KEGG   Sorex araneus (European shrew): 101552331
Entry
101552331         CDS       T07854                                 
Symbol
MET
Name
(RefSeq) hepatocyte growth factor receptor isoform X1
  KO
K05099  proto-oncogene tyrosine-protein kinase Met [EC:2.7.10.1]
Organism
sara  Sorex araneus (European shrew)
Pathway
sara01521  EGFR tyrosine kinase inhibitor resistance
sara04010  MAPK signaling pathway
sara04014  Ras signaling pathway
sara04015  Rap1 signaling pathway
sara04020  Calcium signaling pathway
sara04151  PI3K-Akt signaling pathway
sara04360  Axon guidance
sara04510  Focal adhesion
sara04520  Adherens junction
sara05100  Bacterial invasion of epithelial cells
sara05144  Malaria
sara05200  Pathways in cancer
sara05202  Transcriptional misregulation in cancer
sara05205  Proteoglycans in cancer
sara05206  MicroRNAs in cancer
sara05208  Chemical carcinogenesis - reactive oxygen species
sara05211  Renal cell carcinoma
sara05218  Melanoma
sara05223  Non-small cell lung cancer
sara05225  Hepatocellular carcinoma
sara05226  Gastric cancer
sara05230  Central carbon metabolism in cancer
Brite
KEGG Orthology (KO) [BR:sara00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    101552331 (MET)
   04014 Ras signaling pathway
    101552331 (MET)
   04015 Rap1 signaling pathway
    101552331 (MET)
   04020 Calcium signaling pathway
    101552331 (MET)
   04151 PI3K-Akt signaling pathway
    101552331 (MET)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    101552331 (MET)
   04520 Adherens junction
    101552331 (MET)
 09150 Organismal Systems
  09158 Development and regeneration
   04360 Axon guidance
    101552331 (MET)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    101552331 (MET)
   05202 Transcriptional misregulation in cancer
    101552331 (MET)
   05206 MicroRNAs in cancer
    101552331 (MET)
   05205 Proteoglycans in cancer
    101552331 (MET)
   05208 Chemical carcinogenesis - reactive oxygen species
    101552331 (MET)
   05230 Central carbon metabolism in cancer
    101552331 (MET)
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    101552331 (MET)
   05226 Gastric cancer
    101552331 (MET)
   05218 Melanoma
    101552331 (MET)
   05211 Renal cell carcinoma
    101552331 (MET)
   05223 Non-small cell lung cancer
    101552331 (MET)
  09171 Infectious disease: bacterial
   05100 Bacterial invasion of epithelial cells
    101552331 (MET)
  09174 Infectious disease: parasitic
   05144 Malaria
    101552331 (MET)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    101552331 (MET)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:sara01001]
    101552331 (MET)
Enzymes [BR:sara01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     101552331 (MET)
Protein kinases [BR:sara01001]
 Receptor tyrosine kinases (RTK)
  MET family
   101552331 (MET)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr TIG Pkinase Sema PSI Kinase-like Pkinase_fungal
Other DBs
