttctccgagttctacgtggagctggaggccaacaacgagggtgtggag tgtctgcggctgctcaatgagatcatcgctgactttgatgagattatcagcgaggagcga tttcggcagctggagaagattaagacgatcgggagcacatacatggccgcctcagggctg aacgccagcacctacgaccaggtgggccgctcccacgtcactgccctggctgactacgcc atgcgactcatggagcaaatgaagtacatcaatgagcactccttcaacaacttccagatg aagattgggctgaacatgggccctgtggtggcaggtgtcatcggggcccggaagccgcag tatgacatctggggaaacacagtgaatgtgtctagtcgtatggacagcacgggtgtccct gaccgaattcaggtgaccacagacctgtaccaggtcctcgctgccaaaggctaccagctg gagtgtcgaggggtggtcaaggtgaaaggcaagggcgagatgaccacttacttcctcaat ggaggccccagcagctcatga

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