NCBI-GeneID: 101552331
NCBI-ProteinID: XP_004602131
LinkDB
Position
Unknown
AA seq 1382 aa
MKAPAVLAPGVLVLLFTLVQRSEGECREALVKSEMNVNMKYQLPNFTAETPIQHVVLHKH
HIYLGAVNSLYVLNDKDLQKVAEYKTGPVLEHPDCLPCQDCHHKANSSGGIWKDNVNMAL
LVDTYYDDQLISCGSVHRGTCQRHVLPPDNTADIHSEVHCMYSSQADEEPNQCPDCVVSA
LGTKVLLSEKERFINFFVGNTINSSYPPNHSLHSISVRRLKETQDGFKFLTDQSYIDVLP
EFRDSYPVKYIHAFESNHFIYFLTVQRETLDAQTFHTRIIRFCSTDSGLHSYMEMPLECI
LTEKRRKRATREEVFNILQAAYVSKPGAHLAKQIGANPNDDILYGVFAQSKPDSAEPMNR
SAVCAFPIKYVNEFFNKIVNKNNVRCLQHFYGPNHEHCFNRTLLRNSSGCEARSDEYRTE
FTTALQRVDLFMGQFNQVLLTSISTFIKGDLTIANLGTSEGRFMQVVVSRSGSSTPHVNF
LLDSHPVSPEVIVEHSSEQDGYTLVVTGKKITKIPLNGLGCEHFQSCSQCLSAPAFVQCG
WCQDKCVQVEGCPSGTWTQETCLPTIYKVFPTSAPLEGGTTLTVCGWDFGFRRNNKFDLK
KTKVLLGNESCTLTLSESTTNMLKCTVGPSINEHFNMSLTVSNGREAAQYSTFSYVDPII
TSISPSYGPQTGSTLLTLTGKYLNSGNSRHISIGGKTCTLKSVSDSTLECYTPAQTTSTE
FPVKLKIDLANRETDSFSYRDDPIVYEIHPTKSFISGGSTITGVGKNLDSVSVLRMVITV
HEAGRNFTVACQHRSNSEIICCTTPSLQQLNLQLPLTTKAFFMLDGIHSKYFDLIYVHNP
VFKPFEKPVKISIGNENVLEIKGNDIDPEAVKGEVLKVGNKSCENIHSYSETVLCTVPND
LLKLNSELNIEWKQAVSSTILGKVVVQPDQNLTGMIVGIVLISVMLLLLLGLFLWWKKRK
QIKDLGSELVRYDARVHTPHLDRLVSARSVSPTTEMVSNESVDYRATFPEDQFPNSSQNG
SCRQVQYPLTDLSPILTSGDSDISSPLLQNSVHIDLSALNPELVQAVQHVVIGPSSLIVH
FNEVIGRGHFGCVYHGTLLDNDDKKIHCAVKSLNRITDIEEVSQFLTEGIIMKDFSHANV
LSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHSPTVKDLIGFGLQVAKGMKYLASKK
FVHRDLAARNCMLDENFTVKVADFGLARDIYDKEYYSVHNKTGAKLPVKWMALESLQTQK
FTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITIYLLQGRRLLQPEYCPDPLYEVMLKC
WHPKAELRPSFSELVSRISGIFSTFIGEHYVHVNTTYVNVKCVAPYPSLLSSQGNVEGQG
DT
NT seq 4149 nt   +upstreamnt  +downstreamnt
atgaaagcccctgctgtgcttgcacctggcgtccttgtgcttctgtttaccttggtgcag
aggagtgaaggggaatgcagagaagcgctggtgaagtcggagatgaatgtgaacatgaag
tatcagcttcccaacttcactgccgagacgcccatccagcatgtggttctgcataagcat
catatttacctcggggctgtgaactccctttatgttttaaacgacaaagacctgcagaag
gttgccgaatacaaaacaggcccggtgctggaacacccagactgcttgccctgccaggac
tgccaccacaaagccaattcatcaggtggcatttggaaagataacgtcaacatggcactg
cttgttgacacatactacgatgaccagctcattagctgtggcagcgtccacagagggacc
tgccagcgacacgtgctgcccccggacaatactgctgacatccactcggaggttcactgc
atgtactcctcacaggcggacgaagagccgaaccagtgtcccgactgcgtggtgagcgcc
ctgggaaccaaagtcctgctgtcggagaaggagcgtttcatcaacttctttgtgggcaac
actatcaactcttcttatcctcccaatcattccttgcattctatctccgtgagacggctg
aaggaaacgcaagatggtttcaagttcttgacagaccagtcctatattgatgtcctgcct
gagttccgagactcttaccccgttaagtacatccatgccttcgagagcaaccatttcatt
tacttcctgacagtccagcgggaaacgctggatgctcagactttccacacgagaataatc
aggttctgttccacagactccgggttgcattcttacatggagatgcctctggagtgtatt
ctcacagagaagagaagaaagagggccacaagggaggaagtgttcaatattctccaagct
gcgtatgtcagtaaacccggggcccatctcgctaagcaaataggtgccaacccgaatgat
gacattctctacggggtgtttgcccagagcaagccggattctgccgagccgatgaaccgc
tctgcagtctgtgcattccctatcaagtatgtcaatgaattcttcaacaagattgtcaac
aaaaacaatgtgaggtgtctccagcacttctatggacccaaccacgagcactgctttaac
agaacgcttttaagaaattcatcgggctgtgaagcacgcagtgatgaatatcggacagag
tttaccacggctttgcagcgagttgacttattcatgggccagttcaaccaagtcctccta
acctctatatccaccttcattaaaggagatctcaccatcgcaaatcttggcacttcagag
ggtcgcttcatgcaggttgtggtttcccgatcgggatcatcaactcctcatgtgaatttc
ctcctggattcccaccctgtgtctccagaagtgattgtagaacactcctcggaacaagat
ggttacacattagttgtcacggggaagaagatcaccaagatcccgctgaacggcctgggc
tgtgagcattttcagtcctgcagtcagtgtctctctgcccctgcctttgtgcagtgtggc
tggtgccaggataaatgtgtgcaagtggagggatgccccagtggaacgtggactcaagag
acctgtctgccgacaatctacaaggttttcccaaccagtgcacctcttgaaggaggaaca
acattgacagtatgtggctgggactttggattccggaggaataataaatttgatctaaag
aaaaccaaggttctccttggaaatgagagctgcacgttaaccttgagtgagagcacaaca
aatatgttaaaatgcacagttggtccttcaatcaatgaacattttaatatgtcactaact
gtttcaaatggtcgagaggctgcacaatatagtacattttcttatgttgatcccataata
acaagtatttctccaagttatggccctcagactggcagtactttacttactttaactgga
aaatacctcaacagtggaaattctagacacatttcaattggtggaaagacgtgtacctta
aaaagtgtgtcagatagcactctcgagtgttataccccagcccaaaccacttcaactgag
tttccagttaaactgaaaattgacttagccaaccgagagacggacagcttcagttaccgg
gatgaccccattgtctatgaaattcacccaaccaaatcttttatcagtggtgggagcaca
ataacaggtgttggaaaaaatctggattcggtgagtgtcctgaggatggtgataaccgta
cacgaagcaggaaggaactttacagtggcatgtcaacatcgctctaattcagagataatc
tgctgtaccactccttcattgcaacagctgaatctgcagctccccctgacaaccaaggcc
tttttcatgttagatgggatccattccaaatactttgatctcatttatgtacataatccc
gtgtttaagccttttgaaaagccagtgaagatctcaataggcaatgaaaatgtactggaa
attaaggggaatgatattgaccctgaagcagttaaaggtgaagtgctaaaagtcggaaat
aagagctgtgagaatattcactcatattctgaaaccgttttatgtacagtccccaatgac
ctgttgaaattgaacagtgagttaaatatagagtggaagcaagcagtttcttcaactatt
cttggaaaagttgtagttcaaccagatcagaatctcacgggaatgattgttggtattgtt
ttaatatcagtaatgctcttactactacttggccttttcctgtggtggaaaaagagaaag
caaattaaagatctgggcagtgaattagttcgctatgatgcaagagtacacactcctcat
ttggataggcttgtaagtgcccgaagtgtaagcccaactacagaaatggtttcaaatgaa
tctgtagactacagagctacttttccagaagaccagtttcctaactcatctcagaacgga
tcttgcagacaagttcagtatcctctgacggacctatcccccatcctcactagtggggat
tctgatatatccagtccattactgcaaaatagtgtccacattgacctcagtgctctaaat
ccagagctggtccaggcagtgcagcacgtagtaattgggcccagcagcttgattgtgcat
ttcaatgaagtcataggaagaggacattttgggtgtgtgtatcatggaaccttgctggac
aatgatgacaagaaaatccattgtgctgtgaagtccttgaatagaatcactgacatagaa
gaagtgtctcagtttctgactgagggcatcattatgaaagatttcagccatgccaatgtt
ctctcactgttgggaatctgcctgcgaagtgaggggtctccactggtggttctaccatat
atgaaacatggagatcttcgaaatttcattagaaatgagactcatagtccaactgtaaaa
gatctcattggctttggtcttcaagtagccaaaggcatgaaatatcttgcaagcaaaaag
tttgtccacagagacttggctgcaagaaactgtatgttggatgagaatttcactgttaag
gttgctgattttggtcttgccagagatatatatgataaggaatactatagtgtccacaac
aaaacaggagcgaaactgccagtgaagtggatggctttagaaagtctacaaactcagaag
ttcaccaccaagtcagatgtgtggtcctttggtgtgctcctctgggagctgatgacaaga
ggggcaccgccttatccagacgtcaatacatttgacatcacaatctacttgttgcaaggc
aggaggctcttacaacctgaatactgcccagatcccttgtatgaagtgatgttaaaatgc
tggcaccctaaagctgaactgcgcccatccttctctgaactggtctccaggatatcgggg
atattctccactttcatcggggaacattatgtccatgtgaacactacttatgtgaatgtc
aagtgtgtcgctccctatccttctcttttgtcctcacaaggtaatgttgaaggccagggg
gacacatga

